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Feline infectious peritonitis virus |
Table of Contents |
- General Information
- NCBI Taxonomy ID
- Disease
- Introduction
- Microbial Pathogenesis
- Host Ranges and Animal Models
- Host Protective Immunity
- Vaccine Related Pathogen Genes
- N
(Protective antigen)
- S
(Protective antigen)
- 3a
(Virmugen)
- 3b
(Virmugen)
- 3c
(Virmugen)
- 7a
(Virmugen)
- 7b
(Virmugen)
- Vaccine Information
- Feline infectiour peritonitis virus 3abc mutant vaccine
- Feline Infectious Peritonitis Modified Live Virus Vaccine (USDA: 15A1.20)
- Feline infectious peritonitis virus 7ab mutant vaccine
- References
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I. General Information |
1. NCBI Taxonomy ID: |
11135 |
2. Disease: |
Feline infectious peritonitis (FIP) |
3. Introduction |
Feline infectious peritonitis virus (FIPV) is a feline coronavirus that causes feline infectious peritonitis. Infection is ubiquitous in domestic cats, especially where conditions are crowded. FIPV can survive in for 7 weeks in a dry environment and may be transmitted indirectly via fomites. FPIV is an enveloped single stranded RNA virus. Most FIPV-infected cats either stay healthy or show only a mild enteritis. Only a proportion of FPIV-infected cats will develop FIP, a pyogranulomatous vasculitis (Addie et al., 2009). |
4. Microbial Pathogenesis |
The pathogenesis of FIP may be explained by an increased number of mutants, stochastically arising during bursts of replication (eg, under immune suppression), some of them growing to high concentrations in monocytes and macrophages. Mutations have been identified in non-structural genes, and more may remain to be identified. These highly virulent FPIV mutants have consistently induced FIP under experimental conditions, but their virulence has not been traced to a molecular source. The viral load and the cat’s immune response determine whether FIP will develop. Both viral genetics and host immunity are likely to play a role in the development of FIP. The pathology of FIP has been classified into two forms: an effusive (wet) FIP characterised by polyserositis (eg, thoracic and abdominal effusion)and vasculitis, and a non-effusive (dry) FIP characterised by granulomatous lesions in organs (Addie et al., 2009). |
5. Host Ranges and Animal Models |
Domestic cats |
6. Host Protective Immunity |
It has been suggested that cats mounting a strong cell-mediated immune response do not develop FIP, whereas cats showing a predominantly humoral response progress to disease. Hypergammaglobulinaemia is common in cats with FIP. Also, a drastic depletion of T cells from blood and lymphoid tissues has been described (Addie et al., 2009). |
II. Vaccine Related Pathogen Genes |
1. 3a |
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Gene Name :
3a
-
Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Gene ID :
10040181
-
NCBI Protein GI :
315192965
-
Locus Tag :
FIPV_gp03
-
Genbank Accession :
AY994055
-
Protein Accession :
YP_004070195
-
Taxonomy ID :
11135
-
Gene Starting Position :
24860
-
Gene Ending Position :
25075
-
Gene Strand (Orientation) :
?
-
Protein Name :
putative 3a protein
-
Protein pI :
4.49
-
Protein Weight :
6974.53
-
Protein Length :
71
-
DNA Sequence : Show Sequence
>gi|315192962:24860-25075 Feline infectious peritonitis virus, complete genome
TATGGACATTGTCAAATCTATTGACATATTCGTAGACGCTGTACTTGACGAACTTGACCGTGCATACTTT
GCTGTAACTCTTAAAGTAGAATTTAAGACTGGTAAACTACTTGTGTGTATAGGTTTTGGTGACACACTTC
TTGAGGCTAAGGACAAAGCGTATGCTAAGCTTGGTCTCTCCTTTATTGAAGAAGTCAATAGTCATACAGT
TGTTTA
-
Protein Sequence : Show Sequence
>gi|315192965|ref|YP_004070195.1| putative 3a protein [Feline infectious peritonitis virus]
MDIVKSIDIFVDAVLDELDRAYFAVTLKVEFKTGKLLVCIGFGDTLLEAKDKAYAKLGLSFIEEVNSHTV
V
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Molecule Role :
Virmugen
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Molecule Role Annotation :
A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens (Haijema et al., 2004).
