VIOLIN: Vaccine Investigation and Online Information Network

Canine distemper virus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. CDVgp5 (Protective antigen)
2. CDVgp6 haemagglutinin protein H (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

11232

2. Disease:

Canine distemper

3. Introduction

Canine distemper is a very serious viral disease that affects animals in the families Canidae, Mustelidae, Mephitidae, Hyaenidae, Ailuridae, Procyonidae, Pinnipedia, some Viverridae and Felidae. It is most commonly associated with domestic animals such as dogs and ferrets, although it can infect wild animals as well. It is a single-stranded RNA virus of the family paramyxovirus, and thus a close relative of measles and rinderpest. Despite extensive vaccination in many regions, it remains a major disease of dogs.

Canine distemper virus (CDV) spreads through the aerosol droplets and through contact with infected bodily fluids including nasal and ocular secretions, feces, and urine 6–22 days after exposure. It can also be spread by food and water contaminated with these fluids. The time between infection and disease is 14 to 18 days, although there can be a fever from three to six days postinfection.

The mortality rate of the virus largely depends on the immune status of the infected dogs. Puppies experience the highest mortality rate where complications such as pneumonia and encephalitis are more common. In older dogs that do develop distemper encephalomyelitis, vestibular disease may present. Around 15% of canine inflammatory central nervous system diseases are a result of CDV (Wiki: Canine distemper virus).

4. Microbial Pathogenesis

Canine distemper virus tends to orient its infection towards the lymphoid, epithelial, and nervous tissues. The virus initially replicates in the lymphatic tissue of the respiratory tract. The virus then enters the blood stream and infects the lymphatic tissue followed by respiratory, Gastrointestinal, urogenital epithelium, the Central Nervous System, and optic nerves. Therefore, the typical pathologic features of canine distemper include lymphoid depletion (causing immunosuppression and leading to secondary infections), interstitial pneumonia, encephalitis with demyelination, and hyperkeratosis of foot pads (Wiki: Canine distemper virus).

5. Host Ranges and Animal Models

It is most commonly associated with domestic animals such as dogs and ferrets, although it can infect wild animals as well (Wiki: Canine distemper virus).

II. Vaccine Related Pathogen Genes

1. CDVgp5

Gene Name : CDVgp5
Sequence Strain (Species/Organism) : Canine morbillivirus
VO ID : VO_0011053
NCBI Gene ID : 1489793
NCBI Protein GI : 9630650
Locus Tag : CDVgp5
Genbank Accession : AF014953
Protein Accession : NP_047205
Taxonomy ID : 11232
Gene Starting Position : 4934
Gene Ending Position : 6922
Gene Strand (Orientation) : +
Protein Name : fusion protein F
Protein pI : 9.25
Protein Weight : 69080.65
Protein Length : 662

