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Pathogen Page

Haemophilus parasuis

General Information
Vaccine Related Pathogen Genes
1. csgG
2. FOG
3. gapA
4. gcp
5. hsdS
6. hxuB
7. hxuC
8. LppC
9. ndk
10. omp26
11. oppA
12. outer membrane protein A
13. outer membrane protein D15
14. outer membrane protein P2
15. palA
16. pflA
17. plpA
18. rnfC
19. superoxide dismutase
20. tbpA
21. tbpB
22. TolC
23. VtaA5
24. VtaA6
25. VtaA8
26. VtaA9
27. yfeA
28. ygiW
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

738

2. Disease:

Glasser's disease

3. Introduction

H. parasuis is a non-motile, small, pleomorphic rod in the family Pasteurellaceae, and is the etiologic agent of Glasser's disease. Glasser’s disease is characterized by fibrinous polyserositis, polyarthritis and meningitis. H. parasuis often produces acute septicemia, and its endotoxin induces disseminated intravascular coagulation, resulting in the formation of microthrombi in several organs (Oliveira and Pijoan, 2004).

4. Microbial Pathogenesis

H. parasuis colonizes the respiratory tracts of pigs, and can then cause systemic infection (Oliveira and Pijoan, 2004).

5. Host Ranges and Animal Models

Pigs

6. Host Protective Immunity

Early colonized pigs are protected against systemic infection by maternal antibodies. As maternal immunity decreases, these pigs are able to mount an active immune response to these virulent strains (Oliveira and Pijoan, 2004).

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