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Pathogen Page
Neisseria meningitidis

Table of Contents

  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
    4. Microbial Pathogenesis
    5. Host Ranges and Animal Models
    6. Host Protective Immunity
  2. Vaccine Related Pathogen Genes
    1. ExbB (Neisseria meningitidis MC58)
    2. GNA1030 (Neisseria meningitidis MC58)
    3. GNA1162 (Neisseria meningitidis MC58)
    4. GNA1220 (Neisseria meningitidis MC58)
    5. GNA1870 (Neisseria meningitidis MC58)
    6. GNA1946 (Neisseria meningitidis MC58)
    7. GNA2001 (Neisseria meningitidis MC58)
    8. GNA2091 (Neisseria meningitidis MC58)
    9. GNA2132 (Neisseria meningitidis MC58)
    10. GNA33 (Neisseria meningitidis MC58)
    11. GNA992 (hsf) (Neisseria meningitidis MC58)
    12. gp120 (Human immunodeficiency virus 1)
    13. lctP (Neisseria meningitidis)
    14. lpdA (Neisseria meningitidis)
    15. metH (Neisseria meningitidis MC58)
    16. NadA (Neisseria meningitidis MC58)
    17. NspA from N. meningitidis MC58 (Neisseria meningitidis MC58)
    18. P1 (Neisseria meningitidis MC58)
    19. rfaF (Neisseria meningitidis MC58)
    20. siaD (Neisseria meningitidis MC58)
    21. tbp2 (Neisseria meningitidis)
    22. tbpA (Neisseria meningitidis K454)
  3. Vaccine Information
    1. 0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection
    2. 0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection [Vaxelis]
    3. 0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe
    4. 0.5 ML Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe [Vaxelis]
    5. 0.5 ML diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    6. 0.5 ML diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec]
    7. 0.5 ML diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] by Nuron Biotech
    8. 0.5 ML diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    9. 0.5 ML diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate]
    10. 0.5 ML diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate] by Glaxosmithkline
    11. 0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe
    12. 0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe Box of 1
    13. 0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe [ActHIB]
    14. 0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe [ActHIB] Box of 1
    15. 0.5 ML Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe [ActHIB] Box of 1 by Sanofi
    16. 0.5 ML Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML / meningococcal group C polysaccharide 0.01 MG/ML / meningococcal polysaccharide vaccine group Y 0.01 MG/ML Injection
    17. 0.5 ML Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML Injection
    18. 0.5 ML Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.104 MG/ML Prefilled Syringe
    19. 0.5 ML Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML Injection
    20. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    21. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension Box of 1
    22. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension Box of 10
    23. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec]
    24. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] Box of 1
    25. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] Box of 1 by Nuron Biotech
    26. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] Box of 10
    27. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection
    28. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection Box of 10
    29. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection [Meningitec]
    30. 0.5 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection [Meningitec] Box of 10
    31. 0.6 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    32. 0.6 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension Box of 1
    33. 0.6 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate]
    34. 0.6 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate] Box of 1
    35. 0.6 ML Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate] Box of 1 by Glaxosmithkline
    36. 5CVMB
    37. acellular pertussis vaccine, inactivated / Bordetella Pertussis Filamentous Haemagglutinin Antigen / diphtheria toxoid vaccine, inactivated / pertactin adsorbed / tetanus toxoid vaccine, inactivated Injection
    38. acellular pertussis vaccine, inactivated / Bordetella Pertussis Filamentous Haemagglutinin Antigen / diphtheria toxoid vaccine, inactivated / pertactin adsorbed / tetanus toxoid vaccine, inactivated Injection [Boostrix]
    39. acellular pertussis vaccine, inactivated / Bordetella Pertussis Filamentous Haemagglutinin Antigen / diphtheria toxoid vaccine, inactivated / pertactin adsorbed / tetanus toxoid vaccine, inactivated Injection [Infanrix]
    40. acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine / hepatitis B surface antigen vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Injection
    41. acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine / hepatitis B surface antigen vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Injection [Vaxelis]
    42. acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine / hepatitis B surface antigen vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Prefilled Syringe
    43. acellular pertussis vaccine, inactivated / diphtheria toxoid vaccine, inactivated / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine / hepatitis B surface antigen vaccine / poliovirus vaccine inactivated, type 1 (Mahoney) / poliovirus vaccine inactivated, type 2 (MEF-1) / poliovirus vaccine inactivated, type 3 (Saukett) / tetanus toxoid vaccine, inactivated Prefilled Syringe [Vaxelis]
