|
Haemophilus parasuis |
Table of Contents |
- General Information
- NCBI Taxonomy ID
- Disease
- Introduction
- Microbial Pathogenesis
- Host Ranges and Animal Models
- Host Protective Immunity
- Vaccine Related Pathogen Genes
- csgG
(Protective antigen)
- FOG
(Protective antigen)
- gapA
(Protective antigen)
- gcp
(Protective antigen)
- hsdS
(Protective antigen)
- hxuB
(Protective antigen)
- hxuC
(Protective antigen)
- LppC
(Protective antigen)
- ndk
(Protective antigen)
- omp26
(Protective antigen)
- oppA
(Protective antigen)
- outer membrane protein A
(Protective antigen)
- outer membrane protein D15
(Protective antigen)
- outer membrane protein P2
(Protective antigen)
- palA
(Protective antigen)
- pflA
(Protective antigen)
- plpA
(Protective antigen)
- rnfC
(Protective antigen)
- superoxide dismutase
(Protective antigen)
- tbpA
(Protective antigen)
- tbpB
(Protective antigen)
- TolC
(Protective antigen)
- VtaA5
(Protective antigen)
- VtaA6
(Protective antigen)
- VtaA8
(Protective antigen)
- VtaA9
(Protective antigen)
- yfeA
(Protective antigen)
- ygiW
(Protective antigen)
- Vaccine Information
- Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00)
- pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase
- Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Erysipelothrix Rhusiopathiae-Haemophilus Parasuis Bacterin (USDA: 49V9.20)
- Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Haemophilus Parasuis Bacterin (USDA: 49Q9.20)
- References
|
I. General Information |
1. NCBI Taxonomy ID: |
738 |
2. Disease: |
Glasser's disease |
3. Introduction |
H. parasuis is a non-motile, small, pleomorphic rod in the family Pasteurellaceae, and is the etiologic agent of Glasser's disease. Glasser’s disease is characterized by fibrinous polyserositis, polyarthritis and meningitis. H. parasuis often produces acute septicemia, and its endotoxin induces disseminated intravascular coagulation, resulting in the formation of microthrombi in several organs (Oliveira and Pijoan, 2004). |
4. Microbial Pathogenesis |
H. parasuis colonizes the respiratory tracts of pigs, and can then cause systemic infection (Oliveira and Pijoan, 2004). |
5. Host Ranges and Animal Models |
Pigs |
6. Host Protective Immunity |
Early colonized pigs are protected against systemic infection by maternal antibodies. As maternal immunity decreases, these pigs are able to mount an active immune response to these virulent strains (Oliveira and Pijoan, 2004). |
II. Vaccine Related Pathogen Genes |
1. csgG |
-
Gene Name :
csgG
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
-
NCBI Protein GI :
ACL33081
-
Other Database IDs :
CDD:224379
-
Taxonomy ID :
557723
-
Protein Name :
putative lipoprotein, curli production assembly/transport component CsgG
-
Protein pI :
8.61
-
Protein Weight :
22023.72
-
Protein Length :
345
-
Protein Note :
Curli biogenesis system outer membrane secretion channel CsgG [Cell wall/membrane/envelope biogenesis]; COG1462
-
Protein Sequence : Show Sequence
>ACL33081.1 putative lipoprotein, curli production assembly/transport component CsgG [Glaesserella parasuis SH0165]
MSNLKVGVLCFTVLTLVGCATEGSRVITPTSTQAAITASQYKGVKSVISVGKFDNKSSFQNGVFSDGADQ
LGNQSKTILISHLQQTGRFSVVDRTNMSEIASEAKIKGKKQNLKGATYVITGDVTEFGRKTVGDHQLFGI
LGRGKEQVAYAKVTLNVVNVETSEVVYSSQGAGEYNLSNREVLGFGGTASYDATLNGKVLDLAIREAVNS
LVNGIESGSWQPSH
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Hong et al., 2011)
|
2. FOG |
-
Gene Name :
FOG
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
-
NCBI Protein GI :
ACL32772
-
Other Database IDs :
CDD:276809
CDD:290160 CDD:285020 CDD:304382
-
Taxonomy ID :
557723
-
Protein Name :
possible outer membrane protein, FOG: TPR repeat protein
-
Protein pI :
9.94
-
Protein Weight :
54014.03
-
Protein Length :
584
-
Protein Note :
putative protein binding surface [polypeptide binding]
-
Protein Sequence : Show Sequence
>ACL32772.1 possible outer membrane protein, FOG: TPR repeat protein [Glaesserella parasuis SH0165]
MPDLHFMKSSQFPFILLFVSPILLANPFADPVSFERLSQAVGFEQKFAKKSADLTASPKAVLSLPNPQSL
EAQINQAIIEQQWQRLPTLLQAYQQQSHYDITLVHYALGAFYYGQQRYPEAIEHYQAVLAQQPTLAYPRF
DLGVMLYENQQYRQATEQLTMAKANLAPSMQPLTERYLARMVEEQSWQPDFSLQYVRTDNVNNASSSPVV
NINGRQFVKDKTALPQSAEGFRYGIGVSKAHNLAGNHYLNGSVHYSGVHYWDNQDYSEQSLRFSLGYQYR
NAKMGLGVTPFIEQNWLGSPRYSRQFGATLHGYRYLTQKWIVSSRLTHNQKRYHDSLTASRYNGFQNSGA
LTLRWQAVRSWQIFASIEANRDQTKEKASSSHKIGGTLGVIYRWKNWGSELSGGYAKRNFEGKHYLYGYK
RVDNEYRANWSLWNKQWTWKGLMPKLNFSYVKIQSNIPDFYSRKTGEWFLTVEKRF
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Yuan et al., 2012)
|
3. gapA |
-
Gene Name :
gapA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
-
NCBI Gene ID :
7278596
-
NCBI Protein GI :
498484148
-
Locus Tag :
HAPS_RS00005
-
Genbank Accession :
CP001321
-
Protein Accession :
WP_010785946
-
Taxonomy ID :
557723
-
Gene Starting Position :
1
-
Gene Ending Position :
1020
-
Gene Strand (Orientation) :
+
-
Protein Name :
type I glyceraldehyde-3-phosphate dehydrogenase
-
Protein pI :
6.07
-
Protein Weight :
32717.08
-
Protein Length :
339
-
Protein Note :
COG:G;COG0057
-
DNA Sequence : Show Sequence
