VIOLIN: Vaccine Investigation and Online Information Network

Leptospira spp.

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. ligA (Protective antigen)
2. ligB (Protective antigen)
3. ligB (Protective antigen)
4. lipL21 (Protective antigen)
5. lipL32 (Protective antigen)
6. lipL45 (Protective antigen)
7. loa22 (Protective antigen)
8. lsa21 (Protective antigen)
9. mce (Protective antigen)
10. ompL1 (Protective antigen)
11. ompL1 (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

171

2. Disease:

Leptospirosis

3. Introduction

Leptospirosis (also known as Weil's disease, Weil's syndrome, canicola fever, canefield fever, nanukayami fever, 7-day fever, Rat Catcher's Yellows, Fort Bragg fever, and Pretibial fever) is a bacterial zoonotic disease caused by spirochaetes of the genus Leptospira that affects humans and a wide range of animals, including mammals, birds, amphibians, and reptiles. The disease was first described by Adolf Weil in 1886 when he reported an "acute infectious disease with enlargement of spleen, jaundice and nephritis". Leptospira was first observed in 1907 from a post mortem renal tissue slice. In 1908, Inada and Ito first identified it as the causative organism and in 1916 noted its presence in rats. Though recognised among the world's most common zoonoses, leptospirosis is a relatively rare bacterial infection in humans. The infection is commonly transmitted to humans by allowing water that has been contaminated by animal urine to come in contact with unhealed breaks in the skin, the eyes, or with the mucous membranes. Outside of tropical areas, leptospirosis cases have a relatively distinct seasonality with most of them occurring August–September/February–March.

Leptospirosis is caused by a spirochaete bacterium called Leptospira spp. that has at least 5 serovars of importance in the United States and Canada causing disease in dogs (Icterohaemorrhagiae, Canicola, Pomona, Grippotyphosa, and Bratislava).There are other (less common) infectious strains. Genetically different leptospira organisms may be identical serologically and vice versa. Hence, an argument exists on the basis of strain identification. The traditional serologic system is seemingly more useful from a diagnostic and epidemiologic standpoint at the moment (which may change with further development and spread of technologies like PCR).

Leptospirosis is transmitted by the urine of an infected animal and is contagious as long as it is still moist. Although rats, mice and moles are important primary hosts, a wide range of other mammals including dogs, deer, rabbits, hedgehogs, cows, sheep, raccoons, possums, skunks, and certain marine mammals are able to carry and transmit the disease as secondary hosts. Dogs may lick the urine of an infected animal off the grass or soil, or drink from an infected puddle. There have been reports of "house dogs" contracting leptospirosis apparently from licking the urine of infected mice that entered the house. The type of habitats most likely to carry infective bacteria are muddy riverbanks, ditches, gullies, and muddy livestock rearing areas where there is regular passage of either wild or farm mammals. There is a direct correlation between the amount of rainfall and the incidence of leptospirosis, making it seasonal in temperate climates and year-round in tropical climates.

Leptospirosis is also transmitted by the semen of infected animals. Slaughterhouse workers may contract the disease through contact with infected blood or body fluids.

Humans become infected through contact with water, food, or soil containing urine from these infected animals. This may happen by swallowing contaminated food or water, or through skin contact. The disease is not known to be spread from person to person and cases of bacterial dissemination in convalescence are extremely rare in humans. Leptospirosis is common among water-sport enthusiasts in specific areas as prolonged immersion in water is known to promote the entry of the bacteria. Surfers and whitewater paddlers are at especially high risk in areas that have been shown to contain the bacteria, and can contract the disease by swallowing contaminated water, splashing contaminated water into their eyes or nose, or exposing open wounds to infected water. Occupations at risk include veterinarians, slaughterhouse workers, farmers, sewer workers, and people working on derelict buildings. Rowers are also sometimes known to contract the disease (Wiki: Leptospirosis).

4. Host Ranges and Animal Models

Leptospirosis is transmitted by the urine of an infected animal and is contagious as long as it is still moist. Although rats, mice and moles are important primary hosts, a wide range of other mammals including dogs, deer, rabbits, hedgehogs, cows, sheep, raccoons, possums, skunks, and certain marine mammals are able to carry and transmit the disease as secondary hosts (Wiki: Leptospirosis).

II. Vaccine Related Pathogen Genes

1. ligA

Gene Name : ligA
Sequence Strain (Species/Organism) : Leptospira kirschneri serovar Kambale
NCBI Protein GI : ACH98094
Other Database IDs : CDD:214752
CDD:308144
CDD:322060
Taxonomy ID : 173
Protein Name : LigA
Protein pI : 6.12
Protein Weight : 119806.65
Protein Length : 1285
Protein Note : serogroup: Canicola

Protein Sequence : Show Sequence

>ACH98094.1 LigA [Leptospira interrogans]
MKKIFCISIFLSMFFQSCMSWPLLTSLAGLAAGKRGGDSSFFHLLLGNSDPTITRIELSYQDSSIANGTS
TTLEVTAIFDNGTNQNITDSTSIVPDSQSVVTIQGNRVRGIASGSSIIKAEYNGLYSEQKITVTPATLNS
IQVTSLESGILPKGTNRQFSAIGIFSDGSHQDISNDPLIVWSSSNPDLVQVDDSGLASGINLGTAHIRAS
FQSKQGAEEMTVGDAVLSQIQVTSNNPNIPLGKKQKLIATGIYSDNSNRDISSSVIWNSSNSTIANIQNN
GILETADTGIVTISASSENIIGSVKLIVTPAALVSISVSPTNSTVAKGLQENFKATGIFTDNSNSDITDQ
VTWDSSNTDILSISNASDSHGLASTLNQGNVKVTASIGGIQGSTDFTVTQAALTSIEVSPVLPSIAKGLT
QKFTAIGIFTDNSKKDITDQVTWNSSSAIVSVSNLDDNKGLGKAHAVGDTTITATLGKVSGKTWLTVVPA
VLTSIQINPVNPSLAKGLTQKFTATGIYSDNSNKDITSAVTWFSSDSSIATISNAQKNQGNAYGAATGAT
DIKATFGKVSSPVSTLSVTAAKLVEIQITPAAASKAKGLTERFKATGIFTDNSNSDITNQVTWNSSNTDI
LTVSNTNAKRGLGSTLKQGTVKVTASMGGIEDSVDFTVTQATLTSIEVSPTRASIAKGMTQKFTATGIFT
DHSKKNITEQVTWKSSSKALSMLNAPGEEGTGKAIAVGNISITATLEKLSGKTDITVTPAVLTSIQISPV
KHCLVKGLTEKFSATGIYSDNSSKDITSAVTWHSSNNSVATISNTKGYQGQAHGTGTGTVDIKATLGNVS
SQVSKLSVTAAELIEIVLNPTSSHKAKGLTENFKATGVFTDNSTKDITDQVTWKSSNTAYAKISNATGSK
GVVNALSKGTSHISATLGSISSANATFQVTPAKVVSIEVIPNNISFAKGNSYQFKATGIYTDHSEADITE
QVTWSSSNPKIASVENTFGSAGLVNTTNIGSTNITAKLSDTVSGSSVLNVTPALLRYIMITPSYAGIEKG
YTKQFSAIGTYSDQSTKDLTEDVTWFSSNPSSVVIENTPGKKGLAFASELGEPDITVFYDHHTQSSYTPV
TVTESGIVNITISLSSISKTKGSTHQFKATGKFENGAEIDLTELVTWSSSNPTVVSISNVDDERGLATAL
SVGSSKISVDYNSISSSIDFEVTPEILASIKTEP

