Pathogen Page
Haemophilus parasuis
Table of Contents
I. General Information
II. Vaccine Related Pathogen Genes
1. csgG
Gene Name :
csgG
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Protein GI :
ACL33081
Other Database IDs :
CDD:224379
Taxonomy ID :
557723
Protein Name :
putative lipoprotein, curli production assembly/transport component CsgG
Protein pI :
8.61
Protein Weight :
22023.72
Protein Length :
345
Protein Note :
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis]; COG1462
Protein Sequence : Show Sequence
>ACL33081.1 putative lipoprotein, curli production assembly/transport component CsgG [Glaesserella parasuis SH0165]
MSNLKVGVLCFTVLTLVGCATEGSRVITPTSTQAAITASQYKGVKSVISVGKFDNKSSFQNGVFSDGADQ
LGNQSKTILISHLQQTGRFSVVDRTNMSEIASEAKIKGKKQNLKGATYVITGDVTEFGRKTVGDHQLFGI
LGRGKEQVAYAKVTLNVVNVETSEVVYSSQGAGEYNLSNREVLGFGGTASYDATLNGKVLDLAIREAVNS
LVNGIESGSWQPSH
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Hong et al. , 2011 )
2. FOG
Gene Name :
FOG
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Protein GI :
ACL32772
Other Database IDs :
CDD:276809
Taxonomy ID :
557723
Protein Name :
possible outer membrane protein, FOG: TPR repeat protein
Protein pI :
9.94
Protein Weight :
54014.03
Protein Length :
584
Protein Note :
putative protein binding surface [polypeptide binding]
Protein Sequence : Show Sequence
>ACL32772.1 possible outer membrane protein, FOG: TPR repeat protein [Glaesserella parasuis SH0165]
MPDLHFMKSSQFPFILLFVSPILLANPFADPVSFERLSQAVGFEQKFAKKSADLTASPKAVLSLPNPQSL
EAQINQAIIEQQWQRLPTLLQAYQQQSHYDITLVHYALGAFYYGQQRYPEAIEHYQAVLAQQPTLAYPRF
DLGVMLYENQQYRQATEQLTMAKANLAPSMQPLTERYLARMVEEQSWQPDFSLQYVRTDNVNNASSSPVV
NINGRQFVKDKTALPQSAEGFRYGIGVSKAHNLAGNHYLNGSVHYSGVHYWDNQDYSEQSLRFSLGYQYR
NAKMGLGVTPFIEQNWLGSPRYSRQFGATLHGYRYLTQKWIVSSRLTHNQKRYHDSLTASRYNGFQNSGA
LTLRWQAVRSWQIFASIEANRDQTKEKASSSHKIGGTLGVIYRWKNWGSELSGGYAKRNFEGKHYLYGYK
RVDNEYRANWSLWNKQWTWKGLMPKLNFSYVKIQSNIPDFYSRKTGEWFLTVEKRF
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Yuan et al. , 2012 )
3. gapA
Gene Name :
gapA
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Gene ID :
7278596
NCBI Protein GI :
498484148
Locus Tag :
HAPS_RS00005
Genbank Accession :
CP001321
Protein Accession :
WP_010785946
Taxonomy ID :
557723
Gene Starting Position :
1
Gene Ending Position :
1020
Gene Strand (Orientation) :
+
Protein Name :
type I glyceraldehyde-3-phosphate dehydrogenase
Protein pI :
6.07
Protein Weight :
32717.08
Protein Length :
339
Protein Note :
COG:G;COG0057
DNA Sequence : Show Sequence
>NC_011852.1:1-1020 Haemophilus parasuis SH0165, complete genome
TATGGCAATTAAAATTGGTATTAACGGCTTTGGCCGTATCGGTCGTATCGTATTCCGTGCAGCACAAAAA
CGTGATGACATCGAAGTAGTTGGTATCAACGACTTAATTGATGTTGAGTATATGGCATATATGCTCAAAT
ACGATTCAACTCACGGTCGTTTCGATGGCACTGTCGAAGTAAAAGACGGCAAATTAGTTGTAAACGGTAA
AGAAATCCGTGTTACTTCTGAGCGTGACCCAGCTAACTTAAAATGGAATGAAATTGGTGTGGATATCGCA
GTTGAAGCAACAGGTTTATTCTTGGACGATACAACTGCTCGTAAACACATCGAAGCTGGTGCGAAAAAAG
TCGTTTTAACTGGTCCATCTAAAGATAGCACACCTATGTTCGTAAACGGTGTAAACTTCAACGCTTATGC
TGGTCAAGACATCGTTTCTAACGCTTCTTGTACAACAAACTGCTTAGCACCACTTGCTCGTGTTATCCAC
GAAACATTTGGTATCAAAGAAGGTTTAATGACAACTGTTCATGCAACAACAGCAACACAAAAAACTGTTG
ATGGTCCATCAGCAAAAGACTGGCGCGGTGGTCGTGGTGCGGCACAAAACATCATTCCATCTTCAACAGG
TGCAGCGAAAGCAGTAGGTAAAGTATTACCAGCATTAAACGGTAAATTAACAGGTATGGCGTTCCGTGTT
CCAACAGCAAACGTATCTGTTGTTGATTTAACTGTAAACTTAGAAAAACCAGCAAGCTACGAAGAGATCA
AAAAAGCGATCAAAGATGCAGCAGAAGGTAAAACATTCAACGGCGAATTAAAAGGCGTTTTAGGTTATAC
TGAAGATGCAGTAGTATCAACAGACTTCAACGGTGCAGTTGAAACTTCTGTATTTGATGCAGATGCAGGT
ATCGCATTAACAGATACATTCGTGAAACTTGTTTCTTGGTATGACAACGAAACTGGTTACTCAAACAAAG
TATTAGACTTAGTTGCTCACGTTTACAACTACAAAGGCTA
Protein Sequence : Show Sequence
>WP_010785946.1 type I glyceraldehyde-3-phosphate dehydrogenase [Glaesserella parasuis]
MAIKIGINGFGRIGRIVFRAAQKRDDIEVVGINDLIDVEYMAYMLKYDSTHGRFDGTVEVKDGKLVVNGK
EIRVTSERDPANLKWNEIGVDIAVEATGLFLDDTTARKHIEAGAKKVVLTGPSKDSTPMFVNGVNFNAYA
GQDIVSNASCTTNCLAPLARVIHETFGIKEGLMTTVHATTATQKTVDGPSAKDWRGGRGAAQNIIPSSTG
AAKAVGKVLPALNGKLTGMAFRVPTANVSVVDLTVNLEKPASYEEIKKAIKDAAEGKTFNGELKGVLGYT
EDAVVSTDFNGAVETSVFDADAGIALTDTFVKLVSWYDNETGYSNKVLDLVAHVYNYKG
Molecule Role :
Protective antigen Related Vaccine(s):
Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00)
,
pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase
4. gcp
Gene Name :
gcp
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
EQA95212
Taxonomy ID :
456298
Protein Name :
putative tRNA threonylcarbamoyladenosine biosynthesis protein Gcp
Protein pI :
4.89
Protein Weight :
35809.93
Protein Length :
458
Protein Sequence : Show Sequence
>EQA95212.1 putative tRNA threonylcarbamoyladenosine biosynthesis protein Gcp [Glaesserella parasuis 29755]
MKILGIETSCDETGVAIYDEAKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTA
SDIDGVAYTAGPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLLAPMLEENAPEFPFVALLVSGGHT
QLVDVKNVGEYELLGESIDDAAGEAFDKTAKLLGLDYPGGAALAKLAETGTPNRFTFPRPMTDRPGLDFS
FSGLKTFAANTINANLNEKGELDQQTRCDIAYAFQQAVIETLIIKCRRALQQTGYKRLVIAGGVSANKQL
RHDLSELMKQIGGEVFYPRPQFCTDNGAMIAYAGFLRLKNGEQTDLSVSVKPRWPMVELCPIDV
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2015 )
5. hsdS
Gene Name :
hsdS
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACL32369
Other Database IDs :
CDD:279728
Taxonomy ID :
557723
Protein Name :
type I restriction enzyme specificity protein HsdS
Protein pI :
7.36
Protein Weight :
45559.72
Protein Length :
509
Protein Note :
Type I restriction modification DNA specificity domain; pfam01420
Protein Sequence : Show Sequence
>ACL32369.1 type I restriction enzyme specificity protein HsdS [Glaesserella parasuis SH0165]
MIESRFIEKLLKNREIEFKSLGDVTEMKRGKTITAKDASGGDIPVISGGQKPAYYHNEYNRNGKTITVAG
SGAYAGFIMYWEEPIFVSDAFSIKSDETLLDLKYVYHFLLQHQQKIYGMKKGSGVPHVYPKDLSTLVIPI
PPLDVQQEIVRILDAFTSLTAELTAELTAELTSRQKQYQYFRDKLLNFDDISDRGGYETNPITKALWHNK
KVVFKTLGEVTTISIGLTYTPAYVEKGIKFISAQNTSKDYLDLSNVKYISEEEFENSTDNAKPQRDDILF
TRVGSNIGHPVIVETDEKLCIFVSLGFLRVKDNNFLFNRYLKHWMSTDLFWKQVEKNVHGSAKINLNTGW
LKDFKIPIPPFEEQQRIVAILDKFETLTNSIAEGLPKEIELRRKQYEYYREKLLSFPQ
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2015 )
6. hxuB
Gene Name :
hxuB
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACL33615
Other Database IDs :
CDD:225387
Taxonomy ID :
557723
Protein Name :
heme/hemopexin-binding protein B, hemolysin activation/secretion protein
Protein pI :
9.69
Protein Weight :
61003.04
Protein Length :
690
Protein Note :
Hemolysin activation/secretion protein [Intracellular trafficking, secretion, and vesicular transport]; COG2831
Protein Sequence : Show Sequence
>ACL33615.1 heme/hemopexin-binding protein B, hemolysin activation/secretion protein [Glaesserella parasuis SH0165]
MKHFRRKNVITGIILSCVSGFTYANPIPDSGTLNKQLEQTRQIQVAKVKPSGELFKTPTQEENLPANKES
LKFRLDSIKLLELDGNEIQDNLTSITSPYLHQEITLDDLNRLSQQITNYYRDNNYLVAKAFIPPQEINNG
ELQIFVIKGSLDQVVVRNGSRLKEDLVMRMVNTTVKSHSYLVKNELEKLALLLNDIKGITSALSLKAGQN
TGKTDLTVNLKDNKRWNGYISIDNQGNDNTGKYRTTLGNKIYNLVGLGDELHFDVLASNTFDLYNLRADY
SFIIDGYGTRVGVNSNYLKYKLGANFKDLNAQGSTYNLGGYITHPTIRTASLRLDSKLAFNHQKLSDEQK
SVDLQQKRKVNTTSIGVSGSWNSIKEGVTYFSFNTIFGKESHSTNEKKHYLSENYQPKRTFTTFNYSLSH
EQFLPKSFSITFAASGQFADKNLDSGNKFLLGGLSGVKGYQAGTVSVDEGHIIQAELKHYLPVFSKSILV
SSLFYDEGFGKQYKNTEKLSESVENKVRLKSIGVGLNLIEPNHYSINFAYAKPIGKKYNNVDKNQFWLSA
IKTF
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Wen et al. , 2016 )
7. hxuC
Gene Name :
hxuC
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACL33614
Other Database IDs :
CDD:273807
Taxonomy ID :
557723
Protein Name :
heme/hemopexin utilization protein C/outer membrane receptor protein, mostly Fe transport
Protein pI :
9.8
Protein Weight :
77928.54
Protein Length :
853
Protein Note :
TonB-dependent heme/hemoglobin receptor family protein; TIGR01785
Protein Sequence : Show Sequence
>ACL33614.1 heme/hemopexin utilization protein C/outer membrane receptor protein, mostly Fe transport [Glaesserella parasuis SH0165]
MRLSKIYTALFLSLPTVSLADSNVSAELAEISVIASRDAFHWANHTSEKATLNKNQLLTQQPISTADAIK
RITNVDIAGGSRGIAQKPIIRGLSGNRVVQVIDGVRQNFDLSHRGSYFLPMALTQEIEVIKGPTSTLWGS
GALGGIVAIRTPNALDLLKDNQQIGAKIHQGYQSANSLSETDVSVFAANDKFDGLVSGFYNHADDLRLAD
SKKLVDSRYTQKGGLFKFGWQINDENRLELSHRLSHFEQIAPTNNEVAEEFTNQDVRNLIRNWHRNNPTA
SFAEMTRFYKGLTSVLGSVSYRAKQKITDQSSALHYYFNPKDNDYINSQLTLYRNSTKEKEQRIASGLQD
QTKLSTMGLNIRNSTDLNWLALNYGVDFISDRVVTQREKNATTPFRPNNYDAKSKNSAFYLLTHIPLWNE
RIIVSPSVRYDHFKTQSDEAKYSASRWSPSIAATWKATNWLDLSTRYNKAFRTPSMQERFVSGSHFGTNL
MGQSFNNTFVSNPNLRPETAKNKEIAAKVHFDNLFVHQDKFIFNAAYFQNDVKDFIHLDIFRASQRERIP
SLSQYRNVENARLTGYELEFAYQQERLALGLNYAQTKGKNRQTQEALSNIPANKLGFTIDYALVPQTFMI
GANITHYASQKRVPKTHAMTYPSYTLTDLKASYTPSGEWRNLRLDMMIENVFDKKFQPAFSLMEGAGRNI
KLNASYQF
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Wen et al. , 2016 )
8. LppC
Gene Name :
LppC
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
WP_021117166
Other Database IDs :
CDD:332423
Taxonomy ID :
738
Protein Name :
lppC lipofamily protein
Protein pI :
5.9
Protein Weight :
61497.82
Protein Length :
653
Protein Note :
LppC putative lipoprotein; cl27602
Protein Sequence : Show Sequence
>WP_021117166.1 lppC lipofamily protein [Glaesserella parasuis]
MPTILVQSYGFRQKMKTIFIPTALALLLAACSGNKVTETLKNEAYGNSEFYINKAEQSRNIEEQQSYRLL
AVRKLIEENKVVEAQNTFSEILVAKLNDEQKLEHRLLIAQLAALQGNNSEAQGVLRALPQTLLSQSQRLR
VYQTQARIAENQNDVIAAVNARALMDRYMTDTQSRQANNDKIWEMLRNANRGMLEKAVAGPGEIGLAGWL
ALVVAYNQNMSNPAQLPQVIEMWKQQYPNHSATLLLPIELRNVSSFEQTQLNGVALLLPLSGDAKILGEI
IKRGFDDAKGITTMPVQVFDTDSAPINDLLMQAKQQGAQTIIGPLLKPRVDEMLISPEISNINVLALNST
PNVRAVAKVCYYGLSPEAEAHFAAERFLKDGLQNAVVVAPNGDFGTRSAEAFAQRWRQLTNRDTDIRYYN
QAFEVASLLQGSVLGQGSGLYALGTAEQLSDLKQSLDNSPLANQFPIYTSSRSNSPNNGPDFRLTMEGVK
FSEIPLLSDPSSSEYKKAEQIAESDFSMMRLYAMGSDTWSIANKFNEFRQIPGYKVHGLTGVLRAGPNCN
LEREMNWLQYRGGSIVDAN
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2017 )
9. ndk
Gene Name :
ndk
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
KEZ22119
Taxonomy ID :
738
Protein Name :
Nucleoside diphosphate kinase
Protein pI :
6.53
Protein Weight :
15381.74
Protein Length :
207
Protein Sequence : Show Sequence
>KEZ22119.1 Nucleoside diphosphate kinase [Glaesserella parasuis]
MIQQTLAIIKPDATKRHLIGEILSYMEKNGLAIKALKMLHLTKEQAEGFYAEHQGKDFFDPLVAFMISEP
IVVAVLEGENAVENYRLLMGATKPEERKLGTIRKMFGLGYRENSVHGSDSETSAKREIAYFFTPSEIV
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2015 )
10. omp26
Gene Name :
omp26
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACL32860
Other Database IDs :
CDD:332039
Taxonomy ID :
557723
Protein Name :
outer membrane protein 26
Protein pI :
8.4
Protein Weight :
28348.36
Protein Length :
341
Protein Note :
Outer membrane protein (OmpH-like); cl27218
Protein Sequence : Show Sequence
>ACL32860.1 outer membrane protein 26 [Glaesserella parasuis SH0165]
MKNLFKLAAVASALAFSANTVNANEKIGFVDPNFLIQNHPLTIEANDKFTKFMKDTESKFAPREKQLAAE
NKALSDEEKALLDERKKIEEDAQKLQKEQVTLEAAMKKKVAQLEKDAPRLKAKEIQARQDKINAEAKPFQ
NKVSALQQREVEFGKKAEEFQKRADEFQKKVAAFQEEIAKVQKESGVITPEQVQQKVVEDINAKIKQVAE
SKGYTLVLPPSVALYAKDGNAADITEEILVAMGGKMPEAPKTEVPAAEVTKPEEVKK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2016 )
11. oppA
Gene Name :
oppA
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACL32119
Other Database IDs :
CDD:173869
Taxonomy ID :
557723
Protein Name :
putative oligopeptide transporter, periplasmic-binding protein, OppA
Protein pI :
6.99
Protein Weight :
55956.24
Protein Length :
634
Protein Note :
The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; cd08504
Protein Sequence : Show Sequence
>ACL32119.1 putative oligopeptide transporter, periplasmic-binding protein, OppA [Glaesserella parasuis SH0165]
MASIQRIVQFIKKGLFVTACIVGFVACDPEENNGSVRPLPNAEPTNVLSRAIYATELQLDPHFVRISAEA
GVVRDLFLGLMAFDPKGQIQNAVAKEWFSEDGKNWLFILDENAKWSNDQAVTSADFVASWQRLSDPKNAS
PLAHYLVYMGIVNSRAVLAGELPPDALGVKALNPYTLQVQLEKANYQLPKMLAHSALLPTYLGQKPNSTD
LVSNGSYRVEHFEKNLLQLKARDKNTPFQVVQYHLITSVQNPSRFDIIENPLENYHQHEKRFARLCNYFY
EFNFNDPLFAQKPIRQAVRAMISPIEISKGNGIPSHLMIPKQLFSEMGHSLSHTNVEQLLNEQGIHSGNP
LKLTLSYDRQGQHSQIAARIVRALGQSELFRVQLQAVSWEELLAKREHKDFQLIRSGWCADYPDPVLFLT
QFHSQSPDNKSSYSNAKVDELLLQLQEQPLDTAQRQRIIATIAHQLEEDVAILPLFQYQRRMSIAPTIQG
FDEQNASETIYSKDLTRQYHKDK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Macedo et al. , 2016 )
12. outer membrane protein A
Gene Name :
outer membrane protein A
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
ACN62162
Other Database IDs :
CDD:236764
Taxonomy ID :
738
Protein Name :
outer membrane protein A
Protein pI :
9.52
Protein Weight :
36308.42
Protein Length :
435
Protein Note :
outer membrane protein A; Reviewed
Protein Sequence : Show Sequence
>ACN62162.1 outer membrane protein A [Glaesserella parasuis]
MKKSLIALAVSGLAVASVAQAAPQANTFYVGAKAGWATFHNDINQIDSKYANDARYDATNLKYGISRNSV
TYGVFGGYQIIDNLAVELGYDYFGRVRGNKQEFRAFKHSAHGTHLSLKPSYEVLNGLDVYGKVGAALVRN
DYKRYSQTAGVQTQKAHNLKTSLVLGAGVEYAILPELAFRVEYQWLSNVGNFTKAEAKENRRATYNYSPD
SHSVTAGISYRFGQGAAPVAAAPEVVTKNFAFSSDVLFDFGKANLKPAAAQTLDAVHTEIVNLGLANPAV
QVNGYTDRIGKDAANLTLSQKRAETVANYIVSKGVNPANVTAVGYGEANPVTGNTCDAVKGRKALITCLA
PDRRVEIQVQGSKEVSM
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Tian et al. , 2011 )
13. outer membrane protein D15
Gene Name :
outer membrane protein D15
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki]
NCBI Protein GI :
ACI05267
Other Database IDs :
CDD:236834
Taxonomy ID :
738
Protein Name :
outer membrane protein D15
Protein pI :
7.65
Protein Weight :
85698.04
Protein Length :
881
Protein Note :
outer membrane protein assembly factor YaeT; Provisional
Protein Sequence : Show Sequence
>ACI05267.1 outer membrane protein D15 [Glaesserella parasuis]
MKKLLLSTLLVANGVAFASPFVIKDIRIDGIQTSVSQTMIPTLPVKVGQLATDNDIANVIRHLFVQNRFQ
NISATREGDILIIKVVENPVINNVDIEGNSAIPKEPLEQNLKANLITKGELFNSTKLDAFKSALIEHYHS
IGRYNATIDTVITNSDNGGVNIKLDIKEGDVAYVKAINFEGNQAFTSKVLMKQLDIQPDVSWFNIFQSSK
FEQTAYNQDLENLRNFYMNQGYAKFNVEAEQPVFSDDKKEVSLTYKINEGIPYTVSEIRIVGNTAKLDNE
LNEQLKYYKTGELFSKNELSKIEDNIKQVFGNNGFASAKIELHPTFDDTNKTIRLTFVVDAGQRVYVRQI
RFEGNDVTADSTLRREMRQQEGAWLSTSLAALGKARLERTGFYDSVEMSYPNVPNTADQVDIVYKIKERN
TGSINFGVGYGTESGLSYQAGIKQDNFLGMGSTISLNGTRNDYGTSINLGYTEPYFTKDGVSLGGNIFYE
DYDNSKNNSVASYKRQTYGVNSTLGFPVNEYNSYFLGLGYTQDLIKNARREFNRELYVQSMKFPIDNDLN
VYKKIKANDFDFSFGWNYNSLNRGFLPTEGTLTSISGRITTPGSDNKYYKVSIDFKNYLPVNREHKWVIS
TKANIAYANGFSGKELPFYQTYTAGGIGSLRGFAYGAIGPKAIYLGKDNNGNIRFNSVNRDIVGGNAMAS
ATLELITPTPFVSEKYQHNVRTSLFVDAATVLNTKWKTNPVVNDIQYNYSSLENFKDYKRFRASTGIAFQ
WNSPIGPLVFSYAKPIKKYQGDEIEQFQFSIGGSF
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Zhou et al. , 2009 )
14. outer membrane protein P2
Gene Name :
outer membrane protein P2
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki]
NCBI Protein GI :
EYE71716
Taxonomy ID :
1117322
Protein Name :
outer membrane protein P2 (OMP P2)
Protein pI :
9.55
Protein Weight :
36557.65
Protein Length :
451
Protein Note :
COG3203 Outer membrane protein (porin)
Protein Sequence : Show Sequence
>EYE71716.1 outer membrane protein P2 (OMP P2) [Glaesserella parasuis str. Nagasaki]
MKKTLVALAVAAFAASASAVTVYENEGTKVDFDGQLRLLLEEQATKEKGQSSTGGHTNLKNNGSRFGISI
KHNINENLYGFGRYETRLDSNSKNAAGWGDVKTKYAYVGLGGYGHEISFGKQDVIGDSIGQAGFDKVYGV
GTGGIKYSANNTNKKGFDILTSDSDSAINYTYTGIEGLTLGANYNVANERDKKTGEVNVGSTKSGFGLGA
KYTAKIAESQSVTVAAGYTHDDYKSGSVNKKDKDGVYFGLKYVNAPFTVAVDGGHGVEKTGNVKEKIDFV
RTGARFDVTPKSGVYGNYSYGTYKDKAYKATAHQFMLGADYKLHKQVVTFVEGRLIKNKDSNNKKVTDQA
LGVGLRVLW
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Zhou et al. , 2009 )
15. palA
Gene Name :
palA
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Protein GI :
ACL31779
Other Database IDs :
CDD:274307
Taxonomy ID :
557723
Protein Name :
18K peptidoglycan-associated outer membrane lipoprotein, precursor PalA
Protein pI :
7.56
Protein Weight :
16062.54
Protein Length :
272
Protein Note :
peptidoglycan-associated lipoprotein; TIGR02802
Protein Sequence : Show Sequence
>ACL31779.1 18K peptidoglycan-associated outer membrane lipoprotein, precursor PalA [Glaesserella parasuis SH0165]
MKKLAKVLMIAAPAFVLAACSSSNDNASANASANAGQTFGGMSVQDLQTRYNTVYFDFDSYTLKAEDQQL
LDAHAQYLVASKGKVTVAGHADERGTPEYNIALGQRRADAVKDFLATKGASNVATVSYGEEKPAVLGHSE
ADYSKNRRAVLEY
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Zhou et al. , 2009 )
16. pflA
Gene Name :
pflA
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
AMW15937
Other Database IDs :
CDD:182994
Taxonomy ID :
738
Protein Name :
pyruvate formate lyase-activating enzyme 1
Protein pI :
5.79
Protein Weight :
26955.76
Protein Length :
330
Protein Note :
pyruvate formate lyase-activating enzyme 1; Provisional; PRK11145
Protein Sequence : Show Sequence
>AMW15937.1 pyruvate formate lyase-activating enzyme 1 [Glaesserella parasuis]
MTVLARYHSYESCGTVDGPGIRFILFLQGCLMRCKYCHNRDTWDLEGGKEISVENLMKEVVTYKHFMRAT
GGGVTASGGEAVLQMEFVRDWFRACKAEGIDTCLDTNGFVRNYSELVDEMLDVTDLVMLDLKQLNEEIHK
DFIGVSNKRTLDFARYLHKRNQRTWIRYVVVPGYTDADEDIHLLGQFIQGMDNIEKVELLPYHRLGAHKW
KTLGLEYELEDVMPPTKESLEHIKGIIESYGHTVKY
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2015 )
17. plpA
Gene Name :
plpA
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Protein GI :
ACL32115
Other Database IDs :
CDD:304360
Taxonomy ID :
557723
Protein Name :