>NC_011852.1:1-1020 Haemophilus parasuis SH0165, complete genome
TATGGCAATTAAAATTGGTATTAACGGCTTTGGCCGTATCGGTCGTATCGTATTCCGTGCAGCACAAAAA
CGTGATGACATCGAAGTAGTTGGTATCAACGACTTAATTGATGTTGAGTATATGGCATATATGCTCAAAT
ACGATTCAACTCACGGTCGTTTCGATGGCACTGTCGAAGTAAAAGACGGCAAATTAGTTGTAAACGGTAA
AGAAATCCGTGTTACTTCTGAGCGTGACCCAGCTAACTTAAAATGGAATGAAATTGGTGTGGATATCGCA
GTTGAAGCAACAGGTTTATTCTTGGACGATACAACTGCTCGTAAACACATCGAAGCTGGTGCGAAAAAAG
TCGTTTTAACTGGTCCATCTAAAGATAGCACACCTATGTTCGTAAACGGTGTAAACTTCAACGCTTATGC
TGGTCAAGACATCGTTTCTAACGCTTCTTGTACAACAAACTGCTTAGCACCACTTGCTCGTGTTATCCAC
GAAACATTTGGTATCAAAGAAGGTTTAATGACAACTGTTCATGCAACAACAGCAACACAAAAAACTGTTG
ATGGTCCATCAGCAAAAGACTGGCGCGGTGGTCGTGGTGCGGCACAAAACATCATTCCATCTTCAACAGG
TGCAGCGAAAGCAGTAGGTAAAGTATTACCAGCATTAAACGGTAAATTAACAGGTATGGCGTTCCGTGTT
CCAACAGCAAACGTATCTGTTGTTGATTTAACTGTAAACTTAGAAAAACCAGCAAGCTACGAAGAGATCA
AAAAAGCGATCAAAGATGCAGCAGAAGGTAAAACATTCAACGGCGAATTAAAAGGCGTTTTAGGTTATAC
TGAAGATGCAGTAGTATCAACAGACTTCAACGGTGCAGTTGAAACTTCTGTATTTGATGCAGATGCAGGT
ATCGCATTAACAGATACATTCGTGAAACTTGTTTCTTGGTATGACAACGAAACTGGTTACTCAAACAAAG
TATTAGACTTAGTTGCTCACGTTTACAACTACAAAGGCTA
-
Protein Sequence : Show Sequence
>WP_010785946.1 type I glyceraldehyde-3-phosphate dehydrogenase [Glaesserella parasuis]
MAIKIGINGFGRIGRIVFRAAQKRDDIEVVGINDLIDVEYMAYMLKYDSTHGRFDGTVEVKDGKLVVNGK
EIRVTSERDPANLKWNEIGVDIAVEATGLFLDDTTARKHIEAGAKKVVLTGPSKDSTPMFVNGVNFNAYA
GQDIVSNASCTTNCLAPLARVIHETFGIKEGLMTTVHATTATQKTVDGPSAKDWRGGRGAAQNIIPSSTG
AAKAVGKVLPALNGKLTGMAFRVPTANVSVVDLTVNLEKPASYEEIKKAIKDAAEGKTFNGELKGVLGYT
EDAVVSTDFNGAVETSVFDADAGIALTDTFVKLVSWYDNETGYSNKVLDLVAHVYNYKG
-
Molecule Role :
Protective antigen
- Related Vaccine(s):
Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00)
,
pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase
|
4. gcp |
-
Gene Name :
gcp
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
EQA95212
-
Taxonomy ID :
456298
-
Protein Name :
putative tRNA threonylcarbamoyladenosine biosynthesis protein Gcp
-
Protein pI :
4.89
-
Protein Weight :
35809.93
-
Protein Length :
458
-
Protein Sequence : Show Sequence
>EQA95212.1 putative tRNA threonylcarbamoyladenosine biosynthesis protein Gcp [Glaesserella parasuis 29755]
MKILGIETSCDETGVAIYDEAKGLVANQLYSQIEMHADYGGVVPELASRDHIRKTLPLIQEALKEANLTA
SDIDGVAYTAGPGLVGALLVGSTIARSLAYAWNVPALGVHHMEGHLLAPMLEENAPEFPFVALLVSGGHT
QLVDVKNVGEYELLGESIDDAAGEAFDKTAKLLGLDYPGGAALAKLAETGTPNRFTFPRPMTDRPGLDFS
FSGLKTFAANTINANLNEKGELDQQTRCDIAYAFQQAVIETLIIKCRRALQQTGYKRLVIAGGVSANKQL
RHDLSELMKQIGGEVFYPRPQFCTDNGAMIAYAGFLRLKNGEQTDLSVSVKPRWPMVELCPIDV
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2015)
|
5. hsdS |
-
Gene Name :
hsdS
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACL32369
-
Other Database IDs :
CDD:279728
CDD:223804
-
Taxonomy ID :
557723
-
Protein Name :
type I restriction enzyme specificity protein HsdS
-
Protein pI :
7.36
-
Protein Weight :
45559.72
-
Protein Length :
509
-
Protein Note :
Type I restriction modification DNA specificity domain; pfam01420
-
Protein Sequence : Show Sequence
>ACL32369.1 type I restriction enzyme specificity protein HsdS [Glaesserella parasuis SH0165]
MIESRFIEKLLKNREIEFKSLGDVTEMKRGKTITAKDASGGDIPVISGGQKPAYYHNEYNRNGKTITVAG
SGAYAGFIMYWEEPIFVSDAFSIKSDETLLDLKYVYHFLLQHQQKIYGMKKGSGVPHVYPKDLSTLVIPI
PPLDVQQEIVRILDAFTSLTAELTAELTAELTSRQKQYQYFRDKLLNFDDISDRGGYETNPITKALWHNK
KVVFKTLGEVTTISIGLTYTPAYVEKGIKFISAQNTSKDYLDLSNVKYISEEEFENSTDNAKPQRDDILF
TRVGSNIGHPVIVETDEKLCIFVSLGFLRVKDNNFLFNRYLKHWMSTDLFWKQVEKNVHGSAKINLNTGW
LKDFKIPIPPFEEQQRIVAILDKFETLTNSIAEGLPKEIELRRKQYEYYREKLLSFPQ
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2015)
|
6. hxuB |
-
Gene Name :
hxuB
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACL33615
-
Other Database IDs :
CDD:225387
CDD:285653 CDD:279448
-
Taxonomy ID :
557723
-
Protein Name :
heme/hemopexin-binding protein B, hemolysin activation/secretion protein
-
Protein pI :
9.69
-
Protein Weight :
61003.04
-
Protein Length :
690
-
Protein Note :
Hemolysin activation/secretion protein [Intracellular trafficking, secretion, and vesicular transport]; COG2831
-
Protein Sequence : Show Sequence
>ACL33615.1 heme/hemopexin-binding protein B, hemolysin activation/secretion protein [Glaesserella parasuis SH0165]
MKHFRRKNVITGIILSCVSGFTYANPIPDSGTLNKQLEQTRQIQVAKVKPSGELFKTPTQEENLPANKES
LKFRLDSIKLLELDGNEIQDNLTSITSPYLHQEITLDDLNRLSQQITNYYRDNNYLVAKAFIPPQEINNG
ELQIFVIKGSLDQVVVRNGSRLKEDLVMRMVNTTVKSHSYLVKNELEKLALLLNDIKGITSALSLKAGQN
TGKTDLTVNLKDNKRWNGYISIDNQGNDNTGKYRTTLGNKIYNLVGLGDELHFDVLASNTFDLYNLRADY
SFIIDGYGTRVGVNSNYLKYKLGANFKDLNAQGSTYNLGGYITHPTIRTASLRLDSKLAFNHQKLSDEQK
SVDLQQKRKVNTTSIGVSGSWNSIKEGVTYFSFNTIFGKESHSTNEKKHYLSENYQPKRTFTTFNYSLSH
EQFLPKSFSITFAASGQFADKNLDSGNKFLLGGLSGVKGYQAGTVSVDEGHIIQAELKHYLPVFSKSILV
SSLFYDEGFGKQYKNTEKLSESVENKVRLKSIGVGLNLIEPNHYSINFAYAKPIGKKYNNVDKNQFWLSA
IKTF
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Wen et al., 2016)
|
7. hxuC |
-
Gene Name :
hxuC
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACL33614
-
Other Database IDs :
CDD:273807
CDD:238657
-
Taxonomy ID :
557723
-
Protein Name :
heme/hemopexin utilization protein C/outer membrane receptor protein, mostly Fe transport
