Hepatitis E is a serious liver disease caused by the Hepatitis E virus (HEV) that usually results in an acute infection. It does not lead to a chronic infection. While rare in the United States, Hepatitis E is common in many parts of the world. Transmission: Ingestion of fecal matter, even in microscopic amounts; outbreaks are usually associated with contaminated water supply in countries with poor sanitation (CDC - Hepatitis E).
II. Vaccine Related Pathogen Genes
1. Hepatitis E Virus E2s Domain
Gene Name :
Hepatitis E Virus E2s Domain
Sequence Strain (Species/Organism) :
Hepatitis E virus
1. Al-Ayoubi et al., 2018: Al-Ayoubi J, Behrendt P, Bremer B, Suneetha PV, Gisa A, Rinker F, Manns MP, Cornberg M, Wedemeyer H, Kraft ARM. Hepatitis E virus ORF 1 induces proliferative and functional T-cell responses in patients with ongoing and resolved hepatitis E. Liver international : official journal of the International Association for the Study of the Liver. 2018; 38(2); 266-277. [PubMed: 28718943].
3. He et al., 1997: He J, Hoffman SL, Hayes CG. DNA inoculation with a plasmid vector carrying the hepatitis E virus structural protein gene induces immune response in mice. Vaccine. 1997; 15(4); 357-362. [PubMed: 9141205].
4. Joshi and Arankalle, 2016: Joshi SS, Arankalle VA. Differential Immune Responses in Mice Immunized with Recombinant Neutralizing Epitope Protein of Hepatitis E Virus Formulated with Liposome and Alum Adjuvants. Viral immunology. 2016; 29(6); 350-360. [PubMed: 27285290].
5. Li et al., 2009: Li S, Tang X, Seetharaman J, Yang C, Gu Y, Zhang J, Du H, Shih JW, Hew CL, Sivaraman J, Xia N. Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus-host interaction. PLoS pathogens. 2009; 5(8); e1000537. [PubMed: 19662165].
