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Giardia duodenalis

Table of Contents
  1. Protective Antigens
    1. CWP2
1. CWP2
  • Gene Name : CWP2
  • Sequence Strain (Species/Organism) : Giardia lamblia ATCC 50803
  • VO ID : VO_0011080
  • NCBI Gene ID : 5703171
  • NCBI Protein GI : 159120052
  • Locus Tag : GL50803_5435
  • Genbank Accession : AACB02000001
  • Protein Accession : XP_001710242
  • Taxonomy ID : 50803
  • Gene Starting Position : 1061836
  • Gene Ending Position : 1062924
  • Gene Strand (Orientation) : -
  • Protein pI : 8.13
  • Protein Weight : 37700.21
  • Protein Length : 362
  • DNA Sequence : Show Sequence 
    >NW_002477099.1:1061836-1062924 Giardia lamblia ATCC 50803 SC_592, whole genome shotgun sequence
TTCACCTTCTGCGGACAATAGGCTTGTTCGTGCTGCGAGGCAGAGCTCTCACGGGTGCACGCTTCGATTG
GGTCGGCTTGGTGATCGCACGAGCGGTGGGGCGGGCTACAGCAGAGCGGCTAGCATTGCCAGTCACAGAG
CTCCTCGATTGGACCGTCTTCTTGGGAGCCGTCCTGGAGCGGGACGTTGAGGCCGTCTTGCTAGATGACC
TAACCACTGTCCTGAGCGGTGTTTGGCTGCGGCTGTTTGGCATGTTGCATTTCCTCTGCGCATTGTGTGC
ACTGTTGTGCATGTTGCTCTTGGCCTTGCCACAGTTGGAGGCGCTACGAGCGTTGCAGCTTGTCTTTCGT
CCCGACGCATTGCGGACTACTGTCTGCCTGTAGTACGTGCATCCATCTCTCTCGAGAGTTGTGGGGCAGT
TTGTCGGCGGGAGAGCAGTGCAGTAATCGCAGTCTGTTGTTCCACAGAGGTAGATTCCGGTGTAGGTGTC
AGGCGCAGCTGTGCAAACGAGATCGGTGTTGCACTGGACATGAATCTCCATCATGTAAGGCAGGTCGAAG
AGATCTGCCGGAACGTCGCCAGTCAGCTCGTTGCAGTCAAGGTGGAGCTCCTTGAGGAATTGGAGTTCGT
TGACGCAGGTGGGGATGGGACCAGTGAGAGCATTAATACTCATGTACCAAAACATCATGTGGGTTAAATC
ACAGATGCACTCGGGAATGTCACCCGTCAGCCCAGCGTTGTTAATTTGCAGGTACTGCATTGAGGTGAGG
GCACAAAGATCCGTCGGGATCGGGCCCGCAAGGTCATTATTATTAAGGTACAGCGACCTCAAAAGTGGGA
AGCAGCCTATGTCGGCAGGGAGGGCACCAGTGAGCCCCATGTCAGAGAGGTCGATCCCAATAACGTTATT
GTTAGAGTCGCATGTGATGCCGGTCCAGCTACAGTAAGACACGTCGGGCGTAAGCCAGTTATTCGACTTC
CAATTAGCACCATCCAGGGCATCGTACAAATTGGTCAGGGCCTCCTCCTCGGTGGCAGGGCAAGCGGCGC
GAGCAAGACCAAGAAGTCCTAGAACAAGGGCTGCGATCA
  • Protein Sequence : Show Sequence 
    >XP_001710242.1 Cyst wall protein 2 [Giardia lamblia ATCC 50803]
MIAALVLGLLGLARAACPATEEEALTNLYDALDGANWKSNNWLTPDVSYCSWTGITCDSNNNVIGIDLSD
MGLTGALPADIGCFPLLRSLYLNNNDLAGPIPTDLCALTSMQYLQINNAGLTGDIPECICDLTHMMFWYM
SINALTGPIPTCVNELQFLKELHLDCNELTGDVPADLFDLPYMMEIHVQCNTDLVCTAAPDTYTGIYLCG
TTDCDYCTALPPTNCPTTLERDGCTYYRQTVVRNASGRKTSCNARSASNCGKAKSNMHNSAHNAQRKCNM
PNSRSQTPLRTVVRSSSKTASTSRSRTAPKKTVQSRSSVTGNASRSAVARPTARAITKPTQSKRAPVRAL
PRSTNKPIVRRR
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : The gene encoding the full length cyst wall protein-2 (CWP2) from Giardia lamblia was subcloned into the pCDNA3 mammalian expression vector and stably introduced into S. typhimurium STM1. Challenge infection with live Giardia muris cysts revealed that mice receiving the CWP2-encoding DNA vaccine were able to reduce cyst shedding by approximately 60% compared to control mice (Abdul-Wahid and Faubert, 2007).
  • Related Vaccine(s): G. duodenalis DNA vaccine encoding CWP2
II. References
1. Abdul-Wahid and Faubert, 2007: Abdul-Wahid A, Faubert G. Mucosal delivery of a transmission-blocking DNA vaccine encoding Giardia lamblia CWP2 by Salmonella typhimurium bactofection vehicle. Vaccine. 2007; 25(50); 8372-8383. [PubMed: 17996337].