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Experimental autoimmune uveitis |
| Table of Contents |
- General Information
- Disease
- Introduction
- Vaccine Related Pathogen Genes
- IRBP
(Other)
- IRBP from humans
(Protective antigen)
- Vaccine Information
- EAU DNA vaccine IRBP-DNA encoding IRBP
- References
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| I. General Information |
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1. Disease: |
| Experimental autoimmune uveitis |
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2. Introduction |
| Experimental autoimmune uveitis (EAU) is an organ-specific, T cell–mediated disease that targets the posterior pole of the eye. It is also a valuable, well-characterized model for the study of human idiopathic uveitis. This disease can be induced in susceptible primates and rodents after immunization with retinal self-antigens, such as interphotoreceptor retinoid-binding protein (IRBP) or S-antigen (arrestin), or by the adoptive transfer of uveitis antigen-specific T cells (Commodaro et al., 2010). |
| II. Vaccine Related Pathogen Genes |
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1. IRBP |
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Gene Name :
IRBP
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Sequence Strain (Species/Organism) :
Mus musculus
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NCBI Protein GI :
4689280
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Other Database IDs :
CDD:143479
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Taxonomy ID :
10090
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Gene Strand (Orientation) :
?
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Protein Name :
retinoid-binding protein IRBP
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Protein Length :
610
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Protein Note :
Interphotoreceptor retinoid-binding protein; serine protease family S41; cd07563
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Protein Sequence : Show Sequence
>gi|4689280|gb|AAA39331.2| retinoid-binding protein IRBP [Mus musculus]
MMREWVLVLSTLLWVPAGPTHLFQPSLVLDMAKILLDNYCFPENLMGMQAAIEQAMKSHEILGISDPQTL
AQVLTAGVQSSLSDPRLFISYEPSTLEAPQQAPVLTNLTREELLAQIQRNIRHEVLEGNVGYLRVDDLPG
QEVLSELGEFLVSHVWRQLMSTSSLVLDLRHCSGGHFSGIPYVISYLHPGNTVMHVDTVYDRPSNTTTEI
WTLPEVLGERYSADKDVVVLTSGHTGGVAEDIAYILKQMRRAIVVGERTEGGALDLQKLRIGQSNFFLTV
PVSRSLGPLGGGGQTWEGSGVLPCVGTPAEQALEKALAILTLRRALPGVVLRLQEALQDYYTLVDRVPGL
