Canine parvovirus |
| Table of Contents |
- General Information
- NCBI Taxonomy ID
- Disease
- Introduction
- Vaccine Related Pathogen Genes
- VP1
(Protective antigen)
- VP2
(Protective antigen)
- Vaccine Related Host Genes
- IgG Fc fragment
- Vaccine Information
- Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.20)
- Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.21)
- Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.22)
- Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.25)
- Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.29)
- Canine Coronavirus-Parvovirus Modified Live Virus Vaccine (USDA: 14R1.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.21)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.25)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.29)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.29)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus; Canarypox Vector Vaccine (USDA: 1591.R1)
- Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27)
- Canine Distemper-Adenovirus Type 2-Measles-Parainfluenza Modified Live Virus Vaccine (USDA: 1341.20)
- Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine (USDA: 13C1.20)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.20)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.21)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.22)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.23)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.25)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.27)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.28)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.29)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.T0)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)_
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 13D1.R1)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1)
- Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13G9.20)
- Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D7.20)
- Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D9.27)
- Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22)
- Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.20)
- Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.27)
- Canine parvovirus CPMV-PARVO1 protein vaccine
- Canine parvovirus DNA vaccine pGT36VP1
- Canine Parvovirus Modified Live Virus Vaccine-Leptospira Canicola Icterohaemorrhagiae Bacterin (USDA: 47B1.20)
- Parvovirus Killed Virus Vaccine (USDA: 18P5.20)
- Parvovirus Killed Virus Vaccine (USDA: 18P5.21)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.20)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.21)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.22)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.23)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.25)
- Parvovirus Modified Live Virus Vaccine (USDA: 18M1.29)
- RECOMBITEK Canine Parvo
- References
|
| I. General Information |
| 1. NCBI Taxonomy ID: |
|
10788 |
|
2. Disease: |
| Canine parvovirus infection |
|
3. Introduction |
Canine parvovirus type 2 (CPV2, colloquioally parvo) is a contagious virus mainly affecting dogs. The disease is highly infectious and is spread from dog to dog by direct or indirect contact with their feces. It can be especially severe in puppies that are not protected by maternal antibodies or vaccination. It has two distinct presentations, a cardiac and intestinal form. The common signs of the intestinal form are severe vomiting and dysentery. The cardiac form causes respiratory or cardiovascular failure in young puppies. Treatment often involves veterinary hospitalization. Vaccines can prevent this infection, but mortality can reach 91% in untreated cases.
CPV2 is a non-enveloped single-stranded DNA virus. It has an icosahedral symmetry. The genome is about 5000 nucleotides long. CPV2 continues to evolve, and the success of new strains seems to depend on extending the range of hosts affected and improved binding to its receptor, the canine transferrin receptor. CPV2 has a high rate of evolution, possibly due to a rate of nucleotide substitution that is more like RNA viruses such as Influenzavirus A. In contrast, FPV seems to evolve only through random genetic drift (Wiki: Canine parvovirus). |
| II. Vaccine Related Pathogen Genes |
|
1. VP1 |
-
Gene Name :
VP1
-
Sequence Strain (Species/Organism) :
Canine parvovirus
-
VO ID :
VO_0011055
-
NCBI Gene ID :
1489587
-
Locus Tag :
CPVgp3
-
Taxonomy ID :
10788
-
Gene Starting Position :
2284
-
Gene Ending Position :
2361
-
Gene Strand (Orientation) :
?
-
DNA Sequence : Show Sequence
>NC_001539.1:2284-2361 Canine parvovirus, complete genome
GATGGCACCTCCGGCAAAGAGAGCCAGGAGAGGTAAGGGTGTGTTAGTAAAGTGGGGGGAGGGGAAAGAT
TTAATAAC
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
This study shows that a plasmid DNA (pGT36VP1) encoding the full length VP1 region of canine parvovirus (CPV) induces immunity that protects dogs against challenge with virulent virus (Jiang et al., 1998).
- Related Vaccine(s):
Canine parvovirus DNA vaccine pGT36VP1
|
|
2. VP2 |
-
Gene Name :
VP2
-
Sequence Strain (Species/Organism) :
Canine parvovirus
-
VO ID :
VO_0011054
-
NCBI Gene ID :
1489588
-
Locus Tag :
CPVgp4
-
Taxonomy ID :
10788
-
Gene Starting Position :
2782
-
Gene Ending Position :
4536
-
Gene Strand (Orientation) :
?
-
DNA Sequence : Show Sequence
>NC_001539.1:2782-4536 Canine parvovirus, complete genome
ACCAATGAGTGATGGAGCAGTTCAACCAGACGGTGGTCAACCTGCTGTCAGAAATGAAAGAGCTACAGGA
TCTGGGAACGGGTCTGGAGGCGGGGGTGGTGGTGGTTCTGGGGGTGTGGGGATTTCTACGGGTACTTTCA
ATAATCAGACGGAATTTAAATTTTTGGAAAACGGATGGGTGGAAATCACAGCAAACTCAAGCAGACTTGT
ACATTTAAATATGCCAGAAAGTGAAAATTATAGAAGAGTGGTTGTAAATAATATGGATAAAACTGCAGTT
AACGGAAACATGGCTTTAGATGATATTCATGCACAAATTGTAACACCTTGGTCATTGGTTGATGCAAATG
CTTGGGGAGTTTGGTTTAATCCAGGAGATTGGCAACTAATTGTTAATACTATGAGTGAGTTGCATTTAGT
TAGTTTTGAACAAGAAATTTTTAATGