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Parainfluenza virus |
| Table of Contents |
- General Information
- NCBI Taxonomy ID
- Introduction
- Vaccine Related Pathogen Genes
- Human metapneumovirus genome
(Other)
- Human parainfluenza virus 1 genome
(Other)
- HN
(Protective antigen)
- hPIV3 fusion
(Protective antigen)
- RSV F protein
(Protective antigen)
- Vaccine Information
- MEDI-534
- mRNA-1653
- rHPIV1 84/del170/942A
- rHPIV3cp45 Vaccine
- References
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| I. General Information |
| 1. NCBI Taxonomy ID: |
|
31605 |
|
2. Introduction |
Human parainfluenza viruses (HPIVs) commonly cause upper and lower respiratory illnesses in infants and young children. But, anyone can get respiratory illness from HPIV.
Symptoms of upper respiratory illness may include fever, runny nose, and cough. HPIVs can cause more severe lower respiratory illness, such as croup or pneumonia. Young children are more likely to have these severe illnesses. But, older adults and people with weakened immune systems are also at risk.
You can have multiple HPIV illnesses in your lifetime.
HPIVs spread from person to person through close personal contact, in the air by coughing and sneezing, and by touching objects or surfaces that have HPIVs on them.
People usually get infected with HPIV in the spring, summer, and fall (CDC - Human Parainfluenza Viruses). |
| II. Vaccine Related Pathogen Genes |
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1. HN |
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Gene Name :
HN
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Sequence Strain (Species/Organism) :
Parainfluenza virus
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NCBI Protein GI :
AAL89408
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Other Database IDs :
CDD:278832
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Taxonomy ID :
188538
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Protein Name :
HN glycoprotein
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Protein pI :
7.97
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Protein Weight :
62004.5
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Protein Length :
666
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Protein Note :
Haemagglutinin-neuraminidase; pfam00423
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Protein Sequence : Show Sequence
>AAL89408.1 HN glycoprotein [Human parainfluenza virus 1 strain Washington/1964]
MAEKGKTNSSYWSTTRNDNSTVNTHINTPAGRTHIWLLIATTMHTVLSFIIMILCIDLIIKQDTCMKTNI
MTVSSMNESAKIIKETITELIRQEVISRTINIQSSVQSGIPILLNKQSRDLTQLIEKSCNRQELAQICEN
TIAIHHADGISPLDPHDFWRCPVGEPLLSNNPNISLLPGPSLLSGSTTISGCVRLPSLSIGDAIYAYSSN
LITQGCADIGKSYQVLQLGYISLNSDMYPDLNPVISHTYDINDNRKSCSVIAAGTRGYQLCSLPTVNETT
DYSSEGIEDLVFDILDLKGKTKSHRYKNEDITFDHPFSAMYPSVGSGIKIENTLIFLGYGGLTTPLQGDT
KCVINRCTNVNQSVCNDALKITWLKKRQVVNVLIRINNYLSDRPKIVVETIPITQNYLGAEGRLLKLGKK
IYIYTRSSGWHSNLQIGSLDINNPMTIKWAPHEVLSRPGNQDCNWYNRCPRECISGVYTDAYPLSPDAVN
VATTTLYANTSRVNPTIMYSNTSEIINMLRLKNVQLEAAYTTTSCITHFGKGYCFHIVEINQASLNTLQP
MLFKTSIPKICKITS
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
(Kobayashi et al., 2013)
- Related Vaccine(s):
MEDI-534
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2. hPIV3 fusion |
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Gene Name :
hPIV3 fusion
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Gene Strand (Orientation) :
?
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Molecule Role :
Protective antigen
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3. Human metapneumovirus genome |
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Gene Name :
Human metapneumovirus genome
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Sequence Strain (Species/Organism) :
Human metapneumovirus
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NCBI Nucleotide GI :
340008341
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NCBI Protein GI :
340008342
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Protein Accession :
AEK26903.1
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Taxonomy ID :
162145
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Gene Strand (Orientation) :
?
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Protein Name :
N
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Protein Note :
genotype: B1
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DNA Sequence : Show Sequence
>gi|340008341|gb|JN184401.1| Human metapneumovirus strain TN982-42, complete genome
ACGCGAAAAAAACGCGTATAAATTAAATTCCAAACAAAACGGGACAAATAAAAATGTCTCTTCAAGGGAT
TCACCTAAGTGATCTATCATATAAACATGCTATATTAAAAGAGTCTCAATACACAATAAAAAGAGATGTA
