Currently, Protegen includes 1371 protective antigens for 216 pathogens or host organisms (e.g., human, mouse). These protective antigens have been proven to induce protection against infectious diseases or non-infectious diseases (e.g., cancer, allergy). The detailed curated data is shown below:
Index | Pathogen Name | Disease | No. of Protective Antigens |
Bacteria | |||
G+ Bacteria | |||
1 | Bacillus anthracis | Anthrax | 14 |
2 | Clostridium botulinum | Botulism | 10 |
3 | Clostridium perfringens | Food poisioning, Gas gangrene | 0 |
4 | Clostridium tetani | Tetanus | 1 |
5 | Corynebacterium diphtheriae | Diphtheria | 1 |
6 | Erysipelothrix rhusiopathiae | Erysipelas | 1 |
7 | Listeria monocytogenes | Listeriosis | 2 |
8 | Mycobacterium avium | 0 | |
9 | Mycobacterium bovis | Tuberculosis | 1 |
10 | Mycobacterium marinum | 1 | |
11 | Mycobacterium tuberculosis | Tuberculosis | 26 |
12 | Staphylococcus aureus | Staph infections | 29 |
13 | Streptococcus agalactiae | Group B streptococcus (GBS) infection | 22 |
14 | Streptococcus equi | Strangles (also equine distemper) | 17 |
15 | Streptococcus pneumoniae | Pneumonia | 26 |
16 | Streptococcus pyogenes | Group A streptococcal infections, Strep throat, Scarlet fever | 44 |
17 | Streptococcus suis | 0 | |
G- Bacteria | |||
18 | Actinobacillus pleuropneumoniae | porcine pleuropneumonia | 20 |
19 | Aeromonas hydrophila | 0 | |
20 | Aeromonas salmonicida | Furunculosis, Bald sea urchin disease | 3 |
21 | Bordetella avium | Bordetellosis | 0 |
22 | Bordetella bronchiseptica | Infectious bronchitis, kennel cough | 0 |
23 | Bordetella pertussis | Whooping Cough | 11 |
24 | Borrelia burgdorferi | Lyme Disease | 11 |
25 | Brucella spp. | Brucellosis | 26 |
26 | Burkholderia pseudomallei | Melioidosis | 13 |
27 | Campylobacter fetus | bovine venereal campylobacteriosis (BVC) | 0 |
28 | Campylobacter jejuni | Campylobacterosis | 19 |
29 | Chlamydia muridarum | 15 | |
30 | Chlamydia trachomatis | Chlamydia | 14 |
31 | Chlamydophila abortus | Abortion and fetal death | 12 |
32 | Chlamydophila pneumoniae | Pneumonia | 14 |
33 | Chlamydophila psittaci | Respiratory psittacosis, avian chlamydiosis | 4 |
34 | Coxiella burnetii | Q fever | 12 |
35 | Edwardsiella ictaluri | Enteric septicemia of channel catfish (ESC) | 0 |
36 | Edwardsiella tarda | 22 | |
37 | Escherichia coli | Hemorrhagic colitis | 50 |
38 | Flavobacterium columnare | Columnaris | 0 |
39 | Francisella tularensis | Tularemia | 12 |
40 | Haemophilus influenzae | Meningitis | 16 |
41 | Haemophilus parasuis | Glasser's disease | 28 |
42 | Haemophilus somnus | 0 | |
43 | Helicobacter pylori | Ulcers | 23 |
44 | Lawsonia intracellularis | Lawsonia intracellularis infection | 0 |
45 | Leptospira spp. | Leptospirosis | 11 |
46 | Mannheimia haemolytica | Bovine Respiratory Disease | 0 |
47 | Mycoplasma gallisepticum | Chronic respiratory disease | 2 |
48 | Mycoplasma hyopneumoniae | Porcine Enzootic Pneumonia | 1 |
49 | Mycoplasma synoviae | Respiratory tract disease and synovitis | 0 |
50 | Neisseria meningitidis | Meningitis | 20 |