DNA Sequence : Show Sequence

>NC_001921.1:4934-6922 Canine distemper virus, complete genome
CATGCACAAGGGAATCCCCAAAAGCTCCAAAACCCAAACACATACCCAACAAGACCGCCCCCCACAACCC
AGCACCGAACTCGAAGAGACCAGGACCTCCCGAGCACGACACAGCACAACATCAGCTCAGCGATCCACGC
ACTACGATCCTCGAACATCGGACAGACCCGTCTCCTACACCATGAACAGGACCAGGTCCCGCAAGCAAAC
CAGCCACAGATTGAAGAACATCCCAGTTCACGGAAACCACGAGGCCACCATCCAGCACATACCAGAGAGT
GTCTCAAAAGGAGCGAGATCCCAGATCGAAAGGCGGCAACCCAATGCAATCAACTCAGGCTCTCAGTGCA
CCTGGTTAGTCCTGTGGTGCCTCGGAATGGCCAGTCTCTTTCTTTGTTCCAAGGCTCAGATACATTGGAA
TAATTTGTCAACTATTGGGATTATCGGGACTGATAGTGTCCATTACAAGATCATGACTAGGCCCAGTCAC
CAGTACTTGGTCATAAAACTGATGCCTAATGTTTCACTTATAGAGAATTGTACCAAAGCAGAATTAGGTG
AGTATGAGAAATTATTGAATTCAGTCCTCGAACCAATCAACCAAGCTTTGACTCTAATGACCAAGAATGT
GAAGCCCCTGCAGTCATTAGGGTCAGGTAGGAGACAAAGGCGTTTTGCAGGAGTGGTACTTGCAGGTGTA
GCTTTAGGAGTGGCTACAGCTGCACAAATCACTGCAGGAATAGCTTTACATCAATCCAACCTCAATGCTC
AAGCAATCCAATCTCTTAGAACCAGCCTTGAACAGTCTAACAAAGCTATAGAAGAAATTAGGGAGGCTAC
CCAAGAAACCGTCATTGCCGTTCAGGGAGTCCAGGACTACGTCAACAACGAACTCGTCCCTGCCATGCAA
CATATGTCATGTGAATTAGTTGGGCAGAGATTAGGGTTAAGACTGCTTCGGTATTATACTGAGTTGTTGT
CAATATTTGGCCCGAGTTTACGTGACCCTATTTCAGCCGAGATATCAATTCAGGCACTGATTTATGCTCT
TGGAGGAGAAATTCATAAGATACTTGAGAAGTTGGGATATTCTGGAAGTGATATGATTGCAATCTTGGAG
AGTCGGGGGATAAAAACAAAAATAACTCATGTTGATCTTCCCGGGAAATTCATCATCCTAAGTATCTCAT
ACCCAACTTTATCAGAAGTCAAGGGGGTTATAGTCCACAGACTGGAAGCAGTTTCTTACAACATAGGATC
ACAAGAGTGGTACACCACTGTCCCGAGGTATATTGCAACTAATGGTTACTTAATATCTAATTTTGATGAG
TCATCTTGTGTATTCGTCTCAGAGTCAGCCATTTGTAGCCAGAACTCCCTGTATCCCATGAGCCCACTCT
TACAACAATGTATTAGGGGCGACACTTCATCTTGTGCTCGGACCTTGGTATCTGGGACTATGGGCAACAA
ATTTATTCTGTCAAAAGGTAATATCGTCGCAAATTGTGCTTCTATACTATGTAAGTGTTATAGCACAAGC
ACAATTATTAATCAGAGTCCTGATAAGTTGCTGACATTCATTGCCTCCGATACCTGCCCACTGGTTGAAA
TAGATGGTGCTACTATCCAAGTTGGAGGCAGGCAATACCCTGATATGGTATACGAAGGCAAAGTTGCCTT
AGGCCCTGCTATATCACTTGATAGGTTAGATGTAGGTACAAACTTAGGGAACGCCCTTAAGAAACTGGAT
GATGCTAAGGTACTGATAGACTCCTCTAACCAGATCCTTGAGACGGTTAGGCGCTCTTCCTTTAATTTTG
GCAGTCTCCTCAGTGTTCCTATATTAAGTTGTACAGCCCTGGCTTTGTTGTTGCTGATTTACTGTTGTAA
AAGACGCTACCAACAGACACTCAAGCAGCATACTAAGGTCGATCCGGCATTTAAACCTGATCTAACTGGA
ACTTCGAAATCCTATGTGAGATCACTCTG