GGCACTACAACTGCAGTGACACCTTCATCATTGCAACAAGAAATAACACTTTTGTGTGGGGAAATTCTTT
ACACTAAACACACTGATTACAAATATGCTGCTGAGATAGGAATACAATATATTTGCACAGCTCTAGGATC
AGAAAGAGTACAACAGATTTTGAGAAACTCAGGTAGTGAAGTTCAGGTGATTCTAACCAAAACATACTCT
TTAGGGAAAGGCAAAAACAGCAAAGGGGAAGAGTTGCAGATGTTAGATATACATGGAGTGGAAAAGAGTT
GGGTAGAAGAAATAGACAAAGAGGCAAGAAAGACAATGGTAACTTTGCTTAAGGAATCATCAGGTAACAT
TCCACAAAACCAGAGACCTTCAGCACCAGACACACCAATAATTTTATTATGTGTAGGTGCCCTAATATTC
ACCAAACTAGCATCAACAATAGAAGTTGGATTAGAGACTACAGTTAGAAGAGCTAATAGAGTGCTAAGTG
ATGCACTCAAAAGATACCCTAGAGTAGATATACCAAAGATTGCTAGATCTTTTTATGAACTATTTGAGCA
AAAAGTGTACTACAGAAGTTTATTCATTGAGTATGGAAAAGCTTTAGGCTCATCTTCAACAGGAAGCAAA
GCAGAAAGTTTGTTTGTAAATATATTTATGCAAGCTTATGGAGCTGGTCAAACATTGCTAAGGTGGGGTG
TCATTGCCAGATCATCCAATAACATAATGCTAGGGCATGTATCTGTGCAATCTGAATTGAAGCAGGTTAC
AGAGGTTTATGACTTGGTGAGAGAAATGGGTCCTGAATCTGGGCTTTTACATCTAAGACAAAGTCCAAAG
GCAGGGCTGTTATCGTTGGCCAATTGCCCCAATTTTGCTAGTGTTGTTCTTGGCAATGCTTCAGGTCTGG
GCATAATCGGAATGTACAGAGGGAGAGTACCAAACACAGAGCTATTTTCTGCAGCAGAAAGTTATGCCAG
AAGCTTAAAAGAAAGCAATAAAATCAACTTCTCCTCGTTAGGGCTTACAGATGAAGAAAAAGAAGCTGCA
GAACACTTCTTAAACATGAGTGGTGACAATCAAGATGATTATGAGTAATTAAAAAACTGGGACAAGTCAA
AATGTCATTCCCTGAAGGAAAGGATATCCTGTTCATGGGTAATGAAGCAGCAAAAATAGCCGAAGCTTTC
CAGAAATCACTAAAAAAATCAGGTCACAAGAGAACTCAATCTATTGTAGGGGAAAAAGTAAGCACTATAT
CAGAAACTCTAGAATTACCTACCATCAGCAAACCTGCACGATCATCTACACTGCTGGAACCAAAATTGGC
ATGGGCAGACAACAGCGGAGTCACCAAAATCACAGAAAAACCAGCAACCAAAACAACAGATCCTGCTGAA
GAAGAGGAATTCAGTGAAAAGAAAGCATTGCCTTCCAGTGATGGAAAGACTCCTGCAGAGAAAAAATCAA
AGTTTTCAACCAGTGTAAAAAAGAAAGTTTCCTTTACATCAAATGAACCAGGGAAATATACCAAGCTAGA
GAAAGATGCCCTAGATTTGCTCTCAGACAATGAGGAAGAAGACGCAGAATCCTCAATCCTAACCTTTGAG
GAGAAAGATACATCATCACTAAGCATTGAAGCCAGACTAGAATCTATAGAAGAGAAGTTGAGCATGATAT
TAGGACTGCTTCGTACACTTAACATTGCAACAGCAGGACCAACAGCTGCACGAGATGGAATCAGAGATGC
AATGATTGGTATAAGAGAAGAACTAATAGCAGAGATAATTAAGGAAGCCAAGGGAAAAGCAGCTGAAATG
ATGGAAGAAGAGATGAATCAAAGATCAAAAATAGGAAATGGCAGTGTAAAACTAACCGAGAAGGCAAAAG
AGCTCAACAAAATTGTTGAAGACGAGAGCACAAGCGGTGAATCAGAAGAAGAAGAAGAACCAAAAGAAAC
TCAGGATAACAATCAAGGAGAAGATATTTATCAGTTAATCATGTAGTTTAATAAAAATAAACAACGGGAC
AAGTCAAGATGGAGTCCTATCTGGTGGACACTTATCAAGGCATCCCATATACAGCTGCTGTTCAAGTTGA
CCTGGTAGAAAAAGATTTACTGCCAGCAAGTTTGACAATATGGTTTCCTTTATTTCAGGCTAACACACCA
CCAGCAGTCTTGCTTGATCAGCTAAAAACCTTGACAATAACAACTCTGTATGCTGCATCACAGAATGGTC
CAATACTCAAGGTAAATGCATCTGCCCAAGGTGCTGCCATGTCTGTACTTCCCAAAAAATTCGAGGTAAA
TGCAACTGTAGCACTTGATGAGTACAGCAAACTTGACTTTGACAAGCTGACGGTTTGCGATGTTAAAACA
GTTTATTTGACAACTATGAAACCGTACGGGATGGTGTCAAAATTTGTGAGCTCAGCCAAATCAGTTGGCA
AAAAGACACATGATCTAATTGCACTATGTGACTTCATGGACCTAGAGAAAAATATACCTGTGACAATACC
AGCATTCATAAAGTCAGTTTCAATCAAAGAGAGTGAGTCAGCCACTGTTGAAGCTGCAATAAGCAGTGAA
GCCGACCAAGCCTTGACACAAGCCAAGATTGCGCCCTATGCAGGACTAATTATGATCATGGCCATGAACA
ATCCAAAAGGTATATTCAAGAAACTAGGAGCTGGAACACAAGTGATAGTAGAGCTGGGGGCATATGTTCA
GGCTGAGAGCATCAGCAGGATCCGCAAGAGCTGGAGTCACCAAGGAACAAGATATGTCCTAAAATCCAGA
TAAAAATAACTATCTTAATCAATAATTGCTTATATAACTCCAAAGATTAATAAGCTTATTACTATAGTTA
TATAAAAATAAATTAGACTTAGAAGGGCATCAATAGAAAGCGGGACAAATAAAAATGTCTTGGAAAGTGA
TGATCATCATTTCGTTACTCATAACACCCCAGCACGGGCTAAAGGAGAGTTATTTGGAAGAATCATGCAG
TACTATAACTGAGGGATACCTCAGTGTTTTAAGAACAGGCTGGTACACTAATGTCTTTACATTAGAAGTT
GGTGATGTTGAAAATCTTACATGTACTGATGGACCTAGCTTAATCAAAACAGAACTTGATCTAACAAAAA
GTGCTTTAAGGGAACTCAAAACAGTCTCTGCTGATCAGTTAGCGAGAGAGGAGCAAATTGAAAATCCCAG
ACAATCAAGATTTGTCCTAGGTGCAATAGCCCTCGGAGTTGCTACAGCAGCAGCAGTCACAGCAGGCATT
GCAATAGCCAAAACCATAAGGCTTGAGAGTGAAGTGAATGCAATCAAAGGTGCTCTCAAACAAACTAATG
AAGCAGTATCCACATTAGGAAATGGAGTGCGGGTCCTAGCCACTGCAGTGAGAGAGCTGAAAGAATTTGT
GAGCAAAAATCTGACTAGTGCAATCAACAAGAACAAATGTGACATTGCTGATCTGAAGATGGCTGTCAGC
TTCAGTCAATTCAACAGAAGATTTCTAAATGTTGTGCGGCAGTTTTCAGACAATGCAGGAATAACACCAG
CAATATCATTGGACCTAATGACTGATGCTGAGTTGGCCAGAGCTGTATCATACATGCCAACATCTGCAGG
ACAGATAAAACTGATGTTGGAGAACCGCGCAATGGTAAGGAGGAAAGGATTTGGAATCCTGATAGGGGTC
TACGGAAGCTCTGTGATTTACATGGTTCAATTGCCGATCTTTGGTGTCATAGATACACCTTGTTGGATAA
TCAAGGCAGCTCCCTCTTGCTCAGAAAAAAACGGGAATTATGCTTGCCTCCTAAGAGAGGATCAAGGGTG
GTATTGTAAAAATGCAGGATCCACCGTTTACTACCCAAATGAAAAAGACTGCGAAACAAGAGGTGATCAT
GTTTTTTGTGACACAGCAGCAGGGATCAATGTTGCTGAGCAATCAAGAGAATGCAACATCAACATATCCA
CTACCAACTACCCATGCAAAGTCAGCACAGGAGGACACCCTATAAGTATGGTTGCACTATCACCTCTTGG
CGCTTTGGTGGCTTGCTATAAAGGGGTAAGCTGCTCAATTGGCAGCAATCGGGTTGGAATCATCAAACAA
TTACCTAAAGGCTGCTCATACATAACCAACCAGGATGCAGACACTGTAACAATTGACAACACCGTGTATC
AACTAAGCAAAGTTGAAGGTGAACAGCATGTAATAAAAGGGAGACCAGTTTCAAGCAGCTTTGATCCAAT
CAGGTTTCCTGAGGATCAGTTCAATGTTGCGCTTGATCAAGTCTTTGAAAGTATTGAGAACAGTCAGGCA
CTAGTGGATCAGTCAAACAGAATTCTAAACAGTGCAGAAAAAGGAAACACTGGCTTCATTATTGTAATAA
TTTTGGTTGCTGTTCTTGGTTTAACCATGATTTCAGTGAGCATCATCATCATAATCAAGAAAACAAAGAA
GCCCAAAGGAGCACCTCCAGAGCTGAATGGTGTCACCAACGGAGGTTTCATACCACATAGTTAGTTAATT
AAAAAATGGGACAAATCATCATGTCTCGTAAAGCTCCATGCAAATATGAAGTGCGGGGCAAATGCAACAG
AGGGAGTGATTGCAAGTTCAATCACAATTACTGGAGTTGGCCTGATAGATATTTATTGTTAAGATCAAAT
