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Borna disease virus

Table of Contents
  1. General Information
    1. NCBI Taxonomy ID
  2. Vaccine Related Pathogen Genes
    1. p10 (Protective antigen)
  3. Vaccine Information
    1. Borna Disease Virus BDV-N
    2. rORFV-p40(Borna disease virus)
  4. References
I. General Information
1. NCBI Taxonomy ID:
12455
1. p10
  • Gene Name : p10
  • Sequence Strain (Species/Organism) : Borna disease virus
  • NCBI Protein GI : AAX09334
  • Other Database IDs : CDD:115187
  • Taxonomy ID : 1714621
  • Protein Name : p10
  • Protein pI : 10.74
  • Protein Weight : 7848.852
  • Protein Length : 126
  • Protein Note : Borna disease virus P10 protein; pfam06515
  • Protein Sequence : Show Sequence
    >AAX09334.1 p10, partial [Borna disease virus 1]
    VRANGTRPHQSGKIPGGRRRSPDTTTGTIGVTKTTEGPKECIDPTSRPAPEGPQEEPLHDLRPRPANRKG
    AAVE
    
    
  • Molecule Role : Protective antigen
  • Molecule Role Annotation : (Hashimoto et al., 2003)
III. Vaccine Information
1. Borna Disease Virus BDV-N
a. Type:
Recombinant vector vaccine
b. Status:
Research
c. Host Species for Licensed Use:
Mouse
d. Antigen
Borna Disease Virus Nucleoprotein (Hausmann et al., 2005)
e. Vector:
Parapoxvirus D1701-VrVp40 (Hausmann et al., 2005)
f. Immunization Route
intramuscular (1st dose) and intraperitoneal (2nd dose
g. Description
BVD vaccine expressing nucleoprotein protects wild type and perforin deficient mice against BVD challenge. (Hausmann et al., 2005)
2. rORFV-p40(Borna disease virus)
a. Vaccine Ontology ID:
VO_0004769
b. Type:
Recombinant vector vaccine
c. Status:
Research
d. Host Species for Licensed Use:
Baboon
e. Preparation
The highly attenuated Orf virus strain D1701 was used to generate a recombinant virus (D1701-VrVp40) expressing nucleoprotein p40 of Borna disease virus (Henkel et al., 2005).
f. Immunization Route
Intramuscular injection (i.m.)
g. Rat Response
  • Vaccination Protocol: The rats were immunized at an age of 4 to 5 weeks in 2-week intervals by intramuscular application of D1701-VrVp40 (Henkel et al., 2005).
  • Vaccine Immune Response Type: VO_0000287
  • Challenge Protocol: 2 weeks after the last immunization 5 ×10^3 to 10 ×10^3 FFU of BDV were used for intracerebral challenge infection (Henkel et al., 2005).
  • Efficacy: Rats immunized with D1701-VrVp40 exhibited protection against Borna Disease, and virus clearance from the infected brain was demonstrated in immunized animals. Even 4 and 8 months after the last immunization, all immunized animals were still protected against the disease (Henkel et al., 2005).
IV. References
1. Hashimoto et al., 2003: Hashimoto Y, Chen HS, Cunningham C, Malik TH, Lai PK. Two major histocompatibility complex class I-restricted epitopes of the Borna disease virus p10 protein identified by cytotoxic T lymphocytes induced by DNA-based immunization. Journal of virology. 2003; 77(10); 6076-6081. [PubMed: 12719601].
2. Henkel et al., 2005: Henkel M, Planz O, Fischer T, Stitz L, Rziha HJ. Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant. Journal of virology. 2005; 79(1); 314-325. [PubMed: 15596826].