- Related Vaccine(s):
Feline infectiour peritonitis virus 3abc mutant vaccine
|
2. 3b |
-
Gene Name :
3b
-
Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Gene ID :
10040182
-
NCBI Protein GI :
315192966
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Locus Tag :
FIPV_gp04
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Genbank Accession :
AY994055
-
Protein Accession :
YP_004070196
-
Taxonomy ID :
11135
-
Gene Starting Position :
25020
-
Gene Ending Position :
25235
-
Gene Strand (Orientation) :
?
-
Protein Name :
putative 3b protein
-
Protein pI :
11.43
-
Protein Weight :
7960.26
-
Protein Length :
71
-
DNA Sequence : Show Sequence
>gi|315192962:25020-25235 Feline infectious peritonitis virus, complete genome
TATGCTAAGCTTGGTCTCTCCTTTATTGAAGAAGTCAATAGTCATACAGTTGTTTAGTATTACTGTTTAC
AAGTTTAAAGCCAAATTTTGGTATAAACTACCTTTTGAAACTAGACTTTGTATCATTAAACACACAAGAC
CCAAAGCATTAAGTGTTACAAAACAAGTAAAGAGAGATTATAGAAAAATTGCCATTCTAAATTCCATGCG
AAAATG
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Protein Sequence : Show Sequence
>gi|315192966|ref|YP_004070196.1| putative 3b protein [Feline infectious peritonitis virus]
MLSLVSPLLKKSIVIQLFSITVYKFKAKFWYKLPFETRLCIIKHTRPKALSVTKQVKRDYRKIAILNSMR
K
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Molecule Role :
Virmugen
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Molecule Role Annotation :
A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens (Haijema et al., 2004).
- Related Vaccine(s):
Feline infectiour peritonitis virus 3abc mutant vaccine
|
3. 3c |
-
Gene Name :
3c
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Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Gene ID :
10040183
-
Locus Tag :
FIPV_gp05
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Taxonomy ID :
11135
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Gene Starting Position :
25232
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Gene Ending Position :
25966
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Gene Strand (Orientation) :
?
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DNA Sequence : Show Sequence
>gi|315192962:25232-25966 Feline infectious peritonitis virus, complete genome
AATGATTGGTGGACTTTTTCTTAACACTCTTAGTTTTGTAATTGTTAGTAACCATGTTATTGTTAATAAC
ACAGCAAATGTGCATACTACACAACATGAAAATGTTATAGTACAACAGCATTAGGTTGTTAGTGCTAGAA
CACAAAATTATTACCCAGAGTTCAGCATCGCTGTACTCTTTGTATCATTTTTGGCTTTGTACCGTAGTAC
AAACTTTAAGACGTGTGTCGGCATCTTAATGTTTAAGATTGTATCAATGACACTTGTAGGGCCTATGCTT
ATAGCATATGGTTACTACATTGATGGCATTGTTACAATAACTGTCTTAGCTTTAAGATTTTTCTACTTAG
CATACTTTTGGTATGTTAATAGTAGGTCCGAATTTATTTTATACAATACAACGACACTCATGTTTGTACA
TGGCAGAGCTGCACCGTTTATGAGAAGTTCTCACAGCTCTATTTATGTCACATTGTATGGTGGCATAAAT
TATATGTTTGTGAATGACCTCACGTTGCATTTTGTAGACCCTATGCTTGTAAGAATAGCAATACGTGGCT
TAGCTCATGCTGATCTAACTGTTTTTAGAGCAGTTGAACTTCTCAATGGTGATTTTATATATGTATTTTC
ACAGGAGCCCGTAGCCGGTGTTTACAATGCAGCCTCTTCTCAGGCGGTTCTAAACGAAATTGACTTAAAA
GAAGAAGAAGAAGACCATAACTATGACGTTCCCTA
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Molecule Role :
Virmugen
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Molecule Role Annotation :
A 3abc deletion mutant in Feline infectious peritonitis virus (FIPV) was attenuated and provided protection against virulent FIPV strain 79-1146 challenge in kittens (Haijema et al., 2004).
- Related Vaccine(s):
Feline infectiour peritonitis virus 3abc mutant vaccine
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4. 7a |
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Gene Name :
7a
-
Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Gene ID :
10040187
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NCBI Protein GI :
315192970
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Locus Tag :
FIPV_gp09
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Genbank Accession :
AY994055
-
Protein Accession :
YP_004070200
-
Taxonomy ID :
11135
-
Gene Starting Position :
28151
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Gene Ending Position :
28456
-
Gene Strand (Orientation) :
?
