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Protegen: Protective Antigens

     Protective antigens are specifically targeted by the acquired immune response of the host and are able to induce protection in the host against infectious and non-infectious diseases. Protective antigens play important roles in development of vaccines and biological markers for disease diagnosis and analysis of fundamental host immunity against diseases. Protegen is a web-based central database and analysis system that curates, stores, and analyzes protective antigens.

Protegen Search
Search Field	Search Parameter
Pathogen or Disease	Any pathogen Actinobacillus pleuropneumoniae Aeromonas salmonicida African horse sickness virus African Swine Fever Virus Allergy Arthritis Avian pneumovirus Avian Reovirus Babesia bovis Bacillus anthracis Bluetongue virus Bordetella pertussis Borna disease virus Borrelia burgdorferi Bovine coronavirus Bovine herpesvirus 1 Bovine Leukemia virus Bovine papillomavirus Bovine Respiratory Syncytial Virus Bovine viral diarrhea virus 1 Bovine viral diarrhea virus 2 Brucella spp. Burkholderia pseudomallei Campylobacter jejuni Cancer Canine coronavirus Canine distemper virus Canine parvovirus Chicken Anemia Virus chikungunya virus Chlamydia muridarum Chlamydia trachomatis Chlamydophila abortus Chlamydophila pneumoniae Chlamydophila psittaci Classical swine fever virus Clostridium botulinum Clostridium tetani Coccidioides spp. Corynebacterium diphtheriae Coxiella burnetii Cryptosporidium parvum Dengue Virus Diabetes Duck hepatitis virus 1 Eastern Equine Encephalitis Virus Ebola virus Edwardsiella tarda Eimeria acervulina Eimeria maxima Eimeria spp. Eimeria tenella Entamoeba histolytica Equine arteritis virus Erysipelothrix rhusiopathiae Escherichia coli Experimental autoimmune encephalomyelitis Experimental autoimmune uveitis Feline calicivirus Feline herpesvirus 1 Feline infectious peritonitis virus Feline leukemia virus Feline panleukopenia virus Foot-and-mouth disease virus Fowlpox virus Francisella tularensis Gallid herpesvirus 1 Giardia duodenalis Haemophilus influenzae Haemophilus parasuis Hantavirus Helicobacter pylori Hendra virus Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Herpes simplex virus type 1 and 2 Hirame rhabdovirus Human coxsackievirus Human cytomegalovirus Human Immunodeficiency Virus Human metapneumovirus Human Papillomavirus Human Respiratory Syncytial Virus Infectious Bronchitis Virus (IBV) Infectious Bursal Disease Virus (IBDV) Infectious Hematopoietic Necrosis Virus infectious laryngotracheitis virus Infectious pancreatic necrosis virus Infectious salmon anemia virus Influenza virus Japanese encephalitis virus Klebsiella pneumoniae Lassa Fever Virus Leishmania amazonensis Leishmania donovani Leishmania infantum Leishmania major Leptospira spp. Listeria monocytogenes Lymphocytic choriomeningitis virus Marburg Virus Marek's disease virus Measles virus MERS-CoV Mumps virus Murine Cytomegalovirus Mycobacterium bovis Mycobacterium marinum Mycobacterium tuberculosis Mycoplasma gallisepticum Mycoplasma hyopneumoniae Neisseria meningitidis Neospora caninum Newcastle disease virus Nipah virus Orf Virus Parainfluenza virus Pasteurella multocida Plasmodium spp. Poliovirus Porcine circovirus 2 Porcine parvovirus Porcine respiratory and reproductive syndrome virus Porcine rotavirus Pseudomonas aeruginosa Pseudorabies virus Rabbit hemorrhagic disease virus Rabies virus Reticuloendotheliosis Virus Ricin toxin of Ricinus communis Rickettsia rickettsii Rickettsia spp Rift Valley Fever virus rinderpest virus Rotavirus Rubella virus Salmonella spp. Sarcocystis neurona SARS-CoV SARS-CoV-2 Schistosoma japonicum Schistosoma mansoni Shigella Simian Immunodeficiency Virus Sindbis virus Staphylococcus aureus Streptococcus agalactiae Streptococcus equi Streptococcus pneumoniae Streptococcus pyogenes Theileria annulata Theileria parva Tick-borne Encephalitis Virus (TBEV) Toxoplasma gondii Transmissible gastroenteritis virus Treponema pallidum Trichinella spiralis Trypanosoma brucei Trypanosoma cruzi Vaccinia virus Varicella-zoster virus Variola virus VEE Virus Vibrio anguillarum (Listonella anguillarum) Vibrio cholerae Vibrio vulnificus Viral haemorrhagic septicaemia virus West Nile virus Western equine encephalomyelitis virus Yellow fever virus Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis
Gene Name	(e.g., sodC)
Locus Tag	(e.g., BAB2_0535)
Database ID	NCBI Gene GI NCBI Nucleotide GI NCBI Protein Accesion No NCBI Protein GI Protegen ID VO ID Other Database ID
COG category	Any Amino acid transport and metabolism Carbohydrate transport and metabolism Cell cycle control, cell division, chromosome partitioning Cell motility Cell wall/membrane/envelope biogenesis Chromatin structure and dynamics Coenzyme transport and metabolism Cytoskeleton Defense mechanisms Energy production and conversion Extracellular structures Function unknown General function prediction only Inorganic ion transport and metabolism Intracellular trafficking, secretion, and vesicular transport Lipid transport and metabolism Nuclear structure Nucleotide transport and metabolism Posttranslational modification, protein turnover, chaperones Replication, recombination and repair RNA processing and modification Secondary metabolites biosynthesis, transport and catabolism Signal transduction mechanisms Transcription Translation, ribosomal structure and biogenesis
Subcellular Localization	Any Localization Cellwall Cytoplasmic Cytoplasmic Membrane Extracellular Outer Membrane Periplasmic Unknown
Maximum Number of Transmembrane Helices	(Note: check box to include)
Minimum Adhesin Probability (0-1.0)
No Similarity to Human Proteins
No Similarity to Mouse Proteins
Description	(e.g., superoxide dismutase)

Statistics: Protegen includes 1631 protective antigens for now.

Provenance: The data in Progeten originates from our literature curation and boinformatics analyses.

Publications:

Yang B, Sayers S, Xiang Z, He Y. Protegen: a web-based protective antigen database and analysis system. Nucleic Acids Research. 2010. 2010 Oct 19. [Epub ahead of print]. [PMID: 20959289] [NAR] [PDF]. (Note: Please cite this paper for your use of Protegen)

He Y, Xiang Z. Bioinformatics analysis of bacterial protective antigens in manually curated Protegen database. Procedia in Vaccinology. 2012. Volume 6. Pages 3 – 9.

Ong E, Wong MU, He Y. Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design. Frontiers in Immunology. 2017 Oct 26;8:1382.