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Pathogen Page
Toxoplasma gondii

Table of Contents

  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
    4. Microbial Pathogenesis
    5. Host Ranges and Animal Models
  2. Vaccine Related Pathogen Genes
    1. BiP (Toxoplasma gondii)
    2. CDPK1 (Toxoplasma gondii ME49)
    3. CDPK2 (Toxoplasma gondii ME49)
    4. CDPK6 (Toxoplasma gondii ME49)
    5. CyP (Toxoplasma gondii ME49)
    6. dasd
    7. fad
    8. fsa
    9. GRA1 (Toxoplasma gondii)
    10. GRA16 (Toxoplasma gondii ME49)
    11. GRA17
    12. GRA2 (Toxoplasma gondii)
    13. GRA23
    14. GRA24
    15. GRA41 (Toxoplasma gondii)
    16. GRA5 (Toxoplasma gondii)
    17. GRA6 (Toxoplasma gondii ME49)
    18. GRA7 (Toxoplasma gondii ME49)
    19. GRA8 (Toxoplasma gondii ME49)
    20. hsp70 (Toxoplasma gondii)
    21. ISP3 (Toxoplasma gondii ME49)
    22. MIC1 (Toxoplasma gondii ME49)
    23. MIC11 (Toxoplasma gondii ME49)
    24. MIC13 (Toxoplasma gondii)
    25. mic2
    26. MIC3 (Toxoplasma gondii ME49)
    27. MIC3 (Toxoplasma gondii strain RH(ERP))
    28. MIC4 (Toxoplasma gondii ME49)
    29. MIC6 (Toxoplasma gondii ME49)
    30. MIC8
    31. OMPDC (Toxoplasma gondii ME49)
    32. p30 (Toxoplasma gondii)
    33. PGAM2 (Toxoplasma gondii ME49)
    34. PI1 (Toxoplasma gondii)
    35. PLP1
    36. ROP16 (Toxoplasma gondii ME49)
    37. ROP17 (Toxoplasma gondii ME49)
    38. ROP18 (Toxoplasma gondii ME49)
    39. ROP2 (Toxoplasma gondii RH)
    40. Rop2 (Toxoplasma gondii)
    41. Rop2 (Toxoplasma gondii)
    42. ROP38 (Toxoplasma gondii ME49)
    43. ROP8 (Toxoplasma gondii)
    44. SAG1 (Toxoplasma gondii ME49)
    45. SAG2 (Toxoplasma gondii)
    46. SAG5B
    47. SAG5C
    48. sdfa
    49. SOD (Toxoplasma gondii)
    50. TgADF
    51. TgCST2 (Toxoplasma gondii ME49)
    52. TgNTPase-II
    53. TgPF (Toxoplasma gondii ME49)
    54. TgRACK1
    55. UP (Toxoplasma gondii ME49)
  3. Vaccine Related Host Genes
    1. Ccl2
    2. Ifng (Interferon gamma)
    3. IL-6
    4. Il12b
    5. TNF-alpha
  4. Vaccine Information
    1. CAV-2-ROP16
    2. CAV-2-ROP18
    3. CTLVECNS
    4. GRA7(20–28)SAPN
    5. ISA 201-rTgCST2
    6. ISP3 VLP
    7. licensed Toxoplasmosis human vaccine
    8. Ovilis Toxovax
    9. PLG-rROP38-rROP18
    10. rBCGpMV361-TgCyP
    11. rCDPK6 + rROP18 + PLG
    12. RH-AMA1KO
    13. rTgADF
    14. rTgPGAM 2
    15. rTgRACK1
    16. rTgROP17
    17. T. gondii DNA vaccine encoding MIC8
    18. T. gondii DNA vaccine encoding multi-epitope ROP8
    19. T. gondii DNA vaccine pcDNA3-MIC3
    20. T. gondii DNA vaccine pcDNA3.1-HisGRA6
    21. T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
    22. T. gondii DNA vaccine pcDNA3.1/MIC11
    23. T. gondii DNA vaccine pDREP-TgNTPase-II
    24. T. gondii DNA vaccine pDsRed2-GRA8
    25. T. gondii DNA vaccine pEGFP-C1/GRA41
    26. T. gondii DNA vaccine pIRESneo/MIC6/PLP1
    27. T. gondii DNA vaccine pIRESneo/ROP18/PLP1
    28. T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
    29. T. gondii DNA vaccine pSAG1-ROP2-SAG2
    30. T. gondii DNA vaccine pSAG5B/SAG5C