Molecule Role : Protective antigen
Molecule Role Annotation : (Evangelista et al., 2017)

2. ligB

Gene Name : ligB
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
NCBI Gene ID : 2771118
NCBI Protein GI : 45656362
Locus Tag : LIC10464
Genbank Accession : AE016823
Protein Accession : YP_000448
Taxonomy ID : 267671
Chromosome No : I
Gene Starting Position : 526394
Gene Ending Position : 532066
Gene Strand (Orientation) : -
Protein Name : hypothetical protein
Protein pI : 7.03
Protein Weight : 190366.08
Protein Length : 1890
Protein Note : Big; identified by sequence similarity; ORF located using Blastx/Glimmer

DNA Sequence : Show Sequence

>NC_005823.1:526394-532066 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130, chromosome I, complete sequence
ATTATTGATTCTGTTGTCTGTAAATTTTGACCGGTTTATTTTTGTTTCCTACGCTTATATATACGAAATT
TACACCAAAATTCATTCCGGATATAGCCGAATAAATTTGACGATTGGTAACGTCTCTTAATCCGCCTATT
CCTATAGGTTCCCAGTTGTGTGATGAACTTCCAGGATTTTCAAGATTTGTTCTCCAGATTTGAATTCCGT
TTTCGTTATCAAAACCTATGTAGAGATAAGATCCACTTGCAACCATCATCGTCATACTGTGATTGGAATT
GTCTCCAAAGTTTGTAAATCCGGTTCCGTTATCTCCTACTAAAGACCAATCTTCTGCTTCGCAGGTTGTT
GTATCGCCGGTTAGAGTCGGATCACATTTCCAAAGTTGGGGTCTTCGATTTGTATAACTTCCGTCCGTAC
AACCTTCCACAGTTTGTAAACTTTGTCTGAGTCCGGAGTGATCTTCTTTCGTTACGCAGATCGTTCTTGT
TACATACAATCTTCCGTTAAATTCTGCGAATTGAGAGAATGCTTTATCCGCCGGAATTAAATTCCGATAC
TTTGTAAGCTCCAGTGAAAACCAATTGTTATGAGGAGAGTTATGCCACTTCGGATTGGATCTAGGTGCTG
TGTCTTTCCAACTGGAACAACGATTGCTCCCCTCACAAGGACTAGGATTTGCACTGGTAGAGTGTATTAT
ACTTCCATTATGTAGTGAATTTGGAAATCCTCCGTTTGCGGCGTAAAGTTTTTCTTTAAAAACGAATAGA
GAATCTATTCCCACATAATAACCCCAGTTGATCGAGGAGTTATCAGATGTATAAGTTTCATAATTGTCTG
CATCCTCCACGGAGAGGCCGCCGAAATAAGGCATTCTATCGATTCTAAAACGATTACCGCGGTATCCGTC
AGAGGCGTCACAATTGTTTCCGGCTGCACATCTATTTTGATCGGATGTATTAAAGGTGATTTTACCGAAA
TCAGGTGCGTTTAGATTTTTATTTTTTTTTGCAAAACCCACATGGATCCGATCGTCTATAACCGCGATAG
ATGAAGTTCCTGCAGTCGCCGTTCCAGTAATTTCTCCCATATCGATATATTTAAAATTAAGATTTGTATC
GGTATCTGAGGAATAATAGAGATAGTCGAATCTCCTTGGTCTTGAACCTGCTATAAAAATATGAGATTTT
TTGTTTAATGATCCGATGGCAAAAACTCCACGTCCATCTTCGTTATCCGGACCACATCCAGTAGTAATGT
CTGCACTATTGAGAGTACAACCGGTATGACCGATCGTAACGTAATTCGGAACCGGAATTCCTCCATCTCT
TGAAGACGCACGGTTATCGGCATTTATATCTTTGGTAAAAGAGAAAAAAATAGATTCGGGAAAAGTTCCG
TCGTAATTGAATCGAGCTGCTTGGTTTCCTTTTACATTCGGTCCTAGATAGATTTGATTGTTGTAATCTA
CAAGAAAGCCGAAATCGGAACCGTCTCCAAAAGGATCTGACATGATCGGGCCATCCATAAAGTTGAGAGG
GGAATTTCCACAACCTATAAAGTTGATTCTATCTTTCGGAGAAGATTGTAGGTTTTCTTGATCGAATGAA
TCTCTAATTGCTCCCCAGGATTTGTTGTCAAAGCCGTCTCCGTTCAAATCATTTGCGGCGATGATCGTAT
ATTGACCACCTGATTGAAGAAGGGAGTGTGTTAAACATATTTTCGAGGAGTCTGCCGGTGCTCCACCGCA
TACTTTTCCATCTAAAATTCTAACGCTCGTAATACTTCCCAATGAAGACACACCTGCAAATTTATATCTG
GATTCACACTGGGACGGATTTGAACATTCCACGGATTTTGTTGCTTCCTTTCCCGAATATAAAGGTTTGG
AAAAAGAAACGATCACTTGGTTTAAGGAATTACAAACTGCACTTGTAAGTTTGAGTTGTTCTTTTCCTAT
AAAATCAGAGTTATTTGGACAACTTAAGGAATTTGGAATGGAAGAAAGATCGTGAATTCCTTGTTTGTTG
ACTACAAGTGTGTATGATTTGTTTAAGATTTGTGAATGTGAAAGTGTGATCGTAAAAGTATTTTTACTTC
CTTTGATACTACTAAGAGAAAAATCTGCGGTTTGAGAATTGGAATTGAAGTCCGTATTATCTGAACAATG
TCCTATAAAATTGGAACTATCAATTATTTTGTAATTGGATAAATCAAGGGCTTCCTTATTGTTTATGGAT
TCTGAATATACAACTTGGATGGTAGTAGGTGATAAGGAAACTACCGATTGAACCGTTGGAGCTATCGTGT
CCGTTTTGTTTACTGTGAGGATTGTATTTCCAGATACTGAACCGTAGGTCGCTGTGATTATAGAGTTTCC
AGAAGCAATCCCTGTAACCAATCCTTTCGTTTTAGATGCGTTACTCACCTTTGCCTGAGATTTATTTGAG