ABC-type metal ion transport system, periplasmic component/outer membrane lipoprotein 1 precursor
Protein pI :
6.05
Protein Weight :
27893.2
Protein Length :
425
Protein Note :
Type 2 periplasmic binding fold superfamily; cl21456
Protein Sequence : Show Sequence
>ACL32115.1 ABC-type metal ion transport system, periplasmic component/outer membrane lipoprotein 1 precursor [Glaesserella parasuis SH0165]
MNFKKLLGLAVVSALALTGCKEEKKAEAPAVAPAPAAQAQKIKVGVMSGPEHTVAEKAAQIAKEKYGLEV
EFVLFNDYALPNTAVSKGDLDANAFQHKPYLDKDSASKGLDNLVIVGNTFVYPLAGYSKKIKNVAELQDG
AVIAVPNDPSNLARALILLEKQGLIKLKDNTNLFSTSLDIVENPKNLKIQEVDTSVAAKALDDVDLAVVN
NTYAGQVGLNATEHGVFVENKESPYVNIIVARKDNQASEAVQNFMKAYQTEEVFQEAQKHFKDGVVKGW
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Hong et al. , 2011 )
18. rnfC
Gene Name :
rnfC
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
KEZ22306
Taxonomy ID :
738
Protein Name :
Nitrogen fixation protein rnfC
Protein pI :
8.11
Protein Weight :
75511.08
Protein Length :
819
Protein Sequence : Show Sequence
>KEZ22306.1 Nitrogen fixation protein rnfC [Glaesserella parasuis]
MQADVLSRIREGKLWDFPGGIHPPEMKKQSNQKPIRSLHLPKFFYVPVLQHSGTAGDVIVQQGDLVLKGQ
ALTKGDNYRQLPVHSPTSGKVVAIQPHVSSHPSGLPELTIVIETDGEDKWIERQPIDDFLSLTSDQIIQK
VYQAGIAGLGGAVFPTSHKLHFADKRCKLLIINGAECEPYITCDDRLMQDYADEMIEGVRILRYVLRPED
VVIAIEDNKPKAIQAVEKALKGANDISVRVIPTKYPSGVSDQLVQVLTGLEIPQGKRTIEMGIVMHNVGT
AFAVKRAVMDDEPLIERVVTLTGDKIRNKGNVWARLGTPILHLLEQVDYQADERFPVFLGGPMMGFILPS
LQSPITKTANCIIAPDHFEYAPPEPERNCIRCSSCSDACPVGLLPQQLYWFARAEDHDKSKEYHLDACIE
CGVCAYVCPSYIPLIQYFRQEKAKIQEVDQKAKQAEEAKIRFEAREARLNKEKEARTARIQQAAEKRREE
VANSQGEDPVKAALERLKAKKAETATPVQTKANGEPDNSELMAQRKARRLAKQVEVSPLPDSRDITSLES
VPLPQAGEGNDPRKAAVAAALARAKAKKEAQQAVTSDENTAKAEVAEDPRKAAVAAALARAKAKKEAQQA
AVSDENVAKAEVAEDPRKAAVAAALARAKAKKEAQQAVVSDENVAKAEVAEDPRKAAVAAALARAKAKKE
AQQAVVSDENVAKAEVAEDPRKAAVAAAIARAKAKKEAQK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2015 )
19. superoxide dismutase
Gene Name :
superoxide dismutase
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
AIK91190
Other Database IDs :
CDD:224943
Taxonomy ID :
738
Protein Name :
superoxide dismutase
Protein pI :
7.82
Protein Weight :
18281.37
Protein Length :
241
Protein Note :
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; COG2032
Protein Sequence : Show Sequence
>AIK91190.1 superoxide dismutase [Glaesserella parasuis]
MKKTVLTLALTALFGFSTSAIANSATQIEVKVQQLDLQNGNKDVGTVTITESPYGLVFTPNLKGLSHGLH
GFHIHEKPSCEPKEKDGKLVAGLGAGGHWDPKETKKHGYPWSDEAHLGDLPALAVDHEGNATNPVLAPRL
KKLEEVKGRSLMIHAGGDNHSDHPAPLGGGGARMACGVIN
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Guo et al. , 2017 )
20. tbpA
Gene Name :
tbpA
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
AAV68905
Other Database IDs :
CDD:273799
Taxonomy ID :
1117322
Protein Name :
TbpA
Protein pI :
9.54
Protein Weight :
97840.98
Protein Length :
967
Protein Note :
TonB-dependent lactoferrin and transferrin receptors; TIGR01776
Protein Sequence : Show Sequence
>AAV68905.1 TbpA [Glaesserella parasuis str. Nagasaki]
MKNKLNLISLAILSLFAVQSYAEQAVQLNDVYVTGTKKKAHKKENEVTGLGKVVKTPDSLSKEQVLGMRD
LTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRSSSGAINEIEYENLRSIQIS
KGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTH
RDGKETKAHKDAESRSKSIQRVDLADNNPQGSNWFKVKNDCPSLNCEPRQQVGVSYDGQKYITEQLSAKE
YTGEERALPDPVKYKSDSWLVKLGYSLSPKHYVAGVYEHSKQRYDTRDMTYPAYWQLSDLKNGDKWYPMN
NAKGLYRDNALDGVAIDYFTEDGVKSSKGLRWAKARFIDEWHTRDRLGALYRYTDQDGNRLIDRLSLSFD
QQKINLSTRLRENNCSEYPTIDKNCRATLDKLWSSTKNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNML
LGSDRFNSTLKRHEILSEFSVGTWHRIRGNGYKDTPYIYELKDQAIYSKNECDYSGTIAGRADCATSKIK
GHNHYIALRDNFAITKYLDIGLGYRFDKHEFRSTHRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGF
RVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPEKSLNQEVATTFKGDFGVVEVSYFKNDYKQLIAPAERM
HQTQSMINYFNVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAYSKMRVKEVKNYQGYMNIRSPLLDTI
QPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPNELRGNEQVGFANYERTATKKRTRSWHTFDLTGYITPW
KHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQHTNVKDYARYAAPGRNYVVSFEMKF
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Huang et al. , 2013 )
21. tbpB
Gene Name :
tbpB
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
AAV68899
Other Database IDs :