-
Protein Name :
non-structural protein 7a
-
Protein pI :
8.52
-
Protein Weight :
9843.18
-
Protein Length :
101
-
DNA Sequence : Show Sequence
>gi|315192962:28151-28456 Feline infectious peritonitis virus, complete genome
CATGCTCGTTTTCGTCCATGCTGTACTTGTAACAGCTTTAATCTTACTACTAATTGGTAGAATCCAATTA
CTAGAAAGGTTGTTACTCAGTCATCTGCTTAATCTTACAACAGTCAGTAATGTTTTAGGTGTGCCTGACA
GTAGTCTGCGTGTAAATTGTTTGCAGCTTTTGAAACCAGACTGCCTTGATTTTAATATCTTACATAAAGT
TTTAGCAGAAACCAGGTTACTAGTAGTAGTACTGCGAGTGATCTTTCTAGTTCTTCTAGGGTTTTCCTGC
TATACATTGTTGGGTGCATTATTTTA
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Protein Sequence : Show Sequence
>gi|315192970|ref|YP_004070200.1| non-structural protein 7a [Feline infectious peritonitis virus]
MLVFVHAVLVTALILLLIGRIQLLERLLLSHLLNLTTVSNVLGVPDSSLRVNCLQLLKPDCLDFNILHKV
LAETRLLVVVLRVIFLVLLGFSCYTLLGALF
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Molecule Role :
Virmugen
-
Molecule Role Annotation :
A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens (Haijema et al., 2004).
- Related Vaccine(s):
Feline infectious peritonitis virus 7ab mutant vaccine
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5. 7b |
-
Gene Name :
7b
-
Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Gene ID :
10040188
-
NCBI Protein GI :
315192971
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Locus Tag :
FIPV_gp10
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Genbank Accession :
AY994055
-
Protein Accession :
YP_004070201
-
Taxonomy ID :
11135
-
Gene Starting Position :
28461
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Gene Ending Position :
29081
-
Gene Strand (Orientation) :
?
-
Protein Name :
non-structural protein 7b
-
Protein pI :
7.25
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Protein Weight :
22221.54
-
Protein Length :
206
-
DNA Sequence : Show Sequence
>gi|315192962:28461-29081 Feline infectious peritonitis virus, complete genome
CATGATTGTTGTAATCCTTGTGTGTATCTTTTTGGCTAATGGAATTAAAGCTACTGCTGTGCAAAATGAC
CTTCATGAACATCCCGTTCTTACCTGGGATTTATTACAGCATTTCATAGGACATACCCTCTACATTACAA
CACACCAGGTCTTAGCACTACCGCTTGGATCTCGTGTTGAGTGTGAGGGTATCGAAGGTTTCAATTGCAC
ATGGCCTGGCTTTCAAGATCCTGCACATGATCATATTGATTTCTACTTTGATCTTTCTAATCCTTTCTAT
TCATTTGTAGATAATTTTTATATTGTAAGTGAGGGAAATCAAAGAATCAATCTCAGATTGGTTGGTGCTG
TGCCAAAACAAAAGAGATTAAATGTTGGTTGTCATACATCATTTGCTGTTGATCTTCCATTTGGGATTCA
GATATACCATGACAGGGATTTTCAACACCCTGTTGATGGCAGACATCTAGATTGTACTCACAGAGTGTAC
TTTGTGAAGTACTGTCCACATAACCTGCATGGTTATTGCTTTAATGAGAGGCTGAAAGTTTATGACTTGA
AGCAATTCAGAAGCAAGAAGGTCTTCGACAAAATCAACCAACATCATAAAACTGAGTTATA
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Protein Sequence : Show Sequence
>gi|315192971|ref|YP_004070201.1| non-structural protein 7b [Feline infectious peritonitis virus]
MIVVILVCIFLANGIKATAVQNDLHEHPVLTWDLLQHFIGHTLYITTHQVLALPLGSRVECEGIEGFNCT
WPGFQDPAHDHIDFYFDLSNPFYSFVDNFYIVSEGNQRINLRLVGAVPKQKRLNVGCHTSFAVDLPFGIQ
IYHDRDFQHPVDGRHLDCTHRVYFVKYCPHNLHGYCFNERLKVYDLKQFRSKKVFDKINQHHKTEL
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Molecule Role :
Virmugen
-
Molecule Role Annotation :
A 7ab deletion mutant in Feline infectious peritonitis virus is attenuated and provides protection against virulent FIPV strain 79-1146 challenge in kittens (Haijema et al., 2004).
