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Poliovirus |
| Table of Contents |
- Protective Antigens
- VP4
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| I. Vaccine Related Protective Antigens |
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1. VP4
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Gene Name :
VP4
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Sequence Strain (Species/Organism) :
Human poliovirus 1
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VO ID :
VO_0011244
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NCBI Protein GI :
68532656
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Other Database IDs :
CDD:280403
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Taxonomy ID :
12080
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Gene Strand (Orientation) :
?
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Protein Name :
VP4
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Protein pI :
7.69
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Protein Weight :
7576.69
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Protein Length :
117
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Protein Note :
Picornavirus coat protein (VP4); pfam02226
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Protein Sequence : Show Sequence
>BAE06026.1 VP4, partial [Human poliovirus 1]
MGAQVSSQKVGAHENSNRASGGSTINYTTINYYRDSASNAASKQDFSQDPSKFTEPIKDVLIKTAPMLN
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
To examine the mechanism of immunity in vivo, researchers used poliovirus receptor-transgenic mice on a BALB/c (H-2d) background. Mice immunized with the vaccine strain were protected against a subsequent challenge with wild-type virus. Protection was observed when mice received primed B cells in the presence of a VP4-specific Th1 clone. Findings demonstrate that CD4+ T cells, specific for the internal poliovirus capsid protein, VP4, can provide effective help for a protective antibody response directed against surface capsid proteins (Mahon et al., 1995).
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| II. References |
1. Mahon et al., 1995: Mahon BP, Katrak K, Nomoto A, Macadam AJ, Minor PD, Mills KH. Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. The Journal of experimental medicine. 1995; 181(4); 1285-1292. [PubMed: 7699320].
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