LHHLASMDYSAVVSEEDLVTKLNAGLQAVSEDPRLLVRATGPRDSSSRPETGPNESPAATPEVPTEEDAR
RALVDSVFQVSVLPGNVGYLRFDRFADAAVLETLGPYVLKQVWEPLQDTEHLIMDLRHNPGGPSSAMPLV
LSYFQGPEAGPVRLFTTYDRRTNITQEHFSHRELLGQRYGNQRGVYLLTSHRTATAAEEFAFLMQSLGWA
TLVGEITAGSLLHTCTVPLLDSPQGGLALTVPVLTFIDNHGEAWLGGGVV
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Molecule Role :
Other
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2. IRBP from humans |
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Gene Name :
IRBP from humans
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Sequence Strain (Species/Organism) :
Homo sapiens
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NCBI Gene ID :
5949
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NCBI Protein GI :
4506453
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Genbank Accession :
AH002852
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Protein Accession :
NP_002891
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Taxonomy ID :
9606
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Chromosome No :
10
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Gene Starting Position :
47348370
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Gene Ending Position :
47357874
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Gene Strand (Orientation) :
+
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Protein Name :
retinol binding protein 3
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Protein pI :
4.76
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Protein Weight :
124350.97
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Protein Length :
1247
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Protein Note :
Also known as IRBP; RBPI; D10S64; D10S65; D10S66
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DNA Sequence : Show Sequence
>NC_000010.11:47348370-47357874 Homo sapiens chromosome 10, GRCh38.p12 Primary Assembly
CTGTCCACCAGCTGAGAAGGACAAGGGCGGAAGGCAGCTGCACAGAGCAGGGCCACGGCCTTGCACACAG
TCCAGGGAGCTTTTGTGCAGGAGCCAGGCCTCCCCCTGGGTCCCCATGATGAGAGAATGGGTTCTGCTCA
TGTCCGTGCTGCTCTGTGGCCTGGCTGGCCCCACACACCTGTTCCAGCCAAGCCTGGTGCTGGACATGGC
CAAGGTCCTCTTGGATAACTACTGCTTCCCGGAGAACCTGCTGGGCATGCAGGAAGCCATCCAGCAGGCC
ATCAAGAGCCATGAGATTCTGAGCATCTCAGACCCGCAGACGCTGGCCAGTGTGCTGACAGCCGGGGTGC
AGAGCTCCCTGAACGATCCTCGCCTGGTCATCTCCTATGAGCCCAGCACCCCCGAGCCTCCCCCACAAGT
CCCAGCACTCACCAGCCTCTCAGAAGAGGAACTGCTTGCCTGGCTGCAAAGGGGCCTCCGCCATGAGGTT
CTGGAGGGTAATGTGGGCTACCTGCGGGTGGACAGCGTCCCGGGCCAGGAGGTGCTGAGCATGATGGGGG