- Related Vaccine(s):
Feline infectious peritonitis virus 7ab mutant vaccine
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6. N |
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Gene Name :
N
-
Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
-
NCBI Protein GI :
BAC01159
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Other Database IDs :
CDD:279305
-
Taxonomy ID :
11135
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Protein Name :
nucleocapsid
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Protein pI :
10.35
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Protein Weight :
40532.64
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Protein Length :
447
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Protein Note :
Coronavirus nucleocapsid protein; pfam00937
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Protein Sequence : Show Sequence
>BAC01159.1 nucleocapsid [Feline infectious peritonitis virus]
MATQGQRVNWGDEPSKRRDRSNSRGRKNGNIPLSYFNPITLESGSKFWNICPRDFVPKGIGNKDQQIGYW
NRQVRYRIVRGQRKELPERWFFYFSGTGPHADAKFKDKIDGVFWVARDGAMNKPTTLGTRGTNNESKPLK
FDGKIPPQFQLEVNRSRNNSRSGSQPRSVSRSRSQSRGRQQSNNQNTNVEDTIVAVLSKLGVTDKQRSRS
KSGERNQSKPRDTTPKNANKHTWKKTAGKGDVTNFYGARSSSANFGDSDLVANGNAAKCYPQIAECVPSA
SSILFGSQWSAEEAGDQVKVTLTHTYYLPKDDAKTSQFLEQIDAYKQPSEVAKDQRQRKSRSKSADKKPE
ELSVTLVEAYTDVFDDTQVEMIDEVTN
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Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Takano et al., 2014)
|
7. S |
-
Gene Name :
S
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Sequence Strain (Species/Organism) :
Feline infectious peritonitis virus
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NCBI Protein GI :
AGZ84526
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Other Database IDs :
CDD:279880
CDD:279881
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Taxonomy ID :
11135
-
Protein Name :
spike protein
-
Protein pI :
4.88
-
Protein Weight :
148708.33
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Protein Length :
1538
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Protein Note :
Coronavirus S1 glycoprotein; pfam01600
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Protein Sequence : Show Sequence
>AGZ84526.1 spike protein [Feline infectious peritonitis virus]
MIVLVTCLLLLCSYHTVLSTTNNECIQVNVTQLAGNENLIRDFLFSNFKEEGSVVVGGYYPTEVWYNCSR
TARTTAFQYFNNIHAFYFVMEAMENSTGNARGKPLLFHVHGEPVSVIISAYRDDVQQRPLLKHGLVCITK
NRHINYEQFTSNQWNSTCTGADRKIPFSVIPTDNGTKIYGLEWNDDFVTAYISGRSYHLNINTNWFNNVT
LLYSRSSTATWEYSAAYAYQGVSNFTYYKLNNTNGLKTYELCEDYEHCTGYATNVFAPTSGGYIPDGFSF
NNWFLLTNSSTFVSGRFVTNQPLLINCLWPVPSFGVAAQEFCFEGAQFSQCNGVSLNNTVDVIRFNLNFT
ADVQSGMGATVFSLNTTGGVILEISCYSDTVSESSSYSYGEIPFGITDGPRYCYVLYNGTALKYLGTLPP
SVKEIAISKWGHFYINGYNFFSTFPIGCISFNLTTGVSGAFWTIAYTSYTEALVQVENTAIKNVTYCNSH
INNIKCSQLTANLNNGFYPVASSEVGFVNKSVVLLPSFFTYTAVNITIDLGMKLSGYGQPIASTLSNITL
PMQDNNTDVYCIRSNQFSVYVHSTCKSSLWDNIFNQDCADVLEATAVIKTGTCPFSFDKLNNYLTFNKFC
LSLSPVGANCKFDVAARTRTNEQVVRSLYVIYEEGDNIVGVPSDNSGLHDLSVLHLDSCTDYNIYGRTGV
GIIRRTNSTLLSGLYYTSLSGDLLGFKNVSDGVIYSVTPCDVSAQAAVIDGAIVGAMTSINSELLGLTHW
TTTPNFYYYSIYNYTSERTRGTAIDSNDVDCEPVITYSNIGVCKNGALVFINVTHSDGDVQPISTGNVTI
PTNFTISVQVEYMQVYTTPVSIDCARYVCNGNPRCNKLLTQYVSACQTIEQALAMGARLENMEVDSMLFV
SENALKLASVEAFNSTENLDPIYKEWPSIGGSWLGGLKDILPSHNSKRKYGSAIEDLLFDKVVTSGLGTV
DEDYKRCTGGYDIADLVCAQYYNGIMVLPGVANADKMTMYTASLAGGITLGALGGGAVAIPFAVAVQARL
NYVALQTDVLNKNQQILANAFNQAIGNITQAFGKVNDAIHQTSQGLATVAKALAKVQDVVNTQGQALSHL
TVQLQNNFQAISSSISDIYNRLDELSADAQVDRLITGRLTALNAFVSQTLTRQAEVRASRQLAKDKVNEC
VRSQSQRFGFCGNGTHLFSLANAAPNGMIFFHTVLLPTAYETVTAWSGICASDGDRTFGLVVKDVQLTLF