TATCTCTTGAATCAGCTTTTAAGAAACACTGACAAGGCTGATGGTTTGTCAATAATATCAGGAGCAGGTA
GAGAAGATAGAACTCAAGACTTTGTTCTTGGTTCTACCAATGTGGTTCAAGGGTACATTGATGACAATCA
AGGAATAACCAAGGCTGCGGCTTGCTATAGTCTACACAACATAATCAAGCAACTACAAGAAACAGAAGTA
AGACAGGCTAGAGACAACAAGCTTTCTGATAGCAAACATGTGGCGCTCCACAACTTGATATTATCCTATA
TGGAGATGAGCAAAACTCCTGCATCTCTAATTAACAACCTAAAGAAACTACCAAGGGAAAAACTGAAGAA
ATTAGCAAGATTAATAATTGATTTATCAGCAGGAACTGACAATGACCCTTCATATGCCTTGCAAGACAGT
GAAAGCACTAATCAAGTGCAGTAAACATGGTCCCAAATTCATTACCATAGAGGCAGATGATATGATATGG
ACTCACAAAGAATTAAAAGAAGCACTGTCTGATGGGATAGTAAAATCACACACTAATATTTATAGTTGTT
ACTTAGAAAACATAGAAATAATATATGTTAAAGCTTACTTAAGTTAGTAAAAAATAAAAATAGAATGGGA
TAAATGACAATGAAAACATTAGATGTCATAAAAAGTGATGGACCCTCAGAAACGTGTAATCAACTCAAAA
AAACAATAAAAAAACACTCGGGTAAAGTGCTTATTGCACTAAAACTGATATTGGCTTTACTGACATTTTT
CACAGTAACAATTACTGTTAACTATATAAAAGTAGAAAACAATTTGCAGGCATGTCAATCAAAAAATGAA
TCAGACAAAAAGGTCACAAAGTTAAATACTACATCAACAACAATCAGACCCATACCTGATCTAACTGTAG
TACATTATTTGAAAAGGCTGATTCAGAGACACACCAACTTTGTCATAAAAGACAGTGATACTTGTTGGAG
AATACACAAGAATCAATGTACAAATATAAAAATATACAAGTTCTTATGTTTTGGGTTCATAAATTCAACA
GGTACAGATTGTGAGGAACTAACAGCCTTATGCAACAAAAAGTTAAAAACTATGGCAGGAAAACATAGAA
AGGCAGAATGTCACTGTCTACATACAACCGAGTGGGGGTGCTATTATCTTTAAAATAACACGGCTTTCAA
CATTAAAATCAGAACAAATTCTACCCAGGTCTATTAATACAGTGGTTTAGTTATTTAAAAACTAAATATT
GTCTAGGCTGCGCGACACTTCGCAATAATATGCAATAGCCAATAATCAAACCAATGCTGCAAACTCATCC
ATAATATAATCACTGAGTAATACAAAACAAGAAAATGGGACAAGTGGCTATGGAAGTAAGAGTGGAGAAC
ATTCGAGCGATAGACATGTTCAAAGCAAAGATAAAAAACCGCATAAGAAGCAGCAGGTGCTATAGAAATG
CTACACTGATCCTCATTGGACTAACAGCGCTAAGCATGGCACTTAATATTTTCCTGATCATTGATCATGC
AACATTAAAAAACATGATCAAAACAGAAAACTGTGCTAACATGCCGTCAGCAGAACCAAGCAGAAAGACT
CTGATGTCCTCCACAGCAGGCCCAAACACCAAACCCGATCCACAGCAAGCAACACAGTGGACTACAGAGA
ACTCAACATCCCTAGCAGCAACCTCAGAAGGCTATCTATACACAGGGACAATTCAAACACCAGACACAAC
AGCTCCCCAGCAAACCACAGACAAATACACAGCACTGCTGAAATCAACCAACGAACAGATCACCCAGACA
ACCACAGAGAAAAAGACAACCAGAGCAGCAACCCAAAAAGGGAAAAAAGGGAAAGAAAACACAAACCAAA
CTACAAGTACAGCTGCAACCCAAACAACCAACACCACCAACCAAACCAGAAATGCAAATGAGACAATCAC
AACATCCGACAGACCCAGAACCGACATCACAACCCAAAGCAGCGAACAGACAACCCAGACAACAGACCCA
AGCTCCCCACCACACTATGCGCAGAGAGGCGCACAACTCAAACAAACACAACACACAAACATCCCATCCA
AGTAGTTAACAAAAAACCACAAAATAACCTTGAAAACCAAAAAACCAAAATGTAAATTTAAACCCAGAAA
AACATAAACACTATATGGATGGTTTGAGCATATACACCAATGAAATAGCATCTGTTCATGTATCAATAGT
ACTACCATTATTTAAGGAATAAGAAGAGGCAAAAATTCAAGGGATAAATGACAATGGATCCCTTTTGTGA
ATCTACTGTTAATGTTTATCTCCCTGATTCATATCTCAAAGGAGTGATATCTTTTAGTGAAACCAACGCA
ATTGGATCATGTCTTTTGAAAAGACCCTATCTAAAAAATGATAACACTGCTAAAGTTGCTGTAGAAAACC
CTGTTGTTGAACATGTCAGGCTTAGAAATGCAGTCATGACCAAAATGAAGATATCAGATTATAAAGTGGT
TGAACCAGTTAATATGCAACATGAAATAATGAAAAATATACACAGTTGTGAGCTTACATTATTAAAACAA
TTCTTAACGAGAAGTAAAAATATTAGCTCTCTAAAATTAAATATGATATGTGATTGGTTACAGTTAAAAT
CCACTTCAGATAACACATCAATTCTCAATTTTATAGATGTGGAGTTCATACCTGTTTGGGTGAGCAATTG
GTTCAGTAACTGGTATAATCTCAATAAATTAATCTTAGAGTTTAGAAGAGAAGAAGTAATAAGAACTGGT
TCAATTTTATGTAGATCACTAGGCAAGTTAGTTTTTATTGTATCATCTTATGGATGTGTAGTAAAAAGCA
ACAAAAGTAAAAGAGTGAGCTTCTTCACCTATAACCAACTGTTAACATGGAAAGATGTGATGTTAAGTAG
ATTCAATGCAAACTTTTGTATATGGGTAAGTAACAACCTGAACAAAAATCAAGGAGGACTAGGACTTAGA
AGCAATCTGCAAGGTATGTTAACCAATAAATTATATGAAACTGTTGATTACATGCTAAGCCTATGCTGCA
ATGAAGGATTCTCTCTGGTGAAAGAGTTCGAAGGATTTATTATGAGTGAAATTCTAAAAATTACTGAGCA
TGCTCAATTCAGTACTAGGTTTAGGAATACTTTATTGAATGGGTTAACTGAGCAATTATCAGTGTTGAAA
GCTAAAAACAGGTCTAGAGTTCTTGGAACTATATTAGAAAACAACAATTACCCTATGTATGAAGTAGTAC
TTAAATTATTAGGGGACACCTTGAAAAGCATAAAGTTATTAATTAACAAGAATTTAGAAAATGCTGCAGA
ATTATATTATATATTCAGAATTTTTGGACACCCTATGGTAGATGAGAGGGAAGCAATGGATGCTGTTAAA
TTAAACAATGAGATTACAAAAATTCTTAAATTAGAGAGTTTAACAGAACTAAGAGGAGCATTTATACTAA
GAATTATAAAAGGGTTTGTAGACAATAATAAAAGATGGCCTAAAATTAAGAATTTAAAAGTGCTCAGCAA
AAGATGGGCTATGTATTTCAAAGCTAAAAGTTACCCTAGCCAACTTGAGCTAAGTGTACAAGATTTTCTA
GAACTTGCTGCAGTGCAATTTGAGCAGGAATTCTCTGTACCTGAAAAAACCAACCTTGAGATGGTGTTAA
ATGATAAAGCAATATCACCTCCAAAAAAGCTAATATGGTCTGTATATCCAAAAAACTATCTGCCTGAAAC
TATAAAAAATCAATATTTAGAAGAGGCTTTCAATGCAAGTGACAGTCAAAGAACAAGGAGAGTCTTAGAA
TTTTACTTAAAAGATTGTAAATTTGATCAAAAAGAACTTAAACGTTATGTAATTAAACAAGAGTATCTAA
ATGACAAAGACCACATTGTCTCGTTAACTGGGAAGGAAAGAGAATTAAGTGTGGGTAGGATGTTTGCAAT
GCAACCAGGAAAACAAAGACAAATACAGATACTAGCTGAGAAACTTCTAGCTGATAATATTGTACCTTTT
TTCCCAGAAACTTTAACAAAGTATGGTGACTTAGATCTCCAAAGAATTATGGAAATAAAATCAGAACTTT
CCTCTATTAAAACTAGAAAGAATGATAGCTACAACAATTATATTGCAAGAGCCTCTATAGTAACAGACTT
AAGTAAGTTCAATCAGGCCTTTAGATATGAAACCACAGCTATATGTGCAGATGTAGCTGATGAGTTACAT
GGGACACAAAGCTTATTCTGTTGGTTACATCTTATTGTTCCCATGACTACAATGATATGTGCATACAGAC
ATGCACCACCAGAAACAAAAGGGGAGTATGACATAGACAAAATACAAGAGCAAAGCGGATTATACAGATA
TCATATGGGAGGGATTGAAGGGTGGTGCCAGAAGTTATGGACAATGGAAGCAATATCCTTGTTAGATGTA
GTATCTGTGAAGACTCGCTGTCAGATGACCTCTCTATTAAACGGAGACAATCAGTCAATAGATGTTAGTA
AACCAGTAAAATTGTCTGAAGGTATAGATGAAGTAAAAGCAGACTATAGCTTAGCAATTAGAATGCTTAA
