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Mumps virus |
| Table of Contents |
- Protective Antigens
- F
- HN
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| I. Vaccine Related Protective Antigens |
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1. F
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Gene Name :
F
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Sequence Strain (Species/Organism) :
Mumps virus
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NCBI Protein GI :
AJD08938
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Other Database IDs :
CDD:278924
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Taxonomy ID :
1395179
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Protein Name :
fusion protein
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Protein pI :
7.57
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Protein Weight :
55721.25
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Protein Length :
599
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Protein Note :
genotype: D
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Protein Sequence : Show Sequence
>AJD08938.1 fusion protein [Mumps virus genotype D]
MKAFPVTCLGFAVFSSSICVNINILQQIGYIKQQVRQLSYYSQSSSSYIVVKLLPNIQPTDDSCEFKSVT
QYNKTLSNLLLPIAENINNIASPSPGTRRHKRFAGIAIGIAALGVATAAQVTAAVSLVQAQTNARAIAAM
KNSIQATNRAVFEVKEGTQQLAIAVQALQDHINTIMNTQLNNMSCQILDNQLAASLGLYLTELTTVFQPQ
LINPALSPISIQALRSLLGSMTPAVVQATLSTSISAAEILSAGLMEGQIVSVLLDEMQMIVKINIPTIVT
QSNALVIDFYSISSFINNQESIIQLPDRILEIGNEQWSYPAKNCKLTRHHIFCQYNEAERLSLESKLCLA
GNISACVFSPIAGSYMRRFVALDGTIVANCRSLTCLCKSPSYPIYQPDHHAVTTIDLTACRTLSLDGLDF
SIVSLSNITYAENLTISLSQTINTQPIDISTELSKVNASLQNAVKYIKESNHQLQSVSVNSKIGAIIVAA
LVLSILSIIISILFCCWAYIATKEIRRINFKTNHINTISSSVDDLIRY
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
(Šantak et al., 2015)
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2. HN
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Gene Name :
HN
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Sequence Strain (Species/Organism) :
Mumps rubulavirus
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VO ID :
VO_0011171
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NCBI Gene ID :
1489765
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NCBI Protein GI :
9695422
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Locus Tag :
MuVgp6
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Genbank Accession :
AB040874
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Protein Accession :
NP_054713
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Taxonomy ID :
1979165
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Gene Starting Position :
6613
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Gene Ending Position :
8361
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Gene Strand (Orientation) :
?
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Protein Name :
hemagglutinin-neuraminidase
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Protein pI :
7.68
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Protein Weight :
59974.82
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Protein Length :
582
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DNA Sequence : Show Sequence
>NC_002200.1:6613-8361 Mumps virus, complete genome
GATGGAGCCCTCCAAACTCTTCACAATGTCAGACAATGCCACCTTTGCACCTGGGCCTGTTATCAATGCG
GCTGACAAGAAGACATTCCGAACCTGCTTCCGAATATTGGTACTGTCTGTACAAGCTGTTACCCTTATAT
TAGTTATTGTCACTTTAGGTGAGCTTGTGAGGATGATCAATGATCAAGGCTTGAGCAATCAGTTGTCTTC
