VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo
Pathogen Page
Toxoplasma gondii

Table of Contents

  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
    4. Microbial Pathogenesis
    5. Host Ranges and Animal Models
  2. Vaccine Related Pathogen Genes
    1. BiP
    2. CDPK1
    3. CDPK2
    4. CDPK6
    5. CyP
    6. dasd
    7. fad
    8. fsa
    9. GRA1
    10. GRA16
    11. GRA17
    12. GRA2
    13. GRA23
    14. GRA24
    15. GRA41
    16. GRA5
    17. GRA6
    18. GRA7
    19. GRA8
    20. hsp70
    21. ISP3
    22. MIC1
    23. MIC11
    24. MIC13
    25. mic2
    26. MIC3
    27. MIC3
    28. MIC4
    29. MIC6
    30. MIC8
    31. OMPDC
    32. p30
    33. PGAM2
    34. PI1
    35. PLP1
    36. ROP16
    37. ROP17
    38. ROP18
    39. ROP2
    40. Rop2
    41. Rop2
    42. ROP38
    43. ROP8
    44. SAG1
    45. SAG2
    46. SAG5B
    47. SAG5C
    48. sdfa
    49. SOD
    50. TgADF
    51. TgCST2
    52. TgNTPase-II
    53. TgPF
    54. TgRACK1
    55. UP
  3. Vaccine Related Host Genes
    1. Ccl2
    2. Ifng (Interferon gamma)
    3. IL-6
    4. Il12b
    5. TNF-alpha
  4. Vaccine Information
    1. CAV-2-ROP16
    2. CAV-2-ROP18
    3. CTLVECNS
    4. GRA7(20–28)SAPN
    5. ISA 201-rTgCST2
    6. ISP3 VLP
    7. Ovilis Toxovax
    8. PLG-rROP38-rROP18
    9. rBCGpMV361-TgCyP
    10. rCDPK6 + rROP18 + PLG
    11. RH-AMA1KO
    12. rTgADF
    13. rTgPGAM 2
    14. rTgRACK1
    15. rTgROP17
    16. T. gondii DNA vaccine encoding MIC8
    17. T. gondii DNA vaccine encoding multi-epitope ROP8
    18. T. gondii DNA vaccine pcDNA3-MIC3
    19. T. gondii DNA vaccine pcDNA3.1-HisGRA6
    20. T. gondii DNA vaccine pcDNA3.1-SAG1-ROP2
    21. T. gondii DNA vaccine pcDNA3.1/MIC11
    22. T. gondii DNA vaccine pDREP-TgNTPase-II
    23. T. gondii DNA vaccine pDsRed2-GRA8
    24. T. gondii DNA vaccine pEGFP-C1/GRA41
    25. T. gondii DNA vaccine pIRESneo/MIC6/PLP1
    26. T. gondii DNA vaccine pIRESneo/ROP18/PLP1
    27. T. gondii DNA vaccine pMIC3i encoding the complete MIC3-ORF (RH(ERP) strain)
    28. T. gondii DNA vaccine pSAG1-ROP2-SAG2
    29. T. gondii DNA vaccine pSAG5B/SAG5C
    30. T. gondii DNA vaccine pVAX-CDPK1 with pVAX-IL21-IL15
    31. T. gondii DNA vaccine pVAX-CDPK1 with pVAX-IL7-IL15
    32. T. gondii DNA vaccine pVAX-GRA16
    33. T. gondii DNA vaccine pVAX-GRA24 + pVAX-GRA25 + pVAX-MIC6
    34. T. gondii DNA vaccine pVAX-ROP38
    35. T. gondii DNA vaccine pVAX-TgGRA17
    36. T. gondii DNA vaccine pVAX-TgGRA17 + pVAX-TgGRA23
    37. T. gondii DNA vaccine pVAX-TgGRA23
    38. T. gondii DNA vaccine pVAX-TgMIC13
    39. T. gondii DNA vaccine pVitro-SAG1-GRA7
    40. T. gondii DNA vaccine pVR1020-GRA1
    41. T. gondii DNA vaccine ROP8-pVAX-1
    42. T. gondii DNA vaccine T.g.HSP70
    43. T. gondii GRA17 mutant vaccine
    44. T. gondii irradiated sterilised tachyzoites
    45. T. gondii LDH1 and LDH2 mutant vaccine
    46. T. gondii mic2 mutant vaccine
    47. T. gondii OMPDC mutant vaccine
    48. T. gondii OMPDC/UP mutant vaccine
    49. T. gondii Pru strain cdpk2 mutant vaccine
    50. T. gondii recombinant vaccine vector rBCGpMV361-TgCyP
    51. T. gondii Subunit Rop2-Hsp83 Fusion Protein Vaccine
    52. TgMIC1
    53. TgMIC1-4
    54. TgMIC1-4-6
    55. TgMIC4
    56. TgMIC6
    57. TgPF-OML
    58. UV-attenuated Toxoplasma gondii with DSCG adjuvant
  5. References
I. General Information
1. NCBI Taxonomy ID:
5811
2. Disease:
Toxoplasmosis
3. Introduction
Toxoplasma gondii is a species of parasitic protozoa in the genus Toxoplasma. The definitive host of T. gondii is the cat, but the parasite can be carried by many warm-blooded animals (birds or mammals). Toxoplasmosis, the disease of which T. gondii is the causative agent, is usually minor and self-limiting but can have serious or even fatal effects on a fetus whose mother first contracts the disease during pregnancy or on an immunocompromised human or cat (Wiki: T. gondii).
4. Microbial Pathogenesis
T. gondii is an intestinal coccidian of cat with man as one of the intermediate host. Humans are generally infected by ingesting oocysts released in cat faeces or by consuming meat from infected herd animals containing the long lived tissue cysts. Following ingestion, the outer wall of cysts or oocysts are disrupted by enzymatic degradation and bradyzoites and sporozoites are liberated into intestinal lumen. They rapidly invade and multiply within surrounding cells where they become tachyzoites. Thereafter, tachyzoites are disseminated via blood or lymphatic system to most of the organs of human body. At these sites, the tachyzoites infect host cells, replicate and invade the adjoining cell. In this fashion, the hallmarks of the infection develop: cell death and focal necrosis surrounded by an acute inflammatory response (Bhopale, 2003).
5. Host Ranges and Animal Models
The life cycle of T. gondii has two phases. The sexual part of the life cycle (coccidia like) takes place only in members of the Felidae family (domestic and wild cats), which makes these animals the parasite's primary host. The asexual part of the life cycle can take place in any warm-blooded animal, like other mammals (including felines) and birds (Wiki: T. gondii).
Loading...
Loading Pathogen Genes...
Loading...
Loading Host Genes...
Loading...
Loading Vaccines...
Loading References...