AGAAATAAGAGATGCTTATAAAAACATTGGTCATAAACTCAAAGAAGGTGAAACATATATATCAAGGGAT
CTCCAATTTATAAGTAAGGTGATTCAATCTGAAGGGGTCATGCATCCTACCCCTATAAAAAAGATATTAA
GAGTAGGTCCTTGGATAAATACAATACTAGATGATATTAAAACCAGTGCAGAATCAATAGGGAGTCTATG
TCAAGAACTAGAATTCAGAGGGGAGAGTATACTAGTTAGCTTGATATTAAGGAATTTCTGGCTGTATAAC
TTGTACATGTATGAGTCAAAACAGCACCTGCTAGCTGGAAAGCAACTATTTAAGCAATTGAACAAAACAT
TAACTTCTGTGCAGAGATTTTTTGAACTGAAGAAAGAAAATGACGTGGTTGACATATGGATGAATATACC
AATGCAGTTTGGAGGGGGAGATCCGGTAGTTTTTTACAGATCTTTCTACAGAAGGACTCCCGATTTCCTA
ACTGAAGCAATCAGCCATGTGGATTTACTGTTAAAAGTGTCAAACAATATCAAAGATGAGACTAAGGTAC
GATTCTTCAAAGCCTTATTATCTATAGAAAAGAATGAACGTGCTACATTAACAACACTAATGAGAGACCC
TCAGGCAGTAGGATCAGAACGACAAGCTAAGGTAACAAGTGATATAAATAGAACAGCAGTTACCAGCATA
CTGAGTCTATCTCCGAACCAGCTCTTCTGTGATAGTGCTATACATTATAGTAGAAATGAGGAAGAAGTTG
GGATCATTGCAGACAACATAACACCTGTCTATCCTCATGGGCTGAGAGTGCTCTATGAATCACTACCTTT
TCATAAGGCTGAAAAGGTTGTCAATATGATATCAGGCACAAAGTCTATAACTAATCTATTACAGAGAACA
TCTGCTATCAATGGTGAAGATATTGATAGAGCAGTGTCTATGATGTTAGAGAACTTAGGGTTGTTATCTA
GGATATTGTCAGTAATAATTAATAGTATAGAAATACCAATCAAGCCCAATGGTAGATTGATATGCTGTCA
AATTTCCAAGACCTTGAGAGAAAAATCATGGAACAATATGGAAATAGTAGGAGTGACATCTCCTAGTATT
GTAACATGTATGGATGTTGTGTATGCAACTAGTTCTCATTTAAAAGGAATAATTATTGAAAAATTCAGTA
CTGACAAGACCACAAGAGGTCAGAGGGGACCAAAAAGCCCCTGGGTAGGATCAAGCACTCAAGAGAAAAA
ATTGGTTCCTGTTTATAATAGACAAATTCTTTCAAAACAACAAAAAGAGCAACTGGAAGCAATAGGAAAA
ATGAGGTGGGTGTACAAAGGAACTCCAGGGCTAAGAAGATTGCTCAATAAGATTTGCATAGGAAGTTTAG
GTATTAGCTATAAATGTGTAAAACCTTTATTACCAAGATTCATGAGTGTAAACTTCCTACATAGGTTATC
TGTTAGTAGTAGACCCATGGAATTCCCAGCTTCTGTTCCAGCTTACAGGACAACAAATTACCATTTTGAC
ACTAGTCCAATCAACCAAGCATTAAGTGAGAGGTTCGGGAACGAAGACATTAACCTAGTGTTCCAAAATG
CAATCAGCTGCGGAATTAGTATAATGAGTGTTGTAGAACAGTTAACTGGTAGAAGCCCAAAACAATTAGT
CCTAATCCCTCAATTAGAAGAGATAGATATTATGCCTCCTCCTGTATTTCAAGGAAAATTCAATTATAAA
CTAGTTGATAAGATAACCTCCGATCAACACATCTTCAGTCCTGACAAAATAGACATATTAACACTAGGGA
AGATGCTTATGCCTACCATAAAAGGTCAAAAAACTGATCAGTTCTTAAATAAGAGAGAAAACTATTTTCA
TGGAAATAATTTGATTGAATCTTTATCTGCAGCACTTGCATGCCACTGGTGTGGGATATTAACAGAACAG
TGTATAGAAAACAATATCTTTAGGAAAGATTGGGGTGATGGGTTCATCTCAGATCATGCCTTCATGGATT
TCAAAGTATTTCTATGTGTATTTAAAGCCAAACTTTTATGTAGTTGGGGATCTCAAGGAAAGAATGTAAA
AGATGAAGATATAATAGATGAATCCATTGATAAATTATTAAGAATTGACAACACCTTTTGGAGAATGTTC
AGCAAAGTCATGTTTGAATCAAAAGTCAAAAAAAGAATAATGTTATATGATGTGAAATTCCTATCATTAG
TAGGTTATATAGGATTTAAAAATTGGTTTATAGAACAGTTAAGAGTGGTGGAACTGCACGAGGTACCTTG
GATTGTCAATGCTGAAGGAGAGTTAGTTGAAATTAAATCAATCAAAATTTATCTGCAGTTAATAGAACAA
AGTCTATCTTTGAGAATAACTGTATTGAATTATACAGACATGGCACATGCTCTTACACGATTAATTAGGA
AAAAATTGATGTGTGATAATGCACTCTTCAATCCAAGTTCATCACCAATGTTTAATCTAACACAGGTTAT
TGATCCTACAACACAACCAGACTATTTTCCTAGGATAATATTTGAGAGGTTAAAAAGTTATGATACCAGT
TCAGACTACAACAAAGGGAAGTTAACAAGGAATTACATGACATTATTACCATGGCAACACGTAAACAGGT
ACAATTTTGTCTTTAGTTCTACAGGTTGTAAAATCAGTTTGAAGACATGCATCGGGAAATTGATAAAGGA
TTTAAATCCTAAAGTTCTTTACTTTATTGGAGAAGGAGCAGGTAACTGGATGGCAAGAACAGCATGTGAA
TATCCTGATATAAAATTTGTATATAGGAGTTTAAAGGATGACCTTGATCACCATTACCCATTAGAATATC
AGAGGGTAATAGGTGATCTAAATAGGGTGATAGATAGTGGTGAAGGACTATCAATGGAAACCACAGATGC
AACTCAAAAAACTCATTGGGACTTGATACACAGAATAAGTAAAGATGCTTTATTGATAACATTGTGTGAT
GCAGAATTCAAAAACAGAGATGATTTCTTTAAGATGGTAATCCTTTGGAGAAAACATGTATTATCCTGTA
GAATCTGTACAGCTTATGGAACAGATCTTTACTTATTTGCAAAGTATCATGCGGTGGACTGCAATATAAA
ATTACCATTTTTTGTAAGATCTGTAGCTACTTTTATTATGCAAGGAAGCAAATTATCAGGGTCAGAATGT
TACATACTTTTAACATTAGGTCATCACAATAATCTACCTTGTCATGGAGAAATACAAAATTCCAAAATGA
GAATAGCAGTGTGTAATGATTTTTATGCCTCAAAGAAACTGGACAACAAATCAATTGAAGCAAACTGCAA
ATCTCTTCTATCAGGATTGAGAATACCTATAAACAAAAAGGAATTAAATAGACAAAAGAAATTGTTAACA
CTACAAAGTAACCATTCTTCTGTAGCAACAGTTGGCGGCAGTAAGATTATAGAATCCAAATGGTTAAAGA
ATAAAGCAAGTACAATTATTGATTGGTTAGAGCATATTTTGAATTCTCCAAAAGGTGAATTAAACTATGA
TTTCTTTGAAGCATTAGAGAACACATACCCCAATATGATCAAGCTTATAGATAATCTGGGAAATGCAGAA
ATAAAGAAACTAATCAAGGTCATTGGGTATATGCTTGTGAGTAAGGAGTAATAATAATAATAATGATTAA
CCATAATCTCACACAACTGAGAAAATAATCATCTAACAGTTTAGTTGATCATTAGTTAATTAAAAATTAT
AAATTAGTAACTAACTGATAAAAAATCAGAAATTGAAATTGAATGTATACGGTTTTTTTGCCGT
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Molecule Role :
Other
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4. Human parainfluenza virus 1 genome |
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Gene Name :
Human parainfluenza virus 1 genome
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Sequence Strain (Species/Organism) :
Human parainfluenza virus 1
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NCBI Nucleotide GI :
19718363
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NCBI Protein GI :
19718364
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Protein Accession :
NP_604433.1
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Taxonomy ID :
12730
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Gene Strand (Orientation) :
?