AGTTCCTGGTGGCCCACGTGTGGGGGAATCTCATGGGCACCTCCGCCTTAGTGCTGGATCTCCGGCACTG
CACAGGAGGCCAGGTCTCTGGCATTCCCTACATCATCTCCTACCTGCACCCAGGGAACACCATCCTGCAC
GTGGACACTATCTACAACCGCCCCTCCAACACCACCACGGAGATCTGGACCTTGCCCCAGGTCCTGGGAG
AAAGGTACGGTGCCGACAAGGATGTGGTGGTCCTCACCAGCAGCCAGACCAGGGGCGTGGCCGAGGACAT
CGCGCACATCCTTAAGCAGATGCGCAGGGCCATCGTGGTGGGCGAGCGGACTGGGGGAGGGGCCCTGGAC
CTCCGGAAGCTGAGGATAGGCGAGTCTGACTTCTTCTTCACGGTGCCCGTGTCCAGGTCCCTGGGGCCCC
TTGGTGGAGGCAGCCAGACGTGGGAGGGCAGCGGGGTGCTGCCCTGTGTGGGGACTCCGGCCGAGCAGGC
CCTGGAGAAAGCCCTGGCCATCCTCACTCTGCGCAGCGCCCTTCCAGGGGTAGTCCACTGCCTCCAGGAG
GTCCTGAAGGACTACTACACGCTGGTGGACCGTGTGCCCACCCTGCTGCAGCACTTGGCCAGCATGGACT
TCTCCACGGTGGTCTCCGAGGAAGATCTGGTCACCAAGCTCAATGCCGGCCTGCAGGCTGCGTCTGAGGA
TCCCAGGCTCCTGGTGCGAGCCATCGGGCCCACAGAAACTCCTTCTTGGCCCGCGCCCGACGCTGCAGCC
GAAGACTCACCAGGGGTGGCCCCAGAGTTGCCTGAGGACGAGGCTATCCGGCAAGCACTGGTGGACTCTG
TGTTCCAGGTGTCGGTGCTGCCAGGCAATGTGGGCTACCTGCGCTTCGATAGTTTTGCTGACGCCTCCGT
CCTGGGTGTGTTGGCCCCATATGTCCTGCGCCAGGTGTGGGAGCCGCTACAGGACACGGAGCACCTCATC
ATGGACCTGCGCCACAACCCTGGAGGGCCATCCTCTGCTGTGCCCCTGCTCCTGTCCTACTTCCAGGGCC
CTGAGGCCGGCCCCGTGCACCTCTTCACCACCTATGATCGCCGCACCAACATCACGCAGGAGCACTTCAG
CCACATGGAGCTCCCGGGCCCACGCTACAGCACCCAACGTGGGGTGTATCTGCTCACCAGCCACCGCACC
GCCACGGCCGCGGAGGAGTTCGCCTTCCTTATGCAGTCGCTGGGCTGGGCCACACTGGTAGGTGAGATCA
CCGCGGGCAACCTGCTGCACACCCGCACGGTGCCGCTGCTGGACACACCCGAAGGCAGCCTCGCGCTCAC
CGTGCCGGTCCTCACCTTCATCGACAATCACGGCGAGGCCTGGCTGGGTGGTGGAGTGGTGCCCGATGCC
ATCGTGCTGGCCGAGGAGGCCCTGGACAAAGCCCAGGAAGTGCTGGAGTTCCACCAAAGCCTGGGGGCCT
TGGTGGAGGGCACAGGGCACCTGCTGGAGGCCCACTATGCTCGGCCAGAGGTCGTGGGGCAGACCAGTGC
CCTCCTGCGGGCCAAGCTGGCCCAGGGCGCCTACCGCACAGCTGTGGACTTGGAGTCTCTGGCCTCTCAG
CTCACAGCAGACCTCCAGGAGGTGTCTGGGGACCACCGCTTGCTAGTGTTCCACAGCCCTGGCGAGCTGG
TGGTAGAGGAAGCACCCCCACCACCCCCTGCTGTCCCCTCTCCAGAGGAGCTCACCTACCTTATTGAGGC
CCTGTTCAAGACAGAGGTGCTGCCCGGCCAGCTGGGCTACCTGCGTTTTGACGCCATGGCTGAACTGGAG
ACAGTGAAGGCCGTGGGGCCACAGCTGGTGCGGCTGGTATGGCAACAGCTGGTGGACACGGCTGCGCTGG
TGATCGACCTGCGCTACAACCCTGGCAGCTACTCCACGGCCATCCCGCTGCTCTGCTCCTACTTCTTTGA
GGCAGAGCCCCGCCAGCACCTGTATTCTGTCTTTGACAGGGCCACCTCAAAAGTCACGGAGGTGTGGACC
TTGCCCCAGGTCGCCGGCCAGCGCTACGGCTCACACAAGGACCTCTACATCCTGATGAGCCACACCAGTG
GCTCTGCGGCCGAGGCCTTTGCACACACCATGCAGGACCTGCAGCGGGCCACGGTCATTGGGGAGCCCAC
GGCCGGAGGCGCACTCTCTGTGGGCATCTACCAGGTGGGCAGCAGCCCCTTATATGCATCCATGCCCACC
CAGATGGCCATGAGTGCCACCACAGGCAAGGCCTGGGACCTGGCTGGTGTGGAGCCCGACATCACTGTGC
CCATGAGCGAAGCCCTTTCCATAGCCCAGGACATAGTGGCTCTGCGTGCCAAGGTGCCCACGGTGCTGCA
GACGGCCGGGAAGCTGGTGGCTGATAACTATGCCTCTGCCGAGCTGGGGGCCAAGATGGCCACCAAACTG
