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Canine parvovirus

Table of Contents
  1. Protective Antigens
    1. VP1
    2. VP2
1. VP1
  • Gene Name : VP1
  • Sequence Strain (Species/Organism) : Canine parvovirus
  • VO ID : VO_0011055
  • NCBI Gene ID : 1489587
  • Locus Tag : CPVgp3
  • Taxonomy ID : 10788
  • Gene Starting Position : 2284
  • Gene Ending Position : 2361
  • Gene Strand (Orientation) : ?
  • DNA Sequence : Show Sequence 
    >NC_001539.1:2284-2361 Canine parvovirus, complete genome
GATGGCACCTCCGGCAAAGAGAGCCAGGAGAGGTAAGGGTGTGTTAGTAAAGTGGGGGGAGGGGAAAGAT
TTAATAAC
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : This study shows that a plasmid DNA (pGT36VP1) encoding the full length VP1 region of canine parvovirus (CPV) induces immunity that protects dogs against challenge with virulent virus (Jiang et al., 1998).
  • Related Vaccine(s): Canine parvovirus DNA vaccine pGT36VP1
2. VP2
  • Gene Name : VP2
  • Sequence Strain (Species/Organism) : Canine parvovirus
  • VO ID : VO_0011054
  • NCBI Gene ID : 1489588
  • Locus Tag : CPVgp4
  • Taxonomy ID : 10788
  • Gene Starting Position : 2782
  • Gene Ending Position : 4536
  • Gene Strand (Orientation) : ?
  • DNA Sequence : Show Sequence 
    >NC_001539.1:2782-4536 Canine parvovirus, complete genome
ACCAATGAGTGATGGAGCAGTTCAACCAGACGGTGGTCAACCTGCTGTCAGAAATGAAAGAGCTACAGGA
TCTGGGAACGGGTCTGGAGGCGGGGGTGGTGGTGGTTCTGGGGGTGTGGGGATTTCTACGGGTACTTTCA
ATAATCAGACGGAATTTAAATTTTTGGAAAACGGATGGGTGGAAATCACAGCAAACTCAAGCAGACTTGT
ACATTTAAATATGCCAGAAAGTGAAAATTATAGAAGAGTGGTTGTAAATAATATGGATAAAACTGCAGTT
AACGGAAACATGGCTTTAGATGATATTCATGCACAAATTGTAACACCTTGGTCATTGGTTGATGCAAATG
CTTGGGGAGTTTGGTTTAATCCAGGAGATTGGCAACTAATTGTTAATACTATGAGTGAGTTGCATTTAGT
TAGTTTTGAACAAGAAATTTTTAATGTTGTTTTAAAGACTGTTTCAGAATCTGCTACTCAGCCACCAACT
AAAGTTTATAATAATGATTTAACTGCATCATTGATGGTTGCATTAGATAGTAATAATACTATGCCATTTA
CTCCAGCAGCTATGAGATCTGAGACATTGGGTTTTTATCCATGGAAACCAACCATACCAACTCCATGGAG
ATATTATTTTCAATGGGATAGAACATTAATACCATCTCATACTGGAACTAGTGGCACACCAACAAATATA
TACCATGGTACAGATCCAGATGATGTTCAATTTTATACTATTGAAAATTCTGTGCCAGTACACTTACTAA
GAACAGGTGATGAATTTGCTACAGGAACATTTTTTTTTGATTGTAAACCATGTAGACTAACACATACATG
GCAAACAAATAGAGCATTGGGCTTACCACCATTTCTAAATTCTTTGCCTCAATCTGAAGGAGCTACTAAC
TTTGGTGATATAGGAGTTCAACAAGATAAAAGACGTGGTGTAACTCAAATGGGAAATACAAACTATATTA
CTGAAGCTACTATTATGAGACCAGCTGAGGTTGGTTATAGTGCACCATATTATTCTTTTGAGGCGTCTAC
ACAAGGGCCATTTAAAACACCTATTGCAGCAGGACGGGGGGGAGCGCAAACATATGAAAATCAAGCAGCA
GATGGTGATCCAAGATATGCATTTGGTAGACAACATGGTCAAAAAACTACCACAACAGGAGAAACACCTG
AGAGATTTACATATATAGCACATCAAGATACAGGAAGATATCCAGAAGGAGATTGGATTCAAAATATTAA
CTTTAACCTTCCTGTAACGAATGATAATGTATTGCTACCAACAGATCCAATTGGAGGTAAAACAGGAATT
AACTATACTAATATATTTAATACTTATGGTCCTTTAACTGCATTAAATAATGTACCACCAGTTTATCCAA
ATGGTCAAATTTGGGATAAAGAATTTGATACTGACTTAAAACCAAGACTTCATGTAAATGCACCATTTGT
TTGTCAAAATAATTGTCCTGGTCAATTATTTGTAAAAGTTGCGCCTAATTTAACAAATGAATATGATCCT
GATGCATCTGCTAATATGTCAAGAATTGTAACTTACTCAGATTTTTGGTGGAAAGGTAAATTAGTATTTA
AAGCTAAACTAAGAGCCTCTCATACTTGGAATCCAATTCAACAAATGAGTATTAATGTAGATAACCAATT
TAACTATGTACCAAGTAATATTGGAGGTATGAAAATTGTATATGAAAAATCTCAACTAGCACCTAGAAAA
TTATA
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). Results show that the inactivated CVP is able to protect dogs from a lethal challenge with CPV following parenteral immunization with the vaccine. Dogs immunized with the inactivated CPMV-PARVO1 in adjuvant displayed no clinical signs of disease and shedding of CPV in faeces was limited following CPV challenge. (Langeveld et al., 2001).
  • Related Vaccine(s): Canine parvovirus CPMV-PARVO1 protein vaccine
II. References
1. Jiang et al., 1998: Jiang W, Baker HJ, Swango LJ, Schorr J, Self MJ, Smith BF. Nucleic acid immunization protects dogs against challenge with virulent canine parvovirus. Vaccine. 1998; 16(6); 601-607. [PubMed: 9569471].
2. Langeveld et al., 2001: Langeveld JP, Brennan FR, Martínez-Torrecuadrada JL, Jones TD, Boshuizen RS, Vela C, Casal JI, Kamstrup S, Dalsgaard K, Meloen RH, Bendig MM, Hamilton WD. Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus. Vaccine. 2001; 19(27); 3661-3670. [PubMed: 11395200].