VIOLIN: Vaccine Investigation and Online Information Network

Pathogen Page

Reticuloendotheliosis Virus

I. General Information

1. NCBI Taxonomy ID:

2. Disease:

Tumors, wasting syndrome

3. Introduction

REV is a group of avian viruses in the family Retroviridae, specifically gammaretroviruses in the same genus as mammalian C-type retroviruses. The viruses included in this group are REV strains such as REV-T (replication defective and tumorigenic); REV-A (REV-T helper, replication competent); spleen necrosis virus; chick syncytial virus; duck infectious anemia virus; and other isolates obtained from turkeys, chickens, ducks, pheasants, geese, and prairie chickens. Notably, REV infection of captive prairie chicken can result in a high incidence (up to 100% of infected birds in some outbreaks) of tumors and wasting syndrome, and this infection has had a severe impact on the APC recovery program (Collisson, pers. obs.). Once detected, infected birds were removed from breeding populations, significantly reducing the genetic pool and the number of birds that can be released or kept as breeders. REV infection has been associated with acute reticular cell neoplasia, wasting disease, and chronic cell neoplasia of lymphoid and nonlymphoid tissues (Drechsler et al., 2013).

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