|
Toxoplasma gondii |
Table of Contents |
- General Information
- NCBI Taxonomy ID
- Disease
- Introduction
- Microbial Pathogenesis
- Host Ranges and Animal Models
- Vaccine Related Pathogen Genes
- dasd
- fad
- fsa
- sdfa
- BiP
(Protective antigen)
- GRA1
(Protective antigen)
- GRA2
(Protective antigen)
- GRA5
(Protective antigen)
- hsp70
(Protective antigen)
- MIC13
(Protective antigen)
- MIC3
(Protective antigen)
- MIC3
(Protective antigen)
- MIC8
(Protective antigen)
- p30
(Protective antigen)
- PI1
(Protective antigen)
- ROP16
(Protective antigen)
- Rop2
(Protective antigen)
- ROP2
(Protective antigen)
- Rop2
(Protective antigen)
- ROP8
(Protective antigen)
- SAG1
(Protective antigen)
- SAG2
(Protective antigen)
- SOD
(Protective antigen)
- mic2
(Virmugen)
- OMPDC
(Virmugen)
- UP
(Virmugen)
- Vaccine Related Host Genes
- Ccl2
- Ifng (Interferon gamma)
- IL-6
- Il12b
- TNF-alpha
- Vaccine Information
- Ovilis Toxovax
- rBCGpMV361-TgCyP
- T. gondii DNA vaccine encoding MIC8
- T. gondii DNA vaccine pcDNA3-MIC3
- T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
- T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
- T. gondii DNA vaccine pSAG1-ROP2-SAG2
- T. gondii DNA vaccine pVAX-TgMIC13
- T. gondii DNA vaccine pVR1020-GRA1
- T. gondii DNA vaccine ROP8-pVAX-1
- T. gondii DNA vaccine T.g.HSP70
- T. gondii recombinant vaccine vector rBCGpMV361-TgCyP
- T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine
- Toxoplasma gondii mic2 mutant vaccine
- Toxoplasma gondii OMPDC mutant vaccine
- Toxoplasma gondii OMPDC/UP mutant vaccine
- References
|
I. General Information |
1. NCBI Taxonomy ID: |
5811 |
2. Disease: |
Toxoplasmosis |
3. Introduction |
Toxoplasma gondii is a species of parasitic protozoa in the genus Toxoplasma. The definitive host of T. gondii is the cat, but the parasite can be carried by many warm-blooded animals (birds or mammals). Toxoplasmosis, the disease of which T. gondii is the causative agent, is usually minor and self-limiting but can have serious or even fatal effects on a fetus whose mother first contracts the disease during pregnancy or on an immunocompromised human or cat (Wiki: T. gondii). |
4. Microbial Pathogenesis |
T. gondii is an intestinal coccidian of cat with man as one of the intermediate host. Humans are generally infected by ingesting oocysts released in cat faeces or by consuming meat from infected herd animals containing the long lived tissue cysts. Following ingestion, the outer wall of cysts or oocysts are disrupted by enzymatic degradation and bradyzoites and sporozoites are liberated into intestinal lumen. They rapidly invade and multiply within surrounding cells where they become tachyzoites. Thereafter, tachyzoites are disseminated via blood or lymphatic system to most of the organs of human body. At these sites, the tachyzoites infect host cells, replicate and invade the adjoining cell. In this fashion, the hallmarks of the infection develop: cell death and focal necrosis surrounded by an acute inflammatory response (Bhopale, 2003). |
5. Host Ranges and Animal Models |
The life cycle of T. gondii has two phases. The sexual part of the life cycle (coccidia like) takes place only in members of the Felidae family (domestic and wild cats), which makes these animals the parasite's primary host. The asexual part of the life cycle can take place in any warm-blooded animal, like other mammals (including felines) and birds (Wiki: T. gondii). |
II. Vaccine Related Pathogen Genes |
1. BiP |
-
Gene Name :
BiP
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
AAF23321
-
Other Database IDs :
CDD:331774
-
Taxonomy ID :
5811
-
Protein Name :
heat shock protein 70 precursor
-
Protein pI :
5
-
Protein Weight :
67889.46
-
Protein Length :
743
-
Protein Note :
immunoglobulin binding protein
-
Protein Sequence : Show Sequence
>AAF23321.1 heat shock protein 70 precursor [Toxoplasma gondii]
MTAAKKLSLFSLAALFCLLSVATLRPVAASDAEEGKVKDVVIGIDLGTTYSCVGVYRHGRVDIIPNDQGN
RITPSYVAFTDDDRKIGEAAKNEATINPTNTLFDVKRLIGRRFNEKEVQKDKDLLPYEIINKDGKPYIRV
MVKGEPKVLAPEEVSAMVLTKMKETAEQFLGKEVKNAVVTVPAYFNDAQRQATKDAGAIAGLNVIRIINE
PTAAAIAYGLDKKNEKTILVYDLGGGTFDVSVLVIDNGVFEVLATSGDTHLGGEDFDQRVMDHFIKLVKK
KYDKDLRTDKRGLQKLRREVERAKRALSSQHQAKVEVENLMEGVDFSETLTRAKFEELNSDLFQKTLKPV
KQVLEDADLQKSQVDEIVLVGGSTRIPKIQQLIKDFFNGKEPNRGINPDEAVAYGAAVQAGILSGEGAQD
MVLLDVTPLTLGIETAGGVMAKIINKNTVIPTKKTQTFSTYSDNQSAVLIQVYEGERPMTKHNHLLGKFE
LTGIPPAPRGVPQIEVTFDVDRNGILSVSAVDKGTGKSEKITITNDKGRLTPEEIERMISEAEKFAEEDK
KVKERVDARNALEGYLHSMKTTVEDKDKLADKIEEDDKKTILDKVTEAQEWLNTNPDADAEETRDKLKDV
EAVCNPIISKVYGQSGGPGAGGAAGGADDDDYGGHDEL
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Czarnewski et al., 2017)
|
2. dasd |
-
Gene Name :
dasd
-
Molecule Role Annotation :
Oral immunization of mice with ZJ111/pcDNA3-SAG1 elicited specific humoral responses and stimulated proliferation of splenocytes (P<0.05). Mice immunized with ZJ111/pcDNA3-SAG1 displayed significant protection against an intraperitoneally challenge with 500 tachyzoite forms of T. gondii RH strain. Vaccination at 107 and 108 CFU per mice provided a 20% and 10% survival rate comparing 100% mortality of the non-immunized mice, exhibiting longer living time and better survival rate (Qu et al., 2008).
|
3. fad |
|
4. fsa |
|
5. GRA1 |
-
Gene Name :
GRA1
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
301750620
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
P24 granule antigen
-
Protein pI :
3.92
-
Protein Weight :
18678.03
-
Protein Length :
246
-
Protein Sequence : Show Sequence
>ADK88943.1 P24 granule antigen [Toxoplasma gondii]
MVRVSAIVGAAASVFVCLSAGAYAAEGGDNQSSAVSDRASLFGLLSGGTGQGLGIGESVDLEMMGNTYRV
ERPTGNPDLLKIAIKASDGSYSEVGNVNVEEVIDTMKSMQRDEDIFLRALNKGETVEEAIEDVAQAEGLN
SEQTLQLEDAVSAVASVVQDEMKVIDDVQQLEKDKQQLKDDIGFLTGERE
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pVR1020-GRA1
|
6. GRA2 |
-
Gene Name :
GRA2
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
EPT27242
-
Taxonomy ID :
508771
-
Protein Name :
dense granule protein GRA2
-
Protein pI :
9.71
-
Protein Weight :
18298.13
-
Protein Length :
253
-
Protein Note :
encoded by transcript TGME49_227620;
Signal peptide predicted by SignalP 2.0 HMM (probability 0.997) with cleavage site probability 0.917 at residue 23; GO_component: GO:0020003 - symbiont-containing vacuole;ev_code=EXP; GO_component: GO:0045177 - apical part of cell;ev_code=EXP
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Protein Sequence : Show Sequence
>EPT27242.1 dense granule protein GRA2 [Toxoplasma gondii ME49]
MFAVKHCLLVVAVGALVNVSVRAAEFSGVVNQGPVDVPFSGKPLDERAVGGKGEHTPPLPDERQQEPEEP
VSQRASRVAEQLFRKFLKFAENVGQHSEKAFKKAKVVAEKGFTAAKTHTVRGFKVAKEAAGRGMVTVGKK
LANVESDRSTTTTQAPDSPNGLAETQAPVEPQQRAAHVPVPDFSQ
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Ching et al., 2017)
|
7. GRA5 |
-
Gene Name :
GRA5
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
EPT31025
-
Taxonomy ID :
508771
-
Protein Name :
dense granule protein GRA5
-
Protein pI :
5.01
-
Protein Weight :
12026.38
-
Protein Length :
187
-
Protein Note :
encoded by transcript TGME49_286450;
Signal peptide predicted by SignalP 2.0 HMM (probability 0.923) with cleavage site probability 0.441 at residue 26; Predicted trans-membrane domain (TMHMM2.0):6-26:70-93; GO_component: GO:0020003 - symbiont-containing vacuole;ev_code=EXP; GO_component: GO:0045177 - apical part of cell;ev_code=EXP
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Protein Sequence : Show Sequence
>EPT31025.1 dense granule protein GRA5 [Toxoplasma gondii ME49]
MASVKRVVVAVMIVNVLALIFVGVAGSTRDTGSGGDDSEGAWGGEQQQVQQHGQSEDRSLFERGRAAVTG
HPVRTAVGLAAAVVAVVSLLRLLRRRRRRAIQEESKESATAEEEEVAEEE
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Ching et al., 2017)
|
8. hsp70 |
-
Gene Name :
hsp70
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
12248795
-
Other Database IDs :
CDD:240227
CDD:212675 CDD:295646
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein pI :
5.38
-
Protein Weight :
69239.84
-
Protein Length :
723
-
Protein Note :
heat shock 70 kDa protein; Provisional
-
Protein Sequence : Show Sequence
>BAB20284.1 hsp70 [Toxoplasma gondii]
MGSSHHHHHHSSGLVPRGSHMLEMADSPAVGIDLGTTYSCVGVWKNDAVEIIANDQGNRTTPSYVAFTDT
ERLVGDAAKNQVARNPENTIFDAKRLIGRKFDDPSVQSDMKHWPFKVIAGPGDKPLIEVTYQGEKKTFHP
EEVSAMVLGKMKEIAEAYLGKEVKEAVITVLAYFNDSQRQATKDAGTIAGLSVLRIINEPTAAAIAYGLD
KKGCGEMNVLIFDMGGGTFDVSLLTIEDGIFEVKATAGDTHLGGEDFDNRLVDFCVQDFKRKNRGKDIST
NSRALRRLRTQCERTKRTLSSSIQATIEIDSLFEGIDYSVSISRARFEELCMDYFRNSLLPVEKVLKDSG
IDKRSVSEVVLVGGSTRIPKIQQLITDFFNGKEPCRSINPDEAVAYGAAVQAAILKGVTSSQVQDLLLLD
VALLSLGLETAGGVMTKLIERNTTIPTKKSQTFTTYADNQPGVLIQVYEGERAMTKDNNLLGKFHLDGIP
PAPRGVPQIEVTFDIDANGIMNVTAQDKSTGKSNQITITNDKGRLSASEIDRMVQEAEKYKAEDEQNKHR
VEAKNGLENYCYHMRQTLDDEKLKDKISSEDRDTANKAIQEALDWLDKNQLAEKEEFEAKQKEVESVCTP
IITKLYQAGAAAGGMPGGMGGMPGGMGGMPGGMGGMPGGMGSGC
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine T.g.HSP70
|
9. MIC13 |
-
Gene Name :
MIC13
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
380449403
-
Other Database IDs :
CDD:287526
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
microneme protein 13
-
Protein pI :
6.48
-
Protein Weight :
49684.02
-
Protein Length :
529
-
Protein Note :
Sialic-acid binding micronemal adhesive repeat; pfam10564
-
Protein Sequence : Show Sequence
>AFD54637.1 microneme protein 13 [Toxoplasma gondii]
MVGVFQLCLLTCLLCLLKGSDAIQLRQHRNGLGVEQSFVSEETDIVGGRISSLQAELDSYCHNRYKQLCD
GGNKNFCDKTGVARYGTGIQSQQTAEWRCYFAEVLKPSGRKVQCVDDCGNYFPCLGVVDPNDTFHATAHN
QILNFIKDGVEKHCSPFQMAGNNYCQGVLADTVARKDTGTASQKAKAWRCYKKDSLTYEARSICVDNCGG
EIECPGGRSETSGELLSQHSTREKELLKVIESQSAPCRDSCVATPINPPICADTESLLQSTKRSRAQRFI
DDACQKLFNCHCKKDKKFCTTVVARKDRGRAGSQNDAEWRCYSLEELDFQKTNPSCIDECGNELPCQGAV
PEESTHHITWTKLPSKIDEATQKFCTERQRAANDYCASEFADSLARYGPGAGDQTSQFRCIKKAAMRADA
EGKCADSCKGTETCGGCRSRLDGPLSVNDVLNAHEGISEAMKSASTEC
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pVAX-TgMIC13
|
10. mic2 |
-
Gene Name :
mic2
-
NCBI Protein GI :
1923217
-
3D structure: PDB ID :
2XGG
-
Other Database IDs :
CDD:29244
CDD:154951
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
micronemal protein MIC2
-
Protein Length :
769
-
Protein Note :
Micronemal proteins: The Toxoplasma lytic cycle begins when the parasite actively invades a target cell. In association with invasion, T. gondii sequentially discharges three sets of secretory organelles beginning with the micronemes, which contain...; cd01471
-
Protein Sequence : Show Sequence
>gi|1923217|gb|AAB63303.1| micronemal protein MIC2 [Toxoplasma gondii]
MRLQREAVFGLMFACGMWMWPSEVAGGGWSIVDALRKRYDTSRGGDANGVDTSGVEDVIQSDSAIGAAEG
CTNQLDICFLIDSSGSIGIQNFRLVKQFLHTFLMVLPIGPEEVNNAVVTYSTDVHLQWDLQSPNAVDKQL
AAHAVLEMPYKKGSTNTSDGLKACKQILFTGSRPGREHVPKLVIGMTDGESDSDFRTVRAAKEIRELGGI
VTVLAVGHYVKHSECRSMCGCSGTSDDDSPCPLYLRADWGQLATAIKPMLKEVCKTLPQDAICSDWSAWS
PCSVSCGDGSQIRTRTEVSAPQPGTPTCPDCPAPMGRTCVEQGGLEEIRECSAGVCAVDAGCGVWGEWSA
WSASCGNATRKRERTRYNDPPPQGAGRRCENQDPPVLQEQTEEATLAPCITIPPTPPEWAAWSDCTVTCG
GGNRHRVRNALPPGLGSQNGESDESLVSKLWPGTDLRQEEACNTSPCPINATCGQFEEWSTCSVSCGGGL
KTRSRNPWNEDQQHGGLSCEQQHPGGRTETVTCNPQACPVDERPGEWAEWGECSVTCGDGVRERRRGKSL
VEAKFGGRTIDQQNEALPEDLKIKNVEYEPCSYPACGASCTYVWSDWNKCVCPMGYQARHAAVKFDYRNK
PCDLPTFETKACSCGETNPVPSEGTTPGAPGATGPEQPNQRPLPEGSDENETPTNEEGEQSKKESGSGIA
GAIAGGVIGGLILLGAAGGASYHYYLSSSVGSPSAEIEYEADDGATKVVMEEEKETLVPVDDDSDMWME
-
Molecule Role :
Virmugen
-
Molecule Role Annotation :
A mic2 mutant is attenuated in mice and induces protection from challenge with wild type T. gondii (Huynh and Carruthers, 2006).
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
11. MIC3 |
-
Gene Name :
MIC3
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii ME49
-
VO ID :
VO_0011174
-
NCBI Gene ID :
7901253
-
NCBI Protein GI :
1085201908
-
Locus Tag :
TGME49_325800
-
Genbank Accession :
KE139555
-
Protein Accession :
XP_002369833
-
Taxonomy ID :
508771
-
Chromosome No :
Unknown
-
Gene Starting Position :
8
-
Gene Ending Position :
917
-
Gene Strand (Orientation) :
-
-
Protein pI :
6.46
-
Protein Weight :
26732.05
-
Protein Length :
269
-
DNA Sequence : Show Sequence
>NW_017383630.1:8-917 Toxoplasma gondii ME49 unplaced genomic scaffold asmbl.1555, whole genome shotgun sequence
CTCACGTGAGTACCCTGGTGGGGCACTCGCAGGTGTAGCCATTCTCATGCGAGGCGTCATCAATACATCT
ACCAGGGCTGCAGTTCTCCCTGAAGGCATGACATCCAGTCCTCTTGCATCCTTGTCCCCCTTCCGGGAGG
TTCACTAGAGTTTCGCCGTCGCCGCAGGTGCATGTGTAGCTGACTGAATCGACGACGATGCACGTCCCGT
TGGGTCCGCACTTCGCGTTCCCTCTTTTTGAACAAGGATCCTCGGAGCAAGTCAACCCAGTGCCGACGAA
GCCGTCTTTGCACTTGCAGTGCACACCCCCACCCGCGTCCAAGTTTTCGACGCATTCTGCGTTTTTGTCG
CACCGATGGCCCTGCTTTTCACAGCTGCAGTCTCCTCCATAGCTTTTGTCAGGATGGTAGATGAGCGAAC
TGCTGCAAAAAATCCAGTTGCTGGAGCAGAATTCTCCGCAGCCGCCGGGGCCGCACATGGTCTTGCTGCA
GCAAGCGCTCTTGGGGCAACTGGCCCCGATGAAGTACCCGTTGTCAGTGTGCAACTGACGGTTTCGACAT
GGCTTGCCTTCACTCGAGATAGCACAGAGTTGCGTCTCCTGCTTGCTGGGGGATTGCACAGACGAGTGAG
TCTCAGTCACCGCGAAAGACGGAGCAAGACTCTCAGAGACGACTTCGCGGCTCGGCACAACTTTGTCAAA
GCTGCCCAGCTGCACAGACTTCTGAATCGGCAAAGCCTCCGCTGGGGTGCACATCCACACGGCCCCACTG
AAGGTGAGCGCGTGCAACAGCGCGGACGTCCCGCCTCGCATTTTTACCAGTGTTGGACAAGGAAGTTACA
CACAGAGTAAGGCGCGCAAACGCGCTGCACTGCCCACAGAAATGCACAGAAACGCACTCTCGACGAGCTG
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Protein Sequence : Show Sequence
>XP_002369833.2 EGF family domain-containing protein [Toxoplasma gondii ME49]
MRGGTSALLHALTFSGAVWMCTPAEALPIQKSVQLGSFDKVVPSREVVSESLAPSFAVTETHSSVQSPSK
QETQLCAISSEGKPCRNRQLHTDNGYFIGASCPKSACCSKTMCGPGGCGEFCSSNWIFCSSSLIYHPDKS
YGGDCSCEKQGHRCDKNAECVENLDAGGGVHCKCKDGFVGTGLTCSEDPCSKRGNAKCGPNGTCIVVDSV
SYTCTCGDGETLVNLPEGGQGCKRTGCHAFRENCSPGRCIDDASHENGYTCECPTRVLT
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
Protective experiments of DNA vaccine pcDNA3-MIC3 (pMIC3i) in Kumming mice showed that the vaccine could significantly prolong the survival time of the mice challenged by virulent RH strains of T. gondii (Xiang et al., 2009).