CTGGACCATGTAACCGAAGAAGTTAAATCCGCTTTGGTCCCATCCGAATACGTTCCCACCGCGAAAAATT
GTTTTGATACGGTTGCGTTTATATTTGTATTGATAGGAGATATTGAAATCGAAGAAAGGGTTGCTGCGCT
GACCGTTATGTCTATGTTTTCCGAGATGGAATTGTAAGTCGCAGTGATTTTGCTGTTTCCAATCTGTAAA
GCGGTCGCTTTTCCCTTGGTTTCGGTCGAATTAGAGATGCTGATCGAGTCAGAATTGGAACTGGACCAGG
TAACTGAATCGCTGATGTCCTGAATGGTGGAGTCTGAATAAACGCCAAGCGCAGTATATTGTTGGGTAAG
TCCCTTGGCGATGTTATTGTTGACTGGATTGATTTTAATGGAATCTAACGTGGCAGCACTTACATTAAAA
TTTATTTTATTACTGCTTATAGAATTGTAAATCGCAGAGATGTTGGAAGAACCTATTGAAAGTGCGGTTG
CTAAACCTTTTGCATTGGCAGCGTTATTGATAGGGGCAACGTCGGATTTGGAAGAATACCAGGTCACAAG
ATTCGTAATTTCTTGTTCAGAGCCATCTATAAAAGTTCCGATCGCTTTAAATTGCTGGGTCAATCCTTTG
GCTATTGAACTTGAGGAAGGACTGATAGTTATACTTTTCAGTTTTAAGTCAGTGACTGTAATCGGAATTG
GGGAGCTTTGGATGAATTTGTAGACGGCCTTAATATTCGAACTTCCTAATTTAGAGGCTGTCGCTATACC
TTTTTTACCGGAAGTGTTTTCGATCTCAATCTTAGATGGATCGGAAGAAATCCAAGTTACAAGCTGAGTC
AAATTTTGAGTAGATTTATCTGAAAAGATACCAGTCGCTTTAAATTGTTTTGTAAGACCGTGAGTGATAG
AGTTAATCGTCGGTGTTATCTCGATAGAAGTAAGAAGTGCAGGAGTGACATTCAAAACGGAAGAGCCAGA
TATGGAGTCTATCGTTGCTTTAATATTTGTATTTCCGGTAGCCACTGTTGTAACCGAACCTGTAACGTTG
TTAACCATTGCTTTTCCGGGATTGGAAGAAGACCAGGTAGCTAGGGCAGTCACGTCTTGTACGGAATGAT
CCGTATATGTTCCGGTGGCTTTAAATTGTCGTATTAGACCTTTTGCAACTGACGGATTTATAGGTGTTAC
GGCAATGGAAATCAATTGTGCCGGAGTTACCTTTAAAATTACTTTAGAACTTTTGATTGAACCGAGGGCT
GCGGATATTTCACTCGATCCTGGAGTGAGTGTATTTGTAATACCTTTACTTCCACTGGTATTTTTAATTT
CAGCAATATCCGTATTAGAGGAATTCCAGGTAACTTGATTTGTAATATCGGAATTTGAGTTATCCGTAAA
GATACCAGTAGCCTTGAATCTTTCTGTGAGTCCCTTTGCTTTGGAAGCAGCAGCCGGTGTGATTTGGATT
TCAACAAGCTTTGCAGCTGTAACAGATAACGTAGAAACCGGACTACTTACCTTTCCGAATGTGGCTTTAA
TATCCGTTGCTCCTGTAGCTGCTCCGTAAGCGTTTCCTTGATTTTTTTGGGCGTTTGAAATCGTCGCGAT
TGAAGAATCGGATGAGAACCACGTAACAGCGGAAGTAATGTCCTTGTTAGAGTTGTCAGAGTAGATCCCA
GTAGCCGTAAATTTTTGAGTTAACCCTTTTGCAAGAGAAGGATTTACAGGATTGATTTGAATAGAAGTGA
GAACCGCAGGAACTACAGTAAACCAAGTGTTACCTGAAACTTTTCCTAAGGTTGCGGTAATAGTCGTGTT
TCCAACTGAGTTGGTTTTTCCCAGACCTTTATTGTTGTCTAAGTTAGACACGCTTACGATTGCTGAAGAA
GAATTCCAAGTGACTTGATCCGTAATATCCTTCTTAGAGTTATCCGTAAAAATCCCGATCGCAGTAAACT
TTTGAGTTAGTCCTTTTGCAATGGAAGTGCGAGTTGGAGAGACTTCGATGGAAGTCAATGCAGCTTGTGT
AACTTTAAAATCAGTGGATCCTTGTATTCCACCGATGGAAGCAGTGACTTTAACATTCCCTTGGTTGAGT
GTGGAAGCTAATCCGTGGCTATCACTTGCATTGGAAATTGAGAGAATATCGGTATTAGAAGAATCCCAAG
TAACTTGGTCGGTAATATCCGAGTTTGAATTATCTGTAAAGATCCCTGTAGCTTTAAAGTTTTCTTGTAA
ACCTTTTGCAACTGTAGAATTTGTCGGAGAAACAGAAATAGAAACTAAGGCTGCTGGAGTAACGATTAGT
TTTACGGATCCGATTATATTCTCGCTAGAAGCAGAAACAGTGACAATACCAGTATCAGCTGTTTCTAATA
TTCCGTTGTTTTGAATATTAGCGATAGTGGAATTAGAAGAATTCCAAATAACAGAAGAGGAAATATCCCT
GTTAGAGTTATCCGAATAGATTCCCGTAGCTGTTAGTTTTTGTTTTTTTCCGAGAGGAATATTCAGATCG
TTTGAAGTTACTTGGATTTGAGAGAGAACAGCATCTCCAACGGTCATTTCTTCAGCCCCTTGTTTTGATT
GAAAGGATGCACGAATATGAGCTGTTCCTAAATTGATCCCTGATGCCAACCCTGAATCATCTACTCGAAC
CAAATCAGGATTACTGGAAGACCAAACGATCAGTGGTTCGTTGGAAATATCCTGATGAGAACCATCCGAA
AAGATACCGATGGCTGAGAATTGACGATTAGTACCTTTAGGTAGTATACCTGACTCTAAACTCGTAACTT
GAATTGAGTTAAGAATGGCTGGTGTAACGGTAATTTTTTGTTCAGAGTATAGGCCGTTGTATTCTGCTTT
TATAATGGAAGAACCAGAAGCGATTCCTTTGACTCTGTTGCCTTCGATTGTTACAACGGATTGGGAATCG
GGGACGATGGATGTCAAATCCGTAATATTCTGATTTGTTCCGTTATCAAAGATTGCGGTAACTTCTAGGG
TTGTACTGGTACCGTTTGCGATAGAAGAATCTTGATAACTAAGTTCGATTCTTGTAATAGTCGGATTGAA
GTTACCTAACAGAAGGTGGAAAAAGGACAGCCCATTACTTTTTTTACCAGCGGTTAATCCTACCAGACCG
GTTAAAAGTGGCCAAGACATACAACTTTGAAAAAACATCGAAAGAAAAATCGAAATACAAAATATTTTCT
TCA

Protein Sequence : Show Sequence

>YP_000448.1 hypothetical protein LIC10464 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
MKKIFCISIFLSMFFQSCMSWPLLTGLVGLTAGKKSNGLSFFHLLLGNFNPTITRIELSYQDSSIANGTS
TTLEVTAIFDNGTNQNITDLTSIVPDSQSVVTIEGNRVKGIASGSSIIKAEYNGLYSEQKITVTPAILNS
IQVTSLESGILPKGTNRQFSAIGIFSDGSHQDISNEPLIVWSSSNPDLVRVDDSGLASGINLGTAHIRAS
FQSKQGAEEMTVGDAVLSQIQVTSNDLNIPLGKKQKLTATGIYSDNSNRDISSSVIWNSSNSTIANIQNN
GILETADTGIVTVSASSENIIGSVKLIVTPAALVSISVSPTNSTVAKGLQENFKATGIFTDNSNSDITDQ
VTWDSSNTDILSISNASDSHGLASTLNQGNVKVTASIGGIQGSTDFKVTQAALTSIEVSPTRTSIAKGLT
QKFTAIGIFTDNSKKDITDQVTWNSSSAIVSVSNLDNNKGLGKTNSVGNTTITATLGKVSGNTWFTVVPA
VLTSIQINPVNPSLAKGLTQKFTATGIYSDNSNKDITSAVTWFSSDSSIATISNAQKNQGNAYGAATGAT
DIKATFGKVSSPVSTLSVTAAKLVEIQITPAAASKAKGLTERFKATGIFTDNSNSDITNQVTWNSSNTDI
AEIKNTSGSKGITNTLTPGSSEISAALGSIKSSKVILKVTPAQLISIAVTPINPSVAKGLIRQFKATGTY
TDHSVQDVTALATWSSSNPGKAMVNNVTGSVTTVATGNTNIKATIDSISGSSVLNVTPALLTSIEITPTI
NSITHGLTKQFKATGIFSDKSTQNLTQLVTWISSDPSKIEIENTSGKKGIATASKLGSSNIKAVYKFIQS
SPIPITVTDLKLKSITISPSSSSIAKGLTQQFKAIGTFIDGSEQEITNLVTWYSSKSDVAPINNAANAKG
LATALSIGSSNISAIYNSISSNKINFNVSAATLDSIKINPVNNNIAKGLTQQYTALGVYSDSTIQDISDS
VTWSSSNSDSISISNSTETKGKATALQIGNSKITATYNSISENIDITVSAATLSSISISPINTNINATVS
KQFFAVGTYSDGTKADLTSSVTWSSSNKSQAKVSNASKTKGLVTGIASGNSIITATYGSVSGNTILTVNK
TDTIAPTVQSVVSLSPTTIQVVYSESINNKEALDLSNYKIIDSSNFIGHCSDNTDFNSNSQTADFSLSSI
KGSKNTFTITLSHSQILNKSYTLVVNKQGIHDLSSIPNSLSCPNNSDFIGKEQLKLTSAVCNSLNQVIVS
FSKPLYSGKEATKSVECSNPSQCESRYKFAGVSSLGSITSVRILDGKVCGGAPADSSKICLTHSLLQSGG
QYTIIAANDLNGDGFDNKSWGAIRDSFDQENLQSSPKDRINFIGCGNSPLNFMDGPIMSDPFGDGSDFGF
LVDYNNQIYLGPNVKGNQAARFNYDGTFPESIFFSFTKDINADNRASSRDGGIPVPNYVTIGHTGCTLNS
ADITTGCGPDNEDGRGVFAIGSLNKKSHIFIAGSRPRRFDYLYYSSDTDTNLNFKYIDMGEITGTATAGT
SSIAVIDDRIHVGFAKKNKNLNAPDFGKITFNTSDQNRCAAGNNCDASDGYRGNRFRIDRMPYFGGLSVE
DADNYETYTSDNSSINWGYYVGIDSLFVFKEKLYAANGGFPNSLHNGSIIHSTSANPSPCEGSNRCSSWK
DTAPRSNPKWHNSPHNNWFSLELTKYRNLIPADKAFSQFAEFNGRLYVTRTICVTKEDHSGLRQSLQTVE
GCTDGSYTNRRPQLWKCDPTLTGDTTTCEAEDWSLVGDNGTGFTNFGDNSNHSMTMMVASGSYLYIGFDN
ENGIQIWRTNLENPGSSSHNWEPIGIGGLRDVTNRQIYSAISGMNFGVNFVYISVGNKNKPVKIYRQQNQ

Molecule Role : Protective antigen
Related Vaccine(s): Leptospira interrogans DNA vaccine pTARGET/ LigBrep

3. ligB

Gene Name : ligB
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Pomona
NCBI Protein GI : ACH89908
Other Database IDs : CDD:295441
CDD:214752
CDD:280521
Taxonomy ID : 44276
Protein Name : LigB
Protein pI : 7.08
Protein Weight : 190537.51
Protein Length : 1983
Protein Note : Bacterial Ig-like domain (group 2); cl02708

