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Mycoplasma hyopneumoniae

Table of Contents
  1. Protective Antigens
    1. P97
1. P97
  • Gene Name : P97
  • Sequence Strain (Species/Organism) : Mycoplasma hyopneumoniae 232
  • NCBI Gene ID : 3105444
  • NCBI Protein GI : 54020389
  • Locus Tag : mhp183
  • Genbank Accession : AE017332
  • Protein Accession : YP_115696
  • Taxonomy ID : 295358
  • Gene Starting Position : 224079
  • Gene Ending Position : 227405
  • Gene Strand (Orientation) : -
  • Protein Name : protein p97; cilium adhesin
  • Protein pI : 9.5
  • Protein Weight : 120335.63
  • Protein Length : 1108
  • DNA Sequence : Show Sequence 
    >NC_006360.1:224079-227405 Mycoplasma hyopneumoniae 232, complete genome
TTTATTTAGATTCTGGTTCCTGATTATTATTACTTTGTTTTACTGTTATTTTAACTTTTAGACTTGATTT
TTTAGGATCACCGGATTTTGAATCATCCCTTAGGATAAAGTATAGCAATTTAGCATCTCCAGCGATATTA
TCCTCGATTAGTTCAACCTCTGTTTTTCAATTTTTACCTTGTTTTTTAATGATTTCGTCAATTTTTTTAC
CTAAGTCAGGAAGGTAATTAGTTAATTCGGTAGTTGGGCTTTGTTGACTAGGTGCTCCCTCTGCTTTTTT
CCCTTGGTTAGGAGTTCCTTCGGCTTTTTTACCTTGGTTAGGCGCGCCTTCTGCTTTTTTACCTTGGTTA
GGAGTTCCTTCGCTTTTTTTACCTTGATTTGAAGATCCTTCGGTCATCATTGGGTGGCTAAGTTTCTGAT
ATTGGTCACTAGTTACCTTGACTTCCTGGAATTGATATTGAAGATTTAAAACAGTTTTATCTAGTTCCTT
TATTATTTCTTGTTCTTCATACTCGCTTTGATGAACTAGTTCTAAAAATACATTAATTTCCGGTGTTTTT
AGGCTTAATTTATTTTCGTCAGTATATTCTAATTTATAACTAAAAGCCATTGGGAAATAGTCTTCTTTTG
GTTTATTTGTAAGTGAAAAGCCAGTATTAGTAGCAACTGGTTTTGCTGCTTCTGGTTTAGCCGCTACTGG
TTTTGCTGCTTCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCTGGTTTAGCCGCTACTGGTTTTGCTGCT
TCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCAGGTTTAGCTGCTTCAGGTTTAGCTGCTACTGGTTTTG
TTGTTTCTGGTTTAGCCGCTACTGGTTTTGCTGCTTCTGGTTTTGCTGCTGGGGGCTGAGGCAATATACC
TTTTATTTTATTATCCAATTCCTTAACTTTTTTATCTACTTCTTCTCTTTTACCTTCTTTTGTAGTTTCC
CCTTTTTTGATAGCTTCAAATGAATACTGAAGATTATCGTCTAATTTTGCTCAAGGAGCAAAATTATTAA
ATTGGGCTGCTTTAAGGAAAAATGCTTTTAAAAAATCACCGAAGGTTTTAAAATCAGTCCCTTCAAGTAA
ATTTTTATCTAAAATAGTAGTTTTAAAAGCCGAGTTCTCAATTAAAGAATACTTTTTAAGCGCTTCAAAA
ATTTGCGCCTCATTTTTGCCTTCTAATTCAGTTTTTACACTTTGGGGCAATAATAAAACTCCGTAAAATC
CATCAGATTTTATTACATCGTTACGGGCTAAAATATTAAAGGAAAGTTGGTGAATTTCTTTTATCTGATT
GTAAGGATCCTTTTTCTTCAATTCCAAAAATTTTAATTTATCTGCTTCTGCAAAAATATCTTTTGTATAT
TGGAAAACCCCTTTTGGGAATTGTGCTCTGTTAGTTTCTAGTCCCCATTTTTTTGCTAGATCATAAAGAG
TCTCTAAAATTGTTAATTTGTCCTTGGTGAGTAAATCCTGGAAATAACTTGCAACTTGATGTCCATTTTT
AAAAAAGTTATTACTTTTAAGACTTGAAATTACTTGTTCTTTTGTTGTTTGTGGTTGATTTAAAACTGAA
TTAGAACCAATTTTAACTTGTTCTAAATGTCTTGTAAATCTTTGGATATCAGCTTTTTCAGGATGCTGAA
TTTTTCCTGTTCAGGAATTAAGCACGGATTTAAAGGCCCCGAATTCATAGGCATAATTTCCATCAAGTGC
TTGATAGATTTCTTGGTTTTTATTCCCTTTAAAAAGAGCTTCAACTTCAACTTTGGCAAGTTGAGTATTA
TATGGATTTAAGATATTACCATAGTCTAATTTTGCTTGTTCTTCTTTACCTTTTTCAAAAAATGGTAAAT
ATTCGGTTTTAAAAATTTGCTGATTGATATTAGGGAGATCAATTTTTGAGCCTTTTTTAAATCCAGTTAA
TTTAAGAATCCCTTCTTTTACGAGAATATTATCTTTTGTATCTGGATATAAATCATCGGCAAAAAATTTA
TCTTTAATTTCAAGGCGGTAGGGAATTAAAACTATTGATTTATCTTTTTTATCAAGACTTGCGCTTGCTG
CATCTAGGCTATATTCTAAATTTGGCGAGTTAAGACGGTCGTTGAATTTTCCATTGTATTTACCAAAGTC
ATAAATATTTTCTTTTTTATTTAAAAGATTACTAATTTCTGCCTTGGTATGACTGGATCTCTTGTCTCCA
GGGAAAAATCCAGATTTAATATCTGCTAGAAATTCATAGGCAGAAAGATTTTGACCCTTTGCATTTAAAT
CTTCTTTTTGCATATTTTTCAGTGTTAAATTATTAACAAAATCCTCAAAATTTAGAAAATAAGAAGAATT
ATCTTTTTTCATTAATCTTAAAATGTTAATAACTGGCTGAACTTCATCTGGGCTAGCTAAAATTTCACGG
GCACTTTGACTAAGATCTGCTTTTAAAAACAGCGAAGGAATTTGGTTCTGGATACTTACATATTGATTAG
TTGAACTATCTTTTGCAAAGCTAAATTCAAAAATATTACCCAAATTATTAGGTAATTTATTCTCAGGAGC
ATTATTTAGTCTGTTTATTAAATTTTTAAGTACTGGAAAATAATTAGCAAGCTTTATATCTAAATCCTCA
GGATTTCGCGCTGTATTTAAATCGTATTGGAAGTCAATAGCTCTTAGAGTTGAGGGATCTTTTTGGCTGC
TTGTTTTTTCATCAGCAAAATTTGTAATTTTTGTTGATAAATTTTCAATTTGTTGATTTAATTTTTCGGT
AATTTTTTTAAGCGAAAAATTAAATTCGGCAACTAAAAGATTTGACTGTTTGGCAAAAGCAACTGTTTGC
TCATAAATATCAGATTTGGCAATATCACCATTATGAAGTTTTTGTAATGCCTGAAATTTTACCTTAAAAT
TTTGATTGACATCATCAGGGATAATTTCAAGAATCTCAAAAGTTATCTTCGCCTTGGTATATTCAGGATC
TTGAAAATTAATTTTTTCTAACTGATCACCGTTTTTAGTAAAAAAGGAAAAGGAATCAATAACTTTTTCT
TTATTTCTAATATTGTTATTAGAATCAACTAGTCACCTTTTGACTATTTTATAATCAGAATCAGTCTCAA
AAGCATAAGGACTAAAAGCTAATGTTGAAACTTTTGCGGCAAAATCATTTGCAATCTTTCGTGGACTTTC
TGATCTGTATTTTGCCAAGCTGCTAAGTCCGACAGTTAGACCAAAAACTCCAAGACCAACAATTCCGGCA
GTCAAACCAATTTTAAATGTTTTTGATTTTTTACTCA
  • Protein Sequence : Show Sequence 
    >YP_115696.1 protein p97; cilium adhesin [Mycoplasma hyopneumoniae 232]
MSKKSKTFKIGLTAGIVGLGVFGLTVGLSSLAKYRSESPRKIANDFAAKVSTLAFSPYAFETDSDYKIVK
RWLVDSNNNIRNKEKVIDSFSFFTKNGDQLEKINFQDPEYTKAKITFEILEIIPDDVNQNFKVKFQALQK
LHNGDIAKSDIYEQTVAFAKQSNLLVAEFNFSLKKITEKLNQQIENLSTKITNFADEKTSSQKDPSTLRA
IDFQYDLNTARNPEDLDIKLANYFPVLKNLINRLNNAPENKLPNNLGNIFEFSFAKDSSTNQYVSIQNQI
PSLFLKADLSQSAREILASPDEVQPVINILRLMKKDNSSYFLNFEDFVNNLTLKNMQKEDLNAKGQNLSA
YEFLADIKSGFFPGDKRSSHTKAEISNLLNKKENIYDFGKYNGKFNDRLNSPNLEYSLDAASASLDKKDK
SIVLIPYRLEIKDKFFADDLYPDTKDNILVKEGILKLTGFKKGSKIDLPNINQQIFKTEYLPFFEKGKEE
QAKLDYGNILNPYNTQLAKVEVEALFKGNKNQEIYQALDGNYAYEFGAFKSVLNSWTGKIQHPEKADIQR
FTRHLEQVKIGSNSVLNQPQTTKEQVISSLKSNNFFKNGHQVASYFQDLLTKDKLTILETLYDLAKKWGL
ETNRAQFPKGVFQYTKDIFAEADKLKFLELKKKDPYNQIKEIHQLSFNILARNDVIKSDGFYGVLLLPQS
VKTELEGKNEAQIFEALKKYSLIENSAFKTTILDKNLLEGTDFKTFGDFLKAFFLKAAQFNNFAPWAKLD
DNLQYSFEAIKKGETTKEGKREEVDKKVKELDNKIKGILPQPPAAKPEAAKPVAAKPETTKPVAAKPEAA
KPEAAKPVAAKPEAAKPVAAKPEAAKPVAAKPEAAKPVAAKPEAAKPVATNTGFSLTNKPKEDYFPMAFS
YKLEYTDENKLSLKTPEINVFLELVHQSEYEEQEIIKELDKTVLNLQYQFQEVKVTSDQYQKLSHPMMTE
GSSNQGKKSEGTPNQGKKAEGAPNQGKKAEGTPNQGKKAEGAPSQQSPTTELTNYLPDLGKKIDEIIKKQ
GKNWKTEVELIEDNIAGDAKLLYFILRDDSKSGDPKKSSLKVKITVKQSNNNQEPESK
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : a P97 recombinant replication-defective adenovirus (rAdP97c) subunit vaccine efficiency was evaluated in pigs. The rAdP97c vaccine was found to induce both strong P97 specific humoral and cellular immune responses. The rAdP97c vaccinated pigs developed a lower amount of macroscopic lung lesions (18.5 + or - 9.6%) compared to the unvaccinated and challenged animals (45.8 + or - 11.5%). rAdP97c vaccine reduced significantly the severity of inflammatory response and the amount of M. hyopneumoniae in the respiratory tract. The challenge was performed at day 28 after the first vaccination with 106 CCU of the 232 M. hyopneumoniae strain by intratracheal route (Okamba et al., 2010).
  • Related Vaccine(s): rAd-P97c
II. References
1. Okamba et al., 2010: Okamba FR, Arella M, Music N, Jia JJ, Gottschalk M, Gagnon CA. Potential use of a recombinant replication-defective adenovirus vector carrying the C-terminal portion of the P97 adhesin protein as a vaccine against Mycoplasma hyopneumoniae in swine. Vaccine. 2010; 28(30); 4802-4809. [PubMed: 20472025].