-
Protein Name :
nucleoprotein
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Protein Note :
nucleocapsid protein
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DNA Sequence : Show Sequence
>gi|19718363|ref|NC_003461.1| Human parainfluenza virus 1, complete genome
ACCAAACAAGAGGAAAAACTTGTTTGGAATATATAATAATATTAAATAGTATTTTAGGGTTAAAGTAATA
CTTTAAAGGGACAAGTCACAGACATTTGATCTTAGTATAAATTTTTATAATGGCCGGGCTACTAAGTACT
TTTGACACATTTAGTTCCAGGAGAAGTGAGAGCATCAATAAGTCTGGCGGAGGAGCAATTATACCTGGTC
AAAGAAGTACCGTTTCTGTCTTCACATTAGGCCCGAGTGTGACAGATGATGCAGATAAATTATTAATAGC
AACCACTTTCTTAGCCCACTCATTGGACACAGATAAACAACACTCTCAAAGAGGAGGATTTTTAGTATCA
CTCCTTGCAATGGCCTACAGTAGTCCGGAGTTATATCTCACTACAAACGGTGTCAATGCTGATGTCAAGT
ATGTGATATACAATATAGAGAGAGATCCTAAAAGAACAAAAACAGATGGGTTCATTGTCAAAACAAGAGA
CATGGAGTATGAAAGAACAACAGAGTGGTTGTTTGGACCTATGATCAACAAGAACCCATTGTTCCAAGGG
CAAAGAGAGAATGCGGATCTAGAGGCATTGCTTCAGACATATGGATATCCTGCATGTCTCGGAGCTATAA
TAGTTCAAGTTTGGATAGTGTTGGTTAAAGCCATAACAAGTAGTGCTGGTCTAAGAAAAGGATTCTTCAA
TAGATTAGAAGCATTCAGACAGGATGGAACCGTTAAAAGTGCCCTGGTCTTCACAGGAGACACAGTTGAA
GGTATTGGTGCAGTGATGAGGTCACAACAAAGCTTAGTATCTCTTATGGTAGAAACTCTGGTGACTATGA
ACACATCCAGGTCAGATTTAACTACATTAGAGAAGAACATTCAGATTGTAGGAAATTACATAAGAGATGC
AGGATTAGCATCTTTCATGAACACCATCAAGTATGGTGTAGAAACGAAGATGGCCGCCCTGACACTATCA
AATCTGAGACCAGATATAAACAAATTGAGAAGCCTTGTTGATATCTATCTATCAAAGGGAGCCCGAGCCC
CTTTTATATGTATACTCAGAGACCCAGTTCATGGAGACTTTGCCCCTGGAAACTATCCAGCACTGTGGAG
CTACGCAATGGGCGTTGCTGTGGTACAAAACAAAGCTATGCAACAGTATGTAACTGGAAGAACATATTTG
GACATGGAAATGTTCCTACTTGGACAAGCTGTAGCTAAAGATGCTGATTCCAAAATCAGCAGTGCTCTGG
AGGAAGAACTAGGTGTGACAGATACAGCAAAAGAGAGACTAAGACACCATCTGACAAACCTTTCAGGAGG
GGATGGTGCGTACCACAAGCCTACAGGTGGTGGAGCTATAGAAGTGGCAATTGATCATACAGACATAACA
TTTGGAGTCGAGGACACTGCTGATCGGGACAACAAGAACTGGACAAATGACAGCAATGAAAGATGGATGA
ATCACTCGATCAGCAACCACACAATCACGATTCGTGGTGCAGAAGAACTTGAAGAAGAGACAAATGATGA
AGACATCACTGATATAGAAAACAAGATTGCACGAAGGCTGGCCGACAGAAAACAGAGACTAAGCCAGGCA
AACAATAAACGAGACACCAGCAGTGATGCTGACTATGAGAATGATGATGATGCTACAGCGGCTGCAGGGA
TAGGAGGAATTTAACAGGATACTTGGACAATAGAAGCCAGATCAAAAGTAAGAAAAACTTAGGGTGAATG
ACAATTCACAGATCAGCTCAACCAGACACCACCAGCATACACGAAACCAACCTTCACAGTGGATACCTCA
GCATCCAAAACTCTCCTTCCCGAATGGATCAGGATGCCTTCTTTTTTGAGAGGGATCCTGAAGCCGAAGG
AGAGGCACCACGAAAACAAGAATCACTCTCAGATGTCATCGGACTCCTTGACGTCGTCTTATCCTACAAG
CCCACAGAAATTGGAGAAGACAGAAGCTGGCTCCATGGTATCATCGACAACCCAAAAGAAAACAAGCCAT
CATGCAAAGCCGACGATAACAACAAAGACAGAGCAATCTCAACGTCGACCCAAGATCATAGATCAAGTGA
GGGGAGTGGAATCTCTAGGAGAACAAGTGAGTCAAAAACAGAGACACATGCTAGAATCCTTGATCAACAA
GGTATACACAGGGCCTCTAGGCGAGGAACTAGTCCAAACCCTCTACCTGAGAATATGGGCAATGAAAGAA
ACACCAGAATCGACGAAGATTCTCCAAATGAGAGAAGACATCAGAGATCAGTACTTACGGATGAAGACAG
AAAGATGGCTGAGAACTCTAATAAGAGGGAAGAAGACCAAGTTGAGGGATTTCCAGAAGAGGTACGAAGA
AGTACACCCTTATCTGATGATGGAGAGGGTAGAACAAATAATAATGGAAGAAGCATGGAAACTAGCAGCA
CACATAGTACAAGAATAACTGATGTCATTACCAACCCAAGTCCAGAGCTTGAAGATGCCGTTCTACAAAG
GAACAAAAGACGGCCGACGACCATCAAGCGTAACCAAACAAGATCAGAGAGAACACAGAGTTCAGAACTC
CACAAATCAACAAGTGAAAATAGCTCCAACCTCGAAGACCACAACACCAAAACCAGCCCAAAAGTTCCAC
CGTCAAAGAACGAAGAGTCAGCAGCCACTCCAAAGAACAACCACAACCACAGAAAAACAAGATACACAAC
AAACAATGCAAACAACAACACAAAAAGTCCACCAACTCCCGAACACGACGCAACCGCAAATGAAGAGGAA
ACCAGCAACACATCGGTCGATGAGATGGCCAAGTTATTAGTAAGTCTTGGTGTAATGAAATCACAACATG
AATTTGAATTATCTAGGAGTGCAAGTCATGTATTTGCTAAGCGCATGTTAAAATCTGCAAATTACAAAGA
AATGACATTTAATCTCTGTGGTATGCTTATATCAGTTGAAAAATCACTTGAGAATAAAGTAGAAGAAAAT
AGAACATTACTTAAACAAATTCAAGAGGAAATAAATTCATCCAGGGATCTTCACAAACGGTTCTCGGAAT
ACCAAAAAGAACAGAACTCACTCATGATGGCCAATCTATCCACACTCCATATAATTACAGATAGAGGCGG
GAAAACGGGAAATCCCAGTGATACTACAAGGTCACCATCAGTCTTCACAAAAGGGAAAGACAATAAGGTC
AAAAAGACAAGGTTTGACCCCTCTATGGAAGCTCTAGGAGGTCAAGAGTTCAAGCCTGACTTGATAAGAG
AGGATGAACTGAGAGATGACATCAAAAATCCGGTACTAGAAGAAAACAACAATGAGCCTCAAGCATCCAA
TGCATCACGCCTGATTCCGTCCACTGAAAAACACACTCTGCACTCACTCAAACTAGTTATCGAAAACAGT
CCTCTAAGCAGAGTAGAGAAGAAGGCTTACATCAAATCCCTTTATAAGTGTCGGACAAACCAAGAGGTTA
AAAATGTAATGGAGCTATTCGAGGAAGACATAGATTCACTAACTAACTAAACATGAATCTACAATTTCAA
CCAGCAATCAAAATCAATATCCAGAGCCAACTCAAAAAGCTCCCTCAAAACAATTAAGAAAAACTTAGGG
TCAAAGAAATTTTGCCCGGAGAAAGGAAATGGCTGAAACATACAGGTTCCCCAGATTCTCACACGAAGAA
AATGGGACAGTAGAACCTCTCCCTCTCAAAACAGGTCCTGACAAAAAAGCAATCCCTCACATCAGAATAG
TCAAGGTAGGAGATCCTCCAAAACATGGAGTCAGGTATCTTGATGTGCTACTATTGGGATTCTTTGAAAC
ACCTAAGCAAGGACCTCTATCTGGCAGCATATCTGATCTCACAGAATCAACCAGTTATTCAATCTGTGGA
TCCGGATCCTTACCAATTGGCATAGCCAAGTATTACGGCACAGATCAAGAATTATTAAAAGCCTGCATTG
ACCTCAAAATAACTGTACGAAGAACAGTTAGATCTGGAGAAATGATAGTATACATGGTAGATTCGATCCA
TGCTCCTCTACTACCATGGTCCAGCCGACTGAGACAAGGGATGATATATAATGCCAATAAAGTAGCTCTA
GCACCTCAATGTCTCCCAGTCGACAAAGACATCAGATTCAGGGTTGTATTTGTCAATGGAACATCACTAG
GTACAATTACAATTGCTAAGGTCCCAAAAACTCTTGCAGATCTTGCATTACCGAACTCAATATCAGTGAA
TCTGCTGGTTACACTTAGGGCAGGAGTATCAACGGAACAAAAAGGAATCCTCCCCGTTCTAGACGATGAT
GGAGAAAAGAAGCTCAACTTCATGGTACACCTAGGAATCATAAGAAGAAAAGTTGGGAAGATATATTCAG
TTGAATACTGCAAAAATAAAATTGAGAAGATGAAGCTAATATTCTCTCTCGGGCTTGTAGGTGGAATAAG
TTTCCATGTACATGCAACAGGCACATTATCCAAAACTCTAATGAGCCAACTTGCATGGAAAAAAGCAGTT
TGCTATCCTTTAATGGATGTAAATCCACATATGAATCTAGTCATCTGGGCAGCTTCAGTAGAAATCACAA
GTGTCGATGCTGTGTTCCAACCTGCAATTCCGAAAGAATTTCGCTATTACCCAAATGTTGTTGCAAAAAG
CATCGGGAAAATCAGGAGGATATAAGTCTACACTCCTCAATAATGACACCCATTAGCTCTAAATCGTACC