Protein Sequence : Show Sequence

>NP_047205.1 fusion protein F [Canine morbillivirus]
MHKGIPKSSKTQTHTQQDRPPQPSTELEETRTSRARHSTTSAQRSTHYDPRTSDRPVSYTMNRTRSRKQT
SHRLKNIPVHGNHEATIQHIPESVSKGARSQIERRQPNAINSGSQCTWLVLWCLGMASLFLCSKAQIHWN
NLSTIGIIGTDSVHYKIMTRPSHQYLVIKLMPNVSLIENCTKAELGEYEKLLNSVLEPINQALTLMTKNV
KPLQSLGSGRRQRRFAGVVLAGVALGVATAAQITAGIALHQSNLNAQAIQSLRTSLEQSNKAIEEIREAT
QETVIAVQGVQDYVNNELVPAMQHMSCELVGQRLGLRLLRYYTELLSIFGPSLRDPISAEISIQALIYAL
GGEIHKILEKLGYSGSDMIAILESRGIKTKITHVDLPGKFIILSISYPTLSEVKGVIVHRLEAVSYNIGS
QEWYTTVPRYIATNGYLISNFDESSCVFVSESAICSQNSLYPMSPLLQQCIRGDTSSCARTLVSGTMGNK
FILSKGNIVANCASILCKCYSTSTIINQSPDKLLTFIASDTCPLVEIDGATIQVGGRQYPDMVYEGKVAL
GPAISLDRLDVGTNLGNALKKLDDAKVLIDSSNQILETVRRSSFNFGSLLSVPILSCTALALLLLIYCCK
RRYQQTLKQHTKVDPAFKPDLTGTSKSYVRSL

Molecule Role : Protective antigen
Molecule Role Annotation : Study reports the engineering and the characterization of two replication-competent canine adenovirus type 2 (CAV2)-based vaccines expressing, respectively, the CDV hemagglutinin (HA) and fusion (F) antigens (CDVgp5). We first demonstrated that the intranasal vaccination with a mixture of both recombinant CAV2s provides an excellent level of protection in seronegative puppies, confirming the value of replication-competent adenovirus-based vectors for mucosal vaccination (Fischer et al., 2002).
Related Vaccine(s): ALVAC- CDV-H/F , Canine distemper virus DNA vaccine encoding F and HA , NYVAC- CDV-H/F

2. CDVgp6 haemagglutinin protein H

Gene Name : CDVgp6 haemagglutinin protein H
Sequence Strain (Species/Organism) : Canine morbillivirus
VO ID : VO_0011052
NCBI Gene ID : 1489792
NCBI Protein GI : 9630651
Locus Tag : CDVgp6
Genbank Accession : AB472690
Protein Accession : NP_047206
Taxonomy ID : 11232
Gene Starting Position : 7078
Gene Ending Position : 8892
Gene Strand (Orientation) : +
Protein Name : haemagglutinin protein H
Protein pI : 7.18
Protein Weight : 63919.26
Protein Length : 604