    44. BEXSERO
    45. Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe [Vaxelis]
    46. Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Prefilled Syringe
    47. Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML Injection
    48. Bordetella pertussis filamentous hemagglutinin vaccine, inactivated 0.04 MG/ML / Bordetella pertussis fimbriae 2/3 vaccine, inactivated 0.01 MG/ML / Bordetella pertussis pertactin vaccine, inactivated 0.006 MG/ML / Bordetella pertussis toxoid vaccine, inactivated 0.04 MG/ML / diphtheria toxoid vaccine, inactivated 30 UNT/ML / Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.006 MG/ML / hepatitis B surface antigen vaccine 0.02 MG/ML / poliovirus vaccine inactivated, type 1 (Mahoney) 58 UNT/ML / poliovirus vaccine inactivated, type 2 (MEF-1) 14 UNT/ML / poliovirus vaccine inactivated, type 3 (Saukett) 52 UNT/ML / tetanus toxoid vaccine, inactivated 10 UNT/ML [Vaxelis]
    49. CCPS-P64kR
    50. diphtheria toxoid vaccine, inactivated / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine Injectable Suspension [Meningitec]
    51. diphtheria toxoid vaccine, inactivated / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine Injectable Suspension [Menjugate]
    52. diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML
    53. diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    54. diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec]
    55. diphtheria toxoid vaccine, inactivated 0.03 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML [Meningitec]
    56. diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML
    57. diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    58. diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate]
    59. diphtheria toxoid vaccine, inactivated 0.05 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML [Menjugate]
    60. Haemophilus capsular oligosaccharide 0.015 MG/ML / Neisseria meningitidis 0.25 MG/ML Injectable Solution
    61. Haemophilus capsular oligosaccharide 0.015 MG/ML / Neisseria meningitidis 0.25 MG/ML Injectable Suspension
    62. Haemophilus capsular oligosaccharide 0.015 MG/ML / Neisseria meningitidis 0.25 MG/ML Injectable Suspension [Liquid PedvaxHIB]
    63. Haemophilus capsular oligosaccharide 0.03 MG/ML / Neisseria meningitidis 0.5 MG/ML Injectable Solution
    64. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe
    65. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe Box of 1
    66. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe [ActHIB]
    67. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML Prefilled Syringe [ActHIB] Box of 1
    68. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine 0.02 MG/ML [ActHIB]
    69. Haemophilus influenzae b (Ross strain) capsular polysaccharide meningococcal protein conjugate vaccine 0.265 MG/ML Injection [PedvaxHIB]
    70. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Solution [Begrivac]
    71. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Solution [Enzira]
    72. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Solution [Imuvac]
    73. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Solution [Invivac]
    74. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Injectable Solution [Mastaflu]
    75. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [ActHIB]
    76. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [Begrivac]
    77. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [Enzira]
    78. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [Imuvac]
    79. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [Invivac]
    80. Haemophilus influenzae b (Ross strain) capsular polysaccharide Meningococcal Protein Conjugate Vaccine Prefilled Syringe [Mastaflu]
    81. Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML / meningococcal group C polysaccharide 0.01 MG/ML / meningococcal polysaccharide vaccine group Y 0.01 MG/ML Injection [MenHibrix]
    82. Haemophilus influenzae type b strain 1482, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.005 MG/ML / meningococcal group C polysaccharide 0.01 MG/ML / MENINGOCOCCAL POLYSACCHARIDE VACCINE GROUP Y 0.01 MG/ML [MenHibrix]
    83. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / meningococcal group C polysaccharide Injectable Solution
    84. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / meningococcal group C polysaccharide Injectable Solution [Menitorix]
    85. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine Injectable Solution
    86. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine Injectable Solution [PedvaxHIB]
    87. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine / Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine Injectable Suspension
    88. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.015 MG / Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.25 MG Injectable Solution
    89. Haemophilus influenzae type b, capsular polysaccharide inactivated tetanus toxoid conjugate vaccine 0.015 MG / Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine 0.25 MG [PedvaxHIB]
    90. licensed Meningococcal disease human vaccine
    91. Menactra
    92. MenHibrix
    93. MenHibrix Injectable Product
    94. MENHIBRIX vaccine 0.5 ML Injection
    95. Meningitec
    96. Meningococcal Conjugate and Haemophilis B Vaccine
    97. Meningococcal Polysaccharide Vaccine, Groups A & C, Menomune A/C
    98. Menjugate
    99. Menomune-A/C/Y/W-135
    100. Menveo
    101. Menveo Injectable Product
    102. MENVEO vaccine 0.5 ML Injection