ATTAATCAAATACAGATCAATTCGATACAATCAGTTCAAATAAGAAAAACGTAGGGACAAAGTCCTCTAC
CAACATCAAGGAAGACAAGAGTCTCAAAAAGCTCAGCCTAAGCAGAGAGAAAAACAACAACACAAAGAAA
GAAAAGGACAAGATCACAAACAAGAACAAAAGCAAAAACAAAAACAAGAACAAAAAAGGGAAGAAAAACA
AAAGTATACACAAAAACCAAAAAAGAAAAAAGGCCAGAGACAAAAACGGAGGCAAGAACAAAAATTTAAA
CAAAAACAGAATTTAAATTCATAATAAACACCAAGATAGAGACAAAAATGCAAAAATCAGAGATCCTCTT
CTTAGTATACTCAAGCTTGCTATTATCTTCATCATTATGTCAAATTCCGGTAGAAAAACTTTCAAATGTA
GGGGTTATAATCAATGAGGGCAAATTACTTAAAATAGCAGGATCTTATGAATCTAGATACATAGTGTTAA
GCTTGGTACCTTCAATTGACCTACAAGATGGATGTGGAACAACTCAAATTATTCAATACAAGAATTTATT
AAATAGACTTCTAATTCCTCTGAAGGATGCCTTGGATCTTCAGGAATCCCTGATAACAATAACTAATGAC
ACCACTGTGACAAATGATAATCCACAAACTAGATTCTTTGGTGCTGTCATTGGTACCATAGCACTAGGAG
TAGCCACAGCTGCTCAAATAACTGCGGGCATTGCATTAGCTGAAGCACGAGAAGCCAGGAAGGACATAGC
ACTAATAAAAGATTCCATAGTCAAGACACACAATTCTGTAGAACTCATTCAAAGAGGTATAGGAGAACAG
ATAATTGCATTAAAGACATTACAAGATTTTGTAAATGACGAGATAAGACCTGCAATAGGAGAACTAAGGT
GTGAGACTACGGCATTGAAACTAGGGATCAAGCTCACCCAACACTACTCTGAATTAGCAACAGCATTCAG
CTCCAATCTTGGGACTATAGGAGAAAAAAGTCTTACCTTGCAGGCATTATCATCTCTCTACTCTGCTAAT
ATAACAGAAATTCTAAGTACAACTAAAAAGGATAAATCAGATATATATGACATCATTTACACTGAACAGG
TTAAGGGAACTGTGATAGATGTTGATTTGGAAAAATACATGGTTACCCTCTTAGTTAAAATACCAATTTT
ATCAGAAATACCAGGCGTGTTGATATACAGAGCTTCATCTATATCTTATAATATTGAAGGAGAAGAATGG
CATGTCGCAATCCCAAATTACATAATCAATAAGGCATCATCCTTAGGAGGTGCAGATGTCACAAACTGTA
TAGAATCAAAATTGGCATATATATGTCCTAGAGATCCTACACAATTAATACCTGATAACCAACAGAAGTG
TATACTCGGGGATGTATCAAAGTGCCCTGTGACTAAAGTAATAAACAATCTAGTACCAAAGTTCGCATTC
ATCAATGGTGGTGTAGTGGCTAATTGCATTGCATCCACATGTACATGCGGGACAAACAGAATACCAGTGA
ATCAAGATCGCTCAAGAGGAGTTACATTCTTGACCTATACCAATTGCGGTTTAATAGGTATAAATGGAAT
AGAACTATATGCCAATAAAAGGGGACGAGACACTACTTGGGGGAATCAAATCATCAAAGTGGGTCCAGCA
GTCTCCATTAGACCTGTAGACATTTCTTTAAATCTTGCATCTGCCACAAATTTCCTAGAGGAATCCAAGA
CAGAGCTCATGAAGGCAAGGGCAATCATATCAGCAGTTGGAGGATGGCACAACACAGAGAGTACTCAGAT
AATCATGATAATAATTGTGTGCATACTTATAATAATCATATGTGGTATATTATACTATCTATACAGGGTT
AGAAGACTATTAGTAATGATTAATTCAACTCATAATTCACCTGTTAATGCTTATACTCTGGAGTCAAGAA
TGAGAAATCCCTACATGGGTAACAACTCCAATTAAAAAATCAGATCAAGTACATTGTAGCATACATACAA
CAATCAAATCTATCCACAACTTCACCAATCAGGTGTACAACAAGTAAGAAAAACTTAGGGTTAAAGACAA
TCCAGTCAACCTATAAGGCAACAGCATCCGATTATACAAACGATGGCTGAAAAAGGGAAAACAAATAGTT
CATATTGGTCTACAACCCGAAATGACAATTCCACGGTAAACACACACATTAATACACCAGCAGGAAGGAC
ACACATCTGGCTACTGATTGCAACAACAATGCATACAGTATTGTCCTTCATTATCATGATCCTATGCATT
GACCTAATTATAAAACAAGACACTTGTATGAAGACAAACATCATGACAGTATCCTCCATGAACGAAAGTG
CCAAAATAATCAAAGAGACAATCACAGAATTAATCAGACAAGAAGTAATATCAAGGACCATAAACATACA
AAGTTCAGTACAAAGCGGGATCCCAATATTGTTAAACAAGCAAAGCAGAGATCTCACACAATTAATAGAG
AAGTCATGCAACAGACAGGAATTGGCTCAGATATGCGAAAACACCATTGCTATTCACCATGCAGACGGCA
TATCTCCTCTGGACCCACACGATTTCTGGAGATGTCCCGTAGGGGAACCCCTACTGAGCAACAACCCCAA
TATCTCATTATTACCTGGACCAAGTCTACTTTCTGGATCCACCACAATTTCAGGATGTGTTAGACTACCT
TCATTATCAATTGGTGATGCAATATATGCGTATTCATCAAACTTAATCACTCAAGGATGTGCAGATATAG
GGAAGTCATATCAGGTTTTACAATTAGGTTACATATCCTTAAATTCAGATATGTATCCTGATTTAAACCC
GGTAATTTCTCATACCTATGACATCAACGACAACAGGAAATCATGTTCTGTAATAGCTGCAGGAACAAGG
GGTTATCAGTTATGCTCCTTGCCCACTGTGAATGAGACTACAGACTACTCGAGTGAAGGTATAGAAGATT
TAGTATTTGACATATTAGATCTCAAGGGAAAGACCAAATCTCATCGATACAAAAATGAAGATATAACTTT
TGACCATCCTTTTTCTGCAATGTATCCGAGTGTAGGAAGTGGGATAAAAATTGAAAATACACTCATTTTC
CTAGGGTACGGTGGCTTAACAACTCCGCTCCAAGGCGACACTAAGTGTGTGATAAACAGATGTACCAATG
TTAATCAGAGTGTTTGCAATGATGCTCTTAAGATAACTTGGCTAAAGAAAAGACAAGTTGTCAATGTCTT
AATTCGTATCAATAATTATTTATCTGATAGGCCAAAGATTGTTGTCGAGACAATTCCAATAACTCAAAAT
TACTTAGGTGCCGAAGGTAGGCTACTTAAACTAGGTAAAAAGATCTACATATATACTAGATCTTCAGGTT
GGCACTCCAACCTGCAAATAGGATCATTAGATATCAACAACCCCATGACCATTAAATGGGCGCCTCATGA
AGTCCTGTCTCGACCAGGAAACCAAGACTGCAACTGGTACAACAGATGTCCGAGAGAATGCATATCAGGT
GTATATACTGATGCATATCCACTATCTCCTGATGCAGTCAATGTTGCTACAACCACACTGTACGCAAACA
CATCACGTGTTAATCCCACCATAATGTACTCAAATACCTCAGAAATTATCAACATGCTAAGACTCAAGAA
TGTACAACTAGAGGCAGCATACACTACTACATCATGTATCACTCATTTCGGGAAGGGCTACTGCTTCCAC
ATTGTTGAAATCAACCAAGCCAGCCTTAATACCTTACAACCTATGTTGTTCAAGACAAGTATCCCTAAAA
TATGTAAAATCACATCTTGAGCAGATCAAGACCCAACACTATATCAATTATGTGAAAACCAGATATGATG
TATAAAAATTTAAAAACAAAGCATGAATAGACATTTATATGACAAATAGAATAAGAAAAACTTAGGGTTA
ATGCCTGCCTATTTGTCAAATATGGATAAACAGGAGTCAACTCAGAATTCCTCAGACATCTTATATCCAG
AATGTCACTTGAACTCTCCGATTGTAAAAAGCAAGATTGCTCAACTTCACGTTTTGCTAGATATCAATCA
ACCCTATGATTTAAAAGATAACAGTATAATAAATATCACCAAATACAAAATCAGAAATGGAGGTTTATCG
CCCCGGCAGATCAAAATCAGATCGCTAGGCAAAATCCTTAAACAAGAAATTAAGGATATTGATCGTTACA
CTTTTGAACCTTATCCGATTTTCTCATTAGAGTTACTCAGACTGGATATCCCAGAAATATGTGACAAAAT
AAGATCCATTTTTTCAGTCTCTGATAGATTAATAAGAGAACTATCATCTGGATTTCAAGAATTGTGGTTA
AATATTCTTAGACAATTAGGCTGTGTTGAAGGGAAAGAGGGATTTGACTCATTAAAGGATGTAGATATCA
TCCCAGATATAACTGATAAATATAATAAAAACACATGGTATCGCCCATTCTTAACATGGTTTAGCATCAA
ATATGATATGAGATGGATGCAAAAGAATAAGTCGGGGAACCATTTAGATGTCTCAAATTCTCACAATTTT
CTTGACTGTAAATCATATATTTTGATTATATATAGAGATTTAGTGATAATAATAAATAAATTAAAATTAA
CCGGTTATGTCCTTACACCTGAATTAGTATTAATGTATTGTGATGTTGTCGAAGGAAGATGGAATATGTC
TTCAGCTGGACGACTCGATAAAAGGTCATCAAAAATAACATGTAAGGGGGAAGAATTATGGGAGCTTATC
GACTCTTTATTTCCCAATCTTGGTGAGGATGTATATAATATTATATCACTACTAGAACCTTTATCACTTG
CTTTAATACAGTTGGATGACCCTGTAACTAATTTAAAAGGAGCTTTCATGAGACATGTTTTGACTGAGCT
ACATACAATTTTAATAAAAGATAATATATACACAGATTCAGAAGCAGACAGCATAATGGAATCATTGATA