DNA Sequence : Show Sequence

>NC_001921.1:7078-8892 Canine distemper virus, complete genome
AATGCTCCCCTACCAAGACAAGGTGGGTGCCTTCTACAAGGATAATGCAAGAGCCAATTCAACCAAGCTG
TCCTTAGTGACAGAAGGACATGGGGGCAGGAGACCACCTTATTTGTTGTTTGTCCTTCTCATCTTATTGG
TTGGTATCCTGGCCTTGCTTGCTATCACTGGAGTTCGATTTCACCAAGTATCAACTAGTAATATGGAATT
TAGCAGATTGCTGAAAGAGGATATGGAGAAATCAGAGGCCGTACATCACCAAGTCATAGATGTCTTGACA
CCGCTCTTCAAGATTATTGGAGATGAGATTGGGTTACGGTTGCCACAAAAGCTAAACGAGATCAAACAAT
TTATCCTTCAAAAGACAAATTTCTTCAATCCGAACAGAGAATTCGACTTCCGCGATCTCCACTGGTGCAT
TAACCCGCCTAGTACGGTCAAGGTGAATTTTACTAATTACTGTGAGTCAATTGGGATCAGAAAAGCTATT
GCATCGGCAGCAAATCCTATCCTTTTATCAGCCCTATCTGGGGGCAGAGGTGACATATTCCCACCACACA
GATGCAGTGGAGCTACTACTTCAGTAGGCAAAGTTTTCCCCCTATCAGTCTCATTATCCATGTCTTTGAT
CTCAAGAACCTCAGAGGTAATCAATATGCTGACCGCTATCTCAGACGGCGTGTATGGCAAAACTTACTTG
CTAGTGCCTGATGATATAGAAAGAGAGTTCGACACTCGAGAGATTCGAGTCTTTGAAATAGGGTTCATCA
AAAGGTGGCTGAATGACATGCCATTACTCCAAACAACCAACTATATGGTACTCCCGAAGAATTCCAAAGC
CAAGGTATGTACTATAGCAGTGGGTGAGTTGACACTGGCTTCCTTGTGTGTAGAAGAGAGCACTGTATTA
TTATATCATGACAGCAGTGGTTCACAAGATGGTATTCTAGTAGTGACACTGGGGATATTTTGGGCAACAC
CTATGGATCACATTGAGGAAGTGATACCTGTCGCTCACCCATCAATGAAGAAAATACATATAACAAACCA
CCGTGGTTTTATAAAAGATTCAATTGCAACCTGGATGGTGCCTGCCCTGGCCTCTGAGAAACAAGAAGAA
CAAAAAGGTTGTCTGGAGTCAGCTTGTCAAAGAAAAACCTACCCCATGTGCAACCAAGCGTCATGGGAAC
CCTTCGGAGGAAGACAGTTGCCATCTTATGGGCGGTTGACATTACCTCTAGATGCAAGTGTTGACCTTCA
ACTTAACATATCGTTCACATACGGTCCGGTTATACTGAATGGAGATGGTATGGATTATTATGAAAGCCCA
CTTTTGAACTCCGGATGGCTTACCATTCCCCCCAAAGACGGAACAATCTCTGGATTGATAAACAAAGCAG
GTAGAGGAGACCAGTTCACTGTACTCCCCCATGTGTTAACATTTGCGCCCAGGGAATCAAGTGGAAATTG
TTATTTACCTATTCAAACATCTCAAATTAGAGATAGAGATGTCCTCATTGAGTCCAATATAGTGGTGTTG
CCTACACAGAGTATTAGATATGTCATAGCAACGTATGACATATCACGAAGTGATCATGCTATTGTTTATT
ATGTTTATGACCCAATCCGGACGATTTCTTATACGCACCCATTTAGACTAACTACCAAGGGTAGACCTGA
TTTCCTAAGGATTGAATGTTTTGTGTGGGATGACAATTTGTGGTGTCACCAATTTTACAGATTCGAGGCT
GACATCGCCAACTCTACAACCAGTGTTGAGAATTTAGTCCGTATAAGATTCTCATGTAACCGTTA

Protein Sequence : Show Sequence

>NP_047206.1 haemagglutinin protein H [Canine morbillivirus]
MLPYQDKVGAFYKDNARANSTKLSLVTEGHGGRRPPYLLFVLLILLVGILALLAITGVRFHQVSTSNMEF
SRLLKEDMEKSEAVHHQVIDVLTPLFKIIGDEIGLRLPQKLNEIKQFILQKTNFFNPNREFDFRDLHWCI
NPPSTVKVNFTNYCESIGIRKAIASAANPILLSALSGGRGDIFPPHRCSGATTSVGKVFPLSVSLSMSLI
SRTSEVINMLTAISDGVYGKTYLLVPDDIEREFDTREIRVFEIGFIKRWLNDMPLLQTTNYMVLPKNSKA
KVCTIAVGELTLASLCVEESTVLLYHDSSGSQDGILVVTLGIFWATPMDHIEEVIPVAHPSMKKIHITNH
RGFIKDSIATWMVPALASEKQEEQKGCLESACQRKTYPMCNQASWEPFGGRQLPSYGRLTLPLDASVDLQ
LNISFTYGPVILNGDGMDYYESPLLNSGWLTIPPKDGTISGLINKAGRGDQFTVLPHVLTFAPRESSGNC
YLPIQTSQIRDRDVLIESNIVVLPTQSIRYVIATYDISRSDHAIVYYVYDPIRTISYTHPFRLTTKGRPD
FLRIECFVWDDNLWCHQFYRFEADIANSTTSVENLVRIRFSCNR