AATTGCAGACAAGATAAGAGAGTCAGCTACTATGATTGCATCTGCTGTGGGAGTAATGAATCAAGTTATT
CACGGAGTAACGGTATCCTTACCCCTACAAATTGAGGGAAACCAAAATCAATTGTTATCCACGCTTGCCA
CAATCTGTACAGGCAAAAAACAAGTCTCAAACTGCTCTACAAACATCCCCTTAGTTAATGACCTTAGGTT
TATAAATGGGATCAATAAATTCATCATTGAAGATTATGCAACTCATGATTTCTCTATCGGCCATCCACTC
AACATGCCTAGCTTTATCCCAACTGCAACTTCACCCAATGGTTGCACAAGAATTCCATCCTTTTCTCTAG
GTAAGACACACTGGTGCTACACACATAATGTAATTAATGCCAACTGCAAGGATCATACTTCGTCCAACCA
ATATATTTCCATGGGGATACTTGTTCAGACCGCGTCAGGGTATCCTATGTTCAAAACCTTAAAGATCCAA
TATCTCAGTGATGGCCTGAATCGGAAAAGCTGCTCAATTGCAACAGTCCCTGATGGATGCGCAATGTACT
GTTATGTCTCAACTCAACTTGAAACCGACGACTATGCGGGGTCCAGCCCACCTACCCAGAAACTTACCCT
GTTATTCTATAATGATACCGTCACAGAAAGGACAATATCTCCAACTGGTCTCGAAGGGAACTGGGCCACT
TTGGTTCCAGGAGTGGGGAGTGGAATATATTTCGAGAATAAATTGATCTTTCCTGCATATGGGGGTGTCT
TGCCCAATAGTTCACTCGGAGTTAAATCAGCAAGAGAATTTTTCCGGCCTGTTAATCCATATAATCCATG
TTCAGGACCACAACAAGATTTAGATCAGCGTGCTTTGAGATCATACTTCCCAAGTTACTTCTCTAATCGA
AGAGTACAGAGTGCATTTCTTGTCTGTGCCTGGAATCAGATCCTAGTTACAAATTGCGAGCTAGTTGTCC
CCTCAAACAATCAGACACTGATGGGTGCAGAAGGAAGAGTTTTATTGATCAATAATCGACTATTATATTA
TCAGAGAAGTACCAGCTGGTGGCCGTATGAACTCCTCTATGAGATATCATTCACATTTACAAACTCTGGT
CAATCATCTGTGAATATGTCCTGGATACCTATATATTCATTCACTCGTCCTGGTTCAGGCAACTGCAGTG
GTGAAAATGTGTGCCCAACTGCTTGTGTGTCAGGGGTTTATCTTGATCCCTGGCCATTAACTCCATATAG
CCACCAATCAGGCATTAACAGAAATTTCTATTTCACAGGTGCACTATTAAATTCAAGCACAACTAGAGTA
AATCCTACCCTTTATGTCTCTGCCCTTAATAATCTTAAAGTACTAGCCCCATATGGTAATCAGGGACTGT
TTGCCTCGTACACTACAACCACCTGCTTTCAAGATACCGGTGATGCTAGTGTGTATTGTGTTTATATTAT
GGAACTAGCATCGAATATCGTTGGAGAATTCCAAATTCTACCTGTGCTAACCAGATTGACCATCACTTG
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Protein Sequence : Show Sequence
>NP_054713.1 hemagglutinin-neuraminidase [Mumps rubulavirus]
MEPSKLFTMSDNATFAPGPVINAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLSS
IADKIRESATMIASAVGVMNQVIHGVTVSLPLQIEGNQNQLLSTLATICTGKKQVSNCSTNIPLVNDLRF
INGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQ
YISMGILVQTASGYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTL
LFYNDTVTERTISPTGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSSLGVKSAREFFRPVNPYNPC
SGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSNNQTLMGAEGRVLLINNRLLYY
QRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGNCSGENVCPTACVSGVYLDPWPLTPYS
HQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLKVLAPYGNQGLFASYTTTTCFQDTGDASVYCVYIM
ELASNIVGEFQILPVLTRLTIT
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
A novel mumps vaccine with good immunity and safety was developed by selecting an antigen (HN) component of the mumps virus. The clinical and pathological observations after challenge of vaccinated rhesus monkeys indicated further that the immune response induced by this vaccine provided complete protection from wild-type virus infection (Liang et al., 2008).
- Related Vaccine(s):
Mumps HN Protein Subunit Vaccine
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rvOka-HN (mumps virus)
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| II. References |
1. Liang et al., 2008: Liang Y, Ma S, Yang Z, Liu L, Wang L, Wang J, Jiang L, Shi C, Dong C, Li Q. Immunogenicity and safety of a novel formalin-inactivated and alum-adjuvanted candidate subunit vaccine for mumps. Vaccine. 2008; 26(33); 4276-4283. [PubMed: 18597904].
2. Šantak et al., 2015: Šantak M, Örvell C, Gulija TK. Identification of conformational neutralization sites on the fusion protein of mumps virus. The Journal of general virology. 2015; 96(Pt 5); 982-990. [PubMed: 25614584].
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