- Related Vaccine(s):
T. gondii DNA vaccine pcDNA3-MIC3
|
12. MIC3 |
-
Gene Name :
MIC3
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii strain RH(ERP)
-
NCBI Nucleotide GI :
5931753
-
NCBI Protein GI :
5931754
-
Protein Accession :
CAB56644.1
-
Other Database IDs :
CDD:304395
CDD:283826 InterPro: IPR000742 InterPro: IPR006210 UniProtKB/TrEMBL: Q9GRG4
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
MIC3 microneme protein
-
Protein pI :
6.42
-
Protein Weight :
36421.86
-
Protein Length :
421
-
Protein Note :
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl21504
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DNA Sequence : Show Sequence
>gi|5931753|emb|AJ132530.1| Toxoplasma gondii MIC3 gene
CCGCTGTCCCGCCTGGTCAACAAGTATCACACCCTCGTCCCCGCCATTGGCACGGAGCTCGATGAGCTGC
AGTGTCGCTTTTAGGGGAGTCGTGCAATCACGCCGCAACACAGGCGTGATTCGATCTTCAATTGCTAGGT
AACCACTCGTGCTTGGTAGCTCTGCAATGGCTCGAGCGACGGGGGTGATGCAACATGCTGCTAAAAACTC
GACAGACGTGTCACCGGAACCCACCTAAATAGGAGACCACGGGTCTCTGGTGTGTCGCGTCGCATTCTCG
CGTCGCATTCTCGCGTCGCAATGACCGGCCAGTTGCTCGACGTCGCCAGCCGGGACTGAAGAGCGTTCAT
CGAGTCAGCAGCATTGCGTCCCCTTGCTCGGTGAAAAAAGACTCTCTGGTCGAGTCTAGCTCGTGTCACT
TCTGTTTCTAACCTCCTTCGTTCACCGGTACACCTCCGATGTGACTTTTGGTACACTTGCCCTGTCGCAC
GACGCACGCTGTCACTCAACTTGCTGCTAGCGCAATCGATAGGTTCCCTCGAACCAGCCATCACACACAC
ACCTTTTCCGGGAAGACGTTTGCGGGCGGTGGGTCGCAGCTCGTCGAGAGTGCGTTTCTGTGCATTTCTG
TGGGCAGTGCAGCGCGTTTGCGCGCCTTACTCTGTGTGTAACTTCCTTGTCCAACACTGGTAAAAATGCG
AGGCGGGACGTCCGCGCTGTTGCACGCGCTCACCTTCAGTGGGGCCGTGTGGATGTGCACCCCAGCGGAG
GCTTTGCCGATTCAGAAGTCTGTGCAGCTGGGCAGCTTTGACAAAGTTGTGCCGAGCCGCGAAGTCGTCT
CTGAGAGTCTTGCTCCGTCTTTCGCGGTGACTGAGACTCACTCGTCTGTGCAATCCCCCAGCAAGCAGGA
GACGCAACTCTGTGCTATCTCGAGTGAAGGCAAGCCATGTCGAAACCGTCAGTTGCACACTGACAACGGG
TACTTCATCGGGGCCAGTTGCCCCAAGAGCGCTTGCTGCAGCAAGACCATGTGCGGCCCCGGCGGCTGCG
GAGAATTCTGCTCCAGCAACTGGATTTTTTGCAGCAGTTCGCTCATCTACCATCCTGACAAAAGCTATGG
AGGAGACTGCAGCTGTGAAAAGCAGGGCCATCGGTGCGACAAAAACGCAGAATGCGTCGAAAACTTGGAC
GCGGGTGGGGGTGTGCACTGCAAGTGCAAAGACGGCTTCGTCGGCACTGGGTTGACTTGCTCCGAGGATC
CTTGTTCAAAAAGAGGGAACGCGAAGTGCGGACCCAACGGGACGTGCATCGTCGTCGATTCAGTCAGCTA
CACATGCACCTGCGGCGACGGCGAAACTCTAGTGAACCTCCCGGAAGGGGGACAAGGATGCAAGAGGACT
GGATGTCATGCCTTCAGGGAGAACTGCAGCCCTGGTAGATGTATTGATGACGCCTCGCATGAGAATGGCT
ACACCTGCGAGTGCCCCACAGGGTACTCACGTGAGGTGACTTCCAAGGCGGAGGAGTCGTGTGTGGAAGG
AGTCGAAGTCACGCTGGCTGAGAAATGCGAGAAGGAATTCGGCATCAGCGCGTCATCCTGCAAATGCGAT
AACGGATACTCCGGATCTGCTTCCGCAACCTCCCACCATGGGAAAGGAGAATCGGGATCCGAGGGGAGCT
TGAGTGAAAAAATGAATATTGTCTTCAAGTGCCCCAGTGGCTACCATCCAAGATACCATGCCCACACCGT
GACGTGTGAGAAAATTAAGCAGTGAGCTGGAGTCTGTCCTTTACTTTAGCATTGGAGAATGCGCCCATTC
GCAGCTGTCCGTGCATGCAATCATCGCCGTCTGTATAAAACCGACACAAACTGACCTTTATGTAACTGTA
CAGCTTTGCCCTTGACGGGGCCGGCAACCACGACACGACTACGTATGTCGCAAGACGAAGGTACCCAGCG
AGTCTCTGAGAGCGGAGATCAGCGCAAAGACAAGATGCAGAGTTTGACTCGAGAAACAATAGTAACACGA
AGTAAAAAGTCTCCACACTAAGCCAAGGATTGAGAATATTTCGATTTGTGCCGCTGGCAATAGTGGCCTT
GGCTAGAAAGAAGTTCTGCAACGAAGCGATCGGCTCACACGCGGATACACAGATGGGTTTGTACCGAGAA
CGTTAGGTTTGTGAACCGAGTTCAGGTAAAACAAAGTAGATTGTGTGCCTTTACGCAGACAGCGAGGGAA
AACATAG
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Protein Sequence : Show Sequence
>CAB56644.1 MIC3 microneme protein [Toxoplasma gondii]
MRGGTSALLHALTFSGAVWMCTPAEALPIQKSVQLGSFDKVVPSREVVSESLAPSFAVTETHSSVQSPSK
QETQLCAISSEGKPCRNRQLHTDNGYFIGASCPKSACCSKTMCGPGGCGEFCSSNWIFCSSSLIYHPDKS
YGGDCSCEKQGHRCDKNAECVENLDAGGGVHCKCKDGFVGTGLTCSEDPCSKRGNAKCGPNGTCIVVDSV
SYTCTCGDGETLVNLPEGGQGCKRTGCHAFRENCSPGRCIDDASHENGYTCECPTGYSREVTSKAEESCV
EGVEVTLAEKCEKEFGISASSCKCDNGYSGSASATSHHGKGESGSEGSLSEKMNIVFKCPSGYHPRYHAH
TVTCEKIKQ
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Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
|
13. MIC8 |
-
Gene Name :
MIC8
-
NCBI Nucleotide GI :
13346486
-
NCBI Protein GI :
13346487
-
Protein Accession :
AAK19757.1
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
microneme protein 8
-
Protein pI :
5.13
-
Protein Weight :
71329.71
-
Protein Length :
747
-
DNA Sequence : Show Sequence
>gi|13346486|gb|AF353165.1| Toxoplasma gondii microneme protein 8 (MIC8) gene, complete cds
ATGAAGGCCAATCGAATATGGTGTTTTTTTGCGTGGCGTATGGTTGTGCGGGCCTCATTTCTGAAAGAGA
TGGACAGCATTTTCGTTTCTGCTATCCGACAGAATGTACAGCATACTCATTCTGCCCTTCTCGCCAAACT
GAAGGAACCCCCAGATCCAGATGATGAGAACTCTTGGCTTTGTCGAATATCAAAAAAATATGACGCATGC
GGTAGCAGGGAATATTCCGATAAGGGCCTCAAAGGGACGTACTGTCCCGAGGATTTTTGCTGTAGCAAGA
CGGCATGTTTTTACGGTTCATGTGGGAGTTGGTGCCACGACAACTGGGCTCTGTGCAGCTCATCTATAAT
CTACCACGACGAGTACAGTTACGGGAAATGCAACTGTAAACGGTTTCAAGAAAACTGTGATGTGAATGCA
ATTTGTGTGCATGCGAACAGAGAGGATGGCGGTGCGTATTGTCAGTGCAAGGAAGGATATTGGGGTGATG
GTAAATCGTGCAAGATTGACTTCTGCCAACTGCAGCCCTGTGGTGCAGGGACCTGCACCAGGACGGATGA
AGGATACAAGTGTGATTGCCCAGAAACTCACAAGCTTATTGTCGTTGAAGACAAAGAGACGTGCAAGGCA
AAACCGGACTTTTGCGCGGAAGAGCCTTGCGGACCACCCTCTATGGTTGAAAATTGCGTGAACACCGATG
ACAGCTACGAATGTGTTTGCAAACAGGGGTATGAAGTGAGGAACGGTCGGTGCGAAGAAATTGACTTATG
CGCGGACAAGCCATGTGGGCCAGATGAGGGTGTGCATGAGTGTGTAACAGAGAGGCAACCGAAATTAAGG
TACAGATGCACGTGCAAGGCAGGATTCGATTTGACCACCTTGCCTGATGGTGTTTCCCAGAAGTGCCTGA
AGAACTTCTGTTACGAGGAGCCCTGCGGCACCCGGGACCTAGTTGAAAGCTGTAAGTCAAAGGCATATGG
ATACTCGTGTTTGTGTGCGGCAGGTGCCATGGTTCAAGTGATTAACGGAAAAGAAAAGTGCATCAAGGCG
GACTTGTGCCGCAATGATCCGTGTGGTCCAGAGACAGCAGTGATTCAATGTTACTCTCATGGCACCAGCT
ATAGGTGTTTGTGCAAAGCAGGCTACACTGAAGTTTTTGTTAACGGGAAGAGTTCATGTCAAAAGGGCGA
CCCATGCACTCTGAACATGTGTGGCGGTAACGAAGCGGTCCAGGAGTGCACAACTGATGGCACGGCGTAC
GGGTGTACCTGCAAGCCAGGCTATTCGATAGCCATTAAGCATGGTCAGAAGTTTTGCAACCCTGAAGAGG
AGTGTGCTTCTCATTGTGGCTCGGCAGCTGCAGTGAAAAGCTGTGAAATACTTGACTCTGGCGGATACCA
GTGTACATGCAATCCAGGATACGTCATGAGATACAGCGACTATGTAAAAGGATGCGTCGAGGGAAATCAG
TGTTCTCTCAATCCTTGTGGGGAGCAGGAAGCCGTGCAAAGGTGCATTCCTGAAGGTGACACGTATGATT
GCGAGTGCAATCCGGGGTTCGTCAAAAGAGTCTTGCCGGATGGGAATTTCATTTGCGCCGATCCAGCGAG
CTGTGTAGGGAATCCCTGTGGTAGCTCAGATGCGGTCGATGCGTGCATTGCCGGGACTAGCACGTATACA
TGCAGGTGTAAGGACGGATACACACCTCAGTCAATTGGGTCAAAGTTGCAGTGTTTACCAGAAAGCACTG
ATCAGACAGATTTCGATTCCAAACACAAACCAGAGGACAACAAAGGTCGATATTCGAAAGGAACAATTGC
ATTGGTGGTTGTGGGGTGTGTAGCCTTGTTGGGTATTATAGCCGGAGGAATTTCTTACGCCAGAAACAGA
GGAGGTGAGCGCGATGATGAAGACTTGGCACCACCACCTCGTTCCACACGAGAACGGAGGCTCTCATCAA
TGGGCGAAGGTTTTGAGAATGCCTCATGGGCATCTTCTGTAAGTATGATTCCTAGTGCACCTGCTCCGCC
ACCTTCGGGCGGTATCTGGTCCTAA
-
Protein Sequence : Show Sequence
>AAK19757.1 microneme protein 8 [Toxoplasma gondii]
MKANRIWCFFAWRMVVRASFLKEMDSIFVSAIRQNVQHTHSALLAKLKEPPDPDDENSWLCRISKKYDAC
GSREYSDKGLKGTYCPEDFCCSKTACFYGSCGSWCHDNWALCSSSIIYHDEYSYGKCNCKRFQENCDVNA
ICVHANREDGGAYCQCKEGYWGDGKSCKIDFCQLQPCGAGTCTRTDEGYKCDCPETHKLIVVEDKETCKA
KPDFCAEEPCGPPSMVENCVNTDDSYECVCKQGYEVRNGRCEEIDLCADKPCGPDEGVHECVTERQPKLR
YRCTCKAGFDLTTLPDGVSQKCLKNFCYEEPCGTRDLVESCKSKAYGYSCLCAAGAMVQVINGKEKCIKA
DLCRNDPCGPETAVIQCYSHGTSYRCLCKAGYTEVFVNGKSSCQKGDPCTLNMCGGNEAVQECTTDGTAY
GCTCKPGYSIAIKHGQKFCNPEEECASHCGSAAAVKSCEILDSGGYQCTCNPGYVMRYSDYVKGCVEGNQ
CSLNPCGEQEAVQRCIPEGDTYDCECNPGFVKRVLPDGNFICADPASCVGNPCGSSDAVDACIAGTSTYT
CRCKDGYTPQSIGSKLQCLPESTDQTDFDSKHKPEDNKGRYSKGTIALVVVGCVALLGIIAGGISYARNR
GGERDDEDLAPPPRSTRERRLSSMGEGFENASWASSVSMIPSAPAPPPSGGIWS
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
The gene sequence encoding MIC8 was inserted into the eukaryotic expression vector pVAX I, and the pVAX-MIC8 expression plasmid was constructed, and the plasmid diluted with PBS to 100 mg/100 microl was injected into the Kunming mice muscularly. Levels of IgG antibody, gamma-interferon (IFN-gamma), interleukin-2 (IL-2), interleukin-4, and interleukin-10 were detected. The mice were challenged with tachyzoites of the virulent T. gondii RH strain at the 14th day after the last immunization to observe the survival time. The high level of IFN-gamma, IL-2, and IgG antibody indicated that mice vaccinated with recombinant pVAX-MIC8 plasmid could elicit strong cellular and humoral immune responses and showed a significantly increased survival time (10.3 +/- 0.9 days) compared with control mice which died within 5 days of challenge infection (Liu et al., 2010).
- Related Vaccine(s):
T. gondii DNA vaccine encoding MIC8
|
14. OMPDC |
-
Gene Name :
OMPDC
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii ME49
-
NCBI Gene ID :
7899615
-
NCBI Protein GI :
237831731
-
Locus Tag :
TGME49_059690
-
Genbank Accession :
DS984728
-
Protein Accession :
XP_002365163
-
Taxonomy ID :
508771
-
Gene Starting Position :
2298541
-
Gene Ending Position :
2301456
-
Gene Strand (Orientation) :
+
-
Protein pI :
4.79
-
Protein Weight :
31611.79
-
Protein Length :
320
-
DNA Sequence : Show Sequence
>gi|212659390:2298541-2301456 Toxoplasma gondii ME49 scf_1112359874900, whole genome shotgun sequence
GATGCCGGCAGACGCGCTGCGTGAGAAGCCGGTTGTCCAGGCTGCTGTGAATACCTCGGAAGGGTGCAAG
AACTTCTTCAAGACATTGGATGCAAGGATCGAAGCGGTAGATTCCTTGCTCACAGTCGGCCTTGATCCGC
ACATCGCGGACCTCCCGTCGCCAGCCACAGCTGAGCGTGCCTTTGTATTTTGTGAACGCATCATCAGGGA
AACTCTTCCTTTTACGTGTTGTTACAAACCGAACAGCGCGTTTTTTGAGGCATTTGGTCCCCCGGGTTTG
CAGGTACGTATTTCAATGTGAGGATGGAGCATGGTTGTCATGGCCAGATATACTTTAGCCCGACAACGTT
ACCAGGCATTTGGAGTACCTCCAACTCCTCAGTTGCAAAGATACACTGCACATGCTCGTGTAGTACCGCT
GAGAGACAGAACCACTTGAAACGTCATCTTTCATTAGTATGAAGCGGTTGTCCGAAGTTCGGCCATCATT
CTGGAATCTATCAGTCCTATGTTTCCTCACTGCCTAGGTACTGTTTTCCTGTTTGTGTATATCCCGAAAA
ACTGTATTGAAAGCAAGCAGTGGGGATAGCGGTGAAGCAGGGGGTTGGTGAAGCGGTTTCGGAGGGGACA
GGGAAATACCTTCAATTTTTGAAAGGCGCAGTTCCCTGTTCCTTCGCAGTCACCACGGACAGACTAGAGA
TATGTCTGTTCTGTACGCGCCTTACCAAGACCCGAACCGCGTACAGGGTGCAAACCTTTCGCGCCATAAT
CGAATGCCGCTTGTCGCCACGTGTAGGCACTCGAGAGAGTCTGCGCGCTGATTCCCGACGATGTTCCTAT
TCTTCTAGACGCCAAAAGAGGGGACATAGGATCGACGGCGCAAGCCTACGCATCTTCGGCTTTTGACGCG
TTCAAGGTATGGAACTTCGAGCCCTAAGAGGTTGAAGAGAGTACGTAGAACCATGTTTATTTCATTAACA
TCGAGTCGGTTCTGTATACATACGCGTGCTGCTGCAGTGAATGTATTACAAGATATCTCGTATGCATGCG
CCCGACGAGAATATCGCCAATATCATAGCCTTATGACGTGCGCGATTCGTCTGGTGGCAAATCTGCGGTC
TACAAGTGATCTATTGTCAGCGCATGGCAGTAACGATCTCATCCATTTATGCGGGTGACGCATTACATCG
TGTCTTTTGTCAAAAATGTGCTGCTTGATGTCGCGCAGGCGGACGGTGTCACCGTCAACGCCTACATGGG
CAGAGAAGCAGTTCGACCGTTTCTGTCGTATCGAAACAAAGGCGTATTTGTACTTGTGAAGACGTCGAAT
CAATCGTCCAACGAGTTTCAGACCCTGCCAGTGAGGGTGGAGTCAAGCTCCGACACTCAGGATGTCCCGC
TGTATGTACAGATGGCCAGAGTTTGCAACGAACTTGCCCAAGGTGAGAGTGGGTCCGTCAGCTTCGTTAG
ACCAGCTTCTCTTCCGTTGTATTTGTCTTTTGTGAGCGACCCGTGTCGCCAGAGCTTCATGCTTAGCTAC
ACCGCTCGGCAGAACTGGCATCTCTCTCGCTCCAGGAGTGTGATCCGCGTTTCCAGTTTTTGGTTGATAA
GTCGCACCCCAGAGGAGAAAAATCCTCAGCACCTGCCATACAGATTCAACGGAGTCTCAGGCAGCTTTTT
ACTCCGAGCCCGCACTTGCCCGACCTGCCATTTTCGTTTACACAGAGCCACTTTCTGCGGGGCGGTGGCG
ACAAAAACCGCGAGCTTTGTAGTAAATGAAACCACGTCGTGAGAAGTAGTCCAGTTCTCCCTTCGAACAC
TACGTTGCCTGCTACATATCTGTGCCTCATCGTCGAGTGCCGCTGTCCGTGTCTTGCTCCACTTTGTCAA
TCCGAACTCAGAATGCGTTTCTGAGGAAGACTCTCCATCCACGACTGGACATGGCCTCCGTCATAATGCG
TCGGGCGGTGGTGTCGGACTCGTAGTAGGAGCAACAGATATAGAAGCTCTTCGCGAGGTGCGAAAGGCAT
GCCCGGACCTTTATATTCTTGCTCCCGGAGTCGGTGCCCAAGGAGCGGACCTCGAGAGGGCCTTGAGTGC
CGGTAAGCATGGAGCTGGGTCTCAGTTGAGAGCGAAGTTACACAATTGAATCTGACATTGAGGTTGATTT
GATTGTCGCTTGAGGCGCCTGTGACCCTAATGATCCCGAAACGCAGGAACCATAGAAGCAACGGAGGGAG
ACGGAACCTTGCTGTTTTAGGTCATTGTGCGCTAAACGTGGTTTCTGGTACACCGTGCAAGATCGTATAC
TCACGGGTATGATCGCAGTGAAAATGCTCCTAAGAGCGAAGAAATAAGGTACCACATTTTCAACACCTCT
ACGGTTTTTCCTGTTACTTGGGACTCGTTGCTCTGCCAGGTCTCTGCAAGGACGGCAAAGGGATGCTTAT
TCCCGTCTCTCGTGGCATATCACGAGCGGAGGTAAGGGCAGGTTGTCTTGACACTTGTAGCCCGTAGTTT
TTGAAAATCCAGCACACCGCATAGAACCTTGGTGACAGAGATGCGTGCGTCACTCGAACGAATATTCCGA
TGACGGCGAAGTTGACTGAAGTATTTCTGTTTTCAGCAGTATATTTTTCAGCGTTTGTATGGCCCCAGGA
TGGATGCAAAACCAACCGACTGCGCCCTTCGCTCAGATGTGCGGAATCCACCGGATCCATGCAATAGAAA
ATAGATTTCAGATGACACGGATTTGAGATGAAATCACCCGTTCATAGTACAGCTGTTTGCGTCCACTTTG
TCCGTCCTCCCTGTTCCGTTCCCTTCATTGCAGAATTTAGCTGCCCAAGCTAACGCATACAGAGAACAGA
TCAATGAAGTCAGAAGAGGCATTGTCCAGCAGTACGAGGAAAGCTG
-
Protein Sequence : Show Sequence
>gi|237831731|ref|XP_002365163.1| orotidine-monophosphate-decarboxylase, putative [Toxoplasma gondii ME49]
MPADALREKPVVQAAVNTSEGCKNFFKTLDARIEAVDSLLTVGLDPHIADLPSPATAERAFVFCERIIRE
TLPFTCCYKPNSAFFEAFGPPGLQALERVCALIPDDVPILLDAKRGDIGSTAQAYASSAFDAFKADGVTV
NAYMGREAVRPFLSYRNKGVFVLVKTSNQSSNEFQTLPVRVESSSDTQDVPLYVQMARVCNELAQECVSE
EDSPSTTGHGLRHNASGGGVGLVVGATDIEALREVRKACPDLYILAPGVGAQGADLERALSAGLCKDGKG
MLIPVSRGISRAENLAAQANAYREQINEVRRGIVQQYEES
-
Molecule Role :
Virmugen
-
Molecule Role Annotation :
An OMPDC mutant, alone or in combination with an UP mutation, is attenuated in mice and induces significant protection from challenge with wild type T. gondii (Fox and Bzik, 2010).