Molecule Role : Protective antigen
Molecule Role Annotation : Young mink kits (n=8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). The mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV (Jensen et al., 2009).
Related Vaccine(s): ALVAC- CDV-H/F , Canine distemper virus DNA vaccine encoding F and HA , Canine distemper virus DNA vaccine encoding HA , NYVAC- CDV-H/F

III. Vaccine Information

1. ALVAC- CDV-H/F

a. Vaccine Ontology ID:

VO_0004773

b. Type:

Recombinant vector vaccine

c. Status:

Research

d. Host Species for Licensed Use:

Baboon

e. Gene Engineering of CDVgp6 haemagglutinin protein H

Type: Recombinant vector construction
Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
Detailed Gene Information: Click here.

f. Gene Engineering of CDVgp5

Type: Recombinant protein preparation
Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
Detailed Gene Information: Click here.

g. Preparation

An attenuated canarypox virus (ALVAC) vaccine strain expressing the CDV hemagglutinin (H) and fusion (F) protein genes (ALVAC-HF) (Welter et al., 2000).

h. Immunization Route

intranasal immunization

i. Ferret Response

Vaccination Protocol: Ferrets without maternal antibody were vaccinated intranasally with NYVAC-HF and ALVAC-HF. While ferrets with maternal antibody were vaccinated parenterally with NYVAC-HF and ALVAC-HF (Welter et al., 2000).
Vaccine Immune Response Type: VO_0003057
Challenge Protocol: At 12 weeks of age, the ferrets were challenged with CDV (Welter et al., 2000).
Efficacy: Combined i.n.-parenteral immunization of ferrets with maternal antibody using NYVAC-HF produced higher titers than did i.n. immunization with NYVAC-HF and ALVAC-HF, and survival was also significantly better in the i.n.-parenteral group than in the other HF-vaccinated animals (none of 18) or in controls immunized with RG. Multiple routes were not tested with the ALVAC vaccine (Welter et al., 2000).

2. Canine distemper virus DNA vaccine encoding F and HA

a. Vaccine Ontology ID:

VO_0011489

b. Type:

DNA vaccine

c. Status:

Research

d. Antigen

Canine distemper virus fusion and hemagglutinin antigens

e. Gene Engineering of CDVgp5

Type: DNA vaccine construction
Description: The Onderstepoort strain CDV HA and F cDNAs were amplified by PCR from a recombinant canarypox virus DNA using, respectively, primers pairs LF185 (5′-ATCGTCTCTAGAATGCTCCCCTACCAA-3′)/LF186 (5′-ATCGTCCGCCGCGGTTAACGGTTACATGAG-3′) and LF187 (5′-CTCGAGTCTAGAATGCACAAGGGAATCCCC-3′)/LF188 (5′-ATCCTGCCGCGGTCAGTGTGATCTCACATAGGATTT-3′). Five micrograms of purified CAV2 DNA were transfected into MDCK cells using Lipofectamine as described by the manufacturer (Gibco Lifesciences). After 24 h of incubation at 37 °C, the serum free medium was removed and replaced by supplemented MEM medium. The culture was incubated at 37 °C for 8 days with supplemented MEM medium being added to it on the third day(Fischer et al., 2002).
Detailed Gene Information: Click here.

f. Gene Engineering of CDVgp6 haemagglutinin protein H

Type: DNA vaccine construction
Description: The Onderstepoort strain CDV HA and F cDNAs were amplified by PCR from a recombinant canarypox virus DNA using, respectively, primers pairs LF185 (5′-ATCGTCTCTAGAATGCTCCCCTACCAA-3′)/LF186 (5′-ATCGTCCGCCGCGGTTAACGGTTACATGAG-3′) and LF187 (5′-CTCGAGTCTAGAATGCACAAGGGAATCCCC-3′)/LF188 (5′-ATCCTGCCGCGGTCAGTGTGATCTCACATAGGATTT-3′). Five micrograms of purified CAV2 DNA were transfected into MDCK cells using Lipofectamine as described by the manufacturer (Gibco Lifesciences). After 24 h of incubation at 37 °C, the serum free medium was removed and replaced by supplemented MEM medium. The culture was incubated at 37 °C for 8 days with supplemented MEM medium being added to it on the third day (Fischer et al., 2002).
Detailed Gene Information: Click here.