51 | Pasteurella multocida | Pasteurellosis, fowl cholera | 3 |
52 | Piscirickettsia salmonis | Salmon Rickettsial Disease, Piscirickettsiosis | 0 |
53 | Porphyromonas gulae | Canine periodontitis | 0 |
54 | Pseudomonas aeruginosa | Pseudomonas aeruginosa infection | 15 |
55 | Rickettsia rickettsii | 1 | |
56 | Rickettsia spp | Spotted Fever, Typhus | 14 |
57 | Riemerella anatipestifer | New duck disease, Infectious serositis, Pasteurella anatipestifer infection | 0 |
58 | Salmonella spp. | Salmonellosis | 6 |
59 | Shigella | Shigellosis | 11 |
60 | Treponema pallidum | Syphilis | 17 |
61 | Vibrio anguillarum (Listonella anguillarum) | Vibrosis | 1 |
62 | Vibrio cholerae | Cholera | 6 |
63 | Vibrio vulnificus | 1 | |
64 | Yersinia enterocolitica | Yersiniosis | 1 |
65 | Yersinia pestis | Plague | 26 |
66 | Yersinia pseudotuberculosis | Yersiniosis | 4 |
67 | Yersinia ruckeri | Enteric redmouth disease | 0 |
Viruses | |||
68 | Adenovirus | Respiratory infection | 0 |
69 | African horse sickness virus | 3 | |
70 | African Swine Fever Virus | African Swine Fever | 7 |
71 | Avian Encephalomyelitis Virus | Avian Encephalomyelitis | 0 |
72 | Avian Paramyxovirus | 0 | |
73 | Avian pneumovirus | Turkey rhinotracheitis, Avian rhinotracheitis, Swollen head syndrome | 1 |
74 | Avian Polyomavirus | Papovavirus, Budgerigar fledgling disease, Psittacine polyomavirus | 0 |
75 | Avian Reovirus | Viral Arthritis, Pale Bird Syndrome, Tenosynovitis | 1 |
76 | Bluetongue virus | Bluetongue disesase | 3 |
77 | Borna disease virus | 1 | |
78 | Bovine coronavirus | 1 | |
79 | Bovine herpesvirus 1 | Infectious bovine rhinotracheitis | 7 |
80 | Bovine Leukemia virus | 3 | |
81 | Bovine papillomavirus | Warts | 2 |
82 | Bovine Parainfluenza 3 Virus (BPIV-3) | 0 | |
83 | Bovine Respiratory Syncytial Virus | Respiratory Disease | 5 |
84 | Bovine viral diarrhea virus 1 | Bovine viral Diarrhea (BVD) | 1 |
85 | Bovine viral diarrhea virus 2 | Bovine viral diarrhea | 1 |
86 | Canarypox virus | Canary Pox | 0 |
87 | Canine adenovirus type 1 | Fox Encephalitis, Infectious Canine Hepatitis | 0 |
88 | Canine Adenovirus Type 2 | 0 | |
89 | Canine coronavirus | Intestinal disease | 1 |
90 | Canine distemper virus | Canine distemper | 2 |
91 | Canine parainfluenza virus | 0 | |
92 | Canine parvovirus | Canine parvovirus infection | 2 |
93 | Caprine herpesvirus type 1 (CpHV-1) | 0 | |
94 | Chicken Anemia Virus | Chicken infectious anemia, Blue wing disease, Anemia dermatitis syndrome, Hemorrhagic aplastic anemi | 2 |
95 | chikungunya virus | 1 | |
96 | Classical swine fever virus | Classical swine fever, hog cholera | 5 |
97 | Corynebacterium pseudotuberculosis | 0 | |
98 | Crimean-Congo Haemorrhagic Fever (CCHF) | 0 | |
99 | Dengue Virus | Dengue Fever | 11 |
100 | Duck enteritis virus | Duck Plague | 0 |
101 | Duck hepatitis virus 1 | Duck virus hepatitis (DVH) | 1 |
102 | Eastern Equine Encephalitis Virus | Encephalitis | 4 |
103 | Ebola virus | Ebola hemorrhagic fever | 19 |
104 | Equid herpesvirus | Equine Rhinopneumonitis | 0 |