Protein Sequence : Show Sequence

>ACH89908.1 LigB, partial [Leptospira interrogans serovar Pomona]
MKKIFCISIFLSMFFQGCMSWPLLTGLVGLTAGKKSNGLSFFHLLLGNSNPTITRIELSYQDSSIANGTS
TTLEVTAIFDNGTNQNITDSTSIVPDSQSVVTIQGNRVRGIASGSSIIKAEYNGLYSEQKITVTPATLNS
IQVTSLGSGILPKGTNRQFSAIGIFSDGSHQDISNDPLIVWSSSNPDLVQVDDSGLASGINLGTAHIRAS
FQSKQGAEEMTVGDAVLSQIQVTSNNPNIPLGKKQKLIATGIYSDNSNRDISSSVIWNSSNSTIANIQNN
GILETVDTGIVTISASSENIIGSVKLIVTPAALVSISVSPTNSTVAKGLQENFKATGIFTDNSNSDITDQ
VTWDSSNTDILSISNASDSHGLASTLNQGNVKVTASIGGIQGSTDFKVTQAALTSIEVSPVLPSIAKGLT
QKFTAIGIFTDNSKKDITDQVTWNSSSAIVSVSNLDDNKGLGKAHAVGDTTITATLGKVSGKTWLTVVPA
VLTSIQINPVNPSLAKGLTQKFSATGIYSDNSNKDITSAVTWFSSDSSIATISNAQKNQGNAYGAATGAT
DIKATFGKVSSPVSTLSVTAAKLVEIQITPAAASKAKGLTERFKATGIFTDNSNSDITNQVTWNSSNTDI
AEITNTSGSKGITNTLTPGSSEISAALGSIKSSKVILKVTPAQLISIAVTPINPSVAKGLIRQFKATGTY
TDHSVQDVTALATWSSSNPRKAMVNNVTGSVTTVATGNTNIKATIDSISGSSVLNVTPALLTSIEITPTI
NSITHGLTKQFKATGIFSDKSTQNLTQLVTWISSDPSKIEIENTSGKKGIATASKLGSSNIKAVYKFIQS
SPIPITVTDLKLKSITISPSSSSIAKGLTQQFKAIGTFIDGSEQEITNLVTWYSSKSDVAPINNAANEKG
LATALSIGSSDIYAIYNSISSNKINFNVSAATLDSIKINPVNNNIAKGLTQQYTALGVYSDSTIQDISDS
VTWSSSNSSSISISNSTETKGKATALQIGNSKITATYNSISENIDITVSAATLSSISISPINTNINTTVS
KQFFAVGTYSDGTKADLTSSVTWSSSNQSQAKVSNASETKGLVTGIASGNPTIIATYGSVSGNTILTVNK
TDTIAPTVQSVVSLSPTTIQVVYSESINNKEALDLSNYKIINSSNFIGHCSDNTDFNSNSQTADFSLSSI
KGSKNTFTITLSHSQILNKSYTLVVNKQGIHDLSSIPNSLSCPNNSDFMGKEQLKLTSAVCNSLNQVIVS
FSKPLYSGKEVTKSVECSNPSQCESRYKFAGVSSLGSITSVRILDGKVCGGAPADSSKICLTHSLLQSGG
QYTIIAANDLNGDGFDNKSWGAIRDSFDQENLQPSPKDRINFIGCGNSPLNFMDGPIVSDPFGDGSDFGS
LVDYNNQIYLGPNVKGNQATRFHYDGTFPESIFFSFTKDINATNRASSRDGGIPVPNYVTIGHTGCTLNT
ADITTGCGPDNENGRGVFATGSLNKKSHIFIAGSKPKRFNYLYYSSDTDTNLDFKYIDMGEITGLATAGT
SSIAVLDDRIHVGFAKRNQNLNAPDFGKITFNTSEQNRCAAGNNCEASDGYRGNRFRIDRMPYFGGGSVD
AVNYRTYKSDNSSINWGYYVGIDSLFVFKEKLYAANGGFPNSLHNGSIIHSTSANPSPCEEINRCSNWKD
TAPRSNPKWHNSPHNNWFSLELTKYRNLIPADKAFSQFAEFNGRLYVTRTICVTKEDNSGLRQSLQTVEG
CTDGSYTNRRPQLWKCDPTLTGDTTTCEAEDWSLVGDDGTGFTNFGDHSNHSMTMMVASGSYLYIGFDNE
NGIQIWRTNLENPGSSSHDWEPIGIGGLRDVTNRQIYSAISGMNFGVNFVYISVGNKNKPVKIYRQQNQ

Molecule Role : Protective antigen
Molecule Role Annotation : (Conrad et al., 2017)

4. lipL21

Gene Name : lipL21
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
NCBI Protein GI : AAS68648
Taxonomy ID : 267671
Protein Name : LipL21
Protein pI : 7.72
Protein Weight : 18906.6
Protein Length : 274
Protein Note : outermembrane lipoprotein; identified by sequence similarity; putative; ORF located using Blastx/Glimmer

Protein Sequence : Show Sequence

>AAS68648.1 LipL21 [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
MINRLIALSLATMIFAACSSTDTGQKDATTVGDGGWTFEGWGGPPEQRNDGKTPRDTNPKDWYYIKFSSR
ASGKAVAKKSQAMMQSTCREASRLQGASDVVKKMVGETVESASGVSDGEATASVIVSQSQGVVKGVGVYE
CKATGSGSDPKDVSKDNWEECQCVIYAKFPGGKDALVAKAQEVSKQ

Molecule Role : Protective antigen
Molecule Role Annotation : (Lin et al., 2016)

5. lipL32

Gene Name : lipL32
Sequence Strain (Species/Organism) : Leptospira mayottensis 200901116
NCBI Protein GI : AEZ53269
Other Database IDs : CDD:288920
Taxonomy ID : 1192864
Protein Name : LipL32
Protein pI : 4.31
Protein Weight : 16281.3
Protein Length : 225
Protein Note : Leptospira cf. borgpetersenii

Protein Sequence : Show Sequence

>AEZ53269.1 LipL32, partial [Leptospira mayottensis 200901116]
ISVALFASITACGAFGGLPSLKSSFVLSESTVPGTNETVKTFLPYGTVINYYGYIKPGQAPDGLVDGSKK
AYYLYVWVPAVIAEMGVRMISPTGEIGEPGDGDLVSDAFKAATPEEKSMPNWFDTWIRVERMSAIMPDQI
AKAAKAKPVQKLDDDDDG

Molecule Role : Protective antigen
Molecule Role Annotation : (Lin et al., 2016)

6. lipL45

Gene Name : lipL45
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Lai str. 56601]
NCBI Protein GI : AAN49494
Other Database IDs : CDD:309765
CDD:331332
Taxonomy ID : 189518
Protein Name : LipL45
Protein pI : 8.37
Protein Weight : 38430.65
Protein Length : 462
Protein Note : FecR protein; pfam04773

Protein Sequence : Show Sequence

>AAN49494.2 LipL45 [Leptospira interrogans serovar Lai str. 56601]
MKKFLIVFSSVLTTGLLVFNACKKPTESSKAAATKGNSPSAVVVFSVGEAKILHADLTEEKAALGASLKT
GDKVSTKQKSKVDIQFADGSAIRISENSVIDFDALSINSHGNSDTRLALVSGKVFAKVNKASKEDQFSVV
TPTAIAGVRGTSFIVDRSKSDKAVVKVLDGAVAVAPRVVVLEGLSDEEIAKNEDLKKIQQTVASSEIVLE
KNQASVVKADEKSLDVKDTSKISEKNITGVVKKLDNSGISKKEEEEIRTIVTVDKDTTEKMVRLNEESSG
KVDEQKAAVLEAERKKLESEVAARQEEEAKKFKQVLISAPKELKSSKDIVNYYERIEKIIMMDGSSMIGA
IVDQQGSTMIVHTEQGIKKINQADVQEVIYDFQTKAKF

Molecule Role : Protective antigen
Molecule Role Annotation : (Vijayachari et al., 2015)