AAGATTTTCAGAGAGACATCAATTGATGAAAAAGCAGAAATTTTCTCCTTTTTTAGAACGTTTGGACATC
CTAGCTTAGAAGCAATAACTGCTGCCGATAAAGTAAGGACACATATGTATTCCTCCAAAAAAATCATACT
AAAGACACTATATGAGTGTCATGCAATCTTCTGTGCAATTATAATAAACGGATATAGAGAAAGACACGGT
GGTCAATGGCCGCCATGCGAATTCCCCAATCATGTATGTCTTGAACTCAAGAATGCACAAGGATCCAACT
CTGCAATTTCGTATGAATGTGCCGTAGACAATTATAGTAGTTTTATAGGATTTAAATTTTTAAAATTTAT
TGAGCCTCAATTAGATGAAGATTTGACAATTTATATGAAGGATAAGGCTCTATCACCTAGGAAAGCAGCA
TGGGATTCAGTATATCCCGACAGTAATTTATATTACAAAGTCCCTGAATCAGAAGAGACTCGTAGGTTAA
TCGAGGTTTTTATAAATGATAATAATTTTAACCCTGCGGATATTATTAATTATGTAGAGTCAGGAGAATG
GTTAAATGACGATAGCTTCAACATATCTTACAGTCTCAAAGAAAAAGAAATTAAACAAGAGGGTCGACTC
TTTGCCAAGATGACATATAAGATGAGAGCAGTCCAGGTATTAGCAGAAACACTACTAGCAAAAGGAGTAG
GTGAGTTATTCAGTGAAAATGGGATGGTAAAGGGAGAAATTGACCTACTAAAGAGACTGACTACATTATC
TGTCTCAGGTGTTCCAAGATCCAACTCAGTTTACAATAATCCCATATTACATGAGAAATTGATCAAAAAT
ATGAATAAGTGCAATTCAAATGGGTATTGGGATGAAAGAAAGAAATCTAAAAATGAATTCAAAGCTGCAG
ACTCATCAACCGAGGGGTATGAGACTCTGAGCTGTTTTTTAACCACCGATTTGAAAAAATACTGTCTCAA
CTGGAGATTTGAAAGTACAGCGTTGTTCGGTCAAAGATGTAATGAGATATTCGGGTTTAAAACTTTCTTT
AACTGGATGCACCCTATTCTAGAAAAAAGTACAATTTATGTAGGAGATCCTTACTGTCCAGTACCTGATA
GAATGCACAAAGAACTCCAAGATCATGATGATACCGGAATCTTTATCCATAATCCAAGAGGGGGAATAGA
GGGTTATTGCCAGAAATTATGGACACTAATCTCTATTAGTGCAATCCATCTTGCAGCTGTTAAAGTTGGT
GTCAGAGTGTCAGCAATGGTACAAGGAGACAATCAAGCTATAGCAGTGACATCCAGAGTTCCTGTCACAC
AAACCTATAAGCAAAAAAAGACTCACGTCTATGAAGAAATCACAAGATATTTCGGTGCCTTGAGAGAAGT
TATGTTTGATATTGGACATGAATTAAAATTAAATGAGACCATTATAAGTAGCAAAATGTTTGTATACAGC
AAACGGATATATTATGATGGGAAAATCCTCCCACAGTGCCTCAAAGCTTTAACAAGATGTGTATTTTGGT
CAGAGACTCTTGTAGATGAAAACAGGTCAGCATGCTCAAACATTGCAACATCTATAGCCAAAGCTATTGA
GAATGGATATTCACCTATCTTAGGCTATTGTATTGCTCTTTTTAAAACTTGCCAACAGGTATGTATATCA
TTAGGAATGACCATTAATCCTACTATTACGTCAACTATCAAAGATCAATATTTTAAAGGGAAAAATTGGT
TAAGATGTGCAATATTGATCCCAGCTAACATAGGAGGGTTCAACTATATGTCTACAGCTAGATGTTTTGT
CAGAAATATAGGTGATCCAGCAGTTGCAGCTCTAGCAGACTTAAAGAGATTCATCAAAGCAGGTCTGTTA
GATAAACAGGTATTATATCGTGTGATGAATCAAGAACCAGGAGACTCAAGCTTCTTAGATTGGGCATCAG
ACCCTTATTCATGCAATCTCCCACACTCACAAAGTATAACAACTATAATCAAAAATGTAACAGCTAGATC
AGTATTGCAGGAATCACCTAATCCTCTCCTATCAGGTCTCTTTTCAGAATCAAGTAGTGAAGAAGATCTC
AACTTAGCATCATTTTTGATGGATAGGAAAGCCATATTGCCCAGAGTAGCTCACGAGATCTTAGATAACT
CACTTACAGGTGTAAGAGAAGCTATAGCCGGGATGCTTGATACAACGAAATCTCTAGTAAGAGCTAGTGT
CAGGAGAGGAGGATTATCATATAGTATCTTAAGAAGACTTATAAATTATGATCTATTACAATATGAGACC
TTAACAAGGACACTCAGAAAACCGGTTAAGGATAATATAGAATATGAGTATATGTGTTCAGTAGAATTGG
CAATAGGATTGAGGCAAAAAATGTGGTTTCATCTAACTTATGGAAGACCAATCCACGGTTTAGAAACTCC
AGACCCGTTAGAATTATTAAGAGGATCATTTATTGAAGGCTCAGAAATATGTAAATTTTGTAGATCAGAA
GGGAATAACCCTATGTATACTTGGTTCTATCTTCCTGACAACATCGACTTAGATACACTTAGCAATGGAA
GTCCTGCCATACGTATCCCTTATTTTGGTTCTGCTACTGATGAAAGATCAGAGGCTCAACTAGGTTATGT
TAAGAACTTAAGCAAGCCGGCAAAAGCAGCAATAAGAATCGCAATGGTTTACACTTGGGCTTATGGAACT
GATGAAATATCATGGATGGAAGCAGCACTTATAGCTCAAACCAGGGCTAACTTAAGTTTAGAGAATTTGA
AGTTACTCACCCCTGTATCGACTTCTACAAATTTGTCCCACAGATTGAGAGATACTGCTACACAGATGAA
ATTTTCAAGTGCTACTTTAGTTCGAGCGAGTCGATTTATTACCATATCTAATGATAATATGGCATTAAAA
GAGGCAGGAGAGTCTAAAGATACTAATTTAGTTTATCAACAAATTATGTTAACCGGATTGAGCTTATTTG
AATTCAATATGAGGTATAAACAAGGATCATTATCTAAACCTATGATATTACACTTACATTTGAATAATAA
ATGCTGTATCATAGAATCTCCTCAAGAATTGAATATTCCTCCTAGATCTACATTGGACTTAGAGATCACT
CAGGAAAATAACAAGTTAATCTATGATCCTGATCCTCTCAAGGACATAGATCTAGAGTTATTTAGTAAGG
TTAGGGATGTAGTACACACAATTGATATGAATTATTGGTCTGATGATGAAATAATTAGAGCAACTAGTAT
ATGTACAGCTATGACTATTGCAGACACAATGTCTCAATTAGATAGAGACAATCTTAAAGAAATGATAGCA
CTGATAAATGATGATGATATAAATAGTTTAATCACCGAATTTATGGTTATTGATATACCCTTATTTTGTT
CCACTTTCGGGGGTATTCTAATCAATCAATTTGCATATTCACTTTACGGGTTAAACGTCAGAGGGAGGGA
TGAAATATGGGGATATGTGATACGCATAATTAAAGACACATCACATGCAGTCCTAAAAGTACTGTCCAAT
GCATTATCACATCCTAAAATATTCAAACGATTCTGGGATGCAGGAGTTGTAGAGCCTGTTTATGGACCTA
ACTTGTCCAATCAAGACAAGATACTGTTAGCCATTTCAGTATGTGAATACTCTGTTGACCTCTTCATGCG
TGATTGGCAAGAGGGCATACCGCTTGAAATATTTATTTGTGATAACGACCCAAATATAGCAGAAATGAGA
AAACTTTCATTTTTAGCTAGACATCTAGCATACTTGTGTAGTTTGGCAGAGATAGCTAAAGAGGGACCAA
AATTGGAATCTATGACATCTCTCGAACGACTCGAATCATTGAAAGAGTATCTAGAACTTACTTTTTTAGA
CGATCCTATATTAAGATATAGTCAATTGACAGGCTTAGTTATTAAGATATTCCCTTCAACGTTAACTTAC
ATCAGGAAATCTTCAATTAAGGTGTTGAGAGTAAGAGGTATAGGGATACCAGAAGTCTTAGAGGACTGGG
ATCCTGATGCCGATAGTATGCTACTAGATAATATAACTGCTGAGGTTCAACACAATATACCTTTAAAGAA
GAACGAAAGAACTCCCTTCTGGGGGTTAAGGGTATCAAAATCACAAGTTCTGCGACTTAGAGGTTATGAA
GAGATAAAAAGGGAAGAAAGAGGAAGATCAGGTGTAGGATTAACTCTACCTTTTGATGGGCGATATTTAT
CACACCAATTGAGACTTTTCGGGATTAATAGCACCAGTTGTTTGAAAGCATTGGAACTTACCTATTTACT
GAATCCTCTAGTCAATAAGGATAAAGATAGATTATATCTCGGAGAAGGTGCAGGTGCAATGCTGTCTTGT
TATGATGCTACATTAGGACCCTGCATGAACTATTATAATTCAGGTGTTAATTCTTGTGATCTCAACGGAC
AAAGAGAATTAAATATTTATCCTTCAGAAGTGGCACTGGTAGGGAAGAAATTGAATAATGTCACGAGTTT
ATGTCAAAGAGTTAAGGTTTTATTCAATGGGAATCCTGGATCAACTTGGATAGGGAATGATGAATGTGAA
ACACTAATCTGGAATGAATTACAGAATAATTCAATAGGGTTTATTCATTGTGACATGGAAGGTGGAGAAC
ACAAATGTGATCAGGTGGTCTTACATGAACATTATAGTGTGATCAGGATTGCATACCTTGTTGGGGATAA
GGACGTTATCTTAGTAAGCAAAATTGCACCAAGATTAGGTACAGACTGGACAAAACAATTAAGTTTGTAT
TTAAGATACTGGAGAGATGTCAGCTTAATAGTGTTGAAAACATCTAACCCAGCCTCTACAGAAATGTATC
TGATATCAAAAGATCCTAAATCTGATATTATAGAGGATAGTAATACAGTATTGGCAAACCTTCTTCCATT
ATCTAAAGAGGATAGTATTAAGATAGAAAAATGGATTCTAGTTGAGAAAGCCAAAGTTCATGATTGGATA
GTTAGAGAATTAAAGGAAGGGAGTGCATCGTCAGGTATGCTAAGACCTTACCATCAAGCATTACAAATCT