105 | Equine arteritis virus | Equine arteritis | 4 |
106 | Equine rotavirus | Rotaviral Diarrhea | 0 |
107 | Feline calicivirus | Feline Respiratory Infections | 1 |
108 | Feline herpesvirus 1 | Feline viral rhinotracheitis | 2 |
109 | Feline immunodeficiency virus | Feline AIDS | 0 |
110 | Feline infectious peritonitis virus | Feline infectious peritonitis (FIP) | 2 |
111 | Feline leukemia virus | Feline leukemia virus infection | 5 |
112 | Feline panleukopenia virus | Feline Distemper | 1 |
113 | Foot-and-mouth disease virus | Foot-and-mouth disease | 8 |
114 | Fowlpox virus | Fowlpox | 1 |
115 | Gallid herpesvirus 1 | Avian infectious laryngotracheitis, Fowl Laryngotracheitis | 2 |
116 | Hantavirus | Hantavirus Pulmonary Syndrome | 10 |
117 | Hendra virus | Hendra virus disease | 1 |
118 | Hepatitis A virus | Hepatitis A | 1 |
119 | Hepatitis B virus | Hepatitis B | 8 |
120 | Hepatitis C virus | Hepatitis C | 3 |
121 | Hepatitis D virus | 1 | |
122 | Hepatitis E virus | Hepatitis E | 3 |
123 | Herpes simplex virus type 1 and 2 | Herpes | 12 |
124 | Hirame rhabdovirus | 2 | |
125 | Human coxsackievirus | 1 | |
126 | Human cytomegalovirus | 5 | |
127 | Human Immunodeficiency Virus | Acquired Immunodeficiency Syndrome (AIDS) | 41 |
128 | Human metapneumovirus | Respiratory tract infection | 3 |
129 | Human Papillomavirus | HPV infection | 9 |
130 | Human Respiratory Syncytial Virus | Respiratory tract disease | 2 |
131 | Infectious Bronchitis Virus (IBV) | Infectious Bronchitis | 5 |
132 | Infectious Bursal Disease Virus (IBDV) | Infectious Bursal Disease | 3 |
133 | Infectious Hematopoietic Necrosis Virus | Infectious hematopoietic necrosis | 1 |
134 | infectious laryngotracheitis virus | 1 | |
135 | Infectious pancreatic necrosis virus | 2 | |
136 | Infectious salmon anemia virus | Infectious Salmon Anemia | 1 |
137 | Influenza virus | Influenza (flu) | 50 |
138 | Japanese encephalitis virus | Japanese encephalitis | 10 |
139 | Lassa Fever Virus | Lassa fever | 3 |
140 | Lymphocytic choriomeningitis virus | Lymphocytic choriomeningitis | 1 |
141 | Marburg Virus | Hemorrhagic fever | 9 |
142 | Marek's disease virus | Marek's disease | 2 |
143 | Measles virus | Measles | 5 |
144 | Mink enteritis virus | Mink Enteritis | 0 |
145 | Mumps virus | Mumps | 2 |
146 | Murine Cytomegalovirus | 5 | |
147 | Murine leukemia virus | 0 | |
148 | Newcastle disease virus | Newcastle disease | 3 |
149 | Nipah virus | Nipah virus disease | 2 |
150 | Orf Virus | Orf disease, Sore mouth (Ovine Ecthyma) | 2 |
151 | Parainfluenza virus | 1 | |
152 | Pigeonpox virus | Pigeon Pox | 0 |
153 | Poliovirus | Polio | 1 |
154 | Porcine circovirus 2 | Postweaning multisystemic wasting syndrome | 2 |
155 | Porcine parvovirus | SMEDI, reproductive failure | 3 |
156 | Porcine respiratory and reproductive syndrome virus | Porcine Reproductive and Respiratory Syndrome (PRRS), Blue-Ear Pig Disease | 7 |
157 | Porcine rotavirus | Diarrhea | 3 |
158 | Pseudorabies virus | Aujeszky's disease | 8 |
159 | Psittacid herpesvirus 1 | Pacheco's Parrot Disease | 0 |