CDD:279621
Taxonomy ID :
738
Protein Name :
TbpB
Protein pI :
6.92
Protein Weight :
62210.98
Protein Length :
643
Protein Note :
Transferrin binding protein-like solute binding protein; pfam01298
Protein Sequence : Show Sequence
>AAV68899.1 TbpB [Glaesserella parasuis]
MHFKLNPYALAFTSLFLVACSGGKGGFDLEDVRPNQTAKAEKATTSYQDEETKKKTKEELDKLMEPTLGY
ETQILRRNKAPKTETGEKRNERVVELSEDKITKLYQESVEIIPHLDELNGKTTSNDVYHSHDSKRLDKNR
DLKYVRSGYVYDGSFNEIRRNDSGFHVFKQGIDGYVYYLGVTPSKSYQRESHSYKGTWDLLSNINLDREI
DGFDTSGDGKNVSATSITETVNRDHKVGEKLGDNEVKGVAHSSEFAVDFDNKKLTGSLYRNGYINRNKAQ
EVTKRYSIEADIAGNRFRGKAKAEKAGDPIFTDSNYLEGGFYGPKAEEMAGKFFTNNKSLFAVFAAKSEN
GETTTERIIDATKIDLTQFNAKELNNLGDASVLIIDGQKIDLAGVNFKNSKTVEINGKTMVAVACCSNLE
YMKFGQLWQKEGKQQVKDNSLFLQGERTATDKMPAGGNYKYVGTWDALVSKGTNWIAEADNNRESGYRTE
FDVNFSDKKVNGKLFDKGGVNPVFTVDATINGNGFIGSAKTSDSGFALDAGSSQHGNAVFSDIKVNGGFY
GPTAGELGGQFHHKSDNGSVGAVFGAKRQIEK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Barasuol et al. , 2017 )
22. TolC
Gene Name :
TolC
Sequence Strain (Species/Organism) :
Haemophilus parasuis
NCBI Protein GI :
WP_075604781
Other Database IDs :
CDD:224455
Taxonomy ID :
738
Protein Name :
TolC family protein
Protein pI :
9.06
Protein Weight :
49474.35
Protein Length :
530
Protein Note :
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; COG1538
Protein Sequence : Show Sequence
>WP_075604781.1 TolC family protein [Glaesserella parasuis]
MKVSKLTFTLLSALVLSACTNMSNDGSLQKAQQDYQQYQDITKQYQINEQWWLGYNDTQLNRLVETALGN
NINLAKTAISVNKALYNANLVGANLVPTFTASEKSSASKGVGSSSNLNSTGTSSIGHQIGLNLSYTLDLW
GRLRDTASAAEWEHKATQEDLQAARLSLINAVVSSYYNLAYYQDAIRITQQSVKSYEQLNHILSNKFKQG
LIDQLSVDQSMQAVLSAQNALINLQSAQKSSEQVLRNLLNLKPNEPLVVNYPSILKVKLQDVDVNVPVST
IANRPDVLASLKRLQGAFKNLTATENSWFPTVTLGGSLTGSSTKFNNTSDNPVAGGVVSFDLPFLDWNRV
QNNIKISEEGYKLAKLNYEQTVTTALNEIDTYYSTYQLSKSGYANLQKKYEYDRKISGYYKNRYEQGISE
LREWLSAMNTERSSELSLLENKYTLLKNENAIYQAMAGKYRK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Li et al. , 2017 )
23. VtaA5
Gene Name :
VtaA5
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
NCBI Protein GI :
EYE71559
Taxonomy ID :
1117322
Protein Name :
VtaA5
Protein pI :
9.78
Protein Weight :
102402.53
Protein Length :
1172
Protein Note :
COG5295 Autotransporter adhesin
Protein Sequence : Show Sequence
>EYE71559.1 VtaA5 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSLLSLVLLSIFFSPV
AVGAQLHTGTPYTAGGGSKSDRGSDDGTISIGKKSKASYGAIAIGEESKAEARHNVAIGYKADSGTDANS
ITIGYNTKVSGEQGIAIGKQSKAGGRSVVLGGGAEGTTTQTVVIGNLAKATGSQSIAIGANTKAEGYGSI
SIGGDDLDSTAYHDNNSTKQTRQTTTAKGKASVAIGGLSLATGDGSTVLGPLASASHVEGIAIGARSKST
NEYGIAVGGSATAGKNAVAVGRDSKGAGTDSIAIGNSAKTTGADSVVVGASINVTGEKLVAIGRQANAGS
HSTALGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSRAETRGGIEGAKQTYSV
TTGGSTVENGFKSTENVDGNNIGAVSVGGGSGNKLINRQITNVAAGKELTDAVNVAQLKSLTMKIAGDTG
NSDNEKVGIWEGTLKVLGTSGEIKTSASNDTITLKLDETLKNKIDKIDNLGWKLKIAQGMGGKATNPPAE
QLIKMDQTVTFTAGKNIKLEQAGGNITISTIGKLIEKTEWKNGNLQITYTDGSSDTIAKGKDGKNGEKGD
RGEPGPRGEPGIPGPAGPVGPMGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPAGPR
GPAGPKGDTGQRGETGSAGPAGPKGEPGPKGEQGIPGQAGPAGPRGPQGTAGAQGPKGDKGEPGEAGPAG
PRGPAGPKGDAGPKGDTGQRGETGSAGPTGPKGEPGPKGEQGIPGPAGPAGPKGDKGDTGPAGPQGPAGP
TGPQDPAGPTGNSELKGITSIANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQ
LNTKAAASKTEVEAGKNVKVTSKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGA
RITNVGDGSAEGDIVNVRQLNKVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAIS
VSNAQYRGQSAYAIGYSRISDNGKWLIRASVSSNTQRDTMIGGGVGFVW
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Olvera et al. , 2011 )
24. VtaA6
Gene Name :
VtaA6
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
NCBI Protein GI :
EYE72607
Taxonomy ID :
1117322
Protein Name :
VtaA6
Protein pI :
9.78
Protein Weight :
96152.6
Protein Length :
1125
Protein Note :
COG5295 Autotransporter adhesin
Protein Sequence : Show Sequence
>EYE72607.1 VtaA6, partial [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHDQQAWVVVSELVKSHTKTSACTDKRAQVCTSHYFLDKQQDKFKLSLLSLVLLGIFFSPP
AGSATHSGTPYTADGGSRSNLGSDDGTISIGKESKASYGAIAIGQRSKAEGRHGIAIGYQTNAGTHVNSV
AVGNDIRVSGEEAVAIGSSSKAGKGSVVLGRQADAANIEQAVVIGNLAKASKAQSIAIGANTKAEGYGSI
SIGGDDLKTTKYQTGNQGQSKTTTAKGKASVAIGGLSLATGDGSIVVGPLASASHVEGIAIGARSKSTNE
YGIAVGGGATAGKNAVAVGRDSNGGGTDSIAIGNSAKTTGADSVVVGANINVTGEKLVAIGREANSGSHS
TALGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSNASTAGGVEGLKQTHSVTT
EGSTVANGFKSTQSVDNNAIGAVSVGGGSGNKLINRQITNVAAGKELTDAVNVAQLKSLTLKIEGNENKH
NGVNANLSSADRPKVGLWSGTLKVKGDNGLTSHASGDTITVKLTDDTKSKIDKIDNLGWKLKIAQGMGGK
ATNPPTEHLVKMSDTATVTFTAGNNIKLEQTNGNITISTIGKLIKETKMVNGNLQITYTDGSSNTITRGE
KGDTGPRGETGPAGPPGPMGPAGAAGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPA
GPRGEPGQAGPAGPRGPAGPKGDAGPKGDTGQRGETGPAGPAGPKGEPGPKGEQGIPGPAGPTGPKGDKG
DTGPAGPQGPAGPTGPQGPAGPAGAKGDKGDTGPAGPQGPTGPTGSQDPAGPTGNSELKGITSIANGNDA
TKANGAKITLSADSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAAASKTEVEAGKNVKVTSKTGAN
GQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVGDGSAEGDIVNVRQLNKVVSSV
NTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQYRGQSAYAIGYSRISD
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Olvera et al. , 2011 )
25. VtaA8
Gene Name :
VtaA8
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
NCBI Protein GI :
EYE72886
Taxonomy ID :
1117322
Protein Name :
VtaA8
Protein pI :
9.41
Protein Weight :
94207.97
Protein Length :
1080
Protein Note :
COG5295 Autotransporter adhesin
Protein Sequence : Show Sequence
>EYE72886.1 VtaA8 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSFLSLVLLGIFFSPV
GSARLFLDEARQGSAGVDDGSIGIGRESKVGPGSITIGQKSEAEGRTAVAIGYSAKTGSEHDNAIAIGNS
SKATGPGTVTVGHSSQAKDRSVVLGANAEGKNAQTVVIGTLAKASASQSIAIGADTKAEGYGSISIGGDD
LDQTKYNDNNSTNQPRHTTTAKGKASVAIGGLSLAEGDGSIVVGPLASASDVEGIAIGARSKSTNEYGIA
VGGGATAGKNAVALGRESKGAGTDSIAIGNSARTTGADSVVVGANIDVTDEKLVAIGYQASAKSHATALG
YMASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSRAETRGGIEGAKQSYSVTTGTSS
VDNGFKSTGSVDNNSIPIGAVSVGNNKIKRQIVNVAAGKELTDAVNVAQLKSLTLKIAGNTSEQTQPAVG
LWEGTLKVMGTSGEIKTSASGDTITLKLDETLKNKINTIDNLGWNLKIAKGAGEANPPNAAHLIKMSDTA
TVTFTAGNNIKLEQTNGNITISTIGKLIAKTEWENDGLKITYTDGMHDIIKKGEKGDRGERGLRGETGPA
GPAGPMGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPTGPRGPAGPKGDAGPKGDTG
QRGETGPAGPAGPQGPAGPTGPRGDKGDTGPAGPQGPAGPTGPQGPAGPTGSQDPAGPTGNSELKGITSI
ANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAAAARTEVEAGKNVKVT
SKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVGDGSAEGDIVNVRQLN
KVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQYRGQSAYAIGYSRISD
NGKWLIRASVSSNTQRDTMIGGGVGFVW
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Olvera et al. , 2011 )
26. VtaA9
Gene Name :
VtaA9
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
NCBI Protein GI :
EYE71168
Taxonomy ID :
1117322
Protein Name :
VtaA9
Protein pI :
9.71
Protein Weight :
88376.07
Protein Length :
1024
Protein Note :
COG5295 Autotransporter adhesin
Protein Sequence : Show Sequence
>EYE71168.1 VtaA9 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSLLSLVLLSIFFSPV
AVGAQLHTGTAFLLDGSNKSKLGTDDGTIGIGKDSKAGYGAIAIGQYSKAKARHNVAIGYKADSGVQPNT
ITIGYNTKVSGQEAIAIGKESKAGKESVVLGGQASAANIEQAVVIGHSATASASQSIAIGARSKSTADYG
IAVGGGATAGKNAVAVGRDSKGAGTDSIAIGNSAKTTGVDSVVVGANINVTDGQLVAIGREAKAGSHSTA
LGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSNASTAGGVVGLKQNHSVTTGE
STVDNGFKSTESVDNNPNPIPIGAVSVGNNNIKRQIVNVAAGKELTDAVNVAQLQSLTMKISGDNSSSGK
VGIWDGTLKVVGTSGQIKTSANGDTITLKLDETLKNKIDNIDNLGWKLAITKGSGGEVTTPNTPYLIKMS
DMATVTFTAGNNIKLEQADGNITISTIGKLIAKTEWENDGLKITYTDGMHDIIKKGEKGDRGEKGPKGDR
GETGSAGPAGPAGAQGPVGPAGPAGPTGPQGATGPAGPKGEAGAAGPKGEKGDPGPKGEAGSTGPTGPAG
PKGDPGQAGPKGDTGQKGETGPAGPAGPQGPAGPAGAKGDKGDTGPAGPRGPAGPTGPQGPAGPAGPQDP
AGPTGNSELKGITSIANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAA
ASKTEVEAGKNVKVTSKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVG
DGSAEGDIVNVRQLNKVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQY
RGQSAYAIGYSRISDNGKWLIRASVSSNTQRDTMIGGGVGFVW
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Olvera et al. , 2011 )
27. yfeA
Gene Name :
yfeA
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
NCBI Protein GI :
ACL32714
Other Database IDs :
CDD:238557
Taxonomy ID :
557723
Protein Name :
chelated iron ABC transporter, periplasmic-binding protein
Protein pI :
8.15
Protein Weight :
30617.57
Protein Length :
400
Protein Note :
Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; cd01137
Protein Sequence : Show Sequence
>ACL32714.1 chelated iron ABC transporter, periplasmic-binding protein [Glaesserella parasuis SH0165]
MKKLAALLSMLFLVSNPLAAQQFKVVTTFTVIQDIAQNVAGDKAVVESITKPGAEIHDYQPTPQDIVKAQ
