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Trypanosoma brucei |
| Table of Contents |
- Protective Antigens
- MAPP15
- TSA
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| I. Vaccine Related Protective Antigens |
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1. MAPP15
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Gene Name :
MAPP15
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VO ID :
VO_0011334
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NCBI Protein GI :
777767
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Taxonomy ID :
5691
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Gene Strand (Orientation) :
?
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Protein Name :
microtubule-associated protein
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Protein pI :
12.57
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Protein Weight :
7350.75
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Protein Length :
161
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Protein Sequence : Show Sequence
>AAA65193.1 microtubule-associated protein, partial [Trypanosoma brucei]
ARATAVPKKAVAKKAAPKKTVAKKAAPKKAVAKKVAPKKAVAKKVVAKKAVAKKVVAKKVAPKKVVAKKV
APKKVAGKKAAAKKA
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
The microtubule-associate protein (MAP p15) was tested as a vaccine in mice, and tests showed that p15 (native or recombinant) generated up to 100% protection from an otherwise lethal challenge of a heterologous strain of Trypanosoma brucei (Rasooly and Balaban, 2004).
- Related Vaccine(s):
T. brucei Subunit p15 Protein Vaccine
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2. TSA
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Gene Name :
TSA
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VO ID :
VO_0011338
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NCBI Protein GI :
62175539
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Other Database IDs :
CDD:271234
CDD:290570
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Taxonomy ID :
5691
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Gene Strand (Orientation) :
?
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Protein Name :
trans-sialidase
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Protein pI :
6.57
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Protein Weight :
77957.172
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Protein Length :
833
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Protein Note :
Non-viral sialidases; cd15482
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Protein Sequence : Show Sequence
>AAX69677.1 trans-sialidase [Trypanosoma brucei]
MEELHQQMRMPISRLLLIFTAVCHCCALTSKAAGKGTTREAFLSGGAWALRKKLSEKDGEVWWWQDGPNW
KDKYDKEWERWFKEEKGPWGGSEKRSEWFARMTGGYITLGKTKILSSAIEGSDKVERTVHSFRIPSFVEV
DGVLMGIGDARYLTSTDYFFTDTVAKYSADGGKTWKTEVIIENGRVDPTYSRVVDPTVVAKADSVFVLVA
RYNVTKGYWHNENNAAGIADWEPFMYKGVVTKGADGKTSDVRISWTKTPLKPLYDFTVAGSKGTQFIGGA
GNGVVTLNGTILFPVQARNEDNAVVSMVMYSVDDGVSWHFARGETALLTSEASLTEWNGKLLMSARTDTS
GVNVEGGFRKVFESNNLGATWEESLGTISRVIGNSPDRTKPSPTANYPGSSGALITVTLGDVPVMLITHP
KNTKGAWSRDRLQLWMTDGNRMWLVGQISEGDDNSAYSSLLLARDGLLYCLHEQNIDEVYGLHLVHLVDE
LEKVNATVRKWKAQDALLAGLCSSSRKKNDPTCSGVPTDGLVGLLAGPVGASVWADVYDCVNASISDGVK
VSEGVQLGGKRNSRVLWPVSEQGQDQRYYFANTHFTLLATVRFAGEPKAEAPLMGFSNAEGKTSETLSLT
VGGKKWVLTYGSVRKEGPTTSMDWNQTHQIALTLRDGKVDAHVNGELIIKEVSVGASESSAHLHLSHFFI
GAPVNDSGEGGNNVIVRNVLLYNRKLDEDELQLLYSNREKIQPVVSAVGIPEGMSAPRLCCLLILMYVLA
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
BALB-c mice immunized intramuscularly with a single dose (100 microg) of a plasmid DNA encoding the 5'-terminal region of the trans-sialidase (nTSA) gene of T. brucei brucei are able to produce IgG antibodies that bind to the bloodstream form of T. brucei-protein extract and recognize the recombinant nTSA protein, expressed in Escherichia coli. Furthermore, this DNA vaccination process was able to protect 60% of mice submitted to a challenge assay with the infective form of T. brucei brucei parasites (Silva et al., 2009).
- Related Vaccine(s):
T. brucei DNA Vaccine encoding TSA protein
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| II. References |
1. Rasooly and Balaban, 2004: Rasooly R, Balaban N. Trypanosome microtubule-associated protein p15 as a vaccine for the prevention of African sleeping sickness. Vaccine. 2004; 22(8); 1007-1015. [PubMed: 15161078].
2. Silva et al., 2009: Silva MS, Prazeres DM, Lança A, Atouguia J, Monteiro GA. Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis. Parasitology research. 2009; 105(5); 1223-1229. [PubMed: 19582478].
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