RNLDDKFYLTPRTMYQPRVATSSDFVQIEGCDVLFVNATVIDLPSIIPDYIDINQTVQDILENYRPNWTV
PEFTLDIFNATYLNLTGEIDDLEFRSEKLHNTTVELAILIDNINNTLVNLEWLNRIETYVKWPWYVWLLI
GLVVVFCIPLLLFCCFSTGCCGCIGCLGSCCHSICSRRQFENYEPIEKVHVH
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Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Satoh et al., 2011)
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III. Vaccine Information |
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1. Feline infectiour peritonitis virus 3abc mutant vaccine |
a. Type: |
Live, attenuated vaccine |
b. Status: |
Research |
c. Host Species as Laboratory Animal Model: |
Cat |
d. Gene Engineering of
3a |
- Type:
Gene mutation
- Description:
This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click here.
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e. Gene Engineering of
3b |
- Type:
Gene mutation
- Description:
This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click here.
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f. Gene Engineering of
3c |
- Type:
Gene mutation
- Description:
This 3abc mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click here.
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g. Immunization Route |
Oronasal immunization |
h.
Cat Response |
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2. Feline Infectious Peritonitis Modified Live Virus Vaccine (USDA: 15A1.20) |
a. Manufacturer: |
Pfizer, Inc. |
b. Vaccine Ontology ID: |
VO_0001544 |
c. Type: |
Live, attenuated vaccine |
d. Status: |
Licensed |
e. Location Licensed: |
USA |
f. Host Species for Licensed Use: |
Cat |
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3. Feline infectious peritonitis virus 7ab mutant vaccine |
a. Type: |
Live, attenuated vaccine |
b. Status: |
Research |
c. Host Species as Laboratory Animal Model: |
Cat |
d. Gene Engineering of
7a |
- Type:
Gene mutation
- Description:
This 7ab mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click here.
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e. Gene Engineering of
7b |
- Type:
Gene mutation
- Description:
This 7ab mutant is from Feline infectious peritonitis virus (Haijema et al., 2004).
- Detailed Gene Information: Click here.
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f. Immunization Route |
Oronasal immunization |
g.
Cat Response |
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IV. References |
1. Addie et al., 2009: Addie D, Belák S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie MJ, Lloret A, Lutz H, Marsilio F, Pennisi MG, Radford AD, Thiry E, Truyen U, Horzinek MC. Feline infectious peritonitis. ABCD guidelines on prevention and management. Journal of feline medicine and surgery. 2009; 11(7); 594-604. [PubMed: 19481039].
2. Haijema et al., 2004: Haijema BJ, Volders H, Rottier PJ. Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis. Journal of virology. 2004; 78(8); 3863-3871. [PubMed: 15047802].
3. Satoh et al., 2011: Satoh R, Furukawa T, Kotake M, Takano T, Motokawa K, Gemma T, Watanabe R, Arai S, Hohdatsu T. Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in the spike 2 domain and the nucleocapsid protein of feline infectious peritonitis virus. Vaccine. 2011; 29(9); 1791-1800. [PubMed: 21216312].
4. Takano et al., 2014: Takano T, Tomizawa K, Morioka H, Doki T, Hohdatsu T. Evaluation of protective efficacy of the synthetic peptide vaccine containing the T-helper 1 epitope with CpG oligodeoxynucleotide against feline infectious peritonitis virus infection in cats. Antiviral therapy. 2014; 19(7); 645-650. [PubMed: 24458025].
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