VIOLIN: Vaccine Investigation and Online Information Network

Bovine coronavirus

Table of Contents

General Information
1. NCBI Taxonomy ID
2. Introduction
Vaccine Related Pathogen Genes
1. VP8/S2 fusion protein (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

2. Introduction

Bovine coronavirus (BCoV) is a member of the genus Coronavirus, family Coronaviridae. This genus has been divided into three groups according to its genetic and serological properties. Group 2, to which BCoV belongs, contains mammalian and avian viruses, such as mouse hepatitis virus, chicken enteric coronavirus, sialodacryadenitis virus, porcine hemagglutinating encephalomyelitis virus, and human coronavirus (HCoV) OC43. The BCoV virion is enveloped and spherical in shape. The genome is a single-stranded, positive-sense RNA molecule of 27 to 32 kb. It includes 13 open reading frames (ORFs) flanked by 5' and 3' untranslated regions, and some of the ORFs overlap, whereas others are separated by intergenic sequences. BCoV was first associated with diarrhea in newborn calves and later with winter dysentery in adult cattle. It is now considered an important pathogen causing enteric disease, often in combination with respiratory clinical signs. Fatal respiratory disease caused by BCoV has been reported in young stock. BCoV infections often result in high morbidity but usually in low mortality. The same virus strain can cause disease in both calves and adults, and the animal often sheds virus in both nasal secretions and feces. Although several investigations have focused on discriminating the features of different virus strains causing calf diarrhea, winter dysentery, or respiratory disease, no clear markers have been established. Their separation is complicated, since differences in clinical signs might also rely on host factors (Liu et al., 2006).

II. Vaccine Related Pathogen Genes

1. VP8/S2 fusion protein

Gene Name : VP8/S2 fusion protein
Sequence Strain (Species/Organism) : Bovine coronavirus
NCBI Protein GI : AKS43583
Taxonomy ID : 32630
Protein Name : VP8/S2 fusion protein
Protein pI : 4.71
Protein Weight : 13933.57
Protein Length : 227
Protein Note : fusion of Bovine Rotavirus A VP8/Bovine Coronavirus S2 genes

Protein Sequence : Show Sequence

>AKS43583.1 VP8/S2 fusion protein, partial [synthetic construct]
QLLYNSYSVDLSDEITNIGAEKGGGGSGGGGSGGGGSADTQGDLRVGTYSNPVPNAVVGGGGSGGGGSGG
GGSGLPAMQTTTYVTPISYAIRGGGGSGGGGSGGGGSATSASLFPPWSAAAGVPFYLNVQYRGGGGSGGG
GSGGGGSSGYFVNVNNTW

Molecule Role : Protective antigen
Molecule Role Annotation : (Nasiri et al., 2016)

III. Vaccine Information

1. Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 4570.20)

a. Manufacturer:

Pfizer, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002018

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

2. Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid (USDA: 4570.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002019

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

3. Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Clostridium Perfringens Types C & D-Escherichia Coli Bacterin-Toxoid (USDA: 4575.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002020

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

4. Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Escherichia Coli Bacterin (USDA: 4585.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002021

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

5. Bovine Rotavirus-Coronavirus Killed Virus Vaccine-Escherichia Coli Bacterin (USDA: 4585.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002022

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Cattle

IV. References

1. Nasiri et al., 2016: Nasiri K, Nassiri M, Tahmoorespur M, Haghparast A, Zibaee S. Design and Construction of Chimeric VP8-S2 Antigen for Bovine Rotavirus and Bovine Coronavirus. Advanced pharmaceutical bulletin. 2016; 6(1); 91-98. [PubMed: 27123423].