- Related Vaccine(s):
Toxoplasma gondii OMPDC mutant vaccine
,
Toxoplasma gondii OMPDC/UP mutant vaccine
|
15. p30 |
-
Gene Name :
p30
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Nucleotide GI :
894214
-
NCBI Protein GI :
894215
-
Protein Accession :
AAB33440.1
-
Other Database IDs :
CDD:332018
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
p30 antigen
-
Protein pI :
8.08
-
Protein Weight :
32194.82
-
Protein Length :
386
-
Protein Note :
SRS domain; cl27197
-
DNA Sequence : Show Sequence
>gi|894214|gb|S76248.1| p30=p30 antigen [Toxoplasma gondii, RH, Genomic, 1634 nt]
CGCGTGTTCTAACCACAAACCTTGAGACGCGTGTTCCAACCACGCACCCTGACACGCGTGTTCCAACCAC
GCACCCTGAGACGCGTGTTCTAACCACGCACCCTGAGACGCGTGTTCTAACCACGCACCCTGAGACGCGT
GTTCTGCCGCACAATGTGCACCTGTAGGAAGCTGTAGTCACTGCTGATTCTCACTGTTCTCGGCAAGGGC
CGACGACCGGAGTACAGTTTTTGTGGGCAGAGCCGTTGTGCAGCTTTCCGTTCTTCTCGGTTGTGTCACA
TGTGTCATTGTCGTGTAAACACACGGTTGTATGTCGGTTTCGCTGCACCACTTCATTATTTCTTCTGGTT
TTTTGACGAGTATGTTTCCGAAGGCAGTGAGACGCGCCGTCACGGCAGGGGTGTTTGCCGCGCCCACACT
GATGTCGTTCTTGCGATGTGGCGTTATGGCATCGGATCCCCCTCTTGTTGCCAATCAAGTTGTCACCTGC
CCAGATAAAAAATCGACAGCCGCGGTCATTCTCACACCGACGGAGAACCACTTCACTCTCAAGTGCCCTA
AAACAGCGCTCACAGAGCCTCCCACTCTTGCGTACTCACCCAACAGGCAAATCTGCCCAGCGGGTACTAC
AAGTAGCTGTACATCAAAGGCTGTAACATTGAGCTCCTTGATTCCTGAAGCAGAAGATAGCTGGTGGACG
GGGGATTCTGCTAGTCTCGACACGGCAGGCATCAAACTCACAGTTCCAATCGAGAAGTTCCCCGTGACAA
CGCAGACGTTTGTGGTCGGTTGCATCAAGGGAGACGACGCACAGAGTTGTATGGTCACGGTGACAGTACA
AGCCAGAGCCTCATCGGTCGTCAATAATGTCGCAAGGTGCTCCTACGGTGCAGACAGCACTCTTGGTCCT
GTCAAGTTGTCTGCGGAAGGACCCACTACAATGACCCTCGTGTGCGGGAAAGATGGAGTCAAAGTTCCTC
AAGACAACAATCAGTACTGTTCCGGGACGACGCTGACTGGTTGCAACGAGAAATCGTTCAAAGATATTTT
GCCAAAATTAACTGAGAACCCGTGGCAGGGTAACGCTTCGAGTGATAAGGGTGCCACGCTAACGATCAAG
AAGGAAGCATTTCCAGCCGAGTCAAAAAGCGTCATTATTGGATGCACAGGGGGATCGCCTGAGAAGCATC
ACTGTACCGTGAAACTGGAGTTTGCCGGGGCTGCAGGGTCAGCAAAATCGGCTGCGGGAACAGCCAGTCA
CGTTTCCATTTTTGCCATGGTGATCGGACTTATTGGCTCTATCGCAGCTTGTGTCGCGTGAGTGATCACC
GTTGTGCTCACTTCTCAAATCGACAAAGGAAACACACTTCGTGCAGCATGTGCCCCATTATAAAGAAACT
GAGTTGTTCCGCTGTGGCTTGCAGGTGTCACATCCACAAAAACCGGCCGACTCTAAATAGGAGTGTTTCG
CAGCAAGCAGCGAAAGTTTATGACTGGGTCCGAATCTCTGAACGGATGTGTGGCGGACCTGGCTGATGTT
GATCGCCGTCGACACACGCGCCACATGGGTCAATACACAAGACAGCTATCAGTTGTTTTAGTCGAACCGG
TTAACACAATTCTTGCCCCCCCGA
-
Protein Sequence : Show Sequence
>AAB33440.1 p30 antigen [Toxoplasma gondii]
MSVSLHHFIISSGFLTSMFPKAVRRAVTAGVFAAPTLMSFLRCGVMASDPPLVANQVVTCPDKKSTAAVI
LTPTENHFTLKCPKTALTEPPTLAYSPNRQICPAGTTSSCTSKAVTLSSLIPEAEDSWWTGDSASLDTAG
IKLTVPIEKFPVTTQTFVVGCIKGDDAQSCMVTVTVQARASSVVNNVARCSYGADSTLGPVKLSAEGPTT
MTLVCGKDGVKVPQDNNQYCSGTTLTGCNEKSFKDILPKLTENPWQGNASSDKGATLTIKKEAFPAESKS
VIIGCTGGSPEKHHCTVKLEFAGAAGSAKSAAGTASHVSIFAMVIGLIGSIAACVA
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
,
T. gondii DNA vaccine pSAG1-ROP2-SAG2
|
16. PI1 |
-
Gene Name :
PI1
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
ADJ17341
-
Other Database IDs :
CDD:238052
-
Taxonomy ID :
5811
-
Protein Name :
serine protease inhibitor 1 isoform beta
-
Protein pI :
4.61
-
Protein Weight :
30858.24
-
Protein Length :
373
-
Protein Note :
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; cd00104
-
Protein Sequence : Show Sequence
>ADJ17341.1 serine protease inhibitor 1 isoform beta [Toxoplasma gondii]
MGKNPLLFLAGVLVCSFSVAVFASPETKVCSCPRNLELNCGGDHVTYANHCIRECHGVGLLHDGPCADQE
DQGSSVNEPSEVADTTEQPSITPSGEEDRPPKDAPKERKRLRGCACTRELRLNCGVDGVTYSNHCVRKCE
RVKLLHEGPCRGGPGRTLFSQQDDESENDALEEEEQRLQSCPCPLNLMLNCGVDGVTYDNHCLRRCRRVE
LKHEGPCEADEQKQLPVQHGDNEIDVPERRIEDLKDCACPLILTPNCGTDRKTYPNNCVRECAGVKLLHE
GPCEGDTEEIWDDQ
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Picchio et al., 2018)
|
17. ROP16 |
-
Gene Name :
ROP16
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii ME49
-
NCBI Gene ID :
7894782
-
NCBI Protein GI :
237832151
-
Locus Tag :
TGME49_262730
-
Genbank Accession :
CM002042
-
Protein Accession :
XP_002365373
-
Taxonomy ID :
508771
-
Chromosome No :
VIIb
-
Gene Starting Position :
1053319
-
Gene Ending Position :
1056332
-
Gene Strand (Orientation) :
-
-
Protein pI :
9.07
-
Protein Weight :
71254.93
-
Protein Length :
707
-
DNA Sequence : Show Sequence
>NC_031475.1:1053319-1056332 Toxoplasma gondii ME49 chromosome VIIb, whole genome shotgun sequence
AAATGAACACGAGCTGTTTCCCATGTCTCTTAAGGTGTGCGTCAATTTTTATAAGGGCCGCCCGCAGGTA
TCGGGACCAACTTACACTTCACCTTGTGCTTCATATGAATTCATTTAGCGGACACTACAAATATATACTG
GCAACTTTCCACACCTTTTCGGAGTCTCTTACGCCGTATAGGCGCAAGTACAATTGTCCGCTTCTTGGCG
TTGGTCGTCGTCAACTTCTAGACGTTCCACGTCAACTAACGGCATTGATTCAACAAAGATTCCAAGTCCC
AAAACAATTCATGGGCGCATAGTCAAGTGCTGTACAATTATGGAGTCTATTTGAGGGCCACCGTACCAGA
TGGTGAAATTCACCTTACATAAGATGTCAATGTACTGTAATCGTGACAGGAACATGCGCCGTACATTTTC
CAAACGCATAATACACGCGACCGCATGCAGTAACCTTTCAACCGTTTGGCAATAGAAGGACGAAGAAAGC
GTGGCCGTTTCGTTGCGATATGTCAACGGGACCTAGCTTCCTACTCAGGGATAACTCAAAAGCGGTAACA
TCCTCGGCCCAAGCATCTTGCTACCCCTAGCCTCTCAACCAGTTCCATAAGAAGAGGAAGGAAACACAAC
CTCTTCACACACGAATTCAAGAACTGTACCGGACTAGAAAGGTAGCACAATATCAAAATAACCCTTTCCC
GCCGAAACGTGGCACAGCGACCAAGGCTTCGTACTCAAAATCGGAGGCCTTCTTAGTTGCGGATGAAACC
GTGCCTTCTTTGATTTTCATCCGTGCGTCGCCTTCGAGATCGGTTGATAGACCGTTTCATGAACATGCTG
AAAACCATATACGCGCACAAAAAAATGGTGTTAAGGTGGGAACCTTACACCCTACATCCGATGTGAAGAA
AGTTCGGTAGTTGGAATCCTAGTGAGATGAGAAGTAACTCCAGGGGCTTGCCGAAAGAAGGTGTAACTGC
TGACGAATTTCGGGAGTTCAGGGCGCTCTTCAGGATTTGGATTTAGAAATTGAGCAACAATTCCCATCAC
TGCTGGATCAGATTCGTTACAATCCTTGGCAGAGAAATCTGAGAGGCGAAGGCGCGAAAGGTGTTCAACT
CTCGACCAGAGTGAACTCGGCAGATTCGAAAGGCTGTAAGGAAGTCGGTTGAAGCAGACGAACTCGAAGA
TTGCCAACCCTAAGGCCCACACATCGAGAGCGCCACGCTTCAGACATGTCTGCTGCGACGTGTGCTGTGA
TTTCGCAAGTTCAGGAGCCCACAAACGCAGGTAATATTTATCTTCCTCGCTTACACAGCTGTCAACAGGC
CGCACACTGCCCATGTCAAGCATATGCCCAAAGCCGTGGACATCGATCATCATGTTGTTCAATTTAACAT
CTCCATGCGCGAATCCAAGTTCGTGAAGCTTGGCCAATGCAATAATTGCTTCCCTTGCCACAGCTCGCTG
GAAGAGAAATGGTGGTTGCGACTGGACTAGACTGTTCGATGGGGAGCCATCAATTAATGGCAGCAGCATG
ACTTCTTTAGACACGACAACGAGTCGAGAACCTCGACGTACCACGGTTGCTTTGTTCTCAGGAAGCGTTA
AAGTCATTTGGCACAATGGTAGACCGTATTGCTCCGCAGTCTCTGTAAGTGTGAGCCCTTTAGCCACCAG
CTTATCCCGAACATCCAACTCCTGTCGAATTGTCTTTACCAACTCCGCCCTAGCTGAGGAAATTTCCGCC
TCCAGTTCTGCTGACGTGGCATCAGCATTCGGGACGATCTGGCTGTACGGCACCTTCGCTGCATACAACG
TCCCATCGTCTAAGCTGGCCTTGATGACAGCCCCGAAATGTCCACTGCCGAGGTGCCCACGATTGTATAG
AGCGATCGGCACTCCGTTGGCATTTATCATCATGACACGCTCATTTGGAGGGAACACTTCGTCAACAGCT
GACTCCACCGCTCCTGGAGGTTGCTTTCTCTTCCGCTTACGGGTAGCAACCCTCTGTTCTGAGAGGACCG
CCTCTTGCAGAACAGCCCGCATTGCCTCATAGTCCGGAACCGCTACGAGAAGCTGTGCGGCAGCTGCTTT
CAGCTGCTGAACTTCTTCCAGACCCTCTTCTGAAAGTCGAACGCGCCGGATGCGTTCTGAACGTTTCACA
TGAGGAGTTTGTACTGCTACATAACTAGAAACACTGGAGGCAAGCTGCGAGGCGCCGCTATCCGCTGGAT
TTTCGGTCGACATCGCAATCTGTCTTTGAGGGGATCCCCGACGCTCTTGTGCCGGAGACTGTATTCCTGA
ATCCAATGTAGCGCTCTGAACAGGGAAAAGAGGATTTTCTTGACCAAGCGACGCAGGCGTTGGCACCGCC
TTTCCTGACAATGCACTCGAGCTTGCGCCACTGACGTATCGCTTTGGCGAGGACGCAAGACTGCTCGCTG
CGCCATACTGTTCTTGTGGCTCTTGAAATTCGGTAACGACCACCCCAGATAGAGATGGCTTTCGTTGTGT
CAATGGTTGCGGCGGAGAACTCCATGGCGTAAATATTGACTCTGTTGGAAACCATCCTCCCGGTCCGCTG
CTGCGTGGTGGAAGATGCGAGGGTGAAAGCTGGGTTTGGTAGCCCCTTAGCGAGGCTGAGCTAGTCGCCG
GATAAGCAGATTGGGGGGAAGGACTCCTCCGCTCCTCTCTAGCACCCGCGCTGCCACCGGTGCGTCCCTG
CCCCTGAGTCGAGCCACCAGCACCGAGACCTACTTCAGCCGCCGCTTGTTCAGGTTGTAGTGTGGATTGA
GAAGGTTGCCCTGCCGCAGGAGACCCTCCCCGGTTTCTATGCTTGCTACCTGGATTCGAAAGAGTAGAAT
CTGGAGAGGGGAGTGTGGCAATCTGGCGCTTCGCTGCTTCACTTGCTTTTTGCGCTTCCTCAAACGACAT
GTATCGTGCAGTTGCGCAGCGTGTACAAAACAACAGTGCAAGAGCAAAAGCAAGCCCTTTCGTGGTCACT
TTCA
-
Protein Sequence : Show Sequence
>XP_002365373.1 rhoptry protein ROP16 [Toxoplasma gondii ME49]
MKVTTKGLAFALALLFCTRCATARYMSFEEAQKASEAAKRQIATLPSPDSTLSNPGSKHRNRGGSPAAGQ
PSQSTLQPEQAAAEVGLGAGGSTQGQGRTGGSAGAREERRSPSPQSAYPATSSASLRGYQTQLSPSHLPP
RSSGPGGWFPTESIFTPWSSPPQPLTQRKPSLSGVVVTEFQEPQEQYGAASSLASSPKRYVSGASSSALS
GKAVPTPASLGQENPLFPVQSATLDSGIQSPAQERRGSPQRQIAMSTENPADSGASQLASSVSSYVAVQT
PHVKRSERIRRVRLSEEGLEEVQQLKAAAAQLLVAVPDYEAMRAVLQEAVLSEQRVATRKRKRKQPPGAV
ESAVDEVFPPNERVMMINANGVPIALYNRGHLGSGHFGAVIKASLDDGTLYAAKVPYSQIVPNADATSAE
LEAEISSARAELVKTIRQELDVRDKLVAKGLTLTETAEQYGLPLCQMTLTLPENKATVVRRGSRLVVVSK
EVMLLPLIDGSPSNSLVQSQPPFLFQRAVAREAIIALAKLHELGFAHGDVKLNNMMIDVHGFGHMLDMGS
VRPVDSCVSEEDKYYLRLWAPELAKSQHTSQQTCLKRGALDVWALGLAIFEFVCFNRLPYSLSNLPSSLW
SRVEHLSRLRLSDFSAKDCNESDPAVMGIVAQFLNPNPEERPELPKFVSSYTFFRQAPGVTSHLTRIPTT
ELSSHRM
-
Molecule Role :
Protective antigen
|
18. Rop2 |
-
Gene Name :
Rop2
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
VO ID :
VO_0011340
-
NCBI Protein GI :
115299638
-
3D structure: PDB ID :
2W1Z
-
Other Database IDs :
CDD:291215
CDD:304357
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
Rop2 protein
-
Protein pI :
9.64
-
Protein Weight :
28699.38
-
Protein Length :
316
-
Protein Note :
Kinase-like; pfam14531
-
Protein Sequence : Show Sequence
>ABI93795.1 Rop2 protein, partial [Toxoplasma gondii]
LRLLRGIKNQKQAKVHLRFIFPFDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLQMLGDVLLSH
SSTHKSLVHHARLQLTLQLIRLLASLHHYGLVHADFQVSNILLDQRGGVFLTGFEHLVRDGASAVSPIGR
GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQPVR
ALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAVLPLYQTDGEPA
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
A study to examine the immunostimulatory properties of Leishmania infantum Hsp83 (83) to elicit humoral and cellular response against the Toxoplasma gondii Rop2 protein in an adjuvant-free vaccination system was conducted. Mice immunized with fusion Rop2-83 elicited a stronger humoral and cellular response in comparison to mice immunized with Rop2 alone, or a mix of LiHsp83 and Rop2. The fusion protein induced a Th1 type response, with predominance of specific IgG2a/IgG2c isotype and IFN-gamma secretions, whereas Rop2 alone or mixed with LiHsp83 produced a Th1/Th2 mixed response. Vaccination with fusion protein conferred a remarkable resistance against oral infection with ME49 cysts in C57BL/6 and C3H mice, in comparison to mice immunized with Rop2 alone or the protein mixture. Following lethal challenge, a significant survival rate was observed in Rop2-83 immunized Balb/c and C57BL/6 mice in comparison to control groups (Echeverria et al., 2006).
- Related Vaccine(s):
T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
,
T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine
|
19. ROP2 |
-
Gene Name :
ROP2
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii RH
-
NCBI Protein GI :
563627
-
Other Database IDs :
CDD:291215
CDD:287472 CDD:304357 GOA:Q27007 InterPro: IPR000719 InterPro: IPR011009 InterPro: IPR016815 PDB: 2W1Z UniProtKB/TrEMBL: Q27007
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
ROP 2
-
Protein pI :
8.19
-
Protein Weight :
61058.83
-
Protein Length :
609
-
Protein Note :
Kinase-like; pfam14531
-
Protein Sequence : Show Sequence
>CAA85377.1 ROP 2 [Toxoplasma gondii]
MENCASVRSSSCLIWLAAAFFVSALGHVQQGAGVVRPRHWQNSEAAVSVRPPGGASPRHFHSPIEPVAFI
DGEHVEDKHGGSWLEQEAAEEVTPLLNSHTETPTQSPSAFRRLLRRLRFWRRGRTGGSDGGGEPPQTPRP
SLPTRLFQHLRRAAAAIPAAASRFFRRFRRVQEPVFPPDEFPEDVDTNPMYFRGTDPGDVVIEELFNRIP
ETSVWNENERVLSNANHLVSTALWRNEQSFRVESELGERPRTLVRGPVLRDDGSYICLEATDQETGEPLE
VHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPIDLVKDPKKRKMIRVRLDERDMWV
LSRFFLYPRMQSNLHILGDVLLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQR
GGVFLTGFEHLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPN
TEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQLRTELSAVLPLYQTDGEP
A
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pSAG1-ROP2-SAG2
|
20. Rop2 |
-
Gene Name :
Rop2
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
ABI93795
-
Other Database IDs :
CDD:291215
CDD:304357
-
Taxonomy ID :
5811
-
Protein Name :
Rop2 protein
-
Protein pI :
9.64
-
Protein Weight :
28699.38
-
Protein Length :
316
-
Protein Note :
Kinase-like; pfam14531
-
Protein Sequence : Show Sequence
>ABI93795.1 Rop2 protein, partial [Toxoplasma gondii]
LRLLRGIKNQKQAKVHLRFIFPFDLVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLQMLGDVLLSH
SSTHKSLVHHARLQLTLQLIRLLASLHHYGLVHADFQVSNILLDQRGGVFLTGFEHLVRDGASAVSPIGR
GFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKNIPQPVR
ALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAVLPLYQTDGEPA
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Picchio et al., 2018)
|
21. ROP8 |
-
Gene Name :
ROP8
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii strain RH (EP)
-
NCBI Nucleotide GI :
2293518
-
NCBI Protein GI :
2293519
-
Protein Accession :
AAC47797.1
-
Other Database IDs :
CDD:291215
CDD:304357
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
ROP8
-
Protein pI :
9.42
-
Protein Weight :
61810.69
-
Protein Length :
622
-
Protein Note :
Kinase-like; pfam14531
-
DNA Sequence : Show Sequence
>gi|2293518|gb|AF011377.1| Toxoplasma gondii rhoptry antigen ROP8 gene, complete cds
GAATTCGCTAGTCTCAGGTCGAGTCGCCGGGGCGTCAGGAGACAAGCACCGGCGCCCCGCGCGCCAACTG
TCCGTCCTTCCGGGTGAGTTGACGTTTTGAGCCACGCTGCAGAACTCTGCACTGGAGTGATTGAGCGCGG
CATTTATGTCAATCTGGTTTTTCCACGTGTATTCCAGAAGCTTGCCCTGAGAAATACAGATACACTGTCA
CTTTTGAATCGATGTTTTCTGTGTTACGTAACCGCAACATGAGACACGGTCCCTCGATTGGATCGTCATC
ATGTCTTATCTGGCTAGCTGCCGCATTCTTTGTTTCGGCACTTGGCCACGTACAGCAAGGCGCTGGCGTT
GTGCGGCCTCGCCACTGGCAGAACTCGGAAGCCGCTGTTAGTGTCCGGTCGCCGGGAGGCGCGTCCCCTA
GACATTTCCACAGCCCAATTGAGCCAGTAGCATTTATTGATGGGGAGCACGATGAAGACAAGCATGAAGG
CTCATGGTTGGAGCAGGAAGCGGCCGAGGATGTGACCCCTTTACCGGGCAGCCACACAGAGGCCCAGACA
CAGTCCCCCAGTGCTTTTAGAAGGTTAACCAGGCGTTTGCGTTTTTGGCGACGTGGGGTGACAGGCGGAT
CAGATGCTGGAGAAGAGGCGCCTCAGACGCCTCGACCTCCACTACGTACACGAATCCTTCAGTACTTGCG
GCGTGTGGGAACATTTTTCAGACGAGACATTCCAGCGGCAGCACTTCGATTCTTCAGGCGCTTTCGACGA
GTCCGCCAACCTGTATTCCCTCCCGACGAGTTTCCGGAGGATGTCGACACGAACCCTATTTATTTCCGTG
GTACGGATCCTGGAGACGTTGTCATTGAGGAGCTGTTCAATCGTATACCGCAAGCAAACGTACGGACTAC
AAGTGATTACATGCAGTCCGCAGCTGACAGTCTAGTGTCCACATCGTTGTGGAATATTGGACAGCCCTTC
CGCGTAGAGTCGGAGCTTGGCGAGCGTCCAAGGACGCTAGTCAGGGGCACATTGCTCGGCCAGGAAGACC
CTTATGCCTATGTCGAGGCGACCGACCAGGAGACAGGAGAATCATTTGAGGTGCACGTTCCACTTTCCAA
GGAAAAGCCGTCTTCCAACACGATCAAGCAGATGAAGCAGGAGGTGCTGCGCCTACGCTTGCTACGAGGC
ATCAAAAACCAGAAGCAAGCCAAGGTGCATCTCAGATTTATATTCCCCTTCGATTTGGTGAAGGACCCAC
AGAAAAAGAAGATGATCCAGGGTGTCTCAGATGAGGGGGCTGGCTGGATCGTGAACGGATTCTTTCTGTA
TCCCCGAATGCAGACTAACCTTCAGACGCTTGGAGAAGTCCTACTGAGTCATTCCTCAACACACAAGTCC
CTCGTGCACCACGCTCGGTTGCAGCTCACGCTTCAGGTCATAAGGCTGCTTGCGGGTCTCCACCACTATG
GCCTTGTGCATACCTTTTTTAGGGCCGTCGATATCGTCTTGGACCAGCGTGGTGGCGTGTTTTTGACCGG