SADLVLWNGMNLESWFERFFAQVKDKPAVVVTEGIEPISIYEGPYKDKPNPHAWMSTKNALIYIENIRQA
LVKYDPANAEAYNANAKAYADKIVALDQPLRERLAKVPEAQRWLVTSEGAFSYLARDYGFKELYLWAINQ
DEQGTPKQIRKVIDQVRKHQIPVVFSESTISDKPAKQVAKESKARYGGVLYVDSLSTKDGKVPTYIDLLN
VTVSTIVAGFEK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Hong et al. , 2011 )
28. ygiW
Gene Name :
ygiW
Sequence Strain (Species/Organism) :
Haemophilus parasuis D75
NCBI Protein GI :
EQA00462
Taxonomy ID :
1117322
Protein Name :
ygiW domain protein
Protein pI :
5.7
Protein Weight :
14278.97
Protein Length :
205
Protein Sequence : Show Sequence
>EQA00462.1 ygiW domain protein [Glaesserella parasuis str. Nagasaki]
MKKAIILTTLLAVSTVSMAKGDDDYRHGGYHDGKARTHQSQGFFDESIAVKSVADALKAADDTPALLEGQ
IVKQIDKDEFIFKDATGEIEIDVSKRAWNGLNIGPQDTIQIRGKVDNDWNKVQVDVKQITKK
Molecule Role :
Protective antigen
Molecule Role Annotation :
(Yuan et al. , 2012 )
III. Vaccine Information
1. Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00)
a. Manufacturer:
Newport Laboratories, Inc.
b. Vaccine Ontology ID:
VO_0001794
c. Type:
Live vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Pig
g. Gene Engineering of
gapA
Type:
DNA vaccine construction Description:
Detailed Gene Information: Click here .
2. pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase
a. Vaccine Ontology ID:
VO_0004515
b. Type:
DNA vaccine
c. Status:
Research
d. Gene Engineering of
gapA
Type:
DNA vaccine construction Description:
Detailed Gene Information: Click here .
e. Vector :
pcDNA3.1 Directional TOPO vector (pcDNA3.1D/V5-His-TOPO) (Fu et al. , 2012 )
f. Immunization Route
Intramuscular injection (i.m.)
g.
Mouse Response
Vaccination Protocol:
Four to five week old female BALB/c mice were divided randomly into three groups (30 mice per group): one group was injected intramuscularly in the hind thigh muscle with 100 μg of plasmid dissolved in 100 μl PBS; the other two groups were injected with pcDNA 3.1 vector only as negative control or PBS as blank control. Mice received a vaccination boost of an equivalent dose on day 14 and 28 following the first immunization (Fu et al. , 2012 ). Vaccine Immune Response Type:
VO_0000286 Immune Response:
Although IgG analysis showed production of both IgG1 and IgG2, the higher levels of IgG1 indicated the dominance of Th2 response over Th1 response (Fu et al. , 2012 ). Challenge Protocol:
Two weeks after the second vaccination boost, mice immunized with pCgap were divided into groups 1 and 2 (12 mice/group). The mice from group 1 were challenged intraperitoneally with a lethal dose of 3.0 × 10^9 CFU of H. parasuis SH0165 strain and the mice from group 2 were challenged intraperitoneally with a lethal dose of 3.0 × 10^9 CFU of H. parasuis MD0322 strain. Mice were monitored for seven days post-challenge, and morbidity and mortality were recorded (Fu et al. , 2012 ). Efficacy:
The groups vaccinated with the pCgap vaccine exhibited 83.3% and 50% protective efficacy against the H. parasuis MD0322 serovar 4 or SH0165 serovar 5 challenges, respectively (Fu et al. , 2012 ).
3. Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Erysipelothrix Rhusiopathiae-Haemophilus Parasuis Bacterin (USDA: 49V9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0004214
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Pig
4. Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Haemophilus Parasuis Bacterin (USDA: 49Q9.20)
a. Manufacturer:
Boehringer Ingelheim Vetmedica, Inc.
b. Vaccine Ontology ID:
VO_0004217
c. Type:
Live, attenuated vaccine
d. Status:
Licensed
e. Location Licensed:
USA
f. Host Species for Licensed Use:
Pig
IV. References
1. Barasuol et al. , 2017: Barasuol BM, Guizzo JA, Fegan JE, Martínez-Martínez S, Rodríguez-Ferri EF, Gutiérrez-Martín CB, Kreutz LC, Schryvers AB, Frandoloso R. New insights about functional and cross-reactive properties of antibodies generated against recombinant TbpBs of Haemophilus parasuis. Scientific reports . 2017; 7(1); 10377. [PubMed: 28871190 ].
2. Fu et al. , 2012: Fu S, Zhang M, Ou J, Liu H, Tan C, Liu J, Chen H, Bei W. Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice. Vaccine . 2012; 30(48); 6839-6844. [PubMed: 23000128 ].
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