7. loa22

Gene Name : loa22
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Australis
NCBI Protein GI : AIZ46906
Other Database IDs : CDD:143586
Taxonomy ID : 211882
Protein Name : Loa22
Protein pI : 5.36
Protein Weight : 17568.17
Protein Length : 240
Protein Note : Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; cd07185

Protein Sequence : Show Sequence

>AIZ46906.1 Loa22, partial [Leptospira interrogans serovar Australis]
SFTLCSSAEKKEESAAPEPSTQEQSAAANRNVDVNSPEAIADSLNEKLKDFRYPDGLTRPGFSYKKADVT
PGDFSEWSKTNAPVIKEGLGKLPDSYALEITGHTDAIGPEQAEGAKKGNIFYSELRANAVKQALIKQGIP
ANRIVTKGAGSSEPVSGLDAKDAKNR

Molecule Role : Protective antigen
Molecule Role Annotation : (Umthong et al., 2015)

8. lsa21

Gene Name : lsa21
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Australis
NCBI Protein GI : ADB11053
Taxonomy ID : 211882
Protein Name : Lsa21
Protein pI : 7.25
Protein Weight : 14946.43
Protein Length : 218

Protein Sequence : Show Sequence

>ADB11053.1 Lsa21, partial [Leptospira interrogans serovar Australis]
TQLLNTDCVTSSEVVSDSYNKTTITFENKPQYYNSPSGNVVPKAIMPILIKKGQTIQVSSITTNVKYEAT
NQDLTFLFRKDGCHGTNSEIATYAGATNTNVFLGNTNTVSLTQFKFTADYNGIILIVGKNLGASLPGDIR
VNVF

Molecule Role : Protective antigen
Molecule Role Annotation : (Atzingen et al., 2012)

9. mce

Gene Name : mce
Sequence Strain (Species/Organism) : Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
NCBI Protein GI : ADA57469
Other Database IDs : CDD:224380
CDD:280608
Taxonomy ID : 280499
Protein Name : Mce
Protein pI : 6.07
Protein Weight : 26482.45
Protein Length : 312
Protein Note : ABC-type transporter Mla maintaining outer membrane lipid asymmetry, periplasmic component MlaD [Cell wall/membrane/envelope biogenesis]; COG1463

Protein Sequence : Show Sequence

>ADA57469.1 Mce [Leptospira interrogans serovar Wolffi]
MNMNSLRYLLVGIIFTAAITVVGYFTIITEGGPIKKKGEFMKVTFRNAEGIKVGNKVTVQGVPFGYVSAI
RLIQIDENGTEVQSGEMGIGTRVEITMLLREKISLYDNYDIIIKNESLLTGRVIAIDPGTADLEPKQLKT
RTIPITMIDYKTTGSLKGRVLQDPLVSLSELISENRGDIRKTFSNIADITTKINTGDGSLGRLINNDDVH
KNVNTVLTDAQIVLRELREGLEDTREQTPVTSFIRAALSAF

Molecule Role : Protective antigen
Molecule Role Annotation : (Fernandes et al., 2017)

10. ompL1

Gene Name : ompL1
Sequence Strain (Species/Organism) : Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130
NCBI Gene ID : 2769678
NCBI Protein GI : 45656861
Locus Tag : LIC10973
Genbank Accession : AE016823
Protein Accession : YP_000947
Taxonomy ID : 267671
Chromosome No : I
Gene Starting Position : 1173341
Gene Ending Position : 1174303
Gene Strand (Orientation) : -
Protein Name : outer membrane protein
Protein pI : 8.87
Protein Weight : 31373.06
Protein Length : 320
Protein Note : contains porin activity; identified by sequence similarity; ORF located using Blastx/Glimmer

DNA Sequence : Show Sequence

>NC_005823.1:1173341-1174303 Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130, chromosome I, complete sequence
CTTAGAGTTCGTGTTTATAACCGAATCTGTAGATTTGCCCACCGACAACGATTGGATATGCAGGAAAAGG
AGAAAGGTTCGTAGCTCCTCCTGCAGATTGAGTTTTACCAACTGCATACGCAGCAGACATGATCGTTTCT
AATTCAAGAAAAACGTGTCCTTTATCGGTTACTCTGGCCTGAGTTCCAATTAAAAAGTTAGGAGCAATTC
CAGAAGTTCTAAATCGAACGTGTTCACGAGTCGTGACTGGATCTGTTCCGTCTGCGATCAAGTTTGCAAC
ACTTCCCGCTCCCGCTGCAGCTAAAATGTCATGACCTCCTTTGAGGTTGTTTGATCCGTTTAAACTCCAT
CCACCATTGAAATAGTTTAAACCTGCTCCCATATATATTGCAGCGTCTTCAGTAACATTCAATTTGATAC
CAACGGTTGCAGGAATGACGATAGAACTAAAACCCCAAGTCATATCTACAATGTTATAACCAGCGATGTC
TGCTTTTGTAATACCGCCAGAAATTTTTTGAGTATATTCTGCAGCAACTCTCCAGAAAAAATATTTACCA
AAGTCGGACTCATAACCTACCATCAAGTTTCCTCCGACCATGGCGCCTTTAGTGCTTCTTGCGTTGATCA
AGCCGCCAGTAGTTCTATCGAGGGTAATCAATTTATTTTCAGCAGGAATCGCTTTTCTGGGAGCAACTCC
TAGATAATTTCCTTCACCTGTAGGTTTTCCTGGATTTTGTACACAAGTAGGATCGTTTGGACCTACTGTA
CAAGTATCTGTTGATCGGACCGGGCCATAATAACTTGCAGCGTCTAAACCATCTTTGGTGATGGTTCCTC
CTAATTGTCCTAGGTCTAACTGTAACCCAAATCCTACAATTGCATATGTTTTTGCACTTAGGCTTGCAGC
CGAAGATAATGCTACGGCTAAAATGAGCAATGCCTTACTTATGTTACGGATCA

Protein Sequence : Show Sequence

>YP_000947.1 outer membrane protein [Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130]
MIRNISKALLILAVALSSAASLSAKTYAIVGFGLQLDLGQLGGTITKDGLDAASYYGPVRSTDTCTVGPN
DPTCVQNPGKPTGEGNYLGVAPRKAIPAENKLITLDRTTGGLINARSTKGAMVGGNLMVGYESDFGKYFF
WRVAAEYTQKISGGITKADIAGYNIVDMTWGFSSIVIPATVGIKLNVTEDAAIYMGAGLNYFNGGWSLNG
SNNLKGGHDILAAAGAGSVANLIADGTDPVTTREHVRFRTSGIAPNFLIGTQARVTDKGHVFLELETIMS
AAYAVGKTQSAGGATNLSPFPAYPIVVGGQIYRFGYKHEL

Molecule Role : Protective antigen
Related Vaccine(s): Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)