CTTTGAACATCTGGTGCGAGACGGCGACAGGGTGGTGTCGACCGTCTGTCGAGGATTCGAACCGCCGGAG
CTTGAAGCCAGACGAGCAACCATATCTTACCACAGGGACCGCAGGACGCTGATGACATTTTCGTTTGATG
CATGGGCATTGGGGTTGGTGATCTACTGGATTTGGTGCGCCGATTTGCCCAATACCAAGGACGCGCCGCT
AGGCGGAAGTGACTGGATCTTTCGACGCTGCAAGAATATCCCACAGCCAGTCAGAGCTTTGCTTGCGGGA
TTCTTGCGATACCCGCAAGAGAATCGGCTCCTSCCATTGCAAGCCATGGAGACTCCTGAGTACGAGCAAC
TGCGCACAGAGCTATCAGCCGTTTTGCCCCTGTATCTTTCTGATGGAGAACCGGCATGAGAGGGTGGCGC
GCCACCATCGGGAACATCTCAGCCGGACGAAGCTGGAGTCGCTGAGGCGGTTACGGCAATCTAGAACCTC
GAGGAGGGGCCAGCGATGAGCTTGAATTC
-
Protein Sequence : Show Sequence
>AAC47797.1 ROP8 [Toxoplasma gondii]
MFSVLRNRNMRHGPSIGSSSCLIWLAAAFFVSALGHVQQGAGVVRPRHWQNSEAAVSVRSPGGASPRHFH
SPIEPVAFIDGEHDEDKHEGSWLEQEAAEDVTPLPGSHTEAQTQSPSAFRRLTRRLRFWRRGVTGGSDAG
EEAPQTPRPPLRTRILQYLRRVGTFFRRDIPAAALRFFRRFRRVRQPVFPPDEFPEDVDTNPIYFRGTDP
GDVVIEELFNRIPQANVRTTSDYMQSAADSLVSTSLWNIGQPFRVESELGERPRTLVRGTLLGQEDPYAY
VEATDQETGESFEVHVPLSKEKPSSNTIKQMKQEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKKK
MIQGVSDEGAGWIVNGFFLYPRMQTNLQTLGEVLLSHSSTHKSLVHHARLQLTLQVIRLLAGLHHYGLVH
TFFRAVDIVLDQRGGVFLTGFEHLVRDGDRVVSTVCRGFEPPELEARRATISYHRDRRTLMTFSFDAWAL
GLVIYWIWCADLPNTKDAPLGGSDWIFRRCKNIPQPVRALLAGFLRYPQENRLLPLQAMETPEYEQLRTE
LSAVLPLYLSDGEPA
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine ROP8-pVAX-1
|
22. SAG1 |
-
Gene Name :
SAG1
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii ME49
-
VO ID :
VO_0011000
-
NCBI Gene ID :
7900172
-
NCBI Protein GI :
237839159
-
Locus Tag :
TGME49_234370
-
Genbank Accession :
KE138836
-
Protein Accession :
XP_002368877
-
3D structure: PDB ID :
1KZQ
-
Taxonomy ID :
508771
-
Chromosome No :
X
-
Gene Starting Position :
4326607
-
Gene Ending Position :
4329557
-
Gene Strand (Orientation) :
-
-
Protein Name :
surface antigen SAG1
-
Protein pI :
7.13
-
Protein Weight :
18124
-
Protein Length :
174
-
DNA Sequence : Show Sequence
>NC_031478.1:4326607-4329557 Toxoplasma gondii ME49 chromosome X, whole genome shotgun sequence
AGACTGGCATTGCGACCCGACCAGTAGCAAGCTCTGCTCGAGAGGCAATTTGTAGAGATGTTTTGAGCAG
TTTGATGGTGTGTGAGAAGAGGACACGGTTGGGGTCCTCTGTCATTCGAGAACACGATCCAGCCCTTAGA
AAGCATGACTTATGTCGGCGGCGCCCCCTTTCCTCGGGTACCTGTTTTGTCCCCAGGATGAGCAAGCACC
GCTTGTTACACTCGGCAGATTTGAAGTGGGCAGTCACGAGAAAACTGATGTGGCCAGTACGCTCCACCAT
GTTACTGCACTCTCATCACCCGCGATTCTCTGCAAGAACAGATTCAGAGGGTCCCACAATTCCCTATTCC
ACGACACACTCTCGCAGCAGTGCCACAAGCACAAAAGGGTTTGTTTCGACGCATGAAATAGACCGCCCCT
CCAGAGAAAACCTGTATTGGTGCAGCCATTCAAAGCATAGCGGGGCATGATCAACGACTGCCTGCTGCAT
TTTCGGAGTTGGGGCTCTTCAAAACAAACGACGTGAGATGGCTTTGCCACAAGATAGTGCTAAATGCCTG
TTTTTCCATACGAGGTTCGTTACACCGACTTCGGTGTCGCCCTGCAAAATGCTGACCGCTTCCCGCATTG
TCTATGATCCTGCCAGAATGGAGTCACCCTCATGCCCCCACTTCCCCTCGCGAGTGACAGGGCAGCTCGA
GGTTTGACATGAATGGCAGAAGAGTTCACTTTCCGAACGCCCACTCAAGATTACGCCATCCATCTGCCAC
AAAATATTACGCGCCTCCGCTTCCACTGAAGTGCTGCTTGCGGTGTCGCCTAAGCCCTGAAGTTTGCGTT
TTCTGGTGCTTCTTCTGTCACGAGGGTGATGATGTAAGACTGGTCCTTTGCCTTTGAGTCCTCTATCGCC
TCGCATCTGAACGAGAATGTTTTTGAAACAGGGACATTTTCCGGCACGTTGAGTACAGCAGGTTCTTTTA
TGCCGTCACCCCCCGTCCACCATTGGTGCGAGTCCGGCACACCAGGAAAGAGGGCTTGGAGAGTCTTCTT
ACTCGTGCAACTACTGCCTTTTCCCTCACAAACCAGCTTTTTGAAGTCTTCAGGGACCCAGTTCTTGGCA
TTGTTGCATTCGATCGCCACCTTCCATCCAGGATACACATAAGCGATGTTCTCAGTGCCCGTCCCGCGGA
TGGAACTGAACCACACGATGTTGTACTGTCCAAACGGAAACTGCTGCTCCTTTCGTGCATTCTTGAAAAA
CTTTGGGGCGGTAGCTTGGTCTGCGTCCATTGCAGAGGCATAGGCAAATATGGAAAGAAGCATTGCTACC
GAAGCGAGCTTCATTTTGTCAAGCAGAGCCAGGAAGCCTGGAACAATGAGGTTGGCCAGAGAAGACAACC
TACTGACGTTGGTAGAGAGAGCTCAACAACACTACTGCATGCAAGAAAAAGATGCACGTTCCTCCCACTC
AAACATCACTGGAACTTTTGTAATGCCAGGCAGCAGACTCACAAGAATCGATGTTGGTGCCCCGTGCAGG
GAAAGATCAGTCACCCGCGTATGCGGGTAGGTTGGCTACTAAGACAGCGAAGACGAATGCCCATGAGAGT
GGATTTTCCCGGACTCAAGGACAGCGGCTTGTCTGAAACGAGGCACATGAAAGAACAAAATTCGACGGCA
ACTGTGCGTGTCCGGAGAGTCAGCAAAAAGTTCGACTCTCCAGCGTATACCTGCATTACCCTGCGCTCTT
GGTCACCTCGGCTAGCCGCCTTTCTGCTTCGTGTGTGGCTCTCCCCGTTCTTGTGCCGCTGCAGTCGTTG
ATCCAGAGAGGTGTCACCTGTGCTTCAGCGCGGGGGTGTACACTTGGTGTGAGTTTGGAAGCCTTACGTA
AAAGTGGGGTCCAAAGTGCATTGATCCATGGATTACCAAACGAGTCGTAAAACCCCCGTCTTTGCCGTGC
GTTCCCCGTCCGCGCGTTTTAGATTCGATGCTTCTCCGCGGAGTACGGAAACAAAACGAGCTTTACAAAA
CTTTGGGCACTACTCCGGCATCCTTTGCGGCGATTCGTCTCCTTCCACTGAACGCTGCTGTAACTAATGG
CGCGGTTACTGCCTGCAGAGAAATACCAGCGACACACTCCCGTTCGCTTTTGAGGCGCCCTGCGAGTTCA
TTACCTCTACCGGGCGGGCACTATGGTATCGTCACGCGTCACGGTGCAGTCGGCGTGATGTCACCACACG
CTGCCAGTGGATATATCTACGGAAGCTGTAAGTAGGGCAAGCGTTGTCACCTCTGTGCACTTCATCAAGC
ACTCCGAATGAGAGCTTGCACCTAATTCCTCAATACGTAGGCAGAGGCGATGGAACCGTGTGTGTGCATA
TACTGCCCCAGAGGGCGTGCGTGGAAGTCGGCGGTCCACCACGGGGCGGTCAGTCGTGTGCGTCGTGGAT
TCACTTTTGCACAGTTCCGCGAGACTCCTGCAGAAGCAAAAAGTTAATTAAACATTGTTGTTCGTTAATA
ATCTCCGCGCCTGAACAAGGGCATTTAGCGGGCACGACCAGACAAACTGCTCTTTAGCTGCAGTTCTTAG
TGCCACCTTCACATTGCAGGATGGAAAAGAAACTAGACTCCGGGTAAAAGTAGAAGGATACAGGGATTCC
CACAAAAAATTGAACTGTGCAAGGAATTGGTGTTTTATAGATGAAGCACGGACCAGAAAAACAGTTCGCC
TCTCGTTACTCTAAACCGTAGCGTTGCATCGCCAAGCGGGGCGGCACGGTCTGAACTTGTCTACTCCAGT
CGACCTTAGTGCTGCAGAGACATGTTATCTGCGGCTCCGCTGGCGTGCGTTGACATTTGCCAGAAAGTCT
AAAGAGTTACTACACCATACAGCTTCGCAGAAATCCGCAACAGACGGGTGTCTTCGCTCTGGGAATGCAG
GACAGTTGTCC
-
Protein Sequence : Show Sequence
>XP_002368877.1 SAG-related sequence SRS42 [Toxoplasma gondii ME49]
MKLASVAMLLSIFAYASAMDADQATAPKFFKNARKEQQFPFGQYNIVWFSSIRGTGTENIAYVYPGWKVA
IECNNAKNWVPEDFKKLVCEGKGSSCTSKKTLQALFPGVPDSHQWWTGGDGIKEPAVLNVPENVPVSKTF
SFRCEAIEDSKAKDQSYIITLVTEEAPENANFRA
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
Oral immunization of mice with ZJ111/pcDNA3-SAG1 elicited specific humoral responses and stimulated proliferation of splenocytes (P<0.05). Mice immunized with ZJ111/pcDNA3-SAG1 displayed significant protection against an intraperitoneally challenge with 500 tachyzoite forms of T. gondii RH strain. Vaccination at 10(7) and 10(8)CFU per mice provided a 20% and 10% survival rate comparing 100% mortality of the non-immunized mice, exhibiting longer living time and better survival rate (Qu et al., 2008).
|
23. SAG2 |
-
Gene Name :
SAG2
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Nucleotide GI :
8777958
-
NCBI Protein GI :
8777959
-
Protein Accession :
AAF79156.1
-
Other Database IDs :
CDD:309286
-
Taxonomy ID :
5811
-
Gene Strand (Orientation) :
?
-
Protein Name :
surface antigen P22
-
Protein pI :
8.1
-
Protein Weight :
17781.73
-
Protein Length :
242
-
Protein Note :
SRS domain; pfam04092
-
DNA Sequence : Show Sequence
>gi|8777958|gb|AF249698.1| Toxoplasma gondii isolate C56 surface antigen P22 (SAG2) gene, complete cds
AGTGACCCATCTGCGAAGAAAACGAGCGCTGCTTGCGATCCTGTGTGTTGTTTCACGGGTTGCAGTTCTA
GGAACTGAGTTGTGATTGTGCACAATTGCGGTGTGACACCTTCTGTCTCGTTCCAATCTTTGTCTTGTCG
GAACTATGAGTTTCTCAAAGACCACGAGCCTAGCGTCGCTAGCGCTCACGGGCTTGTTTGTTGTGTTCAA
GTTCGCTCTTGCGTCCACCACCGAGACGCCAGCGCCCATTGAGTGCACTGCCGGCGCAACGAAGACTGTT
GATGCACCCTCCAGTGGTTCCGTTGTCTTCCAATGTGGGGATAAACTAACCATCAGTCCCAGTGGCGAAG
GTGATGTCTTTTATGGCAAGGAATGCACAGACTCGAGGAAGTTGACGACTGTCCTTCCAGGTGCGGTCTT
GACAGCTAAGGTCCAGCAGCCCGCGAAAGGTCCTGCTACCTACACACTGTCTTACGACGGTACTCCCGAG
AAACCTCAGGTTCTCTGTTACAAGTGCGTTGCCGAAGCAGGTGCTCCCGCTGGTCGAAATAATGATGGTT
CTAGCGCTCCGACGCCTAAAGACTGCAAACTCATTGTTCGCGTTCCGGGTGCCGATGGCCGTGTCACATC
TGGGTTTGACCCTGTGTCTCTCACGGGCAAGGTTCTTGCTCCCGGTCTCGCAGGTTTGTTGATCACGTTT
GTGTAAAAGAAAGGGCTGATGATTAAGTAGTCAAAAGGTCACACCAAGATATGCACCCCTGAAGAGACGT
CTTTGGGTCAATGGCCTTCTTTCGGAGAAGAGTTGCGAAAGTCGGTGAACGGTGGTCGCCCTCAGGGGTG
CACTTTGTTGTTTTGCTTGAAGATGCTCTTCCTATAAATCTTCCGAAAATGTTTCTCCGCATGACGGGGG
TTGAGCGAAGTTGGTGGTAACGGGAATAATTAAACGGGGATATCATTCCCCGTAGCGGGGTGGATGGGTG
CCTCCGGGGCTGCCGCAGTTCTGTTCTCCGAAGTGACTCCAGGTGGGCCGTGCGGCTTTTGTCTTTTTCG
TGAGAGCGGTCCGACCCTGCAATTCTCATGCCTCCGCTTCGAAATTGTCGTGCAAAGAAAACGTTGTTGA
GGGGTGGGATTGCGATTGTTCTTGGCGTAGATCCTGGGAGGAACGCGAGAAAATGTATTTCCGGATCTGC
GATTATGTGACAGAGGAACTTGTTTGCCCACACACTGCTGCAGTACTGTGCTTTTCCGCCAGACACAACC
AGTGTTCCGGCGGGTGTGCCTTCGTGAAACGTTCTACACATAGAGAC
-
Protein Sequence : Show Sequence
>AAF79156.1 surface antigen P22 [Toxoplasma gondii]
MSFSKTTSLASLALTGLFVVFKFALASTTETPAPIECTAGATKTVDAPSSGSVVFQCGDKLTISPSGEGD
VFYGKECTDSRKLTTVLPGAVLTAKVQQPAKGPATYTLSYDGTPEKPQVLCYKCVAEAGAPAGRNNDGSS
APTPKDCKLIVRVPGADGRVTSGFDPVSLTGKVLAPGLAGLLITFV
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
T. gondii DNA vaccine pSAG1-ROP2-SAG2
|
24. sdfa |
-
Gene Name :
sdfa
-
Protein Name :
SRS domain-containing protein; SAG
|
25. SOD |
-
Gene Name :
SOD
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii
-
NCBI Protein GI :
AAC63943
-
Other Database IDs :
CDD:223678
-
Taxonomy ID :
5811
-
Protein Name :
superoxide dismutase
-
Protein pI :
7.07
-
Protein Weight :
21705.88
-
Protein Length :
258
-
Protein Note :
Superoxide dismutase [Inorganic ion transport and metabolism]; COG0605
-
Protein Sequence : Show Sequence
>AAC63943.1 superoxide dismutase [Toxoplasma gondii]
MVFTLPPLPYAHDALAPHISSETLQFHHGKHHAGYVAKLNGFIEGTAFAGKTLEEVIRTSTGAIFNNAAQ
VWNHTFYFSSMKPPMSGGGGEPTGRLLDEIKKEFTSVENFKDEFSKVAAGHFGSGWAWLVWDKQGKKVGI
EQTHDAGTPITEPMKVPLLCCDVWEHAYYLDRKNDRPAYIKAWWNVVNWDFASKNLENALK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Liu et al., 2017)
|
26. UP |
-
Gene Name :
UP
-
Sequence Strain (Species/Organism) :
Toxoplasma gondii ME49
-
NCBI Gene ID :
7900273
-
NCBI Protein GI :
237830025
-
Locus Tag :
TGME49_110640
-
Genbank Accession :
DS984727
-
Protein Accession :
XP_002364310
-
Taxonomy ID :
508771
-
Gene Starting Position :
1252500
-
Gene Ending Position :
1256433
-
Gene Strand (Orientation) :
-
-
Protein pI :
7.12
-
Protein Weight :
31157.07
-
Protein Length :
303
-
DNA Sequence : Show Sequence
>gi|212659389:1252500-1256433 Toxoplasma gondii ME49 scf_1112359874864, whole genome shotgun sequence
GCGTCCCCCGCATTTCGGCAATCCGCGTTTGAACGAAACAATTGCTTGAGCAGCACGGAACTGCGTTGGC
TCTAAAGGCCGCCTGGTTGTACATATACTTTGTGAAAGCCTTCCTTTCCGCCGACCGTCCACTCGAGGCA
AAAACATGGGGGCGGAGAAAACCTGGAGAGGCACGGAAACGTGTGTACGTCGCCCCACTCATCTCCAGAA
TCTCTATCCCACATCTGAAACCCGCTGACGGTGCCTTTGTTGCGTTTTTGTAGGCCGGCCGCAGACGTCA
GTTTCCAGTGCGGCACGTGGACTGCGAAGCGCTCGGCGGTCCAGTGAACATTTCCAAGCAGACAGCCTCT
GTGTGGACTGCTCTGGACCGGGAGGAGAAATTTACGCTCTCTGTGCACGTAACTAATGACGAAGAACCCC
TAAAACGCTCACACGCAGTCTCGCGGTGCTTTTTTCGGGAGCAGCTCTCCTGCGTGGGAATGAAACCCAT
CATTTGAATTCATGACACGAGGGCCCAAGGCAAATATGGAACCCCAGAACCACCGTTCCGTTCTCTCTGG
TAACGTGGTACTGTGTGCATCATCTGGTTACAGTCCTAGAGTGCGCAGCGAGGACGACGTCTGCGCGAGG
GCGCTGGATTTGCTCCGTTCGTCTTTGTGCGCCGCGTATCCACAGTACTTTCATCACCGGCCTTGATGCC
TCCGAAGTTGCTGCTCATGACCTGCTCAGTTGCTTTACGCCGCAGGCTTGATGATGCCTTCGGAAACAAG
TGTCACAAGGGCATCAAAGGCAGCTTCGCCCGCTGCCAAAGTAGCCTTATCTTGGTCTTCCGCCTAAACG
CGACACACACACACAAAAAAAAAACAAGAAAAGTACAGAGTGACACAGCGTGGAAAGTCACTCCATCACC
TAGTTTGCGCTTCGTTTTCGTTGACACAGGCGTCGGCGCCTGTTTGCGGCGGAGTCTGTTTTGTCGTATC
TCCATGACACAACACTGTCTTTTCTTCTCTACCGAGGCAACCCAGAAGGAGAGTGTGACCTCACTCCTTG
ACATTTCTCCCCTCCTCCTGTTTCCGCTCACCGTCACGTGAGCTGTCAAGTTCGGATTGCTCCGGTTCAC
AAGGCCGATCATGAGAGAGGCGGCGTACGACTTGGGTCCGTTTGGGATGCTGTGCTGTCTCTGGTGCATG
AGATGGAAGATTTGGTGCGTCTCCATCTCCAGACTCACGACCCCCAGGTCTGTCATGTCCTTCAGGAGGT
TCGCGTTATTGTCGTTCCACAGCGGCAACTCTCTGCCCTGAATCGCATGCACACAAGAAACACGGCATGA
CCACACATTCACCTTCTCATCCTCTTACCGGCAATCTTTCGAGGTTCCCTTTACCTACGCGTCAAGCGCA
CTGGTGCGATCACGCGTGCGATAGCGCGAAGGAAAACACGAATCCAGCAAGCCTCGACAAGTGGTGAGGT
ATGTGTACCTGCGCCAGGCATCGCCGATGCAAAAGGGATGAGGAGGACCCTCGGGTCCCTCCTCAATCGG
TGTATGTGAAAAGACACTGTCCCTCCCTTTCGGCTAAGGTTCCACGCCTTCGGTGACTAGACTATATGCG
CTATACACACAAGGTCAACAAGTGTCAAAGTTTGGCCATCAACAGCCAGTGCCAAAAGCACATACCCGCG
TACCGCAGGCGGGGCAGCCGGTAGGCGCTGGTCGTTACCGCCCCCCCCTTGTGTGCCACCTTGGTCCCCC
CTTTCGGAGAGCGCACACGAGTCAGTACAGTCTTCGAAATCACCTTATTTGATTAACGTAACAGCGCAGA
CGCCTACGGTGCACCGCATGTAAACTGTACATTGGATACGTTTCAGCACTTCAGGGTTGCGAGAACCTTA
TAAATGAGAGAAGAGATGTTCGGTCTAGTGTTCCGTTATCCTACATAGATGACGTGGCTTGTAGCACGTT
TTTGTATCGTGTTTGTAGAAACGGATTACTGCTCACCTGACAAGCGAAGAAAGTCTCCGCCGAGCAGTTG
AGGCCTCGTTTGACTGCTGCACCCTGCGCATTCAAGTTGGCTTCGATAAGATCGGTCAAACGCTTGTCTG
CCTTGACCGGCGCTGTCAGCAAGTAGGGTCGCGGGTCGCGCCCGCACTCCCGTTTGTTTCCCAAAGCTGC
TTCGCCGTCAAAGTGACAGTAGTTCCTAGAAACACAAGCCGAAGCAAACCACCCCCTAGGTTTGTAGATC
CGCGAGAGAGTGCGTGGATTCGACAGCGCACGGACACTTCCGGAGATGCGTGTGCACAACCCGCCCCGCA
GCAGAGCACATGAACGACCAAGCCGAACCCGCTGCGGGTGCACAACACAGCAACTACACAATCAGTCAAG
AGTTCCCGGCCAAAATGCCCGATCAACAATCTACGGCCACACATCAGCTGGGGGTACTTCGTCGTCGTAC
GAGCAGTACCGTGGACACAGCCCATGTAGGGCTTTCTGCCTCTTTACAACCGTGAAATGCCCTTGTCAGT
GAACCGGGTCGCAACTACGAGGTGACAAAAAAAACAGAACTGCACGCCTTTACCTCTGCCCTCACCTGTA
GCAGTACATGCTCTCGTCGCTGAGCATGAGAGTACCCGGCCGGGTCGCGTAGTCGACGATTCCACAACTG
CCAATGCGAACGACGGCCAAGGGTTCTCCTTCCAAAACAAAAGAGGCTTCACGAATGAAAAAATCTGCCA
TCGGAGCACCCATGCCAATGCAGACGATCGACATGCGCTGTCCGCCTTTGATGTATTTGCCTGAAAACAA
GCAGAGAAAAACGAATACTAGAGAGTTGTGAACGCCAAAAAACAATCCGAAGAAAGCCACCGCCGACCAG
CAGGAGTTGCCACGAGCTGGAGGTCCTCGGGTTTGTCGAAGCACTATCATGCTATGACACCCCGAAGCAC
ACGACTTAAAAGATCGTTCAAAGCTCCCTCACCCTGTTCGGGTGCTCCCCATACACAAGATCTACGTGGG
GGTGCTCACGCGTCCAGTTCGGTCTATCATCAGTCTGTGGGTTTTCTAAACTCCCAAAAACGGTAAAGGC
AACCGATACGCGTTTTTTCAGTCGATTCACTGCCTCTGTGCAGGTGTGGAAAGGGTCTTCCAACTGACGT
CGCCAGGTCATCTGCCACCGTTCGCTCTCCCATGTTGTAGAATGCAAATCGCTACTTACCCGTGAAGGTG
TAGAATTGTCGCGAAGAGGAAACCTCCGTGACATCCGTAAGGAATTTCGCTGCGAGAACCCGCGCGCGCT
GTTCGCAGCCGACCGTCACGATCAGTGATGCCAAGTCTCCCTTCTTGACGCCCAGATGGTACGTGCGACC
ATCCGGGGTAAGGAAGATATTCTTTCCTTTGAGTTCCGACTGTCAGCGACAAACACACAACCACAGGACA
CGTCGTCATGCCCCCGTGCATAAGCTAGAAGTTTAGATAGCTAAATACCAGGTAAGCTCATGTTGAAAAC
AGGCTAGAGGCAGAAAAAAAAGCCGGAAAAAGATGTGATCTGCAACTGGTAAAGATGCCACTCTTGAACT
GGCAGGCACTACGCTCGTGTCCTGCACCACTGTATACGTCGTCATTGCTGCAAGAGAATCAACTACATAC
TAGGCAAATCTACGGCAAAACCCCTCGTCAAGAACTGTGAGGGAATGGGGCGGAAGCGCCCGCCCTTTTA
AATGCGACAAAGCCAGAAAGAGAAGCCCCGCTGCGTCAGACAAGAGGGGGAACGCAGGCGGACGCAGCCC
CCCGTGAATCAACGCAGAGCGTAGATGCGTGCCCTATCTTGCTGAAACTCACCATTGTACGCAAAAACAG
AGGCACTATATACACGACCTAAAGGATGGCGAAACGTTTCTTCACTTTTGTTTGGAAGACAAAAGGGAAT
GTTCAGGCAGCAGC
-
Protein Sequence : Show Sequence
>gi|237830025|ref|XP_002364310.1| uridine phosphorylase, putative [Toxoplasma gondii ME49]
MSELKGKNIFLTPDGRTYHLGVKKGDLASLIVTVGCEQRARVLAAKFLTDVTEVSSSRQFYTFTGKYIKG
GQRMSIVCIGMGAPMADFFIREASFVLEGEPLAVVRIGSCGIVDYATRPGTLMLSDESMYCYRNYCHFDG
EAALGNKRECGRDPRPYLLTAPVKADKRLTDLIEANLNAQGAAVKRGLNCSAETFFACQGRELPLWNDNN
ANLLKDMTDLGVVSLEMETHQIFHLMHQRQHSIPNGPKSYAASLMIGLVNRSNPNLTAHVTAEDQDKATL
AAGEAAFDALVTLVSEGIIKPAA
-
Molecule Role :
Virmugen
-
Molecule Role Annotation :
A UP mutant, in combination with an OMPDC mutation, is attenuated in mice and induces significant protection from wild type T. gondii (Fox and Bzik, 2010).
