| 1. NCBI Taxonomy ID: |
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12475 |
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2. Introduction |
| HDV is found only in people who have Hepatitis B virus. It may make symptoms of hepatitis B worse or may cause symptoms in people who carry hepatitis B virus but have never displayed symptoms (A.D.A.M. Medical Encyclopedia). |
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3. Host Ranges and Animal Models |
| Humans (A.D.A.M. Medical Encyclopedia) |
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II. Vaccine Related Pathogen Genes |
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1. p27 |
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Gene Name :
p27
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Sequence Strain (Species/Organism) :
Hepatitis delta virus
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NCBI Protein GI :
226737605
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Other Database IDs :
CDD:279813
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Taxonomy ID :
261991
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Gene Strand (Orientation) :
?
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Protein Name :
Large delta antigen
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Protein pI :
10.45
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Protein Weight :
26158.73
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Protein Length :
329
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Protein Note :
L-HDAg; p27
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Protein Sequence : Show Sequence
>sp|P0C6M5.1|LHDAG_HDVU2 RecName: Full=Large delta antigen; Short=L-HDAg; AltName: Full=p27; Flags: Precursor
MSRSESKKNRGGREEILEQWVGARKKLEELERDLRKIKKKIKKLEEENPWLGNIKGILGKKDREGEGAPP
AKRARADQMEVDSGPRKRPFRGEFTDKERRDHRRRKALENKRKQLSSGGKSLSKEEEEELRKLTEEDERR
ERRVAGPRVGGVNPLEGGTRGAPGGGFVPSMQGVPESPFARTGEGLDVRGNQGFPWDILFPADPPFSPQS
CRPQ
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Molecule Role :
Protective antigen
- Related Vaccine(s):
Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27
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| III. Vaccine Information |
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1. Hepatitis D DNA vaccine pcDNA3p27/Ad5F35p27 |
| a. Vaccine Ontology ID: |
| VO_0004529 |
| b. Type: |
| DNA vaccine |
| c. Status: |
| Research |
| d. Host Species as Laboratory Animal Model: |
| Woodchucks |
| e. Gene Engineering of
p27 |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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| f. Vector: |
| pcDNA3 prime, Ad5/Ad5F35-vector boost (Fiedler et al., 2013) |
| g. Immunization Route |
| Intramuscular injection (i.m.) |
| h.
Woodchuck Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
Immunization with DNA plasmid prime administered via gene gun and Ad5/Ad5F35-vector boost expressing HDAg conferred protection from HDV in WHV/HDV co-infection in 5 out of 7 immunized animals. The two animals with the breakthrough had a shorter HDV viremia as compared to the un-vaccinated controls (Fiedler et al., 2013)
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| IV. References |
1. A.D.A.M. Medical Encyclopedia: Delta agent (Hepatitis D) [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001264/]
2. Fiedler et al., 2013: Fiedler M, Kosinska A, Schumann A, Brovko O, Walker A, Lu M, Johrden L, Mayer A, Wildner O, Roggendorf M. Prime/Boost Immunization with DNA and Adenoviral Vectors Protects from Hepatitis D Virus (HDV) Infection after Simultaneous Infection with HDV and Woodchuck Hepatitis Virus. Journal of virology. 2013; ; . [PubMed: 23637419].
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