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Corynebacterium diphtheriae

Table of Contents
  1. Protective Antigens
    1. tox
1. tox
  • Gene Name : tox
  • Sequence Strain (Species/Organism) : Corynebacterium diphtheriae
  • VO ID : VO_0011287
  • NCBI Protein GI : 38199106
  • Other Database IDs : CDD:280859
    CDD:238651
    CDD:280860
    CDD:279642
    GOA:Q6NK15
    InterPro: IPR000512
    InterPro: IPR022404
    InterPro: IPR022405
    InterPro: IPR022406
    UniProtKB/TrEMBL: Q6NK15
  • Taxonomy ID : 1717
  • Gene Strand (Orientation) : ?
  • Protein Name : Diphtheria toxin precursor
  • Protein pI : 6.37
  • Protein Weight : 56772.07
  • Protein Length : 638
  • Protein Note : biotype gravis
  • Protein Sequence : Show Sequence 
    >CAE48728.1 Diphtheria toxin precursor [Corynebacterium diphtheriae]
MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGN
YDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLM
EQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQA
CAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTAL
EHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNT
EEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYA
VSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAID
GDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : In 1923, it was discovered that treatment with formalin eliminated the toxicity of diphtheria toxin (DT) without destroying its immunogenicity. Formalin‐treated DT, now called diphtheria toxoid, rapidly became the preferred vaccine against diphtheria, and diphtheria toxoid (usually in combined vaccines, such as diphtheria‐tetanus toxoids–pertussis vaccine [DTP] or diphtheria‐tetanus toxoids–acellular pertussis vaccine [DTaP] for children and tetanus‐diphtheria toxoids vaccine for adults [Td]) is still used throughout the world for active immunization against diphtheria (Holmes, 2000).
II. References
1. Holmes, 2000: Holmes RK. Biology and molecular epidemiology of diphtheria toxin and the tox gene. The Journal of infectious diseases. 2000; 181 Suppl 1; S156-167. [PubMed: 10657208].