- Related Vaccine(s):
Toxoplasma gondii OMPDC/UP mutant vaccine
|
III. Vaccine Related Host Genes |
1. Ccl2 |
-
Gene Name :
Ccl2
-
Sequence Strain (Species/Organism) :
Mus musculus
-
NCBI Gene ID :
20296
-
NCBI Protein GI :
6755430
-
Locus Tag :
RP23-350G1.3
-
Genbank Accession :
AJ238892
-
Protein Accession :
NP_035463
-
Taxonomy ID :
10090
-
Chromosome No :
11
-
Gene Starting Position :
82035576
-
Gene Ending Position :
82037451
-
Gene Strand (Orientation) :
+
-
Protein Name :
chemokine (C-C motif) ligand 2
-
Protein pI :
10.38
-
Protein Weight :
14837.89
-
Protein Length :
148
-
Protein Note :
Also known as JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594
-
DNA Sequence : Show Sequence
>gi|372099099:82035576-82037451 Mus musculus strain C57BL/6J chromosome 11, GRCm38 C57BL/6J
TGCAGAGAGCCAGACGGGAGGAAGGCCAGCCCAGCACCAGCACCAGCCAACTCTCACTGAAGCCAGCTCT
CTCTTCCTCCACCACCATGCAGGTCCCTGTCATGCTTCTGGGCCTGCTGTTCACAGTTGCCGGCTGGAGC
ATCCACGTGTTGGCTCAGCCAGGTGAGACCCCCCCAGCTCCCTTCCCAGCATATCACCCCATTTTTGAAT
TGTCGTGGATTGTGATAGCATAGTCTCACATGGTCAGGTACTTTTTTTTTTTTCTTTAACCAAGATAAGG
AGCATAAAGAAGGAAGGACAAAGAGCCAACCCAATTACAAGATTGCTTCTGGAAAGCAACTAGAATTTTA
ATTGTTAGATCTAAATTTGGAATCACACCTTCATATAGTTCCTGTTCCAGTTACTTCCCTCAGTATTTGG
GAACCTGGGTGATCAAACAGAGGCTTGGGTTGGTGCCTTTTTCCAGATAGAGGAGAAAGGGGAAGAGATC
CAAGATCCGAGCTGTGTTTCACCCAGCCCTGCTTCCAGAGATAGCAGCTTAGCGGAGGTGGTTGGGATCA
GAGATACTCATGATTTGATTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTGCAGCCTACAGTAATGTA
CTCAGGTAATCTTCTCAGGTCATAGTAATTTGACTTCTAACTCCCCCAAATGACAGTCCCCAGAGTCACA
TAGTTTTAATGGCATCCCTCTACCCAAGACTGTGAGCCTACTTTAAGCTGCAAATAACTGAGTCTGTTGT
CAAAGATCACATCCCAGATCTGATGTATTGGCATTTATATCCCATCCTGCTGAAACTGCCTTCTCCCCGT
GGTCCTTCTCTTCTCTAAGGTCAGAAGCATCTTTCCTGTCCTAATGTGCTTCTCTTTTACTCTCCAGATG
CAGTTAACGCCCCACTCACCTGCTGCTACTCATTCACCAGCAAGATGATCCCAATGAGTAGGCTGGAGAG
CTACAAGAGGATCACCAGCAGCAGGTGTCCCAAAGAAGCTGTAGTGTGAGTTACATACCCCGGCCCTCCC
TGGTCCAAAGGTTTTTCCTTAAGAACAAGGGATGGTCCTCATATACTTATAGTCAGTCACACACTCAGAT
CCAATGGGGAAACCAAGGCCAAGAAGGCAAAGGCAGTTCTCAACAGCATTGTCTCTATGGCTGCTGTTCA
GGCCCTTTCTACTCCACAAGCTTATCTTAGAAAACCTGCAGGAGAAGCAGGTCACTTTGAGTCCCCTTTT
TCTACCTGCCCTCCCCCGCTGAGCTCTACACAGCCCCTCCATGTATACCAGACTGAACTTCATCTAACAG
TGTCTTTTCTCTTCCCACAGTTTTGTCACCAAGCTCAAGAGAGAGGTCTGTGCTGACCCCAAGAAGGAAT
GGGTCCAGACATACATTAAAAACCTGGATCGGAACCAAATGAGATCAGAACCTACAACTTTATTTAAAAC
TGCATCTGCCCTAAGGTCTTCAGCACCTTTGAATGTGAAGTTGACCCGTAAATCTGAAGCTAATGCATCC
ACTACCTTTTCCACAACCACCTCAAGCACTTCTGTAGGAGTGACCAGTGTGACAGTGAACTAGTGTGACT
CGGACTGTGATGCCTTAATTAATATTAAACTTATTTAACTTATTGATGTTATGGTATTCCCTTTCATGAA
TACTAAAATTTCTTAAATGCAAGGTGTGGATCCATTTTTCCCTCTCTGTGAATCCAGATTCAACACTTTC
AATGTATGAGAGATGAATTTTGTAAAGATGAATGGGTAAACTTTGTGTTTGAGATTCCAAGGTATTGTTT
AAAATATTATTATGGATATTCCTTATTATTAAAAGAAATATATTATTTTTGTACAC
-
Protein Sequence : Show Sequence
>gi|6755430|ref|NP_035463.1| C-C motif chemokine 2 precursor [Mus musculus]
MQVPVMLLGLLFTVAGWSIHVLAQPDAVNAPLTCCYSFTSKMIPMSRLESYKRITSSRCPKEAVVFVTKL
KREVCADPKKEWVQTYIKNLDRNQMRSEPTTLFKTASALRSSAPLNVKLTRKSEANASTTFSTTTSSTSV
GVTSVTVN
-
Molecule Role :
Vaximmutor
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
2. Ifng (Interferon gamma) |
-
Gene Name :
Ifng (Interferon gamma)
-
Sequence Strain (Species/Organism) :
Mouse
-
NCBI Gene ID :
15978
-
NCBI Protein GI :
33468859
-
Genbank Accession :
NM_008337
-
Protein Accession :
NP_032363.1
-
Other Database IDs :
MGI:107656; UniProt: P01580
-
Taxonomy ID :
10090
-
Gene Strand (Orientation) :
?
-
DNA Sequence : Show Sequence
>gi|145966741|ref|NM_008337.3| Mus musculus interferon gamma (Ifng), mRNA
ATAGCTGCCATCGGCTGACCTAGAGAAGACACATCAGCTGATCCTTTGGACCCTCTGACTTGAGACAGAA
GTTCTGGGCTTCTCCTCCTGCGGCCTAGCTCTGAGACAATGAACGCTACACACTGCATCTTGGCTTTGCA
GCTCTTCCTCATGGCTGTTTCTGGCTGTTACTGCCACGGCACAGTCATTGAAAGCCTAGAAAGTCTGAAT
AACTATTTTAACTCAAGTGGCATAGATGTGGAAGAAAAGAGTCTCTTCTTGGATATCTGGAGGAACTGGC
AAAAGGATGGTGACATGAAAATCCTGCAGAGCCAGATTATCTCTTTCTACCTCAGACTCTTTGAAGTCTT
GAAAGACAATCAGGCCATCAGCAACAACATAAGCGTCATTGAATCACACCTGATTACTACCTTCTTCAGC
AACAGCAAGGCGAAAAAGGATGCATTCATGAGTATTGCCAAGTTTGAGGTCAACAACCCACAGGTCCAGC
GCCAAGCATTCAATGAGCTCATCCGAGTGGTCCACCAGCTGTTGCCGGAATCCAGCCTCAGGAAGCGGAA
AAGGAGTCGCTGCTGATTCGGGGTGGGGAAGAGATTGTCCCAATAAGAATAATTCTGCCAGCACTATTTG
AATTTTTAAATCTAAACCTATTTATTAATATTTAAAACTATTTATATGGAGAATCTATTTTAGATGCATC
AACCAAAGAAGTATTTATAGTAACAACTTATATGTGATAAGAGTGAATTCCTATTAATATATGTGTTATT
TATAATTTCTGTCTCCTCAACTATTTCTCTTTGACCAATTAATTATTCTTTCTGACTAATTAGCCAAGAC
TGTGATTGCGGGGTTGTATCTGGGGGTGGGGGACAGCCAAGCGGCTGACTGAACTCAGATTGTAGCTTGT
ACCTTTACTTCACTGACCAATAAGAAACATTCAGAGCTGCAGTGACCCCGGGAGGTGCTGCTGATGGGAG
GAGATGTCTACACTCCGGGCCAGCGCTTTAACAGCAGGCCAGACAGCACTCGAATGTGTCAGGTAGTAAC
AGGCTGTCCCTGAAAGAAAGCAGTGTCTCAAGAGACTTGACACCTGGTGCTTCCCTATACAGCTGAAAAC
TGTGACTACACCCGAATGACAAATAACTCGCTCATTTATAGTTTATCACTGTCTAATTGCATATGAATAA
AGTATACCTTTGCAACC
-
Protein Sequence : Show Sequence
>gi|33468859|ref|NP_032363.1| interferon gamma [Mus musculus]
MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQI
ISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQ
LLPESSLRKRKRSRC
-
Molecule Role Annotation :
IFN-gamma plays a critical role in Th1 type immune response. It is important for protection against infections by various viruses and intracellular bacteria.
-
Additional Molecule Role :
Vaximmutor
-
Additional Molecule Role Annotation :
The experimental data demonstrated that three time vaccinations with BCG in BALB/c mice induced strong TB Ag-specific IFN-gamma immune responses in splenocytes (Wang et al., 2009).
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
3. IL-6 |
-
Gene Name :
IL-6
-
Sequence Strain (Species/Organism) :
Mus musculus
-
NCBI Gene ID :
16193
-
NCBI Protein GI :
13624311
-
Genbank Accession :
AC112933
-
Protein Accession :
NP_112445
-
Taxonomy ID :
10090
-
Chromosome No :
5
-
Gene Starting Position :
30013160
-
Gene Ending Position :
30019967
-
Gene Strand (Orientation) :
+
-
Protein Name :
interleukin 6
-
Protein pI :
7.5
-
Protein Weight :
23291.86
-
Protein Length :
211
-
Protein Note :
Also known as Il-6
-
DNA Sequence : Show Sequence
>gi|372099105:30013160-30019967 Mus musculus strain C57BL/6J chromosome 5, GRCm38 C57BL/6J
ACCAAGAACGATAGTCAATTCCAGAAACCGCTATGAAGTTCCTCTCTGCAAGTAAGTGAAGGCAGTTCCT
TGCCCTCTGGCGGAGCTATTGAGACTGTGAGAGAGGAGTGTGAGGCAGAGAGCCAGCATTGTGGGTTGGC
CAGCAGCCATCAGCTAGCAGCAGGCGCCCAACTGTGCTATCTGCTCACTTGCCGGTTTTCCCTTTTCTCC
ACGCAGGAGACTTCCATCCAGTTGCCTTCTTGGGACTGATGCTGGTGACAACCACGGCCTTCCCTACTTC
ACAAGTCCGGAGAGGAGACTTCACAGAGGATACCACTCCCAACAGACCTGTCTATACCACTTCACAAGTC
GGAGGCTTAATTACACATGTTCTCTGGGAAATCGTGGAAATGAGAAAAGAGGTGGGTAGGCTGTGAAACT
GATGAAGACCCAGTGTGGGCGTCCATTCATTCTCTTTGCTCTTGAATTAGAAATTCTCTGCTGGGATCTA
GGGCCCTTAGGATTTGAAGCTAAAGGTCAGACTAGACTGTGTTCTCTCTTTCTCACCTCTTTGCTGGTTT
TGAGTGGAGGTTGGGAAGGGGTTCCTTTCCTGTCTGGAAGATACAGAATGTGACTGCATTTCTAGAAAAT
TCACAGTGGGCCATTCTCTGTTCCAATTTAGCTATTGCTTCTTAGGTGGGGATTCCTTTTCCCTCATTAT
TCCTTTTTCCTTATCTCTTTGCCTTCATTTATCCCTTGAAGTCTACAAGGACCAGAAAGTGCTTTTTGGC
TGAATGTAGTAAGTTCTGTGTGTGTGAAATCAGGATGCTCTAGGGTCAGCCCAGATAAGATGCATATTGT
ATAGAGCCCAATAAAGTGCTAACACACACACACACACACACACACACACACAACCTAGATTAGGCTGGGC
ATGGTGGTGGATGCCTCCCAGCACTTGGGAGGCACACGCAGGAAGATCTCTGTGAGTTAGAGGCCAGCTT
GGTCTACATATTGAGTTCCAGGATATCCAAGACTACATTGAGAGATCCTTTCTCAAAAAAAAAAAAAAAA
AAAAAAAAACAACAACAACAAACAAACAAACAAACAAGAAAAAAAAAACCCAACCAACCCTACCTAGATT
AAAATATCTCCCATCTTTAAATGAAAAGTATTTTGACTCTGCTTGACAGAAAGGAAAAAAAAAATCACAA
ACAAGATTAATAGCCTAGGTCTGGGTGTGTAGAACCAACTTTGTAATCTTGGGAAAATCCTCAACTATTT
AGTACTCTTTATCTGCATAATTATGGAGTTACAGATAATGGCACAGACCCTTCCAGATGGAATATTCTGT
GACTTAAATTTATTTGCCCCAAGATATCATCAAAATTTCTGTCCTTTACCAAGTTCCTACTCTATGCTGG
GCAGTTTTTATCGTTGAATCCTTGAGACAAATGTATAAGAGGGACATCAATAATTCTTTATTGAAACATA
GGAAATACTTAGGAGAGTAACAAGCTTAAAGCCAAGGGACTGAGCCTAAGGGTGCATTTTTATTTATTGG
GCTGCTTAGTAGGGTTCTAAGAAGGTATAGCTTCCCTTTTCTGTGTCCTGGCTATGAAAGAGCATGACTT
GGCCCTCTAGTGGTGCTTGTTGTAAGAGGTGTTTAAGTGATTGCTCTGGTAATCTTTTGCAGTTGTGCAA
TGGCAATTCTGATTGTATGAACAACGATGATGCACTTGCAGAAAACAATCTGAAACTTCCAGAGATACAA
AGAAATGATGGATGCTACCAAACTGGATATAATCAGGTAGAAACTTGTCACGTTTACTTTCAACAATTCT
TCAAGGTTCTCTCTTGCACGTGATACCTGCATTTGTACAGTCCCAGTCAGGCAACAAAGATGGGGGGATA
CATCCAATACCACTTGGATGTAACTGGCCTGCAGTAGCTTGAATACAAAAGGAGATTGAGAGGTACCTCA
GCAGCTGCTAGGGTGAGGGAAAGTTTACCAACCAGTGCTATAAATGTTCACTCAATCTATGTCCATCAGG
AGCTAAATGTTTAAAGTCTCTATTCTCATCTTGGCTTTGAGGTGTTAGATGATTAAAAAAAAAACATTTT
TTTTGTCTAAAAAAGTGGAAGAGTAGATATAAAACATGTTATGTAAACGTCATGAGGAAAGTAACTTACA
GATTTAATTAAAAAGCAGTTTATTTAAACAGGTAAAGGCCCACTATGCTGGGATTCTTCACCACTGTTAA
ATGTTAGAAGTCATAGCAAGTTTAGCTAGTTCATGAGCCATCTCTTCTCTGGCTGCCCCTGGAAGGATCC
AGGCCTACACTCCCTACTGAGAACACTCTTCACACCCCTCTCCTTCCAGCCGGTGAGATAGTCTACATCA
GGTCTCAGGACAAGTCAGACAAGAACAAGAGTACAGGAAGGGCACTGCAGGATAGAAGGGAAGGAGTGAG
GGTCAGAAGTGGATTCCCACTGCCACACTCTGGGGTAGGGGGTGGGGGGATATTAAGTGGTGCCTCTCTC
TACTTGTCCAGATAATTCAGGAGGTCAGCTGATGCTGCCTGTTGTCTAATTCTGTAGAAGATACTGAACA
GCAGGAATCTTTTTTTCAATTTTTTATTAGATATTTTCTTCATTTACATTTCAAATGCTATCCCCACAGT
CCCCTATACCCTCCCCCCCCTCCCCGCTCCCTTACCCACCAACTCCCACTTCTTGGCCCTGGCATTCCCC
TGTACTGGGGCATATAAAGTTTGCAAGACCAAGGGGCCTCTATTCCCAATGATGGCTGACTAGGCCATCT
TCTGCTACATATGCAGCTAGAGATATGAGCTCTGGGGGTACTGGTTAGTTCATATTGTTGTTCCACCTAT
AGGGTTGCAGACCCCTTCAGCTCCTTGGGTACTTTCTCTAGCTCCTCCATTGGGGGCCCTGTGTTCCATC
CAATAGAAGACTGTGAGCATCCACTTTTTGCCAGGCATTGGCCTAGCCTCACACGAGACAGCTATATCAG
GGTCCTTTCAGCAAAATCTTGCTGGTATATGCAATACTGTCTGGGTTTGGTGGCTGATTATGGGATGGAT
CCCTAGGTGGGGTAGTCTCTGGATCTTCCATCCTTTTGTCTTAGCTCCAAACTTTGTCTCTGTAACTCCT
TCCATGGGTATTTTGTTCCCCATTCTAAGGAGGAATGAAGTATCCACATGTTGGTCTTCCTTCTTCTTGA
TTTTCTTGTGTTTTGGAAATTGTACCTTGGGTATTCTAAGTTTCTGGGCTAATATCCACTTATCAGTGAG
TGCATATCAAGTGACTTCTTTTGTGATTGGGTTACCTCACTAAGGATCATACTCTCCAGATACATCCATT
TGACCAAGAATTTCATAAATCCATTGTTTTTAATAGCTGAATAGTACTCCATTTGTAAATGTACCACATT
TTCTGTATCCATTCCTCTGTTGAGGGACATCTGGGTTCTTTCCAGCTTCTGGCTATTATGAATAAGGCTG
CTATGAACATAGTGGAGCATATGTCCTTATTACCAGTTGGAACATCTTCTGCGTATATGCCCAGAAGAGG
TATTGCTGGATCTTCCGGTAGTACTATGTCTAATTTTTTGAGGAACAGCCAGACTGATTTCCAGAGTGGT
TATACAAGCTTGCAATCCCAACAGCAATGGAGGAGTGTTCCTCTTTCTCCACATCCTTACCAGCATCTGC
TGTCACCTGAATTTTTGATCTTAGCCATTCTGACTGGTGTGAGGTGGAATCTCAGGGTTGTTTTGATTTG
CATTTCCCTGATGATTAAGGATGTTGAACATTTTTTCAAGTGCTTCTCAGCCATTCAGTATTCCTCAGTT
GAGAATTCTTTGTTTAGCTTTGTACCCCATTTTTAATGGGGTTATTTGAATTTCTGGAGTTCAGCTTCTT
GAGCTCTTTGTATATATTGGATATTAGTCCCCTATCAGATTTAGGATTGGTAAAAATCCTTTCCCAATCT
GTTGGTGGCCTTTTTGTCTTATTGACAGTGTCTTTTCCCTTACAGAAGCTTTGCAATTTTATGAGGTCCC
ATTTGTCGATTCTCGATTTTACTGTACAAGCCATTGCTGTTCTGTTCAGGAATTTTTCCCCTGTTCCCAT
ATCTACGAGGGTTTTTTTCCCACTTTCTCCTCTATAAATTTCAGTGTCTCTGGTTTTATGTGGAGTTCTT
TGATCCACTTAGACTTGAGCTTTGTACAAGGAGATAAGAATGGATCAATTCGGGCTGGAGAGATGGCTCA
GTGGTTAAGAGCACTGACTGCTCTTTCAGAAGTCCTGAGTTCAAATCCCAGCAACCACATGGTGGTTCAT
AACCATCTATAATAAGATCTGATGTCCTTTTCTGGTGTGTCTGAAGACAGCTACAGTGTACTTACATGTA
ATAAATAAATAAAACTAGATTATTTAAAAAAAAAAAAAAAGAATGGATCAATTCACACTCTTCTACATGA
TAACCACCAGTTGAGCCCGCACCAATTGTTGAAAATGCTCTCTTTTTCCCACTGGATGGTTTTAGCTCCC
TTGTCAAAGATCAAGTGACCATAAGTGTGTGGGTTCATTTCTGTGTCTTCAATTGTGTTCCATTGATCTA
CCTGTCTGTTGCTGTATCAATACCATGCAGTTTTTTTTATCACAATTGCTCTGTAGTACAGCTTGAGGTC
AGGCATGGTGAGTCCACCAGAGGTTCTTTTATTGTTGAGAATAGTTTTTGCTATCCTAGTTTTTTTTTTT
TTTTTTTTTTGAACAGCAGGAATCTTATTCTCAAATTGAATCTATTCCTAGAAAGAACTGACTTCCTTTT
CCATTTTACTTATAGGAAATTTGCCTATTGAAAATTTCCTCTGGTCTTCTGGAGTACCATAGCTACCTGG
AGTACATGAAGAACAACTTAAAAGATAACAAGAAAGACAAAGCCAGAGTCCTTCAGAGAGATACAGAAAC
TCTAATTCATATCTTCAACCAAGAGGTGAGTGCTTCCCCATCTCTCATGCAGTGTGGGAAAGAGGACACC