TCGGATTTGAGCCTAATTTAAACAAATTATGTAGAGATTTCTTATCTACACTAAATATAGTAGACACAAA
AAATTGTATTATCACATTTGATAGAGTATTAAGAGATACAATCTTTGAGTGGACTCGGATAAAAGACGCA
GATAAGAAGCTAAGACTTACAGGTAAATATGATCTATATCCTCTTAGAGATTCAGGTAAGTTAAAAGTTA
TTTCTAGAAGGCTTGTAATATCTTGGATAGCATTGTCTATGTCTACAAGACTAGTAACAGGGTCATTTCC
AGACATTAAATTTGAATCAAGACTCCAATTAGGTATAGTATCAATATCCTCTCGTGAAATCAAAAATCTT
AGGGTTATATCAAAGATTGTCATTGACAAATTTGAAGATATTATACATAGTGTGACCTATAGGTTCTTGA
CTAAAGAAATAAAAATATTGATGAAAATTTTGGGAGCAGTCAAATTATTTGGGGCAAGACAGAGCACATC
TGCTGATATCACTAATATCGATACATCGGACTCCATACAATGATCTTATATCTTCTCATCTTTATTATCT
AATTTGTTTAAAGAGATGAGTTAACAAGATAAGAAATCCCTTTAACTGACTCATAAAAACATAGTAAGAA
AAACTTACAACAGACAAGAGTATTAATAATATATCGATATTTCTTAAACTCTTGTCTGGT
-
Molecule Role :
Other
|
|
5. RSV F protein |
-
Gene Name :
RSV F protein
-
Gene Strand (Orientation) :
?
-
Molecule Role :
Protective antigen
|
| III. Vaccine Information |
 |
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1. MEDI-534 |
| a. Type: |
| Live, attenuated vaccine |
| b. Status: |
| Research |
| c. Host Species for Licensed Use: |
| Hamster |
| d. Gene Engineering of
HN |
- Type:
Recombinant protein preparation
- Description:
Expresses the hPIV3 fusion (F) protein (Gomez et al., 2009)
- Detailed Gene Information: Click here.
|
| e. Gene Engineering of
HN |
- Type:
Recombinant protein preparation
- Description:
Expresses the hPIV3 hemagglutinin-neuraminidase (Gomez et al., 2009)
- Detailed Gene Information: Click here.
|
| f. Gene Engineering of
HN |
- Type:
Recombinant protein preparation
- Description:
Expresses the hPIV3 F proteins from the bPIV3 viral genome.(Gomez et al., 2009)
- Detailed Gene Information: Click here.
|
| g. Preparation |
| Vaccine virus was recovered from Vero cells using plasmid rescue procedure and was further expanded in Vero cells as previously described by Tang et al. AccuSpray sprayers were filled with a 0.2 mL single intranasal dose of MEDI-534 containing 10^4, 10^5, or 10^6 median tissue culture infectious dose (Gomez et al., 2009) |
| h. Immunization Route |
| intranasal immunization |
| i . Approved Age for Licensed Use |
| 1 to 9 year old children |
| j. Description |
| MEDI-534 is a live, attenuated, intranasal vaccine against RSV and PIV3. It is a chimeric bovine/human (b/h) PIV3 construct that expresses the hPIV3 fusion (F), the hPIV3 hemagglutinin-neuraminidase, and the RSV F proteins from a bPIV3 viral genome. (Gomez et al., 2009) |
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2. mRNA-1653 |
| a. Type: |
| mRNA vaccine |
| b. Status: |
| Licensed |
| c. Host Species for Licensed Use: |
| Human |
| d. Antigen |
| The sources of the encoded antigens were the hMPV A strain, TN/92-4, and the PIV3 strain, PER/FLA4815/2008. (August et al., 2022) |
| e. Immunization Route |
| Intramuscular injection (i.m.) |
| f . Approved Age for Licensed Use |
| 18-49 years of age (August et al., 2022) |
| g. Description |
| The mRNA-1653 vaccine is bivalent, containing 2 distinct nucleoside-modified mRNA sequences encoding the native, membrane-anchored fusion glycoproteins of hMPV and PIV3 encapsulated in a lipid nanoparticle.(August et al., 2022) |
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3. rHPIV1 84/del170/942A |
| a. Type: |
| Live, attenuated vaccine |
| b. Status: |
| Research |
| c. Host Species for Licensed Use: |
| None |
| d. Preparation |
| One immunization of 1x10^6 TCID50 rHPIV1 84/del170/942A administered intranasally via nose drops at study entry (Makula et al., 1978) |
| e. Immunization Route |
| intranasal immunization |
| f. Description |
| rHPIV1 84/del170/942A Is a live attenuated human parainfluenza type 1 virus vaccine administered intranasally via nose drops.(Makula et al., 1978) |
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4. rHPIV3cp45 Vaccine |
| a. Manufacturer: |
| Charles River Laboratories |
| b. Type: |
| Live recombinant vaccine |
| c. Status: |
| Licensed |
| d. Host Species for Licensed Use: |
| Baboon |
| e. Preparation |
| Vaccine virus was stored frozen at −70 °C and had a mean infectivity titer of 107 tissue culture infectious doses (TCID50) per mL. Final vial content was diluted to dose on-site. (Englund et al., 2013) |
| f. Immunization Route |
| Intramuscular injection (i.m.) |
| g. Storage |
| Serum specimens were stored frozen until use.(Englund et al., 2013) |
| h . Approved Age for Licensed Use |
| Between ages of 6 and 36 months (Englund et al., 2013) |
| i. Description |
| The experimental vaccine rHPIV3cp45 is a live recombinant (r)-derived attenuated human (H) PIV3 virus |
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| IV. References |
1. CDC - Human Parainfluenza Viruses: Human Parainfluenza Viruses [http://www.cdc.gov/parainfluenza/about/overview.html]
2. Kobayashi et al., 2013: Kobayashi H, Iwatsuki-Horimoto K, Kiso M, Uraki R, Ichiko Y, Takimoto T, Kawaoka Y. A replication-incompetent influenza virus bearing the HN glycoprotein of human parainfluenza virus as a bivalent vaccine. Vaccine. 2013; 31(52); 6239-6246. [PubMed: 24144478].
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