11. ompL1

Gene Name : ompL1
Sequence Strain (Species/Organism) : Leptospira borgpetersenii serovar Hardjo-bovis str. JB197
NCBI Protein GI : ABJ75260
Other Database IDs : CDD:288277
Taxonomy ID : 355277
Protein Name : OmpL1
Protein pI : 8.88
Protein Weight : 31936.76
Protein Length : 404
Protein Note : Leptospira porin protein OmpL1; pfam11389

Protein Sequence : Show Sequence

>ABJ75260.1 OmpL1 [Leptospira borgpetersenii serovar Hardjo-bovis str. JB197]
MIRNMSKVLFALAVVFSSAESLSAKSYAIVGFGLQLDLGQLGGTITKDGLDAATYYGPVRSTNTCTVNAN
DPTCVQNPSKPAGEGNYVGVGTRRAIAAENRLITLDRTTGGIINARSTKGAMVGGNLMVGYESDFGKYFF
WRVAAEYTQKISGGITKADIAGLNIVDMTWGFSAIVIPATVGIKLNVTEDAAVYMGAGLNYFNGGWSLNG
MNNIKGGHDILAAAGVTSIANLLADGTDPITTREHIRFRATGIAPNFLIGTQARVTDKGHVFLELETIMS
AAYSVGKTQSIGGASTLAPFPTYPIVVGGQIYRFGYKYEL

Molecule Role : Protective antigen
Molecule Role Annotation : (Fernandes et al., 2017)

III. Vaccine Information

1. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4019.00)

a. Manufacturer:

Wyeth, Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001880

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

2. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4059.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001881

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

3. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4069.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001882

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

4. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001883

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

5. Bovine Rhinotracheitis Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4089.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Heska Corporation, Merial, Inc.

b. Vaccine Ontology ID:

VO_0001884

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

6. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4129.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001892

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

7. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4179.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001893

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

8. Bovine Rhinotracheitis-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4209.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001894

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

9. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001903

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

10. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4145.21)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001904

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

11. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4335.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001907

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

12. Bovine Rhinotracheitis-Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4336.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001908

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

13. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4141.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.

b. Vaccine Ontology ID:

VO_0001914

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

14. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4339.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001915

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

15. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4359.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001916

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

16. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Hardjo-Pomona Bacterin (USDA: 4399.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001917

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

17. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001918

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

18. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Merial, Inc.

b. Vaccine Ontology ID:

VO_0001919

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

19. Bovine Rhinotracheitis-Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4389.21)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001920

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

20. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4435.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001922

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

21. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.24)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001931

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

22. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4560.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001932

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

23. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Haemophilus Somnus-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4489.30)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001933

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

24. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001934

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

25. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4439.20)

a. Manufacturer:

Wyeth, Heska Corporation, Merial, Inc.

b. Vaccine Ontology ID:

VO_0001935

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

26. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Grippotyphosa-Hardjo-Pomona Bacterin (USDA: 4479.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0001936

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

27. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4509.00)

a. Manufacturer:

Colorado Serum Company, Heska Corporation

b. Vaccine Ontology ID:

VO_0001937

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

28. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001951

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

29. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44M5.22)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001952

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

30. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B5.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001953

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

31. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001954

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

32. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B6.21)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001955

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

33. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.20)

a. Manufacturer:

Wyeth, Boehringer Ingelheim Vetmedica, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001959

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

34. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D7.22)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001960

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

35. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.20)

a. Manufacturer:

Wyeth, Boehringer Ingelheim Vetmedica, Inc., Merial, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001962

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

36. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001963

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

37. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4465.22)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001964

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

38. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001965

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

39. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4466.21)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0001966

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

40. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona-Mannheimia Haemolytica Bacterin (USDA: 4475.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0001967

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

41. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.21)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001975

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

42. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B9.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001976

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

43. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001978

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

44. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001979

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

45. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001980

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

46. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001981

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

47. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc.

b. Vaccine Ontology ID:

VO_0001982

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

48. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001983

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

49. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001984

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

50. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44B1.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001985

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

51. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001990

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

52. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001991

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

53. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.23)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001992

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

54. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Haemophilus Somnus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 44D9.24)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001993

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

55. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.20)

a. Manufacturer:

Wyeth, Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Heska Corporation

b. Vaccine Ontology ID:

VO_0001994

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

56. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.21)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001995

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

57. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.22)

a. Manufacturer:

Wyeth, Intervet Inc.

b. Vaccine Ontology ID:

VO_0001996

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

58. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4461.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0001997

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

59. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.00)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0001998

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

60. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.01)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0001999

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

61. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.23)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002000

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

62. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.24)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002001

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

63. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4469.26)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002002

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

64. Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza 3-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Hardjo Bacterin (USDA: 4L49.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002003

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

65. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.20)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002013

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

66. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.26)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002014

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

67. Bovine Rhinotracheitis-Virus Diarrhea-Respiratory Syncytial Virus Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4367.30)

a. Manufacturer:

Heska Corporation

b. Vaccine Ontology ID:

VO_0002015

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

68. Bovine Virus Diarrhea Killed Virus Vaccine-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 45B5.21)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002023

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

69. Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.21)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002025

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

70. Bovine Virus Diarrhea Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4595.25)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002026

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

71. Bovine Virus Diarrhea Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4599.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0002027

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

72. Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 47E5.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002244

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

73. Canine Coronavirus Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 47E5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002243

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

74. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002222

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

75. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46E5.24)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002224

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

76. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.23)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002223

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

77. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46E5.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002225

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

78. Canine Coronavirus Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46E5.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002221

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

79. Canine Coronavirus Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46D5.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002220

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

80. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4629.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002207

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

81. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4629.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002206

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

82. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002219

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

83. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002231

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

84. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002234

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

85. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002246

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

86. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002230

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

87. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002232

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

88. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002233

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

89. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002226

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

90. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002227

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

91. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002229

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

92. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002236

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

93. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002235

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

94. Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002237

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

95. Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4659.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002218

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

96. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002211

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

97. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002214

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

98. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002245

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

99. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002215

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

100. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002216

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

101. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)_

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Type:

Live, attenuated vaccine

c. Status:

Licensed

d. Location Licensed:

USA

e. Host Species for Licensed Use:

Gray wolf

102. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002209

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

103. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002210

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

104. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21)

a. Manufacturer:

Wyeth, Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002212

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

105. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002213

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

106. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002228

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

107. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002217

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

108. Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002247

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

109. Canine Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47A9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0004213

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

110. Canine Parvovirus Modified Live Virus Vaccine-Leptospira Canicola Icterohaemorrhagiae Bacterin (USDA: 47B1.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002240

c. Status:

Licensed

d. Location Licensed:

USA

e. Host Species for Licensed Use:

Gray wolf

111. Leptospira interrogans DNA vaccine ompL1-pcDNA3.1(+)

a. Vaccine Ontology ID:

VO_0004562

b. Type:

DNA vaccine

c. Status:

Research

d. Host Species as Laboratory Animal Model:

Hamsters

e. Gene Engineering of ompL1

Type: DNA vaccine construction
Description:
Detailed Gene Information: Click here.

f. Vector:

pcDNA3.1(+) (Maneewatch et al., 2007)

g. Immunization Route

Intramuscular injection (i.m.)

h. Hamster Response

Vaccine Immune Response Type: VO_0003057
Efficacy: The vaccine was shown to confer the delay in the death time and reduced morbidity in the vaccinated animals when compared to animals immunized with the plasmid alone or PBS. Hamsters of group 2 (mock) and group 3 (positive leptospirosis) were all dead between days 5 and 6 post-challenge. For the vaccinated group, two hamsters were dead on day 9, one each died on days 11 and 18, respectively. Two hamsters survived the lethal Leptospira challenge until day 21 when they were sacrificed (Maneewatch et al., 2007).