CGGCACCTCAGGGTAGCGGCACTTTTTCCAGACAGCTGCTCAGAAGGGAGAGAGTCTGAACAACAGTTCT
TGATTATAAGGCCTTGCTTTGTTTTACTTTGGGGTTTTGTTTGAGGTTCTCTTTTGCAAAGAACATCAAT
ACCTGCTTTAAACTGTATTAATAGAATGTTACTAATTGCGTAAGAGGTATGAAAACTATGACAGCCATAC
ATAGTCACCCATTATGAGAGCACAGAGACAAAAGTGACTTTAATATTTAATCCTTGGCAAGTGACATTTT
TGTAACCAGAGTTCTAATGCAGAGAAGTAGCCAAAAGCTAAAATGTCAGGGAAGGAAGGGATCAAGGGCT
TCTGGCTACCATTAGCCAGAAGAATGGTAGATATGGAGGATTAATGACTCAGAGTGTGGGCGAACAAAGC
CAGATGCAATAAGAAGGGCCTGGAATGAAACCCTCTTGCTAAGGCTGCTTTTGCCACTTGTAGTTTCTTG
CCTTAAACCAGAGAGTTTCCCAATTTAATGTGCACAGGAACCACTTAGGGTCTTGTTCCAGCAGGGTCTT
ACTTAGGAGGTCTAGGAAGGGAACTAAGATTCATTTTTGTAAACAGCTGCTTGTTTATGACCCTGCTATA
TAGTATTCAGGCTCCTAAGTAGTGGGGCAAGCCTTCCAGTTAGTCTTCCCCATGCCAGTGGGCCCATGGA
AGGGTGTTTCCAGACTTCTTCATGCTACCACACTAAGAGACTCTCAACAGAGTCTGAATGGAAACCACGA
AGGAACACATTTGTTTTAGATTCCTCTGTGCCACCTTTACTGATGGGAGCTTCTGTTTTCCAGTAGAATA
CAGTATGTTAGCATGGATGCTTGGATAACAGACAAATAAGATGGTGGTGCTGACCTCTGGACGCTTACTC
TCTAGTGGCAGACAGAACAGTAAGGTTAGAATTCTGTTGCTATTAAAAAACTAATAATAATCACCTTGAA
AAAGAATGGAGTTGTTAGGCATGGGTCTCTCTCGAGTAAGCTTGGAACAAAAGCATCTCCCCTGGCTTGG
GTGAGTCAAAGCAGATGGACTTAGCTCGTCTCATTCATTCTAAATTAGAACTTCTTCCCACAGCCCAGAA
CACGCCACAAGAAAAAAAAAATGTGCAATATTTAACCAGTCTTTGTTTTTTCCTCCTTTAGGTAAAAGAT
TTACATAAAATAGTCCTTCCTACCCCAATTTCCAATGCTCTCCTAACAGATAAGCTGGAGTCACAGAAGG
AGTGGCTAAGGACCAAGACCATCCAATTCATCTTGAAATCACTTGAAGAATTTCTAAAAGTCACTTTGAG
ATCTACTCGGCAAACCTAGTGCGTTATGCCTAAGCATATCAGTTTGTGGACATTCCTCACTGTGGTCAGA
AAATATATCCTGTTGTCAGGTATCTGACTTATGTTGTTCTCTACGAAGAACTGACAATATGAATGTTGGG
ACACTATTTTAATTATTTTTAATTTATTGATAATTTAAATAAGTAAACTTTAAGTTAATTTATGATTGAT
ATTTATTATTTTTATGAAGTGTCACTTGAAATGTTATATGTTATAGTTTTGAAATGATAACCTAAAAATC
TATTTGATATAAATATTCTGTTACCTAGCCAGATGGTTTCTTGGAATGTATAAGTTTACCTCAATGAATT
GCTAATTTAAATATGTTTTTAAAGAAATCTTTGTGATGTATTTTTATAATGTTTAGACTGTCTTCAAACA
AATAAATTATATTATATT
-
Protein Sequence : Show Sequence
>gi|13624311|ref|NP_112445.1| interleukin-6 precursor [Mus musculus]
MKFLSARDFHPVAFLGLMLVTTTAFPTSQVRRGDFTEDTTPNRPVYTTSQVGGLITHVLWEIVEMRKELC
NGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHSYLEYMKNNLKDNKKDKAR
VLQRDTETLIHIFNQEVKDLHKIVLPTPISNALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQ
T
-
Molecule Role :
Vaximmutor
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
4. Il12b |
-
Gene Name :
Il12b
-
Sequence Strain (Species/Organism) :
Mus musculus
-
NCBI Gene ID :
16160
-
NCBI Protein GI :
6680397
-
Locus Tag :
RP23-388G23.1
-
Genbank Accession :
AL607030
-
Protein Accession :
NP_032378
-
Taxonomy ID :
10090
-
Chromosome No :
11
-
Gene Starting Position :
44400062
-
Gene Ending Position :
44414016
-
Gene Strand (Orientation) :
+
-
Protein Name :
interleukin 12b
-
Protein pI :
6.5
-
Protein Weight :
35952.67
-
Protein Length :
335
-
Protein Note :
Also known as p40; Il-12b; Il12p40; Il-12p40
-
DNA Sequence : Show Sequence
>gi|372099099:44400062-44414016 Mus musculus strain C57BL/6J chromosome 11, GRCm38 C57BL/6J
CAGAAGGAACAGTGGGTGTCCAGGCACATCAGACCAGGCAGCTCGCAGCAAAGCAAGGTAAGTTCTCTCC
TCTTCCCTGTCGCTAACTCCCTGCATCTAGAGGCTGTCCAGATTCAGACTCCAGGGGACAGGCTACCCCT
GAACCAGGCAGCGTGGGAGTGGGGTAAGTGGATTCTGGGAGCATCTCGGATGGCTTTCCCCGCTGGTGGA
AACCAGGGGCTTTGACGACAGGGGCTTCAAATAGTCATTTAAAAAGTCAGCTAATTACAGATGTGATGGC
GCACACCTGTAATCTCCAAATCTGGGAGGCAGGAAACAGAATGCACAGGAGTTTAAGGCCAGATTCAGCT
GTGTAATGAGTTTGAGAGAGTCTCAAAAAATTGAGCTACTAATAATATGTGCCAAGCATTGTGGACAGAT
GTGTATTTGATAGAAAGGTTTGCTTTGTCTATATAGACACATATACTATGTGCATTTTCTTAAGTATTAA
TGCATATGTGTTAAGGAGTGTTGTTAAAATTCTGTTCTTGCCTTAAGAGTGAAACTTAAAAAAAAAAAAA
GCCTTTCATGTACCCCTTCAAGCCTAAGCTCATCACTGAATGTCCTACCTGTGATGGCCTTTAGAATCAG
CTATGATAATCAAAGTGGAGAGCTGGGTTTGGGGGTTCCTTTGGATTTTAACTAACTTTGCCACCTCTTC
AAAACTGGAAAGCCCAAGGCATGTTCCAAACTATTTCCTAAAGGGTTCTAAAATCTGTGAGAAAGGGAAG
GCTAATCTTCATGGGTTGGCTTCCTCTGCTTGCCCAGGTGAAATCATGAGCACCAGATGGGGCAGGGTGA
TGGGGCAGGGTGACATCTTGCTTTCACCCAGGGATCACTGAGCCTCAGCTGGGGGCTCCGTTTGTTCAAG
CAAGGCATTTCAAGATGAAGTTAGGTCACCCCCAAGAATTCATTTTGCTGAGATCTGAAATACTGTGATT
ATTGCACCAACAATCCATGGACTCTCTCTAGGCTAGATTCTGGATATAAGACTAGACAGATATGACCTCT
GTCACACACCTCGGTATGGGAAAGGGGGGACAGACATTAAAGACGTAATCAAATGATTGTCATTTCAGCG
ATGCTGAAGGGGAAGAGTAGCTATTTGGGGTCCTGTTTTCATTTGGGGCTCAAGCTGGCACTTTCTGTGG
ATCATTTCATGAACTCCTAACCTGACAGAGTTATTTTTAATCTAGGAGTACAGGCTTGACAAAGTCAACA
CAACTTGTCAAGGTCACATAACTAACAAGTGGCAGACTGAGGTCTGTTTGGCTGTAGAACCAAGGCCCTT
TGCCCGTGCCCTCCTTGCCATCCCTGACAGCCACGCCATCTGTACTGTGCATTGTTGTTTCTGGGCATTT
TTATTTTTACATATCATTTCTCTTTTAAATTAAAGAATAACAGAATGAAACTTGCAAAAGGGATGTCCAC
TCAGGCACCCGCTGGCAGCAATGTTTGGAAGCATTTGCATGCTCTAGGGAGCTAGAGTATCCAGCCCAGG
GTTCCTGTGCTCTTTGCACAAGACTTTCAGGACTTAAGAAAACTAATGAAAACAAACAAACAAACAAACA
AACAAAAAAGAATTGTTAAAACATAGCATATGGAAGAATTGTGGAGTGAGAGGGAAACAAAGCCCAGCAT
CTGCCAATCAGCCTGAAAGCCAAAGCCTGGCTACATACTGCACACTTTTTTGCTTGTGCAGATTTGATTA
AGAGGCGACCTGCCATCATCTCCACCCTCTGCTGGTCTTCTATGATCTAAGATGTAGGTGATGCCGAAAT
GAAGATTGTTCCTTGGACCATTGCCAGGGCTCCCTTCAGCCTGAAATATGGTTCACGTGTGATGCTCAAG
TGCATCTGAGGCTGACAGAGGAAATGCTTGGCATGTAGCCAAAGGGGAAATCCCTGTGTTGAGAGCATAT
GAAGAGATCACCAGGAGATGCCAGGAATCTCTGCCTTTTTTCCCTGCCCAGAGTCCTACCATCTGGGTTT
CACAGCCGTGTATAATTGCATCACCTTCTCTGGGCATTTCTCTCTACAGCCTGGCAGATTTTTATTTTTC
AACCCAGTGTGCACAAAACAGAAAGAATTTCAATTTTTTTCCTTAGCTTTTTACTAGTGCAAGGTATTAT
ACAATGTCATCTCACTGCATGCCCAATAGCTCTTGAAGATCACATAAGCCTTATGTCTTTTTATATGAAG
GCAGTCGGGCTCAGAGGAACTAAACCAACACCAAACAGCTACTGAGTAGTAGGGCCAGAATCCAAGTCCA
TGTCTGCTTGACTCCAAGCCTATGAATGTAGCAACCAGCACCATTTCAGCTTGTACTTGTCTTGACTATA
TGATAATTTGGACCTAGACATGTCCTGACTCCTAGTCCTGTCTCTGTCATGAAAAAGAAATCATAGCAGG
GCCCTCAAGAGGTTAGCAGTACTTCTGTTCTCTCAAAGGTCGTGATTTCTGACCAAGGCCTGTTTATTTT
TAAGGCATTTGCCTATAACATTTAAGCCTTAATTCATATGGGTTAGACTGTGGTCTCTCAAATCTTGTTC
CTGACGGGCGGTGGCACCCTCCAGGATAGATGAAAAGTATTTCTGAAGGGAATTAGTAATCTACACTGAT
TATCTCAACCACATTTATGAGTGAGGTATAATCTTTACAGTCTAAAGGTTTGTGTTGCCCTGGTGTTAAT
CTAGACTGGGTTACAATACAGGATGGTTACTGACTTATCTATTTCATGATAGGTTAATCAATATGGTACA
GTCTTCTGCCAAAGAACACCTTGAATTTTAGGAGTTCTGGACTCTCAAACCTAGCTAGCACATTTGCCCT
CACAATGTGTTCAATGGATCATAACATCAGCTTTCAGCACCTCCAAGACATGTTAAGTCAGACACTCTGT
TCTGGGCTGAGACCCAACAGTCTCCGTGAACCCAGGTTATACACACACCCAAGCTTAAGAAATGCTGCAT
TTTGTTGTGAGGGAGAGAATTATTTTAGAATTTGGAGTAATCTCTGCCTAGGTTTAAAAAAACCTAATCC
ACTACAGGTCCTTGTCAGAACTTGAAAGTTTACCCTGTGTCACCTTTCCCACACCTAAGCTGGTCCTCTA
GCCTGGGGCATCCCAGTGCCTACTGCACAGCAGGGTGATTCGGATGCCCAGTGACACTGTTCTCGTCCAT
ACTGGCAGCATGGCAGTACTTTCCCATTCTGTTCAAAGCTCTTTGGGTATTATGTTAATATTACAATCAT
AACTAAGGAAATATCTGATGACTGTGGACCTGGGAAGCCACGGTCATCTCTAAGTTTATGTTTCTGAACC
TTAAAAAAAAATAAATAAGATGGGTGTGGTGGCTCTCGCCTTTAATCCCAGCACTCAGGAAGCAGAGGCA
GGTGGATCCCTGTGAGTTTGGGGTCAGCCTTATCTACATAGAGTTCCAGGACAACGAAGGCTGAAAGTCT
GTCTTAAGAAGAGGGAGGGAGGAGATGATTGTGGATATCAGGAAGACAGTTCAGCAGGTCACATTACTTC
TGCACAAGCCTGGTGACCTGGGTTTGAACCCTGAACCCAGAGTGAAAGGAGACAGTCAACTCCCAAAAGT
TGTCCTCTGACCTCCACACATGCACACATACAATAGTCATACATCAATATATTTTTAAAAAACAAAATGG
TATCAGGTAGCTGGGCCCTATGATTATTTAAGCTCCAGGTAGCCTCTAGTTCTTTATTTGGAGATGTTTT
TACCCAAATCTAGAAGAGACCTCCTATAATCCTGGTCCAACAGTGTGAAAAGAAAGGGGAAAGTGAGTAT
TTGGAAGGCAGATAAGCTGTTGATCGGGTTAATTGGATAACAGTTGACATTCTCTCTCCCATTTCCCCGC
CTTTTCCTTCTCCTCTGCTCCCCTTCTTCCTCCCTCCTGCCCCTCCTCCACACAGATGTGTCCTCAGAAG
CTAACCATCTCCTGGTTTGCCATCGTTTTGCTGGTGTCTCCACTCATGGCCATGTGGGAGCTGGAGAAAG
ACGGTAAGCAGCCTTTTCCCTGTTTTCTTTGGAGCGCCAGCACCTAAACTTGATCTCCAGGCAGCCTGCT
GGGAAGGGATAGTGAAGTCTGAAGTAGGCAACCGTGCATGGGATTGTCTCAGGAAAAATCCTCAGGGAAG
ATGGAGGGTTAGCGTCTCTTCCTCCACCTATCTCTCTCCCTTGTTTGGTTTTCATGTTGGATGACAGGAA
AGGAGTTTCAGGTGAACTATGGTGGTGTGTGGGATATGATCTTGGCCTTAGATACCAGAAAATGACTCTT
CTAAACAATTGAAATTCCCTAATAGAGAATTTGTAACGTAGCAAGATTGTCTTCTACCCTCTCTTGTCTT
GCATATTACAACGTGCTCTCAGTGGGCACCATGATGGTTGTCCTCTGGCTATTTTGGGATTGGCATTCAC
ACTGACTTGGTTTCAGGTCATGGCTCTGCCAGGTATTGATACTGAACCTTTGAGGCTGGGTAGTCTTGTG
ACCTCAGTTTTCTTTCCTTTTTTTTTCCCCCAGACAGGGTTTCTCTATATAGCCTTGACTTGTCCTGAAA
CTCACTCTGTAGACCAGGCTGGCCTTAAACTCAGAAATCTGCCTGCCTCTGCCTCCCGAGTGCTGAGATT
AAAGGAATGCACCACCACTGCCTGGCTGACCTCAGTTTTCTTAATTGGGTGTTCAGTATAGCACAGCCCA
CATGGACTATTGAATATGTTAATAAATACAGAAAATAACATATGGTAGAGTGAGCAAGCACTATTATTTA
AAACAAAAAGTCTCTGAACTTTTCATTATCCCAATGGCAATAAGATTATTAGTAGACAAATAATGAAGGC
ATAGAAGGGGGTGCTCTCTGTCCTCTGTCCTTGTGCCATGTCACAGTTAGCAAATGTCCATCAACTCAGT
CCTCAGATGGTCGTCACAGGATCTCAAATGTTTCATGGAATACAAGGTAATCAAGTCAGGAATTTCTGCT
TTTATAGCTACACTTTAGTAATAATTAATATTTATTTAACACTCAATTTCGCAACAACCATGTAAAGTAG
GAGCTATCTGTATTCCATTTTACAGATAGTAAAAACTGAGGTTCAAGAGGCTAAGTAAGTTTCCCACAAG
GTCCAGAATAGAACTTGATCCCAGTTTAGTCTCACTTCAGAGCCTGTGTGCTTAAATGCTAGATTTTACA
AGTAAGGCGTGAAGCAACTATTTCCTGTGGCCATAAAGAGGAAATGGGTGTAAATTATAAATGAAAAGAT
TTCCCAGCTGCTGATTAGAAATAATCTTCTGAGAATCCAGGAAAAAAAAAAAAGGTGAGCCTTTTTTTCA
TTCTGAAGAATTACAAGAGTTTGAACGATATTCGCAGGTAAAGGTGCTTGCCACCAAGTCCGATGACCTA
GACTTCATCACTGCGATCAGCATGATGGAAGGAGAGGATCGAGTTCTCTAAATTGCCCTCTGCTCTCAAG
ACATGAGCTGTGACACCTGTGCACACACACACACACACACACACACATGAAAGAATTAAATGCAACTTTA
AAAAGAGTAATCTCCAGCCTGGCCACCCACGCCAACAGAATTTTGGATGCTTTCCTAAGTAAAGCCTTTG
CCACAGCCAGATGGACAACTTAGGCCCTGGCAGAGTTAACCCCTTAGTTACTTCTGACCTGATAAACCAC
AGAAATTTCAGAAAAGCAACAGGAGAAACACAGAGAGAGCTTGTGTTGGAGTCACAATGGTGGCCCGAAG
CCCAGCAGATATCTAAGCTCTGATTCCAACGTGTCCAAGAAGTTCTTTCCCTGCCCTGGGGCTAAGGTCT
TCTAGGGTTTCTGAGTTCAGGTTCTAAAAGGAAAATAATAGACAGCCTGTTTCATGGCCTAGGGGACAAA
GGGAAACTGGGAGCCAAAGGGTCCTGTGCACTGGAATCAGCTCAGGCTAACGATTTCTGAAGAGCTTGGC
CTCAAGTGATTTGTACCTCTTATCTTTGCTCCCCATTCAGCAGTGACAAATCCCACTGATGTAAAAGTAA
GAGCTTAGCATTTCACAAGGCTTTAAGCTCCAATGCCAATCACAAAGCCACCATTCACAGGGCACTTAAG
GAAACTGTCTTAAGCTTGCATACAAATTAGTTTAGATGTTACCTTCTAAAGAAAGCACTAATATTTTGCT
TTCTTTTTTCTTTTTTTAAAAGAATGACATCAGACTAGGGCATGGCAGTTCATGCCTGCAATCCCTGAAC
TTGATAGATCAAGACAAGAAGAAAGCCCAATTTTGTGGCCAGCCGGGGCTATAAAGTAAAATTCTAAGTA
GCTGGCTGTCTCTTCCCACCCCCGAGGCCATGGCTCTCTGAAAGCCCTTTGCTGGCTCTGCTCCATAGCC
GTGCTATTCCAAAACCCAGGCTCTTCACCACTATGCCTTCCATATTCAATCAGGCATCAGATGACTGGGG
CCATCCTGATCTGACTCAGCAACCAAGAACAAACCTCACTGATGGGTTTTCAGGTGATGCTGATGATGGA
GGTTGAAAGACGACCCTGCTTTACGGGTCACTGCATTAAGCTAGTCTTTCGATTAATAATTGATATGTAG
GTAACCTTTGAAGCTTTGTCACATGAGGCTTTGGTGTGACCCACTCCAGAATACCTTATGGAGATATTCT
GGAGGCTCCTTCAGAAACTAGCATCAGATATCCATTGCACAACACAGGAGACAAAAGATCCGAAAGACAC
CATTTGTTACCCTTCACACTTGATGGGACCTCACTTAGCCCTTGGCCATCAGCAAAAACAGTTCCTTCAA
AAACTGAGACAATCATCTACTGCTTTGTAAGAGTGTAAAATAGCTTTTAAAAACAAGTAGTTAATGGCAA
TCTCCGTCCACAAATTTCATGCAGAAGAGACTTAAAAAAAAAAAAACCTAAATCTTTCTGGATAATTTTA
AGAGTTTTTCAGTGCATTTGCCTGGCTCTTTGGCCTGTGCATGACAGTGATGATGATGATGGTGGTGGTG
GTGGTGATGATGATGATTTTAAAAAGCTAGCACAGGGTTATCCTGCCGTAACCTTAGCTGTGCTAAGGTG
CATGCTTTTTTACCATCTATCCTCACAGCTAATCCTATTAGCATAGACAATATTGTTCTTACCATTTTGT
GAGGACTCTGGGGCTACTGGTGGTTCAGGACCTTGCTCAAAATCTCCTTTGCAATTAGAGAAGATAGGAT
TTCTGCATCTTTCTTTCTCCACACCTATGCTTTAAGCCACTATGTTATTCTGCTCAATACTCTGCCCTGT
GTATTCCCTGTGAATTACAACTGGAAGCTTACTCCCCCTCATCTCCATTCCCAACACACACACACACACA
CACACACACACACACACACACACACACACTAGTGGCTTCTGACAAGGAATCTTGTGCTGTTTGCATCTTT
TCTTGTTTCAAGGTCTTCCCTTCCTAATCAGAGACCGATTATTACTGGCCACCTGCCAGTTAAATGACTC
GGTGGCAGCTATAGAACTGTTTCTCTGTTCTGTCCCCATGCCCTGAGATCTCTCAGCAAGCACTTGCCAA
ACTCCTGTGAGCTATGACGTTCCAAGGGCCATGGGTGTGTCAAGACACTGAGTGAAACCCAGTTCCCGGG
GTTTGTGAGGCTCCTGGTCCAGGTCCTCACTGCTGGTGCTCTCCAGTTTATGTTGTAGAGGTGGACTGGA
CTCCCGATGCCCCTGGAGAAACAGTGAACCTCACCTGTGACACGCCTGAAGAAGATGACATCACCTGGAC
CTCAGACCAGAGACATGGAGTCATAGGCTCTGGAAAGACCCTGACCATCACTGTCAAAGAGTTTCTAGAT
GCTGGCCAGTACACCTGCCACAAAGGAGGCGAGACTCTGAGCCACTCACATCTGCTGCTCCACAAGAAGG
AAAATGGAATTTGGTCCACTGAAATTTTAAAAAGTAATTCCATCCCCCTTGACAGTATCTTTTCTTCTAC
CCCTCCTTAAAAAGTAATAATTGCAAGTGTGTGTGTGTGTGTGTGTGTGTGCGCGTGCGCGTGCGCGTGC
ACTGAGGCTCAGAAATGTTTCTCATTTCCTTTGAAACAGGAACTCTCATTGGCCCATAGCTTACCAATAA