g. Vector:

pCAT basic vector (Promega)

h. Immunization Route

Intranasal

i. Dog Response

Vaccination Protocol: Dogs of group A were vaccinated on days 0 and 21 via the intranasal route with a mixture containing 105.8 TCID50/ml of vCA13 and 105.8 TCID50/ml of vCA17. Each nostril was infused with 0.5 ml of the vaccine solution. Dogs of group B were vaccinated on days 0 and 21 by the subcutaneous route (1 ml) with an non-relevant vaccine which did not contain CDV and/or CAV2 antigens. Experiment 2: Vaccinations were done with the same experimental design as in experiment 1, with the following exceptions: (1) all vaccinations were performed on days 0 and 28. Dogs of group A and B were vaccinated with 1 ml of a mixture of vCA13 and vCA17 containing 2×10^7 TCID50/ml of vCA13 and 2×107 TCID50/ml of vCA17; and (2) group C remained unvaccinated (Fischer et al., 2002).
Challenge Protocol: All dogs were challenged intravenously with the virulent NVSL strain of CDV on day 42 after receiving an intramuscular administration of diphenhydramine hydrochloride at 1 mg/lb. Challenge consisted of 10 ml (0.5 ml of 1:10 NVSL CDV stock diluted with 9.5 ml of cold PBS) administered intravenously into the cephalic vein. All dogs were observed daily for 2 days until 21 days after challenge to record morbidity and/or mortality (Fischer et al., 2002).
Efficacy: The intranasal vaccination with a mixture of both recombinant CAV2s provides an excellent level of protection in seronegative puppies, confirming the value of replication-competent adenovirus-based vectors for mucosal vaccination (Fischer et al., 2002).

3. Canine distemper virus DNA vaccine encoding HA

a. Vaccine Ontology ID:

VO_0011459

b. Type:

DNA vaccine

c. Status:

Research

d. Antigen

Canine distemper virus hemagglutinin

e. Gene Engineering of CDVgp6 haemagglutinin protein H

Type: DNA vaccine construction
Description: Immunisations were performed with the plasmid vector pV1J containing an insert of the H gene (1815 base pairs, named pCDV-H) of the Onderstepoort strain of CDV (Jensen et al., 2009).
Detailed Gene Information: Click here.

f. Vector:

plasmid vector pV1J

g. Immunization Route

Intramuscular injection (i.m.)

h. Cat Response

Host Strain: Tonkinese cat
Vaccination Protocol: The mink kits were vaccinated 4 times. The first vaccination was administered to 5 days old mink kits, the initial dose was 200 μg of the pCDV-H, and divided between 70 μg injected intradermally and 130 μg injected intramuscularly with 27 G 0.5 ml hypodermic needles. The intradermal injections were distributed on the posterior part of the back. The intramuscular injections were distributed in the quadriceps muscle of each thigh and in the tibialis muscles of each leg. The combination of intradermal and intramuscular injections was chosen because this combination induced solid protective immunity in adult mink. The second vaccination was applied at 3 weeks of age under anaesthesia (1–15 mg/kg each xylazine and ketamine). Anaesthesia was applied for animal welfare reasons and to ascertain correct injections since mink are difficult to restrain. The second vaccination consisted of 400 μg with 140 μg distributed intradermally and 260 μg distributed intramuscularly. The third and fourth vaccinations each of 400 μg were given at 6 and 9 weeks of age following the same procedure as the second vaccination (Jensen et al., 2009).
Challenge Protocol: The wild type virus used for the experimental challenge inoculation was isolated from a distemper outbreak in farmed mink in Denmark in 2004. This virus was named Mink/DK2004. The H gene of Mink/DK2004 showed 90% identity at the amino acid sequence level to the corresponding sequences of the Onderstepoort vaccine strain. A challenge dose of 3 × 10^5 TCID50 was administered partly intraperitoneally and intramuscularly (20% suspension) and to the conjunctival and nasal mucosa (10% suspension) to anaesthetised mink (Jensen et al., 2009).
Efficacy: The mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV (Jensen et al., 2009).

4. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine (USDA: 13A1.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc., Neotech, LLC

b. Vaccine Ontology ID:

VO_0002098

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

5. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine (USDA: 13A1.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002099

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

6. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4629.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002207

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

7. Canine Distemper-Adenovirus Type 2 Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4629.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002206

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

8. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002136

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

9. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.21)

a. Manufacturer:

Wyeth, Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002137

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

10. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002138

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

11. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002139

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

12. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.20)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002241

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

13. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002242

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

14. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002219

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

15. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002231

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

16. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002234

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

17. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002246

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

18. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002230

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

19. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002232

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

20. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002233

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

21. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002226

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

22. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002227

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

23. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002229

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

24. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002236

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

25. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002235

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

26. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus; Canarypox Vector Vaccine (USDA: 1591.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002135

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

27. Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002237

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

28. Canine Distemper-Adenovirus Type 2-Measles-Parainfluenza Modified Live Virus Vaccine (USDA: 1341.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002095

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

29. Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine (USDA: 13C1.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002100

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

30. Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4659.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002218

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

31. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.20)

a. Manufacturer:

Intervet Inc., Aceto Pharma Corp.

b. Vaccine Ontology ID:

VO_0002101

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

32. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.21)

a. Manufacturer:

Wyeth, Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002102

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

33. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.22)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002103

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

34. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.23)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002104

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

35. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002105

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

36. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002106

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

37. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.28)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002107

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

38. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002108

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

39. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.T0)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002110

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

40. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002211

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

41. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002214

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

42. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002245

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

43. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002215

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

44. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002216

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

45. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)_

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Type:

Live, attenuated vaccine

c. Status:

Licensed

d. Location Licensed:

USA

e. Host Species for Licensed Use:

Gray wolf

46. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002209

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

47. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002210

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

48. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21)

a. Manufacturer:

Wyeth, Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002212

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

49. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002213

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

50. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002228

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

51. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 13D1.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002109

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

52. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002217

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

53. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13G9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002111

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

54. Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.20)

a. Manufacturer:

Wyeth, Intervet Inc.

b. Vaccine Ontology ID:

VO_0002090

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

55. Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.25)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002091

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

56. Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002092

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

57. Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus Vaccine (USDA: 1331.30)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002093

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

58. Canine Distemper-Adenovirus Type 2-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 1331.R1)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0002094

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

59. Canine Distemper-Adenovirus Type 2-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13H9.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002112

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

60. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D7.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002117

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

61. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D9.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002118

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

62. Canine Distemper-Hepatitis-Parainfluenza Modified Live Virus Vaccine (USDA: 1381.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002097

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

63. Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002247

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

64. Canine Distemper-Measles Modified Live Virus Vaccine (USDA: 1351.20)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002096

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

65. Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0002113

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

66. Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.27)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002114

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

67. Distemper Live Canarypox Vector Vaccine (USDA: 1471.R0)

a. Manufacturer:

Merial, Inc.

b. Vaccine Ontology ID:

VO_0001748

c. Type:

Live vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

68. Distemper Modified Live Virus Vaccine (USDA: 1471.10)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001749

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Gray wolf

69. Mink Distemper Modified Live Virus Vaccine (USDA: 1451.00)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001536

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

70. Mink Distemper Modified Live Virus Vaccine (USDA: 1451.01)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001537

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

71. Mink Distemper Modified Live Virus Vaccine (USDA: 1451.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001538

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

72. Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine (USDA: 1679.31)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001832

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

73. Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium Botulinum Type C Bacterin-Toxoid (USDA: 4929.31)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001833

