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Protegen: Protective Antigens

     Protective antigens are specifically targeted by the acquired immune response of the host and are able to induce protection in the host against infectious and non-infectious diseases. Protective antigens play important roles in development of vaccines and biological markers for disease diagnosis and analysis of fundamental host immunity against diseases. Protegen is a web-based central database and analysis system that curates, stores, and analyzes protective antigens.

Statistics: Protegen includes 1631 protective antigens for now.

Provenance: The data in Progeten originates from our literature curation and boinformatics analyses.


Yang B, Sayers S, Xiang Z, He Y. Protegen: a web-based protective antigen database and analysis system. Nucleic Acids Research. 2010. 2010 Oct 19. [Epub ahead of print]. [PMID: 20959289] [NAR] [PDF]. (Note: Please cite this paper for your use of Protegen)

He Y, Xiang Z. Bioinformatics analysis of bacterial protective antigens in manually curated Protegen database. Procedia in Vaccinology. 2012. Volume 6. Pages 3 – 9.

Ong E, Wong MU, He Y. Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design. Frontiers in Immunology. 2017 Oct 26;8:1382.