GCTTTCTTGGTTAGCCAATAACATCCAGAGACCTTGTCTCAAAAAAAAAAAAAAAAAAATCTCACCCTTG
TACCATGTAATGGCCAGTGATCCATCCACAGTAAAAAAGAAATAAATAAATAAAATAAAAATAAAAAATA
ACAAAAACAAATTTCTTTATTAAAAGAAAACTCCTAAATATTTAATTTTTCTTTTCTTTTCAAATGCAGA
TTTCAAAAACAAGACTTTCCTGAAGTGTGAAGCACCAAATTACTCCGGACGGTTCACGTGCTCATGGCTG
GTGCAAAGAAACATGGACTTGAAGTTCAACATCAAGAGCAGTAGCAGGTAAGGGAGCTGCCATGATTTCT
CAAGGTTTTGTGTGATCTACTTCATAACAAAAAGAAGTACAAACTGCCCATGGATTATCAGTGACTGGTA
ATGGAACAGCAAAGTCAATTCTGTATTTTTTTTTTCAACTTCCCTCTGCTCGCCTAAGGAAATAGCATGG
AGCTTTAAGCCAGCCCTCTGAGACTAGTTGGCTGGGTAGTTTGAATTCACTCATCCGAATTGCCTGGCCG
TGCTTCATTAAGGCTCACAGCACCATGGGGAGGAATTAAAAAGAAGCCACAGCTACAAATAACTGGCCAG
AGCTCGACCTTGTGTCAAAAGCAGAATTGAGTGCTCCAGGGCCTTGCTGTTGGAAGCCCTGGAACAGATT
CCAGAACCCTCTGAGGCCTTTCGAGATTTTCCTAGAGCCTTTTCAACTTCTTCCCCCCCCCACCCCCACC
CCCCAACCGTTATTCTGAAGTTCAGTTTCCCCAATGCACTTGGGCTTTTCCTAAAAACATCATCTCCCAG
GGCTGCAGAGCGGGTGTGTCAGACTGCTCTACAGCTGACTTTAGTCAGCAACTAAATCCCTGAGCCACAT
GGAGGGCAGGGAGTGAGCGCCCTGGCTCTCCCACTATTTAAATGAATAAACGGGGGACAGGGGGTGTGGG
GGGGACGACTCCCTTTTCCATCTTTATCATGAATTTGCTATGACTTAACTTAGCTAAGGAAAATAATGGT
TCAGGGTGACATCAGAGTCCTTGTTGCTTCTATGAGAATTTTCTGATCTGGTAAAGGTGGCCCCAAAGGA
GACCAGTGTACAATGCAGATGCTTACATATAGAAACATGCCAGACCTCTATGTGCTTTAAAAAATTAGAC
AAGCACGATACATTTTCCTGCTAGAGAAATCTTGCACGTGTTCCTGAAGAAACTAGTACATGGATAAGGG
TCAGTGGAACATTTTGCATAATTAGCAAAAGCATGCTCAAATGGAACATCAATGTGCATCTATTGAAATA
AATAACTCAACTTTCGTGTTCTGTTTAGAGAACTCCCCCACAATACTTTCAGAGAGGAAAAAGACGTTAC
AAACTCATGCATATATATTTTTCATTTGTCTTTAAAGTTGTGCTACTCTTTGGATAAACTACATATGTAC
ATATATGTCTGTGTGCATGTCTATCTTAAATATTCATTTGGAAAAACTCTAGAAGTAACAAACTGTGAAC
AATGTCTATATGTGGGACTCAGATTTGAGTAAAAAGGAGAATTGTGGCGACACGCATGTTTTCTTTATAA
TCATCTTTGTTGTTATAATTCTTTATAATTCAGCAGTTTCTCTTGCATTACGATATTTTCAGGTTCATTT
AGGCAGAGATGCAACTTTCAGTCTCTTACAGCTAAGCTTCCACTCTGCAAAGGGCAAGGGGGTTTTTGTT
TGGTTTTGGTTTTGGTTGTTTTATTCCACTGGAGAAATCCAACCAGCTGGACAGACTGGCCTCGGACTGT
AGACACCAGGCACTCTATCTCTGATCTATAATACAGAACTCATTCTGTCTTTGCCATCAGTTCCCCTGAC
TCTCGGGCAGTGACATGTGGAATGGCGTCTCTGTCTGCAGAGAAGGTCACACTGGACCAAAGGGACTATG
AGAAGTATTCAGTGTCCTGCCAGGAGGATGTCACCTGCCCAACTGCCGAGGAGACCCTGCCCATTGAACT
GGCGTTGGAAGCACGGCAGCAGAATAAATATGAGAACTACAGCACCAGCTTCTTCATCAGGGACATCAGT
GAGTTTTGCCTGGGAGCAGGTGCTAGGGAAGCAAAGACGATGTCTGCCACGTGTCCATGATACCCTGGGG
CATAGGATTGGCCTGCATTCTTTTCCATTCTCCTAAAAAGCATGATACAGACACTACCCTCTTCATCTTA
CAGATGAGGAAATTAAAGGGTTAAGCTAACCTTTTTCCAGATCTCAAATCTCACAGACAGCAGACCAGAC
CCAGACCTGCCCCAATGGTGGCACCTAATGGATTATGGGTTAACTACATGCTTAGTGTAAAGCAGAAACC
AAGCACAGGGAGGGTTCCCTGATTGCTGAGCCCAGATACGAGACTCTATTAAGCAGAATGACTCAACCAG
TAGGGACTTCCGGTCTGTGCAGTGCAGAAAGGGTTCTAAAATGTAGGATATGGCCAATAATGGTGACTTC
CTCGAGTGGAAAGATCACTCTCAGCAGATCCCTCACAGGTGCTGCCCTGATGCTCAGAGAAGTGAAAGAG
CTATTCCAGAGACTAGAAGGTGGAGGGCTCTGTCAGCCAAGCTCAGGAGCCTAAGTCCTAGCTCCAAAGC
CTGGCCAGGATAATAAAGGATGCTTGTCTTCTTCTGCAGTCAAACCAGACCCGCCCAAGAACTTGCAGAT
GAAGCCTTTGAAGAACTCACAGGTGGAGGTCAGCTGGGAGTACCCTGACTCCTGGAGCACTCCCCATTCC
TACTTCTCCCTCAAGTTCTTTGTTCGAATCCAGCGCAAGAAAGAAAAGATGAAGGAGACAGAGGAGGGGT
GTAACCAGGTAGGATTTATGCAGCCCATGTTGGGGCCATTGGAAAGATCCTGACAACCAGGTGCTTGCCT
CAGGACCAGAACTGTGTTAAGGGCTCTCCATGTGAATCACACACAACCTATACAAAGTCCCAAAGGCAGC
CAGTATTGCTGTCACCTCTCCACAGAGGCCAGGAAAGCTCAGAGAGGCTATGTTTTGCCCACGTTCTTCC
AGCTAGAGCAGTGGCAGAACCAGTACCCAGCAATGGTTTGATGGAGAAAGAGATGGTTAGCTCAACCACT
TCAATTCCTCCAGTATAGTCGATTGTCAATCCTCAACCAAAGTTGTTCATGATATAGAAACCTGGGATCC
AGGAGCCTATAATGATTGTTTAAACTGAGTAAATATAGTAAATGCTAAAACATTGATGCTGGGACCCACC
AAATAAGGATAATCTCTACTTCCTTAATATGAGCAATCATTTCACCTTACAAGATGTCCACCTTTACTGG
GCTAATATGGTGACTTTCTACCTTTCGGGTCCTTAGCACAGTGATCTCTTGCTAGGTTTGAGGAACACTT
TTATGAGCATTTAAGTCACAGAGCAAAGGATTCTTCCAACCTAGCATTGAGAATGTGATAGCAATTCAGC
TCAGAGATTCAACCACTTCCTAAAAGCAGGAGCAAAAAATGGGATTATTTTGAAACAGATTTTAACTGCT
ACCTAAGTTTCATCCCTGTGTGTATGTATTTAATATACCAATCTTAAATAGGTAATGTCTAGTGCTTTCT
ACTTGCTAAAAGCTTTCTACGCATTTTTACATAAATGTTGTATTTAGCTGCTGCAATTCTTAGAGGCAGG
CATCCTGGGACCTACTCATGAATAAGGAGAGACACAGAGAACCAGAGATATTTTCCTGAAGCACCACAGC
TGTTTAGTAGCATTGCCAGGATTTGAAGTCACTTTTGTAAGCTGACAGGCATGGTAATTCTTGATGTCAA
GACAGCTAAAGAAAGCTGGTCTCAGTCCCAACATCAGCTTCATATGGGAGTGGTTACCCATGGGACCTTG
GGGTAATGCTGCTACTTCAAGAGGCAGAAGGGGGAGCAAGCCATTTCTGTTGGAGTTTACTAAATAGAAA
AGTGAGAGTGGGGTGGTGGATGAATCATGCTGGAATATGAAGACCTGAATTTTAACCCCCAGAACCTCTG
TAAAACTGAGTAGTAATGCCTGAACCTGGGCTCTGGAAAGAGGTGGGACACATACACACACACACACACA
CACACACACACACACACACACACACACACACACCTCTGATTATAGCTTCTACCAGCAGGTGGTGCAAGGG
GAGCGCCCATGCCAGCCTGCCTTATATTGCCTAAAGCCCTTACTTAAATTTTCCTCTCCTTTGCAGAAAG
GTGCGTTCCTCGTAGAGAAGACATCTACCGAAGTCCAATGCAAAGGCGGGAATGTCTGCGTGCAAGCTCA
GGATCGCTATTACAATTCCTCATGCAGCAAGTGGGCATGTGTTCCCTGCAGGTGTGTGAGCAGGACCGTG
AAGCCCAACCACACCTGCACATTTAGTGGTCCTGGTGGAGGACAACAGGAGGCTTGTGAGGGAGGTGGGG
GTGGAATTCCTGGCATAGGGATTCCAGTCAGAAACACATTTGTTCATCAGCAGATGTTAACTTGATGTGT
ATGTTAGGTCAGGCACTATGCTAGGCCAAGGATATTACAATAAAGAAAACAAGCATGGGTCCTACCCTTG
TACAGGGAAAGGCAAGAAGGACCAGAGGAGGAGGAAATCAGGAGTCAGAGTATGGAGAACTTGGAAGTAG
ACAGAAGTTGGAACCATATCTTAGGGGTTCTGGGGAACCACTGAAGTCTTTTTAATAAGGAAATATCCCA
ATCAAAGCCCTTTTAAGAAAAATCTCTCAAGAGAGTCCCTGGCAAGCATGAGACCAGCTGAAGTCCAAGC
CCTGTAAGGAAGGGTTGGGCTGTCTCGCACAGAAATCCTCAAGACCCAGTGTCTGGGGATAATAATGTGT
GGTGTGAAATAGGAGGGTATTGAGGCTATACCTCTGACCAATATGGACTTACCTACCCACATTCCTTTAC
AGGGTCCGATCCTAGGATGCAACGTTGGAAAGGAAAGAAAAGTGGAAGACATTAAGGAAGAAAAATTTAA
ACTCAGGATGGAAGAGTCCCCCAAAAGCTGTCTTCTGCTTGGTTGGCTTTTTCCAGTTTTCCTAAGTTCA
TCATGACACCTTTGCTGATTTCTACATGTAAATGTTAAATGCCCGCAGAGCCAGGGAGCTAATGTATGCA
TAGATATTCTAGCATTCCACTTGGCCTTATGCTGTTGAAATATTTAAGTAATTTATGTATTTATTAATTT
ATTTCTGCATTTCACATTTGTATACCAAGATGTATTGAATATTTCATGTGCTCGTGGCCTGATCCACTGG
GACCAGGCCCTATTATGCAAATTGTGAGCTTGTTATCTTCTTCAACAGCTCTTCAATCAGGGCTGCGTAG
GTACATTAGCTTTTGTGACAACCAATAAGAACATAATATTCTGACACAAGCAGTGTTACATATTTGTGAC
CAGTAAAGACATAGGTGGTATTTGGAGACATGAAGAAGCTGTAAAGTTGACTCTGAAGAGTTTAGCACTA
GTTTCAACACCAAGAAAGACTTTTTAGAAGTGATATTGATAAGAAACCAGGGCCTTCTTTAGAAGGGTAC
CTAAATTTAAAAGAATTTTGAAAGGCTGGGTATCGGTGGTATATGCTTTTAATTCCAGCACTCAGGAGAC
CAAGGCAGGCAGATCTCTGTGAGTTTGAGGACAGCCTGGTGTACAGAGGGAGTTCCAGCACAGCCAGTGC
CACACAGAAATTCTGTCTCAAAAAC
-
Protein Sequence : Show Sequence
>gi|6680397|ref|NP_032378.1| interleukin-12 subunit beta precursor [Mus musculus]
MCPQKLTISWFAIVLLVSPLMAMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIG
SGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCS
WLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELAL
EARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEK
MKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS
-
Molecule Role :
Vaximmutor
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
5. TNF-alpha |
-
Gene Name :
TNF-alpha
-
Sequence Strain (Species/Organism) :
Mus musculus
-
NCBI Gene ID :
21926
-
NCBI Protein GI :
7305585
-
Genbank Accession :
AB039224
-
Protein Accession :
NP_038721
-
Taxonomy ID :
10090
-
Chromosome No :
17
-
Gene Starting Position :
35199389
-
Gene Ending Position :
35201995
-
Gene Strand (Orientation) :
-
-
Protein Name :
tumor necrosis factor
-
Protein pI :
4.75
-
Protein Weight :
24010.47
-
Protein Length :
235
-
Protein Note :
Also known as DIF; Tnfa; TNFSF2; Tnfsf1a; TNFalpha; TNF-alpha; MGC151434
-
DNA Sequence : Show Sequence
>gi|372099093:35199389-35201995 Mus musculus strain C57BL/6J chromosome 17, GRCm38 C57BL/6J
CTTTATTTCTCTCAATGACCCGTAGGGCGATTACAGTCACGGCTCCCGTGGGGAGCAGAGGTTCAGTGAT
GTAGCGACAGCCTGGTCACCAAATCAGCGTTATTAAGACAATTGGGTTAGATAAATATTTTGTTTTAAAC
ATAAGCAAAAGAGGAGGCAACAAGGTAGAGAGGCCAGGTGGGGACAGCTCAGCTCCGTTTTCACAGAAAA
CATGTCTGTCTGAAGACAGCTTCCCACACTGGGTCCTCCAGGACACCCCGGCCTTCCAAATAAATACATT
CATAAGCAAATAAATAAATAATAAATAAATAATAAATAATAAGTGCAAATATAAATAGAGGGGGGCTGGC
TCTGTGAGGAAGGCTGTGCATTGCACCTCAGGGAAGAATCTGGAAAGGTCTGAAGGTAGGAAGGCCTGAG
ATCTTATCCAGCCTCATTCTGAGACAGAGGCAACCTGACCACTCTCCCTTTGCAGAACTCAGGAATGGAC
ATTCGAGGCTCCAGTGAATTCGGAAAGCCCATTTGAGTCCTTGATGGTGGTGCATGAGAGGCCCACAGTC
CAGGTCACTGTCCCAGCATCTTGTGTTTCTGAGTAGTTGTTGAAAGCTCTGAGCACAGAGTTGGACCCTG
AGCCATAATCCCCTTTCTAAGTTAGAAGGATACAGACTGGGGGCTCTGAGGAGTAGACAATAAAGGGGTC
AGAGTAAAGGGGTCAGAGTGGGGGCTGGGTAGAGAATGGATGAACACCCATTCCCTTCACAGAGCAATGA
CTCCAAAGTAGACCTGCCCGGACTCCGCAAAGTCTAAGTACTTGGGCAGATTGACCTCAGCGCTGAGTTG
GTCCCCCTTCTCCAGCTGGAAGACTCCTCCCAGGTATATGGGCTCATACCAGGGTTTGAGCTCAGCCCCC
TCAGGGGTGTCCTTGGGGCAGGGGCTCTTGACGGCAGAGAGGAGGTTGACTTTCTCCTGGTATGAGATAG
CAAATCGGCTGACGGTGTGGGTGAGGAGCACGTAGTCGGGGCAGCCTTGTCCCTTGAAGAGAACCTGGGA
GTAGACAAGGTACAACCCATCGGCTGGCACCACTAGTTGGTTGTCTTTGAGATCCATGCCGTTGGCCAGG
AGGGCGTTGGCGCGCTGGCTCAGCCACTCCAGCTGCTCCTCCACTTGGTGGTTTGCTGAGGGGGGGGGGG
AGGATTGAGTCAGTGTCACCCTCTTAGTTCACACTCCACATCCTGAGCCTCAGCAGCTACCCACACTTCA
CTTCCGGTTCCTGCACCCTCTGTCTTTCCACATCCCATTGGCTATGAGGTCCCGGGTGGCCCCCTGATGC
CTTGCTTTTGAGTCACTGCTCTGACTCTCACGTGCTGTCTCTAAGAGCTCTGTCTTTTCTCAGCCTGGCT
CGACACCCCTCAACCCGCCCCCCAAAATCATGCCCCTTCATTCTCAAGGCACATGTAAAGAAATCTTACC
TACGACGTGGGCTACAGGCTTGTCACTCGAATTTTGAGAAGATGATCCTGGAGGGGAAGAGACAAAGGCA
AGGATGAGCCTTTTAGGCTTCCCAGCAAGCATCTATGCACTTAGACCCCTTTCCTCCCAAACCAAAGCTT
TAAGTTCTCCCCCCACCCCATCTCATCCCATGCCTAACTGCCCTTCCTCCATCTTAAATTAAGAGAGAGG
TGTGGGAACACTTACTGAGTGTGAGGGTCTGGGCCATAGAACTGATGAGAGGGAGGCCATTTGGGAACTT
CTGTGTAGGAAAAGGAGGTTAGTTAAGACAGACTCACCCCAAAGGAGAAGCCTCCCGGCTGATTGCCCCG
CTTACAGTTCCTCTTTGCCCCACCCCACCCCCCAGCTTTGTGTTTTTCTTCTTCATTCATTCATCTGTCC
AACCCACGGCTTCTTTCTGCGGTGCCCTCTGTGCTTGATCTCCCGTTATCTCCCCTTCATCTTCCTCCTT
ATCTCTCATGCCTCTCTCATTTCTGTCTCTGAGTTTTATCTCTTGCTTATCCCCTCTTCCCCTGGCCACA
TCTTTCCAGATCTCTCCACGTGTGAACACACTTGTTCGTTCATTCATCTCTCTGTGCATCCGACGAAGGA
TGTTTAGTCAGCTGGACGCATGGGTCCGAGGTCCTGACTCTGTCCCCTCCACACTCTCCTCCACCTTGCC
CTGCCCATTAGCCCACTTCTTTCCCTCACACTGTCCTTCTTGCCCTCCTAACCCGTTTTGCTTGTGAGCG
AGAATAAGGGTTGCCCAGACACTCACCTCATCCCTTTGGGGACCGATCACCCCGAAGTTCAGTAGACAGA
AGAGCGTGGTGGCCCCTGCCACAAGCAGGAATGAGAAGAGGCTGAGACATAGGCACCGCCTGGAGTTCTG
GAAGCCCCCCATCTTTTGGGGGAGTGCCTCTTCTGCCAGTTCCACGTCGCGGATCATGCTTTCTGTGCTC
ATGGTGTCTTTTCTGGAGGGAGATGTGGCGCCTTGGGCCAGTGAGTGAAAGGGACAGAACCTGCCTGGTT
GGCTGCTTGCTTTTCTGGGAGCTATTTCCAAGATGTTCTGGAGTTTCTGTTCTCCCTCCTGGCTAGTCCC
TTGCTGTCCTCGCTGAG
-
Protein Sequence : Show Sequence
>gi|7305585|ref|NP_038721.1| tumor necrosis factor [Mus musculus]
MSTESMIRDVELAEEALPQKMGGFQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPQRDEKFPNGLPL
ISSMAQTLTLRSSSQNSSDKPVAHVVANHQVEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQ
VLFKGQGCPDYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDTPEGAELKPWYEPIYLGGVFQLEKGDQL
SAEVNLPKYLDFAESGQVYFGVIAL
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Molecule Role :
Vaximmutor
- Related Vaccine(s):
Toxoplasma gondii mic2 mutant vaccine
|
IV. Vaccine Information |
 |
|
 |
|
|
|
1. Ovilis Toxovax |
a. Tradename: |
Ovilis Toxovax |
b. Manufacturer: |
Intervet |
c. Vaccine Ontology ID: |
VO_0001138 |
d. Type: |
Live, attenuated vaccine |
e. Status: |
Clinical trial |
f. Host Species for Licensed Use: |
Sheep |
g. Immunization Route |
Intramuscular injection (i.m.) |
h. Description |
S48 strain with a lost ability to form cysts after passages in mice(Buxton and Innes, 1995) |
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2. rBCGpMV361-TgCyP |
a. Vaccine Ontology ID: |
VO_0004656 |
b. Type: |
Recombinant vector vaccine |
c. Status: |
Research |
d. Host Species for Licensed Use: |
Baboon |
e. Preparation |
Following amplification of the T. gondii cyclophilin gene, the shuttle expression plasmid pMV261-TgCyP and integrative expression plasmid pMV361-TgCyP were constructed, and their expression was stimulated after transfection into BCG (Yu et al., 2013). |
f. Immunization Route |
Intramuscular injection (i.m.) |
g.