160 | Rabbit hemorrhagic disease virus | Rabbit hemorrhagic disease | 1 |
161 | Rabies virus | Rabies | 4 |
162 | Reticuloendotheliosis Virus | Tumors, wasting syndrome | 3 |
163 | Rift Valley Fever virus | Rift valley fever | 4 |
164 | rinderpest virus | 3 | |
165 | Rotavirus | Gastroenteritis | 9 |
166 | Rubella virus | Rubella | 1 |
167 | SARS-CoV | Severe Acute Respiratory Syndrome (SARS) | 3 |
168 | Simian Immunodeficiency Virus | Simian AIDS | 1 |
169 | Sindbis virus | Encephalitis | 1 |
170 | Tick-borne Encephalitis Virus (TBEV) | Tick-borne Encephalitis | 4 |
171 | Transmissible gastroenteritis virus | Porcine transmissible gastroenteritis | 1 |
172 | Turkey hemorrhagic enteritis virus | Hemorrhagic enteritis | 0 |
173 | Vaccinia virus | 12 | |
174 | Varicella-zoster virus | chickenpox / shingles | 2 |
175 | Variola virus | Smallpox | 4 |
176 | VEE Virus | Venezuelan equine encephalitis | 4 |
177 | Viral haemorrhagic septicaemia virus | 3 | |
178 | West Nile virus | West Nile fever | 2 |
179 | Western equine encephalomyelitis virus | Western equine encephalomyelitis (WEE) | 6 |
180 | Yellow fever virus | Yellow fever | 5 |
Parasites | |||
181 | Babesia bovis | Babesiosis, Texas Cattle Fever | 8 |
182 | Babesia canis | Piroplasmosis | 0 |
183 | Cryptosporidium parvum | Cryptosporidiosis | 4 |
184 | Eimeria acervulina | 1 | |
185 | Eimeria maxima | Coccidiosis | 7 |
186 | Eimeria spp. | Coccidiosis | 1 |
187 | Eimeria tenella | Hemorrhagic cecal coccidiosis | 6 |
188 | Entamoeba histolytica | Amoebiasis | 6 |
189 | Giardia duodenalis | Giardiasis (Beaver fever) | 1 |
190 | Leishmania amazonensis | Leishmaniasis | 6 |
191 | Leishmania donovani | Visceral leishmaniasis | 15 |
192 | Leishmania infantum | Infantile visceral leishmaniasis | 8 |
193 | Leishmania major | Cutaneous leishmaniasis | 13 |
194 | Neospora caninum | Neosporosis | 10 |
195 | Plasmodium spp. | Malaria | 33 |
196 | Sarcocystis neurona | Equine protozoal myeloencephalitis | 3 |
197 | Schistosoma japonicum | Schistosomiasis | 8 |
198 | Schistosoma mansoni | Schistosomiasis | 7 |
199 | Theileria annulata | Theileriosis | 3 |
200 | Theileria parva | East Coast Fever | 3 |
201 | Toxoplasma gondii | Toxoplasmosis | 18 |
202 | Trichinella spiralis | 2 | |
203 | Trichomonas foetus | 0 | |
204 | Trypanosoma brucei | African trypanosomiasis (African Sleeping Sickness) | 2 |
205 | Trypanosoma cruzi | Chagas disease | 19 |
Fungi | |||
206 | Coccidioides spp. | Coccidioidomycosis (California disease, Desert rheumatism, San Joaquin valley fever, and Valley fev | 9 |
Other diseases | |||
207 | Allergy | Allergy | 15 |
208 | Arthritis | 4 | |
209 | Atherosclerosis | Atherosclerosis, arteriosclerotic vascular disease (ASVD) | 0 |
210 | Cancer | Cancer | 73 |
211 | Diabetes | Diabetes | 5 |
212 | Experimental autoimmune encephalomyelitis | Experimental autoimmune encephalomyelitis (EAE) | 2 |
213 | Experimental autoimmune uveitis | Experimental autoimmune uveitis | 1 |
214 | Ricin toxin of Ricinus communis | Ricin poisoning | 1 |
Total | 216 | 1371 |