-
Protein pI :
9.8
-
Protein Weight :
77928.54
-
Protein Length :
853
-
Protein Note :
TonB-dependent heme/hemoglobin receptor family protein; TIGR01785
-
Protein Sequence : Show Sequence
>ACL33614.1 heme/hemopexin utilization protein C/outer membrane receptor protein, mostly Fe transport [Glaesserella parasuis SH0165]
MRLSKIYTALFLSLPTVSLADSNVSAELAEISVIASRDAFHWANHTSEKATLNKNQLLTQQPISTADAIK
RITNVDIAGGSRGIAQKPIIRGLSGNRVVQVIDGVRQNFDLSHRGSYFLPMALTQEIEVIKGPTSTLWGS
GALGGIVAIRTPNALDLLKDNQQIGAKIHQGYQSANSLSETDVSVFAANDKFDGLVSGFYNHADDLRLAD
SKKLVDSRYTQKGGLFKFGWQINDENRLELSHRLSHFEQIAPTNNEVAEEFTNQDVRNLIRNWHRNNPTA
SFAEMTRFYKGLTSVLGSVSYRAKQKITDQSSALHYYFNPKDNDYINSQLTLYRNSTKEKEQRIASGLQD
QTKLSTMGLNIRNSTDLNWLALNYGVDFISDRVVTQREKNATTPFRPNNYDAKSKNSAFYLLTHIPLWNE
RIIVSPSVRYDHFKTQSDEAKYSASRWSPSIAATWKATNWLDLSTRYNKAFRTPSMQERFVSGSHFGTNL
MGQSFNNTFVSNPNLRPETAKNKEIAAKVHFDNLFVHQDKFIFNAAYFQNDVKDFIHLDIFRASQRERIP
SLSQYRNVENARLTGYELEFAYQQERLALGLNYAQTKGKNRQTQEALSNIPANKLGFTIDYALVPQTFMI
GANITHYASQKRVPKTHAMTYPSYTLTDLKASYTPSGEWRNLRLDMMIENVFDKKFQPAFSLMEGAGRNI
KLNASYQF
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Wen et al., 2016)
|
8. LppC |
-
Gene Name :
LppC
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
WP_021117166
-
Other Database IDs :
CDD:332423
-
Taxonomy ID :
738
-
Protein Name :
lppC lipofamily protein
-
Protein pI :
5.9
-
Protein Weight :
61497.82
-
Protein Length :
653
-
Protein Note :
LppC putative lipoprotein; cl27602
-
Protein Sequence : Show Sequence
>WP_021117166.1 lppC lipofamily protein [Glaesserella parasuis]
MPTILVQSYGFRQKMKTIFIPTALALLLAACSGNKVTETLKNEAYGNSEFYINKAEQSRNIEEQQSYRLL
AVRKLIEENKVVEAQNTFSEILVAKLNDEQKLEHRLLIAQLAALQGNNSEAQGVLRALPQTLLSQSQRLR
VYQTQARIAENQNDVIAAVNARALMDRYMTDTQSRQANNDKIWEMLRNANRGMLEKAVAGPGEIGLAGWL
ALVVAYNQNMSNPAQLPQVIEMWKQQYPNHSATLLLPIELRNVSSFEQTQLNGVALLLPLSGDAKILGEI
IKRGFDDAKGITTMPVQVFDTDSAPINDLLMQAKQQGAQTIIGPLLKPRVDEMLISPEISNINVLALNST
PNVRAVAKVCYYGLSPEAEAHFAAERFLKDGLQNAVVVAPNGDFGTRSAEAFAQRWRQLTNRDTDIRYYN
QAFEVASLLQGSVLGQGSGLYALGTAEQLSDLKQSLDNSPLANQFPIYTSSRSNSPNNGPDFRLTMEGVK
FSEIPLLSDPSSSEYKKAEQIAESDFSMMRLYAMGSDTWSIANKFNEFRQIPGYKVHGLTGVLRAGPNCN
LEREMNWLQYRGGSIVDAN
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2017)
|
9. ndk |
-
Gene Name :
ndk
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
KEZ22119
-
Taxonomy ID :
738
-
Protein Name :
Nucleoside diphosphate kinase
-
Protein pI :
6.53
-
Protein Weight :
15381.74
-
Protein Length :
207
-
Protein Sequence : Show Sequence
>KEZ22119.1 Nucleoside diphosphate kinase [Glaesserella parasuis]
MIQQTLAIIKPDATKRHLIGEILSYMEKNGLAIKALKMLHLTKEQAEGFYAEHQGKDFFDPLVAFMISEP
IVVAVLEGENAVENYRLLMGATKPEERKLGTIRKMFGLGYRENSVHGSDSETSAKREIAYFFTPSEIV
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2015)
|
10. omp26 |
-
Gene Name :
omp26
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACL32860
-
Other Database IDs :
CDD:332039
-
Taxonomy ID :
557723
-
Protein Name :
outer membrane protein 26
-
Protein pI :
8.4
-
Protein Weight :
28348.36
-
Protein Length :
341
-
Protein Note :
Outer membrane protein (OmpH-like); cl27218
-
Protein Sequence : Show Sequence
>ACL32860.1 outer membrane protein 26 [Glaesserella parasuis SH0165]
MKNLFKLAAVASALAFSANTVNANEKIGFVDPNFLIQNHPLTIEANDKFTKFMKDTESKFAPREKQLAAE
NKALSDEEKALLDERKKIEEDAQKLQKEQVTLEAAMKKKVAQLEKDAPRLKAKEIQARQDKINAEAKPFQ
NKVSALQQREVEFGKKAEEFQKRADEFQKKVAAFQEEIAKVQKESGVITPEQVQQKVVEDINAKIKQVAE
SKGYTLVLPPSVALYAKDGNAADITEEILVAMGGKMPEAPKTEVPAAEVTKPEEVKK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2016)
|
11. oppA |
-
Gene Name :
oppA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACL32119
-
Other Database IDs :
CDD:173869
CDD:185059
-
Taxonomy ID :
557723
-
Protein Name :
putative oligopeptide transporter, periplasmic-binding protein, OppA
-
Protein pI :
6.99
-
Protein Weight :
55956.24
-
Protein Length :
634
-
Protein Note :
The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; cd08504
-
Protein Sequence : Show Sequence
>ACL32119.1 putative oligopeptide transporter, periplasmic-binding protein, OppA [Glaesserella parasuis SH0165]
MASIQRIVQFIKKGLFVTACIVGFVACDPEENNGSVRPLPNAEPTNVLSRAIYATELQLDPHFVRISAEA
GVVRDLFLGLMAFDPKGQIQNAVAKEWFSEDGKNWLFILDENAKWSNDQAVTSADFVASWQRLSDPKNAS
PLAHYLVYMGIVNSRAVLAGELPPDALGVKALNPYTLQVQLEKANYQLPKMLAHSALLPTYLGQKPNSTD
LVSNGSYRVEHFEKNLLQLKARDKNTPFQVVQYHLITSVQNPSRFDIIENPLENYHQHEKRFARLCNYFY
EFNFNDPLFAQKPIRQAVRAMISPIEISKGNGIPSHLMIPKQLFSEMGHSLSHTNVEQLLNEQGIHSGNP
LKLTLSYDRQGQHSQIAARIVRALGQSELFRVQLQAVSWEELLAKREHKDFQLIRSGWCADYPDPVLFLT
QFHSQSPDNKSSYSNAKVDELLLQLQEQPLDTAQRQRIIATIAHQLEEDVAILPLFQYQRRMSIAPTIQG
FDEQNASETIYSKDLTRQYHKDK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Macedo et al., 2016)
|
12. outer membrane protein A |
-
Gene Name :
outer membrane protein A
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
ACN62162
-
Other Database IDs :
CDD:236764
CDD:279698 CDD:143586
-
Taxonomy ID :
738
-
Protein Name :
outer membrane protein A
-
Protein pI :
9.52
-
Protein Weight :
36308.42
-
Protein Length :
435
-
Protein Note :
outer membrane protein A; Reviewed
-
Protein Sequence : Show Sequence