112. Leptospira interrogans DNA vaccine pTARGET/ LigBrep

a. Vaccine Ontology ID:

VO_0004563

b. Type:

DNA vaccine

c. Status:

Research

d. Host Species as Laboratory Animal Model:

Hamsters

e. Gene Engineering of ligB

Type: DNA vaccine construction
Description:
Detailed Gene Information: Click here.

f. Vector:

pTARGET (Forster et al., 2013)

g. Immunization Route

Intramuscular injection (i.m.)

h. Hamster Response

Vaccine Immune Response Type: VO_0003057
Immune Response: The vaccine induced an IgG antibody response and, additionally, conferred sterilizing immunity in 80% of the surviving animals (Forster et al., 2013).
Efficacy: Immunization with a DNA vaccine encoding LigBrep resulted in the survival of 5/8 (62.5%) hamsters against lethal infection (P < 0.05). None of the control hamsters or animals immunized with the other vaccine preparations survived (Forster et al., 2013).

113. Parainfluenza 3 Modified Live Virus Vaccine-Leptospira Pomona Bacterin (USDA: 4989.00)

a. Manufacturer:

Colorado Serum Company

b. Vaccine Ontology ID:

VO_0002295

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

114. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.20)

a. Manufacturer:

Wyeth, Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002321

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

115. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.21)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002322

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

116. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002323

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

117. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.01)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002277

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

118. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.20)

a. Manufacturer:

Pfizer, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002278

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

119. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Pfizer, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002279

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

120. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002280

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

121. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.01)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002292

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

122. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002293

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

123. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.22)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002294

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

124. Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4960.00)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002291

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

125. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002309

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

126. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002310

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

127. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.24)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002311

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

128. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002312

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

129. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002313

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

130. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.24)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002314

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

131. Porcine Reproductive & Respiratory Syndrome-Parvovirus Reproductive Form, Modified Live & Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4P19.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002324

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

132. Trichomonas Foetus Vaccine, Killed Protozoa-Campylobacter Fetus-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4990.00)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002296

c. Status:

Licensed

d. Location Licensed:

USA

e. Host Species for Licensed Use:

Cattle

IV. References

1. Atzingen et al., 2012: Atzingen MV, Vieira ML, Oliveira R, Domingos RF, Mendes RS, Barros AT, Gon�ales AP, de Morais ZM, Vasconcellos SA, Nascimento AL. Evaluation of immunoprotective activity of six leptospiral proteins in the hamster model of leptospirosis. The open microbiology journal. 2012; 6; 79-87. [PubMed: 23173023].

2. Conrad et al., 2017: Conrad NL, Cruz McBride FW, Souza JD, Silveira MM, F�lix S, Mendon�a KS, Santos CS, Athanazio DA, Medeiros MA, Reis MG, Dellagostin OA, McBride AJ. LigB subunit vaccine confers sterile immunity against challenge in the hamster model of leptospirosis. PLoS neglected tropical diseases. 2017; 11(3); e0005441. [PubMed: 28301479].

3. Evangelista et al., 2017: Evangelista KV, Lourdault K, Matsunaga J, Haake DA. Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis. PloS one. 2017; 12(7); e0180004. [PubMed: 28704385].

4. Fernandes et al., 2017: Fernandes LGV, Teixeira AF, Filho AFS, Souza GO, Vasconcellos SA, Heinemann MB, Romero EC, Nascimento ALTO. Immune response and protective profile elicited by a multi-epitope chimeric protein derived from Leptospira interrogans. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2017; 57; 61-69. [PubMed: 28161462].

5. Forster et al., 2013: Forster KM, Hartwig DD, Seixas FK, Bacelo KL, Amaral M, Hartleben CP, Dellagostin OA. A Conserved Region of Leptospiral Immunoglobulin-Like A and B Proteins as a DNA Vaccine Elicits a Prophylactic Immune Response against Leptospirosis. Clinical and vaccine immunology : CVI. 2013; 20(5); 725-731. [PubMed: 23486420].

6. Humphryes et al., 2014: Humphryes PC, Weeks ME, AbuOun M, Thomson G, N��ez A, Coldham NG. Vaccination with leptospiral outer membrane lipoprotein LipL32 reduces kidney invasion of Leptospira interrogans serovar canicola in hamsters. Clinical and vaccine immunology : CVI. 2014; 21(4); 546-551. [PubMed: 24521782].

7. Lin et al., 2016: Lin X, Xiao G, Luo D, Kong L, Chen X, Sun D, Yan J. Chimeric epitope vaccine against Leptospira interrogans infection and induced specific immunity in guinea pigs. BMC microbiology. 2016; 16(1); 241. [PubMed: 27737644].

8. Maneewatch et al., 2007: Maneewatch S, Tapchaisri P, Sakolvaree Y, Klaysing B, Tongtawe P, Chaisri U, Songserm T, Wongratanacheewin S, Srimanote P, Chongsa-nguanz M, Chaicumpa W. OmpL1 DNA vaccine cross-protects against heterologous Leptospira spp. challenge. Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand. 2007; 25(1); 75-82. [PubMed: 17891923].

9. Umthong et al., 2015: Umthong S, Buaklin A, Jacquet A, Sangjun N, Kerdkaew R, Patarakul K, Palaga T. Immunogenicity of a DNA and Recombinant Protein Vaccine Combining LipL32 and Loa22 for Leptospirosis Using Chitosan as a Delivery System. Journal of microbiology and biotechnology. 2015; 25(4); 526-536. [PubMed: 25348693].

10. Vijayachari et al., 2015: Vijayachari P, Vedhagiri K, Mallilankaraman K, Mathur PP, Sardesai NY, Weiner DB, Ugen KE, Muthumani K. Immunogenicity of a novel enhanced consensus DNA vaccine encoding the leptospiral protein LipL45. Human vaccines & immunotherapeutics. 2015; 11(8); 1945-1953. [PubMed: 26020621].

11. Wiki: Leptospirosis: Wiki: Leptospirosis [http://en.wikipedia.org/wiki/Leptospirosis]