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

74. Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium Botulinum Type C-Pseudomonas Aeruginosa Bacterin-Toxoid (USDA: 4949.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001834

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

75. Mink Distemper-Enteritis Modified Live & Killed Virus Vaccine-Clostridium Botulinum Type C-Pseudomonas Aeruginosa Bacterin-Toxoid (USDA: 4949.31)

a. Manufacturer:

United Vaccines, Inc.

b. Vaccine Ontology ID:

VO_0001835

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

76. Mink Distemper-Enteritis Modified Live Virus & Killed Virus Vaccine-Clostridium Botulinum Type C Bacterin-Toxoid (USDA: 4929.20)

a. Manufacturer:

Intervet Inc.

b. Vaccine Ontology ID:

VO_0001836

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Carnivores

77. NYVAC- CDV-H/F

a. Vaccine Ontology ID:

VO_0004772

b. Type:

Recombinant vector vaccine

c. Status:

Research

d. Host Species for Licensed Use:

Baboon

e. Gene Engineering of CDVgp6 haemagglutinin protein H

Type: Recombinant vector construction
Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
Detailed Gene Information: Click here.

f. Gene Engineering of CDVgp5

Type: Recombinant vector construction
Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
Detailed Gene Information: Click here.

g. Preparation

An attenuated vaccinia virus (NYVAC) vaccine strain expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF) (Welter et al., 2000).

h. Immunization Route

Intramuscular injection (i.m.)

i. Ferret Response

Vaccination Protocol: Ferrets without maternal antibody were vaccinated intranasally with NYVAC-HF and ALVAC-HF. While ferrets with maternal antibody were vaccinated parenterally with NYVAC-HF and ALVAC-HF (Welter et al., 2000).
Vaccine Immune Response Type: VO_0003057
Challenge Protocol: At 12 weeks of age, the ferrets were challenged with CDV (Welter et al., 2000).
Efficacy: Both the NYVAC and attenuated CDV vaccines protected against the development of some clinical signs of infection. The results suggest that infant ferrets are less responsive to i.n. vaccination (Welter et al., 2000).

78. PUREVAXFerret Distemper

a. Tradename:

PUREVAXFerret Distemper

b. Manufacturer:

Merial

c. Vaccine Ontology ID:

VO_0001159

d. Type:

Recombinant vector vaccine

e. Status:

Licensed

f. Immunization Route

Intramuscular injection (i.m.)

g. Description

Canarypox virus-vectored vaccine

79. RECOMBITEK rDistemper

a. Tradename:

RECOMBITEK rDistemper

b. Manufacturer:

Merial

c. Vaccine Ontology ID:

VO_0001097

d. Type:

Recombinant vector vaccine

e. Status:

Licensed

f. Host Species for Licensed Use:

Dog

g. Immunization Route

Intramuscular injection (i.m.)

h. Description

Canarypox virus-vectored vaccine (HA and F antigens)

IV. References

1. Fischer et al., 2002: Fischer L, Tronel JP, Pardo-David C, Tanner P, Colombet G, Minke J, Audonnet JC. Vaccination of puppies born to immune dams with a canine adenovirus-based vaccine protects against a canine distemper virus challenge. Vaccine. 2002; 20(29-30); 3485-3497. [PubMed: 12297394].

2. Jensen et al., 2009: Jensen TH, Nielsen L, Aasted B, Blixenkrone-Møller M. Early life DNA vaccination with the H gene of Canine distemper virus induces robust protection against distemper. Vaccine. 2009; 27(38); 5178-5183. [PubMed: 19596418].

3. Welter et al., 2000: Welter J, Taylor J, Tartaglia J, Paoletti E, Stephensen CB. Vaccination against canine distemper virus infection in infant ferrets with and without maternal antibody protection, using recombinant attenuated poxvirus vaccines. Journal of virology. 2000; 74(14); 6358-6367. [PubMed: 10864646].

4. Wiki: Canine distemper virus: Canine distemper virus [http://en.wikipedia.org/wiki/Canine_distemper_virus]