>ACN62162.1 outer membrane protein A [Glaesserella parasuis]
MKKSLIALAVSGLAVASVAQAAPQANTFYVGAKAGWATFHNDINQIDSKYANDARYDATNLKYGISRNSV
TYGVFGGYQIIDNLAVELGYDYFGRVRGNKQEFRAFKHSAHGTHLSLKPSYEVLNGLDVYGKVGAALVRN
DYKRYSQTAGVQTQKAHNLKTSLVLGAGVEYAILPELAFRVEYQWLSNVGNFTKAEAKENRRATYNYSPD
SHSVTAGISYRFGQGAAPVAAAPEVVTKNFAFSSDVLFDFGKANLKPAAAQTLDAVHTEIVNLGLANPAV
QVNGYTDRIGKDAANLTLSQKRAETVANYIVSKGVNPANVTAVGYGEANPVTGNTCDAVKGRKALITCLA
PDRRVEIQVQGSKEVSM
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Tian et al., 2011)
|
13. outer membrane protein D15 |
-
Gene Name :
outer membrane protein D15
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki]
-
NCBI Protein GI :
ACI05267
-
Other Database IDs :
CDD:236834
CDD:284624 CDD:279448
-
Taxonomy ID :
738
-
Protein Name :
outer membrane protein D15
-
Protein pI :
7.65
-
Protein Weight :
85698.04
-
Protein Length :
881
-
Protein Note :
outer membrane protein assembly factor YaeT; Provisional
-
Protein Sequence : Show Sequence
>ACI05267.1 outer membrane protein D15 [Glaesserella parasuis]
MKKLLLSTLLVANGVAFASPFVIKDIRIDGIQTSVSQTMIPTLPVKVGQLATDNDIANVIRHLFVQNRFQ
NISATREGDILIIKVVENPVINNVDIEGNSAIPKEPLEQNLKANLITKGELFNSTKLDAFKSALIEHYHS
IGRYNATIDTVITNSDNGGVNIKLDIKEGDVAYVKAINFEGNQAFTSKVLMKQLDIQPDVSWFNIFQSSK
FEQTAYNQDLENLRNFYMNQGYAKFNVEAEQPVFSDDKKEVSLTYKINEGIPYTVSEIRIVGNTAKLDNE
LNEQLKYYKTGELFSKNELSKIEDNIKQVFGNNGFASAKIELHPTFDDTNKTIRLTFVVDAGQRVYVRQI
RFEGNDVTADSTLRREMRQQEGAWLSTSLAALGKARLERTGFYDSVEMSYPNVPNTADQVDIVYKIKERN
TGSINFGVGYGTESGLSYQAGIKQDNFLGMGSTISLNGTRNDYGTSINLGYTEPYFTKDGVSLGGNIFYE
DYDNSKNNSVASYKRQTYGVNSTLGFPVNEYNSYFLGLGYTQDLIKNARREFNRELYVQSMKFPIDNDLN
VYKKIKANDFDFSFGWNYNSLNRGFLPTEGTLTSISGRITTPGSDNKYYKVSIDFKNYLPVNREHKWVIS
TKANIAYANGFSGKELPFYQTYTAGGIGSLRGFAYGAIGPKAIYLGKDNNGNIRFNSVNRDIVGGNAMAS
ATLELITPTPFVSEKYQHNVRTSLFVDAATVLNTKWKTNPVVNDIQYNYSSLENFKDYKRFRASTGIAFQ
WNSPIGPLVFSYAKPIKKYQGDEIEQFQFSIGGSF
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Zhou et al., 2009)
|
14. outer membrane protein P2 |
-
Gene Name :
outer membrane protein P2
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki]
-
NCBI Protein GI :
EYE71716
-
Taxonomy ID :
1117322
-
Protein Name :
outer membrane protein P2 (OMP P2)
-
Protein pI :
9.55
-
Protein Weight :
36557.65
-
Protein Length :
451
-
Protein Note :
COG3203 Outer membrane protein (porin)
-
Protein Sequence : Show Sequence
>EYE71716.1 outer membrane protein P2 (OMP P2) [Glaesserella parasuis str. Nagasaki]
MKKTLVALAVAAFAASASAVTVYENEGTKVDFDGQLRLLLEEQATKEKGQSSTGGHTNLKNNGSRFGISI
KHNINENLYGFGRYETRLDSNSKNAAGWGDVKTKYAYVGLGGYGHEISFGKQDVIGDSIGQAGFDKVYGV
GTGGIKYSANNTNKKGFDILTSDSDSAINYTYTGIEGLTLGANYNVANERDKKTGEVNVGSTKSGFGLGA
KYTAKIAESQSVTVAAGYTHDDYKSGSVNKKDKDGVYFGLKYVNAPFTVAVDGGHGVEKTGNVKEKIDFV
RTGARFDVTPKSGVYGNYSYGTYKDKAYKATAHQFMLGADYKLHKQVVTFVEGRLIKNKDSNNKKVTDQA
LGVGLRVLW
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Zhou et al., 2009)
|
15. palA |
-
Gene Name :
palA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
-
NCBI Protein GI :
ACL31779
-
Other Database IDs :
CDD:274307
CDD:143586
-
Taxonomy ID :
557723
-
Protein Name :
18K peptidoglycan-associated outer membrane lipoprotein, precursor PalA
-
Protein pI :
7.56
-
Protein Weight :
16062.54
-
Protein Length :
272
-
Protein Note :
peptidoglycan-associated lipoprotein; TIGR02802
-
Protein Sequence : Show Sequence
>ACL31779.1 18K peptidoglycan-associated outer membrane lipoprotein, precursor PalA [Glaesserella parasuis SH0165]
MKKLAKVLMIAAPAFVLAACSSSNDNASANASANAGQTFGGMSVQDLQTRYNTVYFDFDSYTLKAEDQQL
LDAHAQYLVASKGKVTVAGHADERGTPEYNIALGQRRADAVKDFLATKGASNVATVSYGEEKPAVLGHSE
ADYSKNRRAVLEY
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Zhou et al., 2009)
|
16. pflA |
-
Gene Name :
pflA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
AMW15937
-
Other Database IDs :
CDD:182994
CDD:302752 CDD:100105
-
Taxonomy ID :
738
-
Protein Name :
pyruvate formate lyase-activating enzyme 1
-
Protein pI :
5.79
-
Protein Weight :
26955.76
-
Protein Length :
330
-
Protein Note :
pyruvate formate lyase-activating enzyme 1; Provisional; PRK11145
-
Protein Sequence : Show Sequence
>AMW15937.1 pyruvate formate lyase-activating enzyme 1 [Glaesserella parasuis]
MTVLARYHSYESCGTVDGPGIRFILFLQGCLMRCKYCHNRDTWDLEGGKEISVENLMKEVVTYKHFMRAT
GGGVTASGGEAVLQMEFVRDWFRACKAEGIDTCLDTNGFVRNYSELVDEMLDVTDLVMLDLKQLNEEIHK
DFIGVSNKRTLDFARYLHKRNQRTWIRYVVVPGYTDADEDIHLLGQFIQGMDNIEKVELLPYHRLGAHKW
KTLGLEYELEDVMPPTKESLEHIKGIIESYGHTVKY
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2015)
|
17. plpA |
-
Gene Name :
plpA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
-
NCBI Protein GI :
ACL32115
-
Other Database IDs :
CDD:304360
CDD:270316
-
Taxonomy ID :
557723
-
Protein Name :
ABC-type metal ion transport system, periplasmic component/outer membrane lipoprotein 1 precursor
-
Protein pI :
6.05
-
Protein Weight :
27893.2
-
Protein Length :
425
-
Protein Note :
Type 2 periplasmic binding fold superfamily; cl21456
-
Protein Sequence : Show Sequence
>ACL32115.1 ABC-type metal ion transport system, periplasmic component/outer membrane lipoprotein 1 precursor [Glaesserella parasuis SH0165]