AGCGGTCTGCAGAGCCGCTACTCCAGGGTGACCTCAGAAGTGGCCCTAGCCGAGATCCTGGGGGCTGACC
TGCAGATGCTCTCCGGAGACCCACACCTGAAGGCAGCCCATATCCCTGAGAATGCCAAGGACCGCATTCC
TGGAATTGTGCCCATGCAGGTGAGACCCAAGAGAGACCTGGCTGAACCCAGTCCCGGGAGTGAGTTGACC
CATTGTCCGCACATGCAGGGCTCTGTGCACAGTGCGTGACAATGGCTTTTAGATTTGTTCTCACGTTTAA
GTTTTGACCGGTCAAGTCCTTTCCTCTTTCTCAACCTGTTCCATCCACTCTCTGTGACCCTGGGGTTGCT
GAACACCTCTGTAGAACATTCATATTAGGTTGGTGCAAAAGTACTTTCAATGGCAAAACCCGCAATTACT
TTTGCACCCACCTCACAGGAAGCCAGTTTGAAAGCCAACCAATACTCACAGGAAGCCAGTTCGGAAGCTC
CTGGGATAGAAGGCATTTCAGCCTTGGCTGGGTGGAAGGTGAGTGTTGGCAGGGCTTCTCATTGTCAGTG
CTAGGGAAGAGGCCAACACCTGTCAGAGGTGGCCAATGGACTTCACCAAGTGCCCCACGCTGGCCGAGAG
CTCCACCTAGGCAGCACTCACACCTCCACACTGTTCTACCTGTGGTCTGCTGCATCGTCACAATTGGGCA
GGGCAGCATTTGCCATGGGATCCCTTGCAAGGAGGGTCTGAGACCAGGGCTTGGGTGCAGGCGCTTTGTC
TGGGAGGCGGTTACTGAAGCAGGCATGAAGGAGGGAGCAGGGAGAGTGGGTTGGGAAGCTGACAGGCAGG
TGCCTCAAAGCTGTTCTGCTGAAGCCAGGACCCTGACGAGTGCAGGGATGCTCCCAGGCATAGCCCTCTG
CAGGCAGGGCCCAGTGGTTCCTGTCCCGCATTGGCCAAGAGTTGCCCTGAGACATGCCTCAGGGTGGGGC
AGGCTCCCTCTTCTTGGAGAAGGCCTGAGCTACGGGTGGAAAGGCAGGGCTGTGCTATAGGAGAGCCTGT
CAGTGGGGTCGGGTGCAGCTGAAAGCAGAGGGGGCTGAGAGTGCCAAAAGCATCTACTACAGAATTGTTA
TCCCCATTTTCCGCAACTGAGGCCCGGAGAGGAGCAGAGGGGAGTGGCCTGAGGCCAGAGAGCTGTGACT
GAGGGCAGGGCAGGGCCTGGAGGGCAGTGTCTCTGTCAATGAAGTCTCCTTGCCTGTCAATCTCACCAAG
ACCTGCCTCCCTCCAGCAGCCTTAGAGAGGGAGGAGGAGGTGCATCCACGTGCGAGTAGCCTGTGCTAGG
CTTGCAGAATCCCCAGTTTCCAAATCAACATCTCCTTCCTTTCCAGTATAGCCAAGGTTCACGATTTGGA
GTCAGATGTGGATTCAGATTCTGGCTCCACCACTTACTGACTGTGTGACCTGAGACTAGTTACTTAATCT
CTCTGTGCTTCAGTTTTTCCATGGAAAAGATGGGGATCGTGTTATCTCCTGTACAGGTGGCTGTGAGGAT
GATGATAAGCTCTACAAAGTGCTTAGTACCGGGCCAGGTGCCTGGTAAAGGTAACTAACATCTTCCAATC
CTGCCCCAGTGGAGCAGCTTAGAGACATAGGAAGTATCTGGTAAGGTTGGAGAGGTCAGAGGGGAGTCCA
TTCCTGGGCCTTCTAGCTCAGGACACCAGGGCATGTGGGTGGCAGACAGGAGCATCCTCTGCAAGGAGGC
TGCCCATAGATCACACATGTCCCAGTGGCATGTCACATCCAGACATGCCACTGGGAAAGTCCCTGGTGTC
TACTAATTCCTTCAGAAATGTTAGTTCCTGTCCCATGCCCTTAATATTTCCCATGGCGCCTGCTTTCCTG
GGCTCTAAAACTGGCTGCTCCTCCTGACACTGAGTAGGACCTCCAACTCTTACAGATCCCTTCCCCTGAA
GTATTTGAAGAGCTGATCAAGTTTTCCTTCCACACTAACGTGCTTGAGGACAACATTGGCTACTTGAGGT
TTGACATGTTTGGGGACGGTGAGCTGCTCACCCAGGTCTCCAGGCTGCTGGTGGAGCACATCTGGAAGAA
GATCATGCACACGGATGCCATGATCATCGACATGAGGTCAGTGGCCAGGGGTCAGTGCTTCCTAGCCAGG
ACGCAGGGCTGCCAGGGGACAGTCAAAGCTATGGGCCACAGCAGGGAAGAAAAGGAACCCTGTGACACAG
CAGAGGACCTGAGGGGGGCCAGGCCTCCTGCCTATCAGGGCTTCGGCCAGCTAGCCCAGCAGATCTGCTG
TCATTGCAGGTGGGGCCCAGCACTGGTAGTTTTTGCAAGCTTCTCCAGTGATTCCAATGTGCATTCCAGA
TTGAGAATTACCCCAGATTTGCCTGGTCATAGGATTCAGTGGGGAGGAGAGGAAGGAGATGTTAAAAACA
