VIOLIN: Vaccine Investigation and Online Information Network

Porcine parvovirus

Table of Contents

General Information
Vaccine Related Pathogen Genes
1. non-structural protein 1 (Protective antigen)
2. VP1 (Protective antigen)
3. VP2 (Protective antigen)
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

10796

2. Disease:

SMEDI, reproductive failure

3. Introduction

Porcine parvovirus (PPV) is the cause of reproductive failure in swine characterized by embryonic and fetal infection and death (SMEDI), generally without outward maternal clinical signs. The virus is ubiquitous throughout the world and is endemic in most swine herds. PPV can also potentiate the effects of infection with porcine circovirus type 2. The most common routes of infection for postnatal and prenatal pigs are oronasal and transplacental. Infection is endemic in most herds, and generally sows are immune. The virus can persist in the environment, as it is themostable and resistant to many common disinfectants. The major and usually only clinical response of PPV infection is maternal reproductive failure, such as infertility, abortion, stillbirth, neonatal death and reduced neonatal vitality (Mengeling, 2006).

4. Host Ranges and Animal Models

Pigs

II. Vaccine Related Pathogen Genes

1. non-structural protein 1

Gene Name : non-structural protein 1
Sequence Strain (Species/Organism) : Porcine parvovirus
NCBI Protein GI : AAS93262
Other Database IDs : CDD:255001
CDD:289218
CDD:279406
CDD:288933
Taxonomy ID : 10796
Protein Name : non-structural protein 1
Protein pI : 6.85
Protein Weight : 73222.28
Protein Length : 731
Protein Note : Rep protein catalytic domain like; pfam08724

Protein Sequence : Show Sequence

>AAS93262.1 non-structural protein 1 [Porcine parvovirus]
MAAGNTYSEEVLKATDWLQDNAQKEAFSYVFKTQKVNLNGKEIAWNNYNKDTTDAEMINLQRGAETSWDQ
ATDMEWESEIDSLTKRQVLIFDSLVKKCLFEGILQKNLSPSDCYWFIQHEHGQDTGYHCHVLLGGKGLQQ
AMGKWFRKQLNNLWSRWLIMQCKVPLTPVERIKLRELAEDGEWVSLLTYTHKQTKKQYTKMTHFGNMIAY
YFLNKKRKTTEREHGYYLSSDSGFMTNFLKEGERHLVSHLFTEANKPETVETTVTTAQEAKRGRIQTKKE
VSIKCTIRDLVNKGCTSIEDWMMTDPDSYIEMMAQTGGENLIKNTLEITTLTLARTKTAYDLILEKAKPS
MLPTFNISNTRTCKIFSMHNWNYIKVCHAITCVLNRQGGKRNTILFHGPASTGKSIIAQHIANLVGNVGC
YNAANVNFPFNDCTNKNLIWIEEAGNFSNQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNEDITK
VRVGCEERPEHTQPIRDRMLNINLTRKLPGDFGLLEETEWPLICAWLVKKGYQATMASYMHHWGNVPDWS
EKWEEPKMQTPINTPTDSQISTSVKTSPADNNYAATPIQEDLDLALALEPWSEPTTPTFTNLHLTPTPPD
SAIRTPSPTWSEIETDIRACFGENCAPTTNLE

Molecule Role : Protective antigen
Molecule Role Annotation : (Qi and Cui, 2009)

2. VP1

Gene Name : VP1
Sequence Strain (Species/Organism) : Porcine parvovirus
NCBI Protein GI : AFR43265
Other Database IDs : CDD:285583
CDD:279128
Taxonomy ID : 10796
Protein Name : VP1 protein
Protein pI : 8.35
Protein Weight : 79417.77
Protein Length : 786
Protein Note : Parvovirus coat protein VP1; pfam08398