MNFKKLLGLAVVSALALTGCKEEKKAEAPAVAPAPAAQAQKIKVGVMSGPEHTVAEKAAQIAKEKYGLEV
EFVLFNDYALPNTAVSKGDLDANAFQHKPYLDKDSASKGLDNLVIVGNTFVYPLAGYSKKIKNVAELQDG
AVIAVPNDPSNLARALILLEKQGLIKLKDNTNLFSTSLDIVENPKNLKIQEVDTSVAAKALDDVDLAVVN
NTYAGQVGLNATEHGVFVENKESPYVNIIVARKDNQASEAVQNFMKAYQTEEVFQEAQKHFKDGVVKGW
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Hong et al., 2011)
|
18. rnfC |
-
Gene Name :
rnfC
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
KEZ22306
-
Taxonomy ID :
738
-
Protein Name :
Nitrogen fixation protein rnfC
-
Protein pI :
8.11
-
Protein Weight :
75511.08
-
Protein Length :
819
-
Protein Sequence : Show Sequence
>KEZ22306.1 Nitrogen fixation protein rnfC [Glaesserella parasuis]
MQADVLSRIREGKLWDFPGGIHPPEMKKQSNQKPIRSLHLPKFFYVPVLQHSGTAGDVIVQQGDLVLKGQ
ALTKGDNYRQLPVHSPTSGKVVAIQPHVSSHPSGLPELTIVIETDGEDKWIERQPIDDFLSLTSDQIIQK
VYQAGIAGLGGAVFPTSHKLHFADKRCKLLIINGAECEPYITCDDRLMQDYADEMIEGVRILRYVLRPED
VVIAIEDNKPKAIQAVEKALKGANDISVRVIPTKYPSGVSDQLVQVLTGLEIPQGKRTIEMGIVMHNVGT
AFAVKRAVMDDEPLIERVVTLTGDKIRNKGNVWARLGTPILHLLEQVDYQADERFPVFLGGPMMGFILPS
LQSPITKTANCIIAPDHFEYAPPEPERNCIRCSSCSDACPVGLLPQQLYWFARAEDHDKSKEYHLDACIE
CGVCAYVCPSYIPLIQYFRQEKAKIQEVDQKAKQAEEAKIRFEAREARLNKEKEARTARIQQAAEKRREE
VANSQGEDPVKAALERLKAKKAETATPVQTKANGEPDNSELMAQRKARRLAKQVEVSPLPDSRDITSLES
VPLPQAGEGNDPRKAAVAAALARAKAKKEAQQAVTSDENTAKAEVAEDPRKAAVAAALARAKAKKEAQQA
AVSDENVAKAEVAEDPRKAAVAAALARAKAKKEAQQAVVSDENVAKAEVAEDPRKAAVAAALARAKAKKE
AQQAVVSDENVAKAEVAEDPRKAAVAAAIARAKAKKEAQK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2015)
|
19. superoxide dismutase |
-
Gene Name :
superoxide dismutase
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
AIK91190
-
Other Database IDs :
CDD:224943
CDD:238186
-
Taxonomy ID :
738
-
Protein Name :
superoxide dismutase
-
Protein pI :
7.82
-
Protein Weight :
18281.37
-
Protein Length :
241
-
Protein Note :
Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; COG2032
-
Protein Sequence : Show Sequence
>AIK91190.1 superoxide dismutase [Glaesserella parasuis]
MKKTVLTLALTALFGFSTSAIANSATQIEVKVQQLDLQNGNKDVGTVTITESPYGLVFTPNLKGLSHGLH
GFHIHEKPSCEPKEKDGKLVAGLGAGGHWDPKETKKHGYPWSDEAHLGDLPALAVDHEGNATNPVLAPRL
KKLEEVKGRSLMIHAGGDNHSDHPAPLGGGGARMACGVIN
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Guo et al., 2017)
|
20. tbpA |
-
Gene Name :
tbpA
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
AAV68905
-
Other Database IDs :
CDD:273799
CDD:238657
-
Taxonomy ID :
1117322
-
Protein Name :
TbpA
-
Protein pI :
9.54
-
Protein Weight :
97840.98
-
Protein Length :
967
-
Protein Note :
TonB-dependent lactoferrin and transferrin receptors; TIGR01776
-
Protein Sequence : Show Sequence
>AAV68905.1 TbpA [Glaesserella parasuis str. Nagasaki]
MKNKLNLISLAILSLFAVQSYAEQAVQLNDVYVTGTKKKAHKKENEVTGLGKVVKTPDSLSKEQVLGMRD
LTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRSSSGAINEIEYENLRSIQIS
KGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTH
RDGKETKAHKDAESRSKSIQRVDLADNNPQGSNWFKVKNDCPSLNCEPRQQVGVSYDGQKYITEQLSAKE
YTGEERALPDPVKYKSDSWLVKLGYSLSPKHYVAGVYEHSKQRYDTRDMTYPAYWQLSDLKNGDKWYPMN
NAKGLYRDNALDGVAIDYFTEDGVKSSKGLRWAKARFIDEWHTRDRLGALYRYTDQDGNRLIDRLSLSFD
QQKINLSTRLRENNCSEYPTIDKNCRATLDKLWSSTKNEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNML
LGSDRFNSTLKRHEILSEFSVGTWHRIRGNGYKDTPYIYELKDQAIYSKNECDYSGTIAGRADCATSKIK
GHNHYIALRDNFAITKYLDIGLGYRFDKHEFRSTHRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGF
RVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPEKSLNQEVATTFKGDFGVVEVSYFKNDYKQLIAPAERM
HQTQSMINYFNVQDIKLDGINLIGKLDWNGVFDKIPEGIYTTLAYSKMRVKEVKNYQGYMNIRSPLLDTI
QPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPNELRGNEQVGFANYERTATKKRTRSWHTFDLTGYITPW
KHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQHTNVKDYARYAAPGRNYVVSFEMKF
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Huang et al., 2013)
|
21. tbpB |
-
Gene Name :
tbpB
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
AAV68899
-
Other Database IDs :
CDD:279621
-
Taxonomy ID :
738
-
Protein Name :
TbpB
-
Protein pI :
6.92
-
Protein Weight :
62210.98
-
Protein Length :
643
-
Protein Note :
Transferrin binding protein-like solute binding protein; pfam01298
-
Protein Sequence : Show Sequence
>AAV68899.1 TbpB [Glaesserella parasuis]
MHFKLNPYALAFTSLFLVACSGGKGGFDLEDVRPNQTAKAEKATTSYQDEETKKKTKEELDKLMEPTLGY
ETQILRRNKAPKTETGEKRNERVVELSEDKITKLYQESVEIIPHLDELNGKTTSNDVYHSHDSKRLDKNR
DLKYVRSGYVYDGSFNEIRRNDSGFHVFKQGIDGYVYYLGVTPSKSYQRESHSYKGTWDLLSNINLDREI
DGFDTSGDGKNVSATSITETVNRDHKVGEKLGDNEVKGVAHSSEFAVDFDNKKLTGSLYRNGYINRNKAQ
EVTKRYSIEADIAGNRFRGKAKAEKAGDPIFTDSNYLEGGFYGPKAEEMAGKFFTNNKSLFAVFAAKSEN
GETTTERIIDATKIDLTQFNAKELNNLGDASVLIIDGQKIDLAGVNFKNSKTVEINGKTMVAVACCSNLE
YMKFGQLWQKEGKQQVKDNSLFLQGERTATDKMPAGGNYKYVGTWDALVSKGTNWIAEADNNRESGYRTE
FDVNFSDKKVNGKLFDKGGVNPVFTVDATINGNGFIGSAKTSDSGFALDAGSSQHGNAVFSDIKVNGGFY
GPTAGELGGQFHHKSDNGSVGAVFGAKRQIEK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Barasuol et al., 2017)
|
22. TolC |
-
Gene Name :
TolC
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis
-
NCBI Protein GI :
WP_075604781
-
Other Database IDs :
CDD:224455
-
Taxonomy ID :
738
-
Protein Name :
TolC family protein
-
Protein pI :
9.06
-
Protein Weight :
49474.35
