Yersinia ruckeri is the causative agent of yersiniosis or enteric redmouth disease leading to significant economic losses in salmonid aquaculture worldwide. Infection may result in a septicaemic condition with haemorrhages on the body surface and in the internal organs. Despite the significance of the disease, very little information is available on the pathogenesis, hampering the development of preventive measures to efficiently combat this bacterial agent (Tobback et al., 2007).
Molecule Role Annotation :
An aroA mutant is highly attenuated in rainbow trout and induces significant protection from challenge with wild type Y. ruckeri (Temprano et al., 2005).
Efficacy:
An aroA mutant provided significant protection from challenge with wild type Y. ruckeri (Temprano et al., 2005).
IV. References
1. Temprano et al., 2005: Temprano A, Riaño J, Yugueros J, González P, de Castro L, Villena A, Luengo JM, Naharro G. Potential use of a Yersinia ruckeri O1 auxotrophic aroA mutant as a live attenuated vaccine. Journal of fish diseases. 2005; 28(7); 419-427. [PubMed: 16083447].
2. Tobback et al., 2007: Tobback E, Decostere A, Hermans K, Haesebrouck F, Chiers K. Yersinia ruckeri infections in salmonid fish. Journal of fish diseases. 2007; 30(5); 257-268. [PubMed: 17501736].
3. Yang et al., 2009: Yang H, Chen J, Yang G, Zhang XH, Liu R, Xue X. Protection of Japanese flounder (Paralichthys olivaceus) against Vibrio anguillarum with a DNA vaccine containing the mutated zinc-metalloprotease gene. Vaccine. 2009; 27(15); 2150-2155. [PubMed: 19356619].