Protein Sequence : Show Sequence

>AFR43265.1 VP1 protein [Porcine parvovirus]
MAPPAKRARGLTLPGYKYLGPGNSLDQGEPTNPSDAAAKEHDEAYDKYIKSGKNPYFYFSAADEKFIKET
EHAKDYGGKIGHYFFRAKRAFAPKLSETDSPTTSQQPEVRRSPRKHPGSKPPGKRPAPRHIFINLAKKKA
KGTSNTNSNSMSENVEQHNPINAGTELSATGNESGGGGGGGGGRGAGGVGVSTGTFNNQTEFQYLGEGLV
RITAHASRLIHLNMPEHETYKRIHVLNSESGVAGQMVQDDAHTQMVTPWSLIDANAWGVWFNPADWQLIS
NNMTEINLVSFEQEIFNVVLKTITESATSPPTKIYNNDLTASLMVALDTNNTLPYTPAAPRSETLGFYPW
LPTKPTQYRYYLSCIRNLNPPTYTGQSQQITDSIQTGLHSDIMFYTIENAVPIHLLRTGDEFSTGIYHFD
TKPLKLTHSWQTNRSLGLPPKLLTEPTTEGDQHSGTLPAANTRKGYHQTINNSYTEATAIRPAQVGYNTP
YMNFEYSNGGPFLTPIVPTADTQYNDDEPNGAIRFTMDYQHGHLTTSSQELERYTFNPQSKCGRAPKQQF
NQQAPLNLENTNNGTLLPSDPIGGKSNMHFMNTLNTYGPLTALNNTAPVFPNGQIWDKELDTDLKPRLHV
TAPFVCKNNPPGQLFVKIAPNLTDDFNADSPQQPRIITYSNFWWKGTLTFTAKMRSSNMWNPIQQHTTTA
ENIGNYIPTNIGGIRMFPEYSQLIPRKLY

Molecule Role : Protective antigen
Molecule Role Annotation : (Xie et al., 2010)

3. VP2

Gene Name : VP2
Sequence Strain (Species/Organism) : Porcine parvovirus
NCBI Protein GI : AGZ94859
Other Database IDs : CDD:279128
Taxonomy ID : 10796
Protein Name : VP2
Protein pI : 6.16
Protein Weight : 62794.25
Protein Length : 626
Protein Note : Parvovirus coat protein VP2; pfam00740

Protein Sequence : Show Sequence

>AGZ94859.1 VP2 [Porcine parvovirus]
MSENVEQHNPINAGTELSATGNESGGGGGGGGGRGAGGVGVSTGTFNNQTEFQYLGEGLVRITAHASRLI
HLNMPEHETYKRIHVLNSESGVAGQMVQDDAHTQMVTPWSLIDANAWGVWFNPADWQLISNNMTEINLVS
FEQEIFNVVLKTITESATSPPTKIYNNDLTASLMVALDTNNTLPYTPAAPRSETLGFYPWLPTKPTQYRY
YLSCIRNLNPPTYTGQSQQITDSIQTGLHSDIMFYTIENAVPIHLLRTGDEFSTGIYHFDTKPLKLTHSW
QTNRSLGLPPKLLTEPTTEGDQHPGTLPAANTRKGYHQTMNNSYTEATAIRPAQVGYNTPYMNFEYSNGG
PFLTPIVPTADTQYNDDEPNGAIRFTMDYQHGHLTTSSQELERYTFNPQSKCGRAPKQQFNQQAPLNLEN
TNNGTLLPSDPIGGKSNMHFMNTLNTYGPLTALNNTAPVFPNGQIWDKELDTDLKPRLHVTAPFVCKNNP
PGQLFVKIAPNLTDDFNADSPQQPRIITYSNFWWKGTLTLTAKMRSSNMWNPIQQHTTTAENIGNYIPTN
IGGMRMFPEYSQLIPRKLY

Molecule Role : Protective antigen
Molecule Role Annotation : (Ji et al., 2017)

III. Vaccine Information

1. ERYSENG® PARVO

a. Type:

Inactivated or "killed" vaccine

b. Status:

Licensed

c. Host Species for Licensed Use:

Baboon

d. Preparation

The vaccines were prepared and diluted following the manufacturer’s recommendations. (Sánchez-Matamoros et al., 2019)

e. Immunization Route

Intramuscular injection (i.m.)

f. Description

ERYSENG® PARVO (HIPRA) is a bivalent inactivated vaccine based on the inactivated E. rhusiopathiae strain R32E11 and the inactivated PPV strain NADL-2.(Sánchez-Matamoros et al., 2019)

2. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae Bacterin (USDA: 4906.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002290