-
Protein Length :
530
-
Protein Note :
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis]; COG1538
-
Protein Sequence : Show Sequence
>WP_075604781.1 TolC family protein [Glaesserella parasuis]
MKVSKLTFTLLSALVLSACTNMSNDGSLQKAQQDYQQYQDITKQYQINEQWWLGYNDTQLNRLVETALGN
NINLAKTAISVNKALYNANLVGANLVPTFTASEKSSASKGVGSSSNLNSTGTSSIGHQIGLNLSYTLDLW
GRLRDTASAAEWEHKATQEDLQAARLSLINAVVSSYYNLAYYQDAIRITQQSVKSYEQLNHILSNKFKQG
LIDQLSVDQSMQAVLSAQNALINLQSAQKSSEQVLRNLLNLKPNEPLVVNYPSILKVKLQDVDVNVPVST
IANRPDVLASLKRLQGAFKNLTATENSWFPTVTLGGSLTGSSTKFNNTSDNPVAGGVVSFDLPFLDWNRV
QNNIKISEEGYKLAKLNYEQTVTTALNEIDTYYSTYQLSKSGYANLQKKYEYDRKISGYYKNRYEQGISE
LREWLSAMNTERSSELSLLENKYTLLKNENAIYQAMAGKYRK
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Li et al., 2017)
|
23. VtaA5 |
-
Gene Name :
VtaA5
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
-
NCBI Protein GI :
EYE71559
-
Taxonomy ID :
1117322
-
Protein Name :
VtaA5
-
Protein pI :
9.78
-
Protein Weight :
102402.53
-
Protein Length :
1172
-
Protein Note :
COG5295 Autotransporter adhesin
-
Protein Sequence : Show Sequence
>EYE71559.1 VtaA5 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSLLSLVLLSIFFSPV
AVGAQLHTGTPYTAGGGSKSDRGSDDGTISIGKKSKASYGAIAIGEESKAEARHNVAIGYKADSGTDANS
ITIGYNTKVSGEQGIAIGKQSKAGGRSVVLGGGAEGTTTQTVVIGNLAKATGSQSIAIGANTKAEGYGSI
SIGGDDLDSTAYHDNNSTKQTRQTTTAKGKASVAIGGLSLATGDGSTVLGPLASASHVEGIAIGARSKST
NEYGIAVGGSATAGKNAVAVGRDSKGAGTDSIAIGNSAKTTGADSVVVGASINVTGEKLVAIGRQANAGS
HSTALGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSRAETRGGIEGAKQTYSV
TTGGSTVENGFKSTENVDGNNIGAVSVGGGSGNKLINRQITNVAAGKELTDAVNVAQLKSLTMKIAGDTG
NSDNEKVGIWEGTLKVLGTSGEIKTSASNDTITLKLDETLKNKIDKIDNLGWKLKIAQGMGGKATNPPAE
QLIKMDQTVTFTAGKNIKLEQAGGNITISTIGKLIEKTEWKNGNLQITYTDGSSDTIAKGKDGKNGEKGD
RGEPGPRGEPGIPGPAGPVGPMGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPAGPR
GPAGPKGDTGQRGETGSAGPAGPKGEPGPKGEQGIPGQAGPAGPRGPQGTAGAQGPKGDKGEPGEAGPAG
PRGPAGPKGDAGPKGDTGQRGETGSAGPTGPKGEPGPKGEQGIPGPAGPAGPKGDKGDTGPAGPQGPAGP
TGPQDPAGPTGNSELKGITSIANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQ
LNTKAAASKTEVEAGKNVKVTSKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGA
RITNVGDGSAEGDIVNVRQLNKVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAIS
VSNAQYRGQSAYAIGYSRISDNGKWLIRASVSSNTQRDTMIGGGVGFVW
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Olvera et al., 2011)
|
24. VtaA6 |
-
Gene Name :
VtaA6
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
-
NCBI Protein GI :
EYE72607
-
Taxonomy ID :
1117322
-
Protein Name :
VtaA6
-
Protein pI :
9.78
-
Protein Weight :
96152.6
-
Protein Length :
1125
-
Protein Note :
COG5295 Autotransporter adhesin
-
Protein Sequence : Show Sequence
>EYE72607.1 VtaA6, partial [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHDQQAWVVVSELVKSHTKTSACTDKRAQVCTSHYFLDKQQDKFKLSLLSLVLLGIFFSPP
AGSATHSGTPYTADGGSRSNLGSDDGTISIGKESKASYGAIAIGQRSKAEGRHGIAIGYQTNAGTHVNSV
AVGNDIRVSGEEAVAIGSSSKAGKGSVVLGRQADAANIEQAVVIGNLAKASKAQSIAIGANTKAEGYGSI
SIGGDDLKTTKYQTGNQGQSKTTTAKGKASVAIGGLSLATGDGSIVVGPLASASHVEGIAIGARSKSTNE
YGIAVGGGATAGKNAVAVGRDSNGGGTDSIAIGNSAKTTGADSVVVGANINVTGEKLVAIGREANSGSHS
TALGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSNASTAGGVEGLKQTHSVTT
EGSTVANGFKSTQSVDNNAIGAVSVGGGSGNKLINRQITNVAAGKELTDAVNVAQLKSLTLKIEGNENKH
NGVNANLSSADRPKVGLWSGTLKVKGDNGLTSHASGDTITVKLTDDTKSKIDKIDNLGWKLKIAQGMGGK
ATNPPTEHLVKMSDTATVTFTAGNNIKLEQTNGNITISTIGKLIKETKMVNGNLQITYTDGSSNTITRGE
KGDTGPRGETGPAGPPGPMGPAGAAGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPA
GPRGEPGQAGPAGPRGPAGPKGDAGPKGDTGQRGETGPAGPAGPKGEPGPKGEQGIPGPAGPTGPKGDKG
DTGPAGPQGPAGPTGPQGPAGPAGAKGDKGDTGPAGPQGPTGPTGSQDPAGPTGNSELKGITSIANGNDA
TKANGAKITLSADSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAAASKTEVEAGKNVKVTSKTGAN
GQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVGDGSAEGDIVNVRQLNKVVSSV
NTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQYRGQSAYAIGYSRISD
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Olvera et al., 2011)
|
25. VtaA8 |
-
Gene Name :
VtaA8
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
-
NCBI Protein GI :
EYE72886
-
Taxonomy ID :
1117322
-
Protein Name :
VtaA8
-
Protein pI :
9.41
-
Protein Weight :
94207.97
-
Protein Length :
1080
-
Protein Note :
COG5295 Autotransporter adhesin
-
Protein Sequence : Show Sequence
>EYE72886.1 VtaA8 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSFLSLVLLGIFFSPV
GSARLFLDEARQGSAGVDDGSIGIGRESKVGPGSITIGQKSEAEGRTAVAIGYSAKTGSEHDNAIAIGNS
SKATGPGTVTVGHSSQAKDRSVVLGANAEGKNAQTVVIGTLAKASASQSIAIGADTKAEGYGSISIGGDD
LDQTKYNDNNSTNQPRHTTTAKGKASVAIGGLSLAEGDGSIVVGPLASASDVEGIAIGARSKSTNEYGIA
VGGGATAGKNAVALGRESKGAGTDSIAIGNSARTTGADSVVVGANIDVTDEKLVAIGYQASAKSHATALG
YMASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSRAETRGGIEGAKQSYSVTTGTSS
VDNGFKSTGSVDNNSIPIGAVSVGNNKIKRQIVNVAAGKELTDAVNVAQLKSLTLKIAGNTSEQTQPAVG
LWEGTLKVMGTSGEIKTSASGDTITLKLDETLKNKINTIDNLGWNLKIAKGAGEANPPNAAHLIKMSDTA
TVTFTAGNNIKLEQTNGNITISTIGKLIAKTEWENDGLKITYTDGMHDIIKKGEKGDRGERGLRGETGPA
GPAGPMGPAGAAGLVGPMGPQGPAGPPGPVGPAGAAGPKGDKGEPGQAGPTGPRGPAGPKGDAGPKGDTG
QRGETGPAGPAGPQGPAGPTGPRGDKGDTGPAGPQGPAGPTGPQGPAGPTGSQDPAGPTGNSELKGITSI
ANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAAAARTEVEAGKNVKVT
SKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVGDGSAEGDIVNVRQLN
KVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQYRGQSAYAIGYSRISD
NGKWLIRASVSSNTQRDTMIGGGVGFVW
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Olvera et al., 2011)
|
26. VtaA9 |
-
Gene Name :
VtaA9
-
Sequence Strain (Species/Organism) :
Haemophilus parasuis str. Nagasaki
-
NCBI Protein GI :
EYE71168
-
Taxonomy ID :
1117322
-
Protein Name :
VtaA9
-
Protein pI :
9.71
-
Protein Weight :
88376.07
-
Protein Length :
1024
-
Protein Note :
COG5295 Autotransporter adhesin
-
Protein Sequence : Show Sequence
>EYE71168.1 VtaA9 [Glaesserella parasuis str. Nagasaki]
MNKIFRVIWSHAQQAWVVVSELVKSHTKTSAYTDKRAQVCTSDYFLDKQQDKFKLSLLSLVLLSIFFSPV
AVGAQLHTGTAFLLDGSNKSKLGTDDGTIGIGKDSKAGYGAIAIGQYSKAKARHNVAIGYKADSGVQPNT
ITIGYNTKVSGQEAIAIGKESKAGKESVVLGGQASAANIEQAVVIGHSATASASQSIAIGARSKSTADYG
IAVGGGATAGKNAVAVGRDSKGAGTDSIAIGNSAKTTGVDSVVVGANINVTDGQLVAIGREAKAGSHSTA
LGYKASAGGMHSVAVGESAMTNDGAARATALGNNTVVTVGGGVALGYGSNASTAGGVVGLKQNHSVTTGE
STVDNGFKSTESVDNNPNPIPIGAVSVGNNNIKRQIVNVAAGKELTDAVNVAQLQSLTMKISGDNSSSGK
VGIWDGTLKVVGTSGQIKTSANGDTITLKLDETLKNKIDNIDNLGWKLAITKGSGGEVTTPNTPYLIKMS
DMATVTFTAGNNIKLEQADGNITISTIGKLIAKTEWENDGLKITYTDGMHDIIKKGEKGDRGEKGPKGDR
GETGSAGPAGPAGAQGPVGPAGPAGPTGPQGATGPAGPKGEAGAAGPKGEKGDPGPKGEAGSTGPTGPAG
PKGDPGQAGPKGDTGQKGETGPAGPAGPQGPAGPAGAKGDKGDTGPAGPRGPAGPTGPQGPAGPAGPQDP
AGPTGNSELKGITSIANGNDATKANGAKITLSAGSTDKTVNVNDAKITNVAAGTADTDAVNVSQLNTKAA
ASKTEVEAGKNVKVTSKTGANGQNIYNVSVSGDLSDITSISNGDTKVSLGKDKQGNPVVNMNGARITNVG
DGSAEGDIVNVRQLNKVVSSVNTGFNQLSRDIGRVDVNARAGIASAGAMANLPQISLPGKSAISVSNAQY
RGQSAYAIGYSRISDNGKWLIRASVSSNTQRDTMIGGGVGFVW
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
(Olvera et al., 2011)
|
27. yfeA |
-
Gene Name :
yfeA
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Sequence Strain (Species/Organism) :
Haemophilus parasuis SH0165
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NCBI Protein GI :
ACL32714
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Other Database IDs :
CDD:238557
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Taxonomy ID :
557723
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Protein Name :
chelated iron ABC transporter, periplasmic-binding protein
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Protein pI :
8.15
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Protein Weight :
30617.57
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Protein Length :
400
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Protein Note :
Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; cd01137
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Protein Sequence : Show Sequence
>ACL32714.1 chelated iron ABC transporter, periplasmic-binding protein [Glaesserella parasuis SH0165]
MKKLAALLSMLFLVSNPLAAQQFKVVTTFTVIQDIAQNVAGDKAVVESITKPGAEIHDYQPTPQDIVKAQ
SADLVLWNGMNLESWFERFFAQVKDKPAVVVTEGIEPISIYEGPYKDKPNPHAWMSTKNALIYIENIRQA
LVKYDPANAEAYNANAKAYADKIVALDQPLRERLAKVPEAQRWLVTSEGAFSYLARDYGFKELYLWAINQ
DEQGTPKQIRKVIDQVRKHQIPVVFSESTISDKPAKQVAKESKARYGGVLYVDSLSTKDGKVPTYIDLLN
VTVSTIVAGFEK
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
(Hong et al., 2011)
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28. ygiW |
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Gene Name :
ygiW
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Sequence Strain (Species/Organism) :
Haemophilus parasuis D75
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NCBI Protein GI :
EQA00462
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Taxonomy ID :
1117322
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Protein Name :
ygiW domain protein
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Protein pI :
5.7
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Protein Weight :
14278.97
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Protein Length :
205
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Protein Sequence : Show Sequence
>EQA00462.1 ygiW domain protein [Glaesserella parasuis str. Nagasaki]
MKKAIILTTLLAVSTVSMAKGDDDYRHGGYHDGKARTHQSQGFFDESIAVKSVADALKAADDTPALLEGQ
IVKQIDKDEFIFKDATGEIEIDVSKRAWNGLNIGPQDTIQIRGKVDNDWNKVQVDVKQITKK
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
(Yuan et al., 2012)
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III. Vaccine Information |
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1. Haemophilus Parasuis Avirulent Live Culture Vaccine (USDA: 19J1.00) |
a. Manufacturer: |
Newport Laboratories, Inc. |
b. Vaccine Ontology ID: |
VO_0001794 |
c. Type: |
Live vaccine |
d. Status: |
Licensed |
e. Location Licensed: |
USA |
f. Host Species for Licensed Use: |
Pig |
g. Gene Engineering of
gapA |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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2. pCgap DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase |
a. Vaccine Ontology ID: |
VO_0004515 |
b. Type: |
DNA vaccine |
c. Status: |
Research |
d. Gene Engineering of
gapA |
- Type:
DNA vaccine construction
- Description:
- Detailed Gene Information: Click here.