    31. T. gondii DNA vaccine pVAX-CDPK1 with pVAX-IL21-IL15
    32. T. gondii DNA vaccine pVAX-CDPK1 with pVAX-IL7-IL15
    33. T. gondii DNA vaccine pVAX-GRA16
    34. T. gondii DNA vaccine pVAX-GRA24 + pVAX-GRA25 + pVAX-MIC6
    35. T. gondii DNA vaccine pVAX-ROP38
    36. T. gondii DNA vaccine pVAX-TgGRA17
    37. T. gondii DNA vaccine pVAX-TgGRA17 + pVAX-TgGRA23
    38. T. gondii DNA vaccine pVAX-TgGRA23
    39. T. gondii DNA vaccine pVAX-TgMIC13
    40. T. gondii DNA vaccine pVitro-SAG1-GRA7
    41. T. gondii DNA vaccine pVR1020-GRA1
    42. T. gondii DNA vaccine ROP8-pVAX-1
    43. T. gondii DNA vaccine T.g.HSP70
    44. T. gondii GRA17 mutant vaccine
    45. T. gondii irradiated sterilised tachyzoites
    46. T. gondii LDH1 and LDH2 mutant vaccine
    47. T. gondii mic2 mutant vaccine
    48. T. gondii OMPDC mutant vaccine
    49. T. gondii OMPDC/UP mutant vaccine
    50. T. gondii Pru strain cdpk2 mutant vaccine
    51. T. gondii recombinant vaccine vector rBCGpMV361-TgCyP
    52. T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine
    53. TgMIC1
    54. TgMIC1-4
    55. TgMIC1-4-6
    56. TgMIC4
    57. TgMIC6
    58. TgPF-OML
    59. UV-attenuated Toxoplasma gondii with DSCG adjuvant
  5. References
I. General Information
1. NCBI Taxonomy ID:
5811
2. Disease:
Toxoplasmosis
3. Introduction
Toxoplasma gondii is a species of parasitic protozoa in the genus Toxoplasma. The definitive host of T. gondii is the cat, but the parasite can be carried by many warm-blooded animals (birds or mammals). Toxoplasmosis, the disease of which T. gondii is the causative agent, is usually minor and self-limiting but can have serious or even fatal effects on a fetus whose mother first contracts the disease during pregnancy or on an immunocompromised human or cat (Wiki: T. gondii).
4. Microbial Pathogenesis
T. gondii is an intestinal coccidian of cat with man as one of the intermediate host. Humans are generally infected by ingesting oocysts released in cat faeces or by consuming meat from infected herd animals containing the long lived tissue cysts. Following ingestion, the outer wall of cysts or oocysts are disrupted by enzymatic degradation and bradyzoites and sporozoites are liberated into intestinal lumen. They rapidly invade and multiply within surrounding cells where they become tachyzoites. Thereafter, tachyzoites are disseminated via blood or lymphatic system to most of the organs of human body. At these sites, the tachyzoites infect host cells, replicate and invade the adjoining cell. In this fashion, the hallmarks of the infection develop: cell death and focal necrosis surrounded by an acute inflammatory response (Bhopale, 2003).
5. Host Ranges and Animal Models
The life cycle of T. gondii has two phases. The sexual part of the life cycle (coccidia like) takes place only in members of the Felidae family (domestic and wild cats), which makes these animals the parasite's primary host. The asexual part of the life cycle can take place in any warm-blooded animal, like other mammals (including felines) and birds (Wiki: T. gondii).
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