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

3. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.20)

a. Manufacturer:

Wyeth, Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002321

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

4. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.21)

a. Manufacturer:

Intervet Inc., Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002322

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

5. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4BC5.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002323

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

6. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.01)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002277

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

7. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.20)

a. Manufacturer:

Pfizer, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002278

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

8. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.21)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., Pfizer, Inc., Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002279

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

9. Parvovirus Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 48C5.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002280

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

10. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.01)

a. Manufacturer:

Wyeth

b. Vaccine Ontology ID:

VO_0002292

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

11. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.20)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002293

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

12. Parvovirus Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4975.22)

a. Manufacturer:

Novartis Animal Health US, Inc.

b. Vaccine Ontology ID:

VO_0002294

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

13. Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4960.00)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002291

c. Type:

Live, attenuated vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

14. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002309

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

15. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002310

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

16. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Bratislava-Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49F6.24)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002311

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

17. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.22)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002312

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

18. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.23)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002313

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

19. Parvovirus-Swine Influenza H1N1 & H3N2, Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 49G6.24)

a. Manufacturer:

Pfizer, Inc.

b. Vaccine Ontology ID:

VO_0002314

c. Type:

Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

20. Porcilis® Ery + Parvo + Lepto

a. Type:

Inactivated or "killed" vaccine

b. Status:

Licensed

c. Host Species for Licensed Use:

None

d. Antigen

Six relevant swine Leptospira antigens (serogroups Canicola, Icterohaemorrhagiae, Australis (Bratislava), Grippotyphosa, Pomona and Tarassovi) to an existing vaccine, Porcilis® Ery + Parvo(van et al., 2020)

e. Immunization Route

Intramuscular injection (i.m.)

f. Virulence

Virulent PPV-27a strain. (van et al., 2020)

g. Description

Porcilis® Ery+Parvo+Lepto is an octavalent inactivated ready-to-use vaccine that contains Erysipelothrix rhusiopathiae (Ery), porcine parvovirus (PPV), and six serogroups of Leptospira (Lepto).(van et al., 2020)

21. Porcine Reproductive & Respiratory Syndrome-Parvovirus Reproductive Form, Modified Live & Killed Virus Vaccine-Erysipelothrix Rhusiopathiae-Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin (USDA: 4P19.20)

a. Manufacturer:

Boehringer Ingelheim Vetmedica, Inc.

b. Vaccine Ontology ID:

VO_0002324

c. Type:

Live, attenuated vaccine; Inactivated or "killed" vaccine

d. Status:

Licensed

e. Location Licensed:

USA

f. Host Species for Licensed Use:

Pig

22. ReproCyc® ParvoFLEX

a. Type:

Subunit vaccine

b. Status:

Licensed

c. Location Licensed:

European (EU) market

d. Host Species for Licensed Use:

Pig

e. Antigen

Produces the protective viral protein (VP) 2 of PPV1. (Garcia-Morante et al., 2019)

f. Immunization Route

Intramuscular injection (i.m.)

g. Description

ReproCyc® ParvoFLEX (Boehringer Ingelheim Vetmedica GmbH, Ingelheim am Rhein, Germany) is a recently licensed monovalent subunit vaccine for pigs based on a recombinant baculoviral expression system producing the protective viral protein (VP) 2 of PPV1.(Garcia-Morante et al., 2019)

IV. References

1. Ji et al., 2017: Ji P, Liu Y, Chen Y, Wang A, Jiang D, Zhao B, Wang J, Chai S, Zhou E, Zhang G. Porcine parvovirus capsid protein expressed in Escherichia coli self-assembles into virus-like particles with high immunogenicity in mice and guinea pigs. Antiviral research. 2017; 139; 146-152. [PubMed: 28063996].

2. Qi and Cui, 2009: Qi T, Cui SJ. Expression, purification, and characterization of recombinant NS-1, the porcine parvovirus non-structural protein. Journal of virological methods. 2009; 157(1); 93-97. [PubMed: 19101593].

3. Xie et al., 2010: Xie HL, Wang Z, Cui SJ, Zhang CF, Cui YD. The epitope of the VP1 protein of porcine parvovirus. Virology journal. 2010; 7; 161. [PubMed: 20637107].