    103. N. meningitidis DNA vaccine P3A
    104. N. meningitidis ExbB Protein Vaccine
    105. N. meningitidis LctP Protein Vaccine
    106. N. meningitidis NspA Protein Vaccine
    107. N. meningitidis TbpA Protein Vaccine
    108. N. miningitidis TBP2 Protein Vaccine
    109. Neisseria meningitidis metH/siaD mutant vaccine
    110. Neisseria meningitidis rfaF/siaD mutant vaccine
    111. Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine Injection
    112. Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine Injection [Menactra]
    113. Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine Prefilled Syringe
    114. Neisseria meningitidis serogroup A capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup C capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup W-135 capsular polysaccharide diphtheria toxoid protein conjugate vaccine / Neisseria meningitidis serogroup Y capsular polysaccharide diphtheria toxoid protein conjugate vaccine Prefilled Syringe [Menactra]
    115. Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine Injection
    116. Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine Injection [Menveo]
    117. Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML Injection [Menveo]
    118. Neisseria meningitidis serogroup A oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML / Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup W-135 oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML / Neisseria meningitidis serogroup Y oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.01 MG/ML [Menveo]
    119. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension
    120. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension Box of 1
    121. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension Box of 10
    122. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec]
    123. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] Box of 1
    124. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Meningitec] Box of 10
    125. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate]
    126. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injectable Suspension [Menjugate] Box of 1
    127. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection
    128. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection Box of 10
    129. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection [Meningitec]
    130. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML Injection [Meningitec] Box of 10
    131. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML [Meningitec]
    132. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine 0.02 MG/ML [Menjugate]
    133. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine Injectable Suspension [Meningitec]
    134. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine Injectable Suspension [Menjugate]
    135. Neisseria meningitidis serogroup C oligosaccharide diphtheria CRM197 protein conjugate vaccine Injection [Meningitec]
    136. Neisvac-C
    137. NIMENRIX
    138. TRUMENBA
    139. VAXELIS vaccine
  4. References
I. General Information
1. NCBI Taxonomy ID:
487
2. Disease:
Meningitis
3. Introduction
Neisseria meningitidis, also simply known as meningococcus, is a Gram-negative β-proteobacterium and member of the bacterial family Neisseriaceaeis. There are 13 serogroups based on different capsular polysaccharide structures. Among them, six serogroups (A, B, C, W-135, X, and Y) cause most life-threatening disease (Stephens et al., 2007).
4. Microbial Pathogenesis
Meningococcus is spread through the exchange of saliva and other respiratory secretions during activities like coughing, kissing, and chewing on toys. Those with impaired immunity may be easier to get meningococcus. Meningococcal virulence is related to both capsule expression, expression of other surface structures, and underlying genotype. N meningitidis pathogenesis is related to its ability to express and modify capsule with serogroups A, B, C, W-135, X, and Y. Capsules of N meningitidis facilitate transmission and colonisation, and protect the meningococcus from desiccation, phagocytic killing, opsonisation, and complement-mediated bactericidal killing. Outer membrane proteins (e.g., PorB, PorA , Opa and Opc) contribute to meningococcal virulence. Outer membrane porins are involved in host-cell interactions and as targets for bactericidal antibodies. Endotoxin, or lipo-oligosaccharide, a major component of the outer membrane, differs in structure from enteric endotoxins and is crucial in inflammatory signalling via Toll-like receptor 4 (TLR4) (Stephens et al., 2007).
5. Host Ranges and Animal Models
It only infects humans; there is no animal reservoir.
6. Host Protective Immunity
N. mengingitidis establishes systemic infections only in individuals who lack serum bacterial antibodies directed against the capsular or noncapsular (cell wall) antigens of the invading strain, or in patients deficient in the late-acting complement components. The presence of serum bactericidal IgG and IgM is probably the most important host factor in preventing invasive disease. The role of bactericidal antibodies in prevention of invasive disease explains why high attack rates are seen in infants from 6 to 9 months old, the time at which maternal antibodies are being lost. Individuals with complement deficiencies (C5, C6, C7, or C8) may develop meningococcemia despite protective antibody. This emphasizes the importance of the complement system in defense against meningococcal disease (Textbook of Bacteriology).
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