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Pathogen Page
SARS-CoV

Table of Contents

  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
    4. Microbial Pathogenesis
    5. Host Ranges and Animal Models
    6. Host Protective Immunity
  2. Vaccine Related Pathogen Genes
    1. envelope protein (E) gene of SARS-CoV
    2. membrane protein (M) gene of SARS-CoV
    3. nucleocapsid protein (N) gene of SARS-CoV
    4. S protein gene from SARS Urbani
    5. S protein gene of SARS-CoV
  3. Vaccine Information
    1. ADS-MVA vaccine
    2. Double Inactivated whole SARS-CoV vaccine
    3. Double Inactivated whole SARS-CoV vaccine + alum
    4. β-propiolactone-inactivated SARS-CoV vaccine
    5. licensed Severe acute respiratory syndrome human vaccine
    6. MA-ExoN vaccine
    7. MVA/S vaccine
    8. NDV-BC/S vaccine
    9. NDV-VF/S vaccine
    10. RBD-rAAV-SARS-CoV
    11. RBD-rAAV-SARS-CoV-version-02
    12. rDNA-expressed S protein + alum vaccine
    13. rDNA-expressed S protein vaccine
    14. Recombinant spike polypeptide vaccine
    15. rMA15-ΔE vaccine
    16. rMV-S + rMV-N vaccine
    17. rMV-SARS-CoV-S/Ssol
    18. SARS Subunit Spike Protein with subunit boosting Vaccine
    19. SARS-CoV Ad S/N vaccine
    20. SARS-CoV CRT-N vaccine
    21. SARS-CoV CTLA4-S DNA vaccine
    22. SARS-CoV E gene mutant vaccine
    23. SARS-CoV M protein DNA vaccine
    24. SARS-CoV N + SARS-CoV M DNA vaccine
    25. SARS-CoV N protein DNA vaccine
    26. SARS-CoV pCI-N DNA from vaccine
    27. SARS-CoV rVV-SARS-N
    28. SARS-CoV S Baculovirus Vaccine
    29. SARS-CoV Salmonella-CTLA4-S DNA vaccine
    30. SARS-CoV Salmonella-tPA-S DNA vaccine
    31. SARS-CoV tPA-S DNA vaccine
    32. SARS-CoV VLP-MHV + alum vaccine
    33. SARS-CoV VLP-MHV vaccine
    34. UV Inactivated SARS-CoV vaccine
    35. UV-Inactivated SARS-CoV + TLR Agonist Vaccine
    36. VRC-SRSDNA015-00-VP vaccine
    37. VRP-MERS-N vaccine
    38. VRP-SARS-N vaccine
  4. References
I. General Information
1. NCBI Taxonomy ID:
694009
2. Disease:
Severe Acute Respiratory Syndrome (SARS)
3. Introduction
Severe acute respiratory syndrome (SARS; pronounced /ˈsɑrz/ sarz) is a respiratory disease in humans which is caused by the SARS coronavirus (SARS-CoV). There has been one near pandemic to date, between the months of November 2002 and July 2003, with 8,096 known infected cases and 774 confirmed human deaths (a case-fatality rate of 9.6%) worldwide being listed in the World Health Organization's (WHO) 21 April 2004 concluding report. Within a matter of weeks in early 2003, SARS spread from the Guangdong province of China to rapidly infect individuals in some 37 countries around the world (Wiki: SARS).
4. Microbial Pathogenesis
Infection by different coronaviruses cause in the host alteration in the transcription and translation patterns, in the cell cycle, the cytoskeleton, apoptosis and coagulation pathways, inflammation and immune and stress responses. The balance between genes up- and down-regulated could explain the pathogenesis caused by these viruses (Wiki: SARS).
5. Host Ranges and Animal Models
SARS-CoV has been isolated from humans, civet cats, raccoon dogs, swine and bats, suggesting that several animal species may function as natural reservoirs for future outbreaks. The Chinese horseshoe bat, which is abundant across Southeast Asia, is probably the natural reservoir for SARS-CoV. Ciliated airway epithelium models derived from tracheobronchial airway epithelium of Balb-c mice (MAE), Golden Syrian hamsters (HmAE), and rhesus macaques (RhMAE) have been successfully developed (Sims et al., 2008).
6. Host Protective Immunity
Passive immunization has been successful in establishing protection from SARS-CoV suggesting an important role for neutralizing antibodies (Wiki: SARS).
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