CTGATTCCTGGGCCCCACTCCCCTCTTACTGACTCAGAAGCTCCAGGGGACAGGCCCGATAATCTCTATT
TGACAGGCATCCCAGGTGATTCTGATGGTCAGTGGTGTGTGAGACAGCCAGGCCCCCCACCTGGGAGTGT
GCCTCACATCATACAAAATCAACACATGACAACCCTGGTCATATGAATCGTACAGGCAGAATTTGGAAAT
CACACAGGGAAAATTTAGAAGTTAATCACTATTGTTAACAAAAGAATTCTTTGCATCACCAAATGATTGT
CAGAAGGATGTCTTCAGCTAGCCACCTCCCCTCTGTTTCTGTAAAAATGTGCCTCATATGTCATGAGTTT
ACCTCATGGACCAGGGGTAGGAGGTGGATGAGTACCCTCAGGCAGTGGCCAGACCTGGCATCCCATGACT
CTGGGGTCCATTGGTGGACATGCCCCAGCACCCTCCCTGGGCAGGTTGCCTTCCTCAGACGGGACCCTTC
CATGCTCCCGTGTTGTCTGAAAGAAGTGGCAGGGGGTGGCAGACCAGAAGCATTCACCCAGCTCCAGTTC
TCTAGCCCTCAGCGCTCACTCACATGGTTCTTAGTGGTCACTAGGTGGCTCTCGGTCCTGCACCCACTGC
TTCTCCTCCCTGGGAGATAAAACATTAGCCCTGGCTCCAGTTCTGTGTGTGTTCACAGCCTGAGCTTGAG
GCTCCTGGGGTCTCTCTGATCATTTTATTCTTTAGAAGTTCTGTTGAGCACCCAAATGACACTCATGCTA
AGTCTCTTTCTTCTGAATATGCCATTTACACTTTTTAAAGAGGAGATGGCCCCAGCCTGCAAGTGCACTT
TGCTTAAAGACCCTCCCACCCCTGAGGTTTGTTTGGAGGTTCAGACACTGACATCACAGGCCCCGAACCC
AGCCAGGCCATCCCAGGCCATCAGTTGGACGAGGCTCCTTAACACATCACTAGCCCCAGTGGGGAGACAG
GGGCCCAACGAGGTCACACAGTGGGACAAATCTAAATGGCCTGGGAGAAATACAGGCTCCCCTGCTCCCA
ATGCAGCTCCACAAGCCTGAATATTTCAATACACTAAGTGCCCTGTTAAGACACCTGAACTAAGACAGCT
GGTAGGTGTCATAAGATTGTCACAGAATGCAACGGGAAAAACAATGTTTCCCAAAATGTGTTCCACTCAT
AGGAAGATATGGGTGCAGGGGAGCAGTCCATGGTCAATAAATGGGGGAAATTTATCAACAAGTTTCTGAC
TGCAGGACTTGTCAGGGCCTTTAATATATTAACATGTATTAATTACATAGCAGAAGGAAAGGATAACATA
TTTGATCACTAAGTTTCTTGTTCTAAAGAGACTAGTACTCTTGGAAATACTCTGGAAAATGCCAACCCAT
GGAATTCTAAAGGAGGAAGAGGCACTAGACTGAGGCTGCCAAGAATTAGAACCCTCCATGGGACAAAGAT
CCTGGCCTCCCCGAGGGGCACACAGGGCCTCACTGTGAGCTCAGCCCCTGAACAGGCTCTGCTTCCCATC
CTTCAGGTTCAACATCGGTGGCCCCACATCCTCCATTCCCATCTTGTGCTCCTACTTCTTTGATGAAGGC
CCTCCAGTTCTGCTGGACAAGATCTACAGCCGGCCTGATGACTCTGTCAGTGAACTCTGGACACACGCCC
AGGTTGTAGGTACGTGGAGAAGCTTTCTCCTTTCTGCTGTCATTCTAGAAGCTTCTGGGAAACCAGGGAA
AGACAGCTTGGGTGTAGGTAAAAGTCATAGTAACCAGAATGTAAGGCCCTGTCCTAGTCCAGGCACTAGA
TGTGCATGATCTCGAATCCCTGAAAAGCATGTATCACTATGCCCGTTTTCTAGAGGAAAAAAAAGGGGGT
GTTGACTAGGTCAAATATCTTTTCTAGGGTCATGCAGCTAATAAGTGAAACCCAAAATGTGAATATTAGT
TTGTCTAATACCAAAATTTCCCCCAGGCTTAGCACCATAATCACCAGCCTGCAGGACAAATGCAGAATTT
GAAGGATTCTCCCCGCCCCTCACCAACCCCAGTGGGCATTGCCAGTGCTCACAGTACTTGAGCTCTCAAG
CCACAGTGCCACAAACTTGCCTGGAAAGGTCATGATGCTGATCGGGCTTCTGTTCCCCGCCCTGGGCCCA
GAGCAGTGGCTATAGGAGCAAAGGCAGGCCCTGAGCTTTACAGAACCATAACTCTCAAAGCCCCATTCCA
GGGTGGATGGCCTCCATCTATCTTCCCTGCCCAGTGTGTAAGACCAAGGAACTTGTGCTCCTACCCAACA
AGAAAGGACTGGAGAGACCGATGGGGGTGTGCCTGTGACCAGAGAAACACCCCACCATTTTCATGTCCAT
GCTTCTGTAATACACAGGCATTTTGCTGTAGCTCCTAGGACATACGTTCAATAATATTACAAGTGTAAAT
GCAAATCAGAACCAGGTGAATTCTAAATTCAAATAGATGTTCAAGACTGGAAGTTAAAGATAGACTCAAT
TCTGCAGATAATGAGGCCCCAAAACCGCAAGGTCCAATATGGGAGCCACAAGCCACCTGCGGCCACCAAG
CATTTGAAATGTGGCTCTCCCAAGTTGAGATGTGCTGGAAGTGTGATGTGCTGGAAGTGTAATGTGCATA
CCAGATTTTGAAGACATTATGAAAAGAAAACCTCATTAATAATTTTATTTGATTACATTTTGAAAAGAAT
GTATTTTGGATACATTGGCTTAAACAAAACATGATTAAAATTAACACCATGGGTTTCTTTTTGCTTGCTT
AACATGGCTACTAGGGAACCTAAAATGACATCTATGGCCAGCATTCTGGCTCACGTTGCATTCCTGTTGG
ACAGTGCTGTCCTGGAGAGTTGTTCTTATACATCACAAATTGGGCTTTTCTGAGTCCAAAGTGAAAAGGA
AGTCAGGTCGGTTTAGGTGTTCTCATTATTCATGAAGAGAGAGGATGCTCCTTTCTCAGGAGAGTCAAGC
CTTTCCTATCACTTGGCATAAAAAGGCCTCGTTGGGAGTTGTCAAGCACTGAAATCCTCGTGATTGGGCA
TGCATTCTTGTCCCCATTTTACGGATGCAGAAATCAAGGCTCAGAGAAGTCAAGTGGCTCACAAGTGGAC
ACAAGGACACAGACCTAAACCCCCGGGCCTCCTCCATCACTGCAGGCCCAGGCAGGATAGAGAAGACAGG
TGCTCCAGGGTCCTGACATGACCCCCATCCTGAAGGGCCTTATGTCTTCCAGGTGAACGCTATGGCTCCA
AGAAGAGCATGGTCATTCTGACCAGCAGTGTGACGGCCGGCACCGCGGAGGAGTTCACCTATATCATGAA
GAGGCTGGGCCGGGCCCTGGTCATTGGGGAGGTGACCAGTGGGGGCTGCCAGCCACCACAGACCTACCAC
GTGGATGACACCAACCTCTACCTCACTATCCCCACGGCCCGTTCTGTGGGGGCCTCGGATGGCAGCTCCT
GGGAAGGGGTGGGGGTGACACCCCATGTGGTTGTCCCTGCAGAAGAGGCTCTCGCCAGGGCCAAGGAGAT
GCTCCAGCACAACCAGCTGAGGGTGAAGCGGAGCCCAGGCCTGCAGGACCACCTGTAGGGAAGGGCCCCA
TAGGCAGAGCCCCAGGGCAGACAGAACCTCTGGGACACACACCAAGGGCACTCCTGCAGGTGGCCCGGCC
TGAGGTTCCCAGGAGCAGCAAAGGGGCCTGCTGAGCTCTGGTTAGGTTACAGCTGGAGGTGTGTATATAT
ACACACACACACATGTATATACACATATATATGTGTATGTATATATATGTATATATATATGGCTTTCCAA
TAACCACCTAAATTTTAACAAAGGTTCCTTCTAAGTGGTAGAACTTGGGGTGGTATTTTTACCTTCCTTC
TTCATACTTTGCTCTTTTTCTTAAATACTCATTAATGTGCATATATCATTATTTTCAGATGCAGCTATCA
TTATTCCAAAATACAAAATAAAGAAGATAAAATAAATTATATACCCGAGCCATTA
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Protein Sequence : Show Sequence
>NP_002891.1 retinol-binding protein 3 precursor [Homo sapiens]
MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTL
ASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPG
QEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEI
WTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTV
PVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTL
LQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEA
IRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVP
LLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLG
WATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVL
EFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLL
VFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQ
QLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDL
YILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLA
GVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVA
LAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMF
GDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVS
ELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYL
TIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL
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Molecule Role :
Protective antigen
- Related Vaccine(s):
EAU DNA vaccine IRBP-DNA encoding IRBP
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| III. Vaccine Information |
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1. EAU DNA vaccine IRBP-DNA encoding IRBP |
| a. Vaccine Ontology ID: |
| VO_0004402 |
| b. Type: |
| DNA vaccine |
| c. Status: |
| Research |
| d. Host Species as Laboratory Animal Model: |
| Mouse |
| e. Gene Engineering of
IRBP from humans |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3.1 expressed the uveitogenic retinal Ag interphotoreceptor retinoid-binding protein (IRBP) (Silver et al., 2007).
- Detailed Gene Information: Click here.
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| f. Vector: |
| pcDNA3.1 (Silver et al., 2007) |
| g. Immunization Route |
| Intravenous injection (i.v.) |
| h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Immune Response:
IRBP-specific CD4+CD25high T cells could be cultured from vaccinated mice and transferred protection to unvaccinated, EAU-challenged recipients. Expression of IRBP in the periphery by DNA vaccination results in tolerance that acts at least in part through induction of IRBP-specific, FoxP3+CD4+CD25+ regulatory T cells (Silver et al., 2007).
- Efficacy:
Vaccinated mice were highly protected from EAU induced by immunization with IRBP for at least 10 weeks after vaccination (Silver et al., 2007).
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| IV. References |
1. Commodaro et al., 2010: Commodaro AG, Peron JP, Lopes CT, Arslanian C, Belfort R Jr, Rizzo LV, Bueno V. Evaluation of experimental autoimmune uveitis in mice treated with FTY720. Investigative ophthalmology & visual science. 2010; 51(5); 2568-2574. [PubMed: 20019358].
2. Silver et al., 2007: Silver PB, Agarwal RK, Su SB, Suffia I, Grajewski RS, Luger D, Chan CC, Mahdi RM, Nickerson JM, Caspi RR. Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. Journal of immunology (Baltimore, Md. : 1950). 2007; 179(8); 5146-5158. [PubMed: 17911600].
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