Mouse Response |
- Vaccination Protocol:
rBCGpMV261-TgCyP and rBCGpMV361-TgCyP (106 CFU) were used to immunise the mice in two different manners (through an i.v. or oral route) (Yu et al., 2013).
- Vaccine Immune Response Type:
VO_0003057
- Challenge Protocol:
Two weeks after the third vaccination, mice were selected randomly from each group and challenged intraperitoneally (i.p.) with 103 highly virulent T. gondii RH strain tachyzoites (Yu et al., 2013).
- Efficacy:
The levels of Th1-type IFN-γ, IL-2 and IL-12 were significantly increased following immunisation with the rBCG vaccines via the i.v. or oral route, which indicated that catalytic activity against T. gondii infection was generated in the mice. rBCGpMV361-TgCyP i.v. inoculation resulted in a higher protection efficiency, as demonstrated by the increased survival time and survival rate (17%) of BALB/c mice (Yu et al., 2013).
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3. T. gondii DNA vaccine encoding MIC8 |
a. Vaccine Ontology ID: |
VO_0004219 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Antigen |
MIC8 |
e. Gene Engineering of
MIC8 |
- Type:
DNA vaccine construction
- Description:
To construct the pVAX-MIC8 expression plasmid, the coding sequence of the T. gondii MIC8 gene was amplified by polymerase chain reaction (PCR) from genomic DNA of T. gondii. The PCR product was cloned in pGEM-T easy vector (Promega, USA) and sequenced in both directions to ensure fidelity and generated pGEM-MIC8. The MIC8 fragment was inserted into the BamH I/Xba I sites of pVAX I by double digestion with BamH I/Xba I restriction enzymes, and ligation was finally done using T4 DNA ligase. The resulting plasmid was named pVAX-MIC8 (Liu et al., 2010).
- Detailed Gene Information: Click here.
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f. Vector: |
pVAX1 (Liu et al., 2010) |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Host Strain:
Kunming
- Vaccination Protocol:
Mice (20 per group) received injections of 100 μl of pVAXMIC8 plasmid or empty pVAX I vector into each anterior tibial muscle (final plasmid concentration, 100 μg/100 μl). The injections were repeated using the same protocol 2 and 4 weeks after vaccination. Tail bleeds were performed on vaccinated mice on the day of first vaccination, second vaccination, and third vaccination and pre-challenge to ascertain the presence of specific anti-T. gondii antibodies (Liu et al., 2010).
- Challenge Protocol:
Mice in all groups were intraperitoneally challenged with the virulent T. gondii RH strain (103 tachyzoites per mouse) 2 weeks after the last immunization (Liu et al., 2010).
- Efficacy:
Immunization of mice with pVAXMIC8 dramatically increased the survival time (10.3± 0.9 days) compared with control mice which died within 5 days of challenge (Liu et al., 2010).
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4. T. gondii DNA vaccine pcDNA3-MIC3 |
a. Vaccine Ontology ID: |
VO_0011523 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Gene Engineering of
MIC3 |
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e. Vector: |
pcDNA3 (Xiang et al., 2009) |
f. Immunization Route |
Footpad injection |
g.
Mouse Response |
- Host Strain:
Kunming
- Vaccination Protocol:
All studies were done with 6–8 weeks old Kunming mice. For experimental group, 100 μg pcDNA3-MIC3 were injected into mouse hind footpad three times, at week 0, 3 and 6, respectively. The mice of control groups were vaccinated with 100 μg pcDNA3 or normal saline (NS) three times (Xiang et al., 2009).
- Challenge Protocol:
Immunized Kunming mice were challenged intraperitoneally with 500 tachyzoites of RH strain T. gondii 9 weeks after the first immunization (Xiang et al., 2009).
- Efficacy:
The survival time of mice in pcDNA3-MIC3 group was significantly longer than those of in group pcDNA3 and NS (Xiang et al., 2009).
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5. T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2 |
a. Vaccine Ontology ID: |
VO_0004313 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
p30 |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3.1 expressed SAG1 (Xue et al., 2008).
- Detailed Gene Information: Click here.
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f. Gene Engineering of
Rop2 |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3.1 expressed ROP2 (Xue et al., 2008).
- Detailed Gene Information: Click here.
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g. Vector: |
pcDNA3.1 (Xue et al., 2008) |
h. Immunization Route |
Intramuscular injection (i.m.) |
i.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
When challenged with Toxoplasma gondii RH strain, mice immunized with pIL-12 co-administration had significantly higher survival rates compared to co-administration with pCTA2/B or pcDNA3.1-SAG1-ROP2 alone (control) (Xue et al., 2008).
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6. T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain) |
a. Vaccine Ontology ID: |
VO_0004453 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
MIC3 |
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f. Vector: |
pCDNA3 (Ismael et al., 2009) |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
Mice immunized with pMIC3i displayed significant protection against an oral challenge with 76K T. gondii strain cysts, exhibiting fewer brain cysts than the control mice immunized with the empty plasmid pcDNA3. The co-administration of pGM-CSF enhanced this protection (Ismael et al., 2009).
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7. T. gondii DNA vaccine pSAG1-ROP2-SAG2 |
a. Vaccine Ontology ID: |
VO_0004312 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
p30 |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3·1 (–) expressed SAG1-ROP2 and SAG2 gene fragments (Cui et al., 2008).
- Detailed Gene Information: Click here.
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f. Gene Engineering of
SAG2 |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3·1 (–) expressed SAG1-ROP2 and SAG2 gene fragments (Cui et al., 2008).
- Detailed Gene Information: Click here.
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g. Gene Engineering of
ROP2 |
- Type:
DNA vaccine construction
- Description:
Vector pcDNA3·1 (–) expressed SAG1-ROP2 and SAG2 gene fragments (Cui et al., 2008).
- Detailed Gene Information: Click here.
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h. Vector: |
pcDNA3.1 (Cui et al., 2008) |
i. Immunization Route |
Intramuscular injection (i.m.) |
j.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
Higher survival rates after lethal challenge were obtained in mice immunized with pSAG1-ROP2-SAG2 as compared to the mice immunized with PBS, expression vector alone or pSAG2, or pSAG1-ROP2. In addition, the protection induced by pSAG1-ROP2-SAG2 was remarkably enhanced by pIL-12 co-administration (Cui et al., 2008).
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8. T. gondii DNA vaccine pVAX-TgMIC13 |
a. Vaccine Ontology ID: |
VO_0004528 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
MIC13 |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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f. Vector: |
pVAX I (Yuan et al., 2013) |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Immune Response:
Immunization with pVAX-TgMIC13 induced a strong immune responses demonstrated by significant lymphocyte proliferation, cytokine production and antibody responses (Yuan et al., 2013).
- Efficacy:
Immunized mice showed increased survival time (21.3±11.3 days) and reduced number of cysts in brain of mice (57.14%) after challenge with tachyzoites of the virulent T. gondii RH strain and cysts of the T. gondii PRU strain, respectively (Yuan et al., 2013).
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9. T. gondii DNA vaccine pVR1020-GRA1 |
a. Vaccine Ontology ID: |
VO_0004454 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
GRA1 |
- Type:
DNA vaccine construction
- Description:
Vector VR1020 expressed T. gondii excreted-secreted dense granule proteins GRA1 (Scorza et al., 2003).
- Detailed Gene Information: Click here.
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f. Vector: |
VR1020 (Scorza et al., 2003) |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
All control pVR1020-vaccinated mice succumbed to infection after challenge, while 75% of the mice vaccinated with pVR1020-GRA1 were protected against infection with strain IPB-G. In the second experiment, all mice vaccinated with GRA1 DNA survived, while 75% of the mice vaccinated with control DNA succumbed to infection (P < 0.05) (Scorza et al., 2003).
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10. T. gondii DNA vaccine ROP8-pVAX-1 |
a. Vaccine Ontology ID: |
VO_0004531 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
ROP8 |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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f. Vector: |
pVAX1 (Parthasarathy et al., 2013) |
g. Immunization Route |
Intramuscular injection (i.m.) |
h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Immune Response:
splenocytes from mice immunized with ROP8-pVAX-1 secreted significantly high levels of IFN-γ (816 ± 26.3 pg/mL) compared with spleen cells cultured from mice immunized with pVAX-1 (48 ± 10.8) or PBS (45 ± 6.6). Only a low level of IL-4 was detected in the culture supernatant of splenocytes from mice immunized with ROP8-pVAX-1 (148 ± 18.3) but was significantly higher compared with mice immunized with pVAX-1 (50 ± 13.6) or PBS (47 ± 6.1) (Parthasarathy et al., 2013).
- Efficacy:
Mice immunized with ROP8-pVAX-1 DNA had a 100% survival rate until Day 9, whereas all the control mice died. On top of that, mice immunized with ROP8-pVAX-1 DNA showed a significant increase in the survival time (29 days, P < 0.05) (Parthasarathy et al., 2013).
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11. T. gondii DNA vaccine T.g.HSP70 |
a. Vaccine Ontology ID: |
VO_0004455 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
hsp70 |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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f. Vector: |
pME18100 (Kikumura et al., 2010) |
g. Immunization Route |
Gene gun |
h.
Mouse Response |
- Vaccine Immune Response Type:
VO_0000286
- Efficacy:
The T.g.HSP70 gene vaccination induced protective immunity against T.g.HSP70-induced anaphylactic reaction not only at the acute phase but also at acute exacerbation of the chronic phase of infection, although the protective effect was partial (Kikumura et al., 2010).
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12. T. gondii recombinant vaccine vector rBCGpMV361-TgCyP |
a. Vaccine Ontology ID: |
VO_0004602 |
b. Type: |
Recombinant vector vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Antigen |
TgCyP(Yu et al., 2013) |
f. Vector: |
BCG |
g. Immunization Route |
Intravenous injection (i.v.) |
h.
Mouse Response |
- Host Strain:
BALB/c mice
- Vaccine Immune Response Type:
VO_0003057
- Immune Response:
Greater proliferation of CD4+ and CD8+ T cells; levels of Th1-type IFN-γ, IL-2 and IL-12 were significantly increased (Yu et al., 2013)
- Efficacy:
rBCGpMV361-TgCyP i.v. inoculation protected the BALB/c mice, as shown by the 17% increased survival rate compared to those mice not inoculated (Yu et al., 2013)
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13. T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine |
a. Vaccine Ontology ID: |
VO_0011521 |
b. Type: |
Subunit vaccine |
c. Status: |
Research |
d. Gene Engineering of
Rop2 |
- Type:
Recombinant protein preparation
- Description:
- Detailed Gene Information: Click here.
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e. Immunization Route |
Footpad Injection |
f.
Mouse Response |
- Host Strain:
Balb/c, C57BL/6 and C3H
- Vaccination Protocol:
The immunization doses and boosters of each antigen were the following: Rop2 (44 kDa, 2 μg), LiHsp83 (86 kDa, 6 μg), Rop2-LiHsp83 (not, vert, similar120 kDa, 9 μg) and the mixture of Rop2 and LiHsp83 (2 + 6 μg, respectively). Balb/c, C57BL/6 and C3H mice were immunized by footpad injections on days 0, 21, 35 and 45 with PBS (control) or recombinant proteins (Echeverria et al., 2006).
- Challenge Protocol:
To analyze protection against virulent T. gondii strain (lethal challenge) immunized mice were challenged intraperitoneally with 105 T. gondii RH tachyzoites 2 weeks after the last immunization. To analyze protection against non-lethal challenge, immunized mice were orally infected with 20 cysts of the ME49 T. gondii strain 2 weeks after the last booster. The brain parasite load was evaluated 1 month after infection (Echeverria et al., 2006).
- Efficacy:
Vaccination with fusion protein conferred a remarkable resistance against oral infection with ME49 cysts in C57BL/6 and C3H mice, in comparison to mice immunized with Rop2 alone or the protein mixture. Following lethal challenge, a significant survival rate was observed in Rop2-83 immunized Balb/c and C57BL/6 mice in comparison to control groups (Echeverria et al., 2006).
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14. Toxoplasma gondii mic2 mutant vaccine |
a. Vaccine Ontology ID: |
VO_0003012 |
b. Type: |
Live, attenuated vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
mic2 |
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f. Immunization Route |
Intraperitoneal injection (i.p.) |
g.
Mouse Response |
- Persistence:
A mic2 mutant is attenuated in mice (Huynh and Carruthers, 2006).
- Efficacy:
A mic2 mutant induces protection in mice from challenge with wild type T. gondii (Huynh and Carruthers, 2006).
- Host Gene Response of
Ccl2
- Gene Response:
Levels of serum MCP-1 (Ccl2) were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click here.
- Host Gene Response of
Ifng (Interferon gamma)
- Gene Response:
Levels of serum IFN-gamma were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click here.
- Host Gene Response of
IL-6
- Gene Response:
Levels of serum IL-6 were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click here.
- Host Gene Response of
Il12b
- Gene Response:
Levels of serum IL-12p40 (IL-12b) were higher than those of uninfected mice on days 4, 6 and 8 post-infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click here.
- Host Gene Response of
TNF-alpha
- Gene Response:
Levels of serum TNF-alpha were higher in mice infected with MIC2 deletion mutants than in uninfected mice on days 4, 6 and 8 post infection (Huynh and Carruthers, 2006).
- Detailed Gene Information: Click here.
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15. Toxoplasma gondii OMPDC mutant vaccine |
a. Vaccine Ontology ID: |
VO_0003013 |
b. Type: |
Live, attenuated vaccine |
c. Status: |
Research |
d. Host Species as Laboratory Animal Model: |
Mouse |
e. Gene Engineering of
OMPDC |
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f. Immunization Route |
Intraperitoneal injection (i.p.) |
g.
Mouse Response |
- Persistence:
An OMPDC mutant is attenuated in mice (Fox and Bzik, 2010).
- Efficacy:
An OMPDC mutant induces significant protection in mice from challenge with wild type T. gondii (Fox and Bzik, 2010).
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16. Toxoplasma gondii OMPDC/UP mutant vaccine |
a. Type: |
Live, attenuated vaccine |
b. Status: |
Research |
c. Host Species as Laboratory Animal Model: |
Mouse |
d. Gene Engineering of
OMPDC |
- Type:
Recombinant protein preparation
- Description:
This OMPDC/UP mutant is from Toxoplasma gondii (Fox and Bzik, 2010).
- Detailed Gene Information: Click here.
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e. Gene Engineering of
UP |
- Type:
Gene mutation
- Description:
This OMPDC/UP mutant is from Toxoplasma gondii (Fox and Bzik, 2010).
- Detailed Gene Information: Click here.
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f. Immunization Route |
Intraperitoneal injection (i.p.) |
g.
Mouse Response |
- Persistence:
An OMPDC/UP mutant is attenuated in mice (Fox and Bzik, 2010).
- Efficacy:
An OMPDC/UP mutant induces significant protection in mice from challenge with wild type T. gondii (Fox and Bzik, 2010).
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V. References |
1. Bhopale, 2003: Bhopale GM. Pathogenesis of toxoplasmosis. Comparative immunology, microbiology and infectious diseases. 2003; 26(4); 213-222. [PubMed: 12676122].
2. Buxton and Innes, 1995: Buxton D, Innes EA. A commercial vaccine for ovine toxoplasmosis. Parasitology. 1995; 110 Suppl; S11-16. [PubMed: 7784124].
3. Ching et al., 2017: Ching XT, Fong MY, Lau YL. Evaluation of the Protective Effect of Deoxyribonucleic Acid Vaccines Encoding Granule Antigen 2 and 5 Against Acute Toxoplasmosis in BALB/c Mice. The American journal of tropical medicine and hygiene. 2017; 96(6); 1441-1447. [PubMed: 28719288].
4. Cong et al., 2008: Cong H, Gu QM, Yin HE, Wang JW, Zhao QL, Zhou HY, Li Y, Zhang JQ. Multi-epitope DNA vaccine linked to the A2/B subunit of cholera toxin protect mice against Toxoplasma gondii. Vaccine. 2008; 26(31); 3913-3921. [PubMed: 18555564].
5. Cui et al., 2008: Cui YL, He SY, Xue MF, Zhang J, Wang HX, Yao Y. Protective effect of a multiantigenic DNA vaccine against Toxoplasma gondii with co-delivery of IL-12 in mice. Parasite immunology. 2008; 30(5); 309-313. [PubMed: 18331395].
6. Czarnewski et al., 2017: Czarnewski P, Araújo ECB, Oliveira MC, Mineo TWP, Silva NM. Recombinant <i>Tg</i>HSP70 Immunization Protects against <i>Toxoplasma gondii</i> Brain Cyst Formation by Enhancing Inducible Nitric Oxide Expression. Frontiers in cellular and infection microbiology. 2017; 7; 142. [PubMed: 28487847].
7. Echeverria et al., 2006: Echeverria PC, de Miguel N, Costas M, Angel SO. Potent antigen-specific immunity to Toxoplasma gondii in adjuvant-free vaccination system using Rop2-Leishmania infantum Hsp83 fusion protein. Vaccine. 2006; 24(19); 4102-4110. [PubMed: 16545504].
8. Fox and Bzik, 2010: Fox BA, Bzik DJ. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infection and immunity. 2010; 78(9); 3744-3752. [PubMed: 20605980].
9. Huynh and Carruthers, 2006: Huynh MH, Carruthers VB. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS pathogens. 2006; 2(8); e84. [PubMed: 16933991].
10. Ismael et al., 2009: Ismael AB, Hedhli D, Cérède O, Lebrun M, Dimier-Poisson I, Mévélec MN. Further analysis of protection induced by the MIC3 DNA vaccine against T. gondii: CD4 and CD8 T cells are the major effectors of the MIC3 DNA vaccine-induced protection, both Lectin-like and EGF-like domains of MIC3 conferred protection. Vaccine. 2009; 27(22); 2959-2966. [PubMed: 19428907].
11. Kikumura et al., 2010: Kikumura A, Fang H, Mun HS, Uemura N, Makino M, Sayama Y, Norose K, Aosai F. Protective immunity against lethal anaphylactic reaction in Toxoplasma gondii-infected mice by DNA vaccination with T. gondii-derived heat shock protein 70 gene. Parasitology international. 2010; 59(2); 105-111. [PubMed: 20346412].
12. Liu et al., 2010: Liu MM, Yuan ZG, Peng GH, Zhou DH, He XH, Yan C, Yin CC, He Y, Lin RQ, Song HQ, Zhu XQ. Toxoplasma gondii microneme protein 8 (MIC8) is a potential vaccine candidate against toxoplasmosis. Parasitology research. 2010; 106(5); 1079-1084. [PubMed: 20177910].
13. Liu et al., 2017: Liu Y, Cao A, Li Y, Li X, Cong H, He S, Zhou H. Immunization with a DNA vaccine encoding Toxoplasma gondii Superoxide dismutase (TgSOD) induces partial immune protection against acute toxoplasmosis in BALB/c mice. BMC infectious diseases. 2017; 17(1); 403. [PubMed: 28592247].
14. Parthasarathy et al., 2013: Parthasarathy S, Fong MY, Ramaswamy K, Lau YL. Protective Immune Response in BALB/c Mice Induced by DNA Vaccine of the ROP8 gene of Toxoplasma gondii. The American journal of tropical medicine and hygiene. 2013; 88(5); 883-887. [PubMed: 23509124].
15. Picchio et al., 2018: Picchio MS, Sánchez VR, Arcon N, Soto AS, Perrone Sibilia M, Aldirico MLA, Urrutia M, Moretta R, Fenoy IM, Goldman A, Martin V. Vaccine potential of antigen cocktails composed of recombinant Toxoplasma gondii TgPI-1, ROP2 and GRA4 proteins against chronic toxoplasmosis in C3H mice. Experimental parasitology. 2018; 185; 62-70. [PubMed: 29309783].
16. Qu et al., 2008: Qu D, Wang S, Cai W, Du A. Protective effect of a DNA vaccine delivered in attenuated Salmonella typhimurium against Toxoplasma gondii infection in mice. Vaccine. 2008; 26(35); 4541-4548. [PubMed: 18590785].
17. Scorza et al., 2003: Scorza T, D'Souza S, Laloup M, Dewit J, De Braekeleer J, Verschueren H, Vercammen M, Huygen K, Jongert E. A GRA1 DNA vaccine primes cytolytic CD8(+) T cells to control acute Toxoplasma gondii infection. Infection and immunity. 2003; 71(1); 309-316. [PubMed: 12496180].
18. Wiki: T. gondii: Wiki: T. gondii [http://en.wikipedia.org/wiki/T._gondii]
19. Xiang et al., 2009: Xiang W, Qiong Z, Li-peng L, Kui T, Jian-wu G, Heng-ping S. The location of invasion-related protein MIC3 of Toxoplasma gondii and protective effect of its DNA vaccine in mice. Veterinary parasitology. 2009; 166(1-2); 1-7. [PubMed: 19800170].
20. Xue et al., 2008: Xue M, He S, Zhang J, Cui Y, Yao Y, Wang H. Comparison of cholera toxin A2/B and murine interleukin-12 as adjuvants of Toxoplasma multi-antigenic SAG1-ROP2 DNA vaccine. Experimental parasitology. 2008; 119(3); 352-357. [PubMed: 18442818].
21. Yu et al., 2013: Yu Q, Huang X, Gong P, Zhang Q, Li J, Zhang G, Yang J, Li H, Wang N, Zhang X. Protective immunity induced by a recombinant BCG vaccine encoding the cyclophilin gene of Toxoplasma gondii. Vaccine. 2013; ; . [PubMed: 24176493].
22. Yuan et al., 2013: Yuan ZG, Ren D, Zhou DH, Zhang XX, Petersen E, Li XZ, Zhou Y, Yang GL, Zhu XQ. Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model. Vaccine. 2013; ; . [PubMed: 23707448].
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