VIOLIN: Vaccine Investigation and Online Information Network

Pathogen Page

Experimental autoimmune uveitis

General Information
1. Disease
2. Introduction
Vaccine Related Pathogen Genes
1. IRBP
2. IRBP from humans
Vaccine Information
1. EAU DNA vaccine IRBP-DNA encoding IRBP
References

I. General Information

1. Disease:

Experimental autoimmune uveitis

2. Introduction

Experimental autoimmune uveitis (EAU) is an organ-specific, T cell–mediated disease that targets the posterior pole of the eye. It is also a valuable, well-characterized model for the study of human idiopathic uveitis. This disease can be induced in susceptible primates and rodents after immunization with retinal self-antigens, such as interphotoreceptor retinoid-binding protein (IRBP) or S-antigen (arrestin), or by the adoptive transfer of uveitis antigen-specific T cells (Commodaro et al., 2010).

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