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e. Vector: |
pcDNA3.1 Directional TOPO vector (pcDNA3.1D/V5-His-TOPO) (Fu et al., 2012) |
f. Immunization Route |
Intramuscular injection (i.m.) |
g.
Mouse Response |
- Vaccination Protocol:
Four to five week old female BALB/c mice were divided randomly into three groups (30 mice per group): one group was injected intramuscularly in the hind thigh muscle with 100 μg of plasmid dissolved in 100 μl PBS; the other two groups were injected with pcDNA 3.1 vector only as negative control or PBS as blank control. Mice received a vaccination boost of an equivalent dose on day 14 and 28 following the first immunization (Fu et al., 2012).
- Vaccine Immune Response Type:
VO_0000286
- Immune Response:
Although IgG analysis showed production of both IgG1 and IgG2, the higher levels of IgG1 indicated the dominance of Th2 response over Th1 response (Fu et al., 2012).
- Challenge Protocol:
Two weeks after the second vaccination boost, mice immunized with pCgap were divided into groups 1 and 2 (12 mice/group). The mice from group 1 were challenged intraperitoneally with a lethal dose of 3.0 × 10^9 CFU of H. parasuis SH0165 strain and the mice from group 2 were challenged intraperitoneally with a lethal dose of 3.0 × 10^9 CFU of H. parasuis MD0322 strain. Mice were monitored for seven days post-challenge, and morbidity and mortality were recorded (Fu et al., 2012).
- Efficacy:
The groups vaccinated with the pCgap vaccine exhibited 83.3% and 50% protective efficacy against the H. parasuis MD0322 serovar 4 or SH0165 serovar 5 challenges, respectively (Fu et al., 2012).
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3. Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Erysipelothrix Rhusiopathiae-Haemophilus Parasuis Bacterin (USDA: 49V9.20) |
a. Manufacturer: |
Boehringer Ingelheim Vetmedica, Inc. |
b. Vaccine Ontology ID: |
VO_0004216 |
c. Type: |
Live, attenuated vaccine |
d. Status: |
Licensed |
e. Location Licensed: |
USA |
f. Host Species for Licensed Use: |
Pig |
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4. Porcine Reproductive & Respiratory Syndrome Respiratory Form, Modified Live Virus Vaccine-Haemophilus Parasuis Bacterin (USDA: 49Q9.20) |
a. Manufacturer: |
Boehringer Ingelheim Vetmedica, Inc. |
b. Vaccine Ontology ID: |
VO_0004218 |
c. Type: |
Live, attenuated vaccine |
d. Status: |
Licensed |
e. Location Licensed: |
USA |
f. Host Species for Licensed Use: |
Pig |
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IV. References |
1. Barasuol et al., 2017: Barasuol BM, Guizzo JA, Fegan JE, Martínez-Martínez S, Rodríguez-Ferri EF, Gutiérrez-Martín CB, Kreutz LC, Schryvers AB, Frandoloso R. New insights about functional and cross-reactive properties of antibodies generated against recombinant TbpBs of Haemophilus parasuis. Scientific reports. 2017; 7(1); 10377. [PubMed: 28871190].
2. Fu et al., 2012: Fu S, Zhang M, Ou J, Liu H, Tan C, Liu J, Chen H, Bei W. Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice. Vaccine. 2012; 30(48); 6839-6844. [PubMed: 23000128].
3. Guo et al., 2017: Guo L, Xu L, Wu T, Fu S, Qiu Y, Hu CA, Ren X, Liu R, Ye M. Evaluation of recombinant protein superoxide dismutase of Haemophilus parasuis strain SH0165 as vaccine candidate in a mouse model. Canadian journal of microbiology. 2017; 63(4); 312-320. [PubMed: 28177794].
4. Hong et al., 2011: Hong M, Ahn J, Yoo S, Hong J, Lee E, Yoon I, Jung JK, Lee H. Identification of novel immunogenic proteins in pathogenic Haemophilus parasuis based on genome sequence analysis. Veterinary microbiology. 2011; 148(1); 89-92. [PubMed: 20817421].
5. Huang et al., 2013: Huang X, Li Y, Fu Y, Ji Y, Lian K, Zheng H, Wei J, Cai X, Zhu Q. Cross-protective efficacy of recombinant transferrin-binding protein A of Haemophilus parasuis in guinea pigs. Clinical and vaccine immunology : CVI. 2013; 20(6); 912-919. [PubMed: 23616407].
6. Li et al., 2015: Li M, Song S, Yang D, Li C, Li G. Identification of secreted proteins as novel antigenic vaccine candidates of Haemophilus parasuis serovar 5. Vaccine. 2015; 33(14); 1695-1701. [PubMed: 25704800].
7. Li et al., 2016: Li M, Li C, Song S, Kang H, Yang D, Li G. Development and antigenic characterization of three recombinant proteins with potential for Glässer's disease prevention. Vaccine. 2016; 34(19); 2251-2258. [PubMed: 26993332].
8. Li et al., 2017: Li M, Cai RJ, Song S, Jiang ZY, Li Y, Gou HC, Chu PP, Li CL, Qiu HJ. Evaluation of immunogenicity and protective efficacy of recombinant outer membrane proteins of Haemophilus parasuis serovar 5 in a murine model. PloS one. 2017; 12(4); e0176537. [PubMed: 28448603].
9. Macedo et al., 2016: Macedo N, Oliveira S, Torremorell M, Rovira A. Immune response to oligopeptide permease A (OppA) protein in pigs naturally and experimentally infected with Haemophilus parasuis. Research in veterinary science. 2016; 107; 62-67. [PubMed: 27473976].
10. Oliveira and Pijoan, 2004: Oliveira S, Pijoan C. Haemophilus parasuis: new trends on diagnosis, epidemiology and control. Veterinary microbiology. 2004; 99(1); 1-12. [PubMed: 15019107].
11. Olvera et al., 2011: Olvera A, Pina S, Pérez-Simó M, Aragón V, Segalés J, Bensaid A. Immunogenicity and protection against Haemophilus parasuis infection after vaccination with recombinant virulence associated trimeric autotransporters (VtaA). Vaccine. 2011; 29(15); 2797-2802. [PubMed: 21320547].
12. Tian et al., 2011: Tian H, Fu F, Li X, Chen X, Wang W, Lang Y, Cong F, Liu C, Tong G, Li X. Identification of the immunogenic outer membrane protein A antigen of Haemophilus parasuis by a proteomics approach and passive immunization with monoclonal antibodies in mice. Clinical and vaccine immunology : CVI. 2011; 18(10); 1695-1701. [PubMed: 21832103].
13. Wen et al., 2016: Wen Y, Yan X, Wen Y, Cao S, He L, Ding L, Zhang L, Zhou P, Huang X, Wu R, Wen X. Immunogenicity of the recombinant HxuCBA proteins encoded by hxuCBA gene cluster of Haemophilus parasuis in mice. Gene. 2016; 591(2); 478-483. [PubMed: 27378742].
14. Yuan et al., 2012: Yuan F, Fu S, Hu J, Li J, Chang H, Hu L, Chen H, Tian Y, Bei W. Evaluation of recombinant proteins of Haemophilus parasuis strain SH0165 as vaccine candidates in a mouse model. Research in veterinary science. 2012; 93(1); 51-56. [PubMed: 21596404].
15. Zhou et al., 2009: Zhou M, Guo Y, Zhao J, Hu Q, Hu Y, Zhang A, Chen H, Jin M. Identification and characterization of novel immunogenic outer membrane proteins of Haemophilus parasuis serovar 5. Vaccine. 2009; 27(38); 5271-5277. [PubMed: 19576561].
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