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Clostridium tetani |
| Table of Contents |
- Protective Antigens
- TTC
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| I. Vaccine Related Protective Antigens |
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1. TTC
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Gene Name :
TTC
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VO ID :
VO_0010909
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NCBI Protein GI :
157829735
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3D structure: PDB ID :
1A8D
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Other Database IDs :
CDD:285228
CDD:285226
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Taxonomy ID :
1513
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Gene Strand (Orientation) :
?
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Protein pI :
6.63
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Protein Weight :
50172.35
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Protein Length :
506
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Protein Note :
NCBI Domains
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Protein Sequence : Show Sequence
>pdb|1A8D|A Chain A, Tetanus Toxin C Fragment
MKNLDCWVDNEEDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIHLVNNESSEV
IVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEYSIISSMKKHSLSIGSGWSVSLKGNNLIWT
LKDSAGEVRQITFRDLPDKFNAYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLK
LDRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRYDTEYYLIPVASSSKDVQLK
NITDYMYLTNAPSYTNGKLNIYYRRLYNGLKFIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPK
DGNAFNNLDRILRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQIGNDPNRDI
LIASNWYFNHLKDKILGCDWYFVPTDEGWTND
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
The fragment C of tetanus toxin was amplified from Clostridium tetani DNA by PCR. Immunization of mice with rTTC resulted in the production of antibodies that were able to protect mice against a challenge with tetanus toxin furthermore, rTTC in vivo appeared to be able to undergo retrograde axonal transport (He et al., 2000).
- Related Vaccine(s):
C. tetani DNA vaccine pcDNA3tetC encoding fragment C
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| II. References |
1. He et al., 2000: He HJ, He ZY, Shi HJ, Zhu W, Yang GZ, Yuan QS, Wu XF. Cloning and Expression of Tetanus Toxin Fragment C in E.coli. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica. 2000; 32(4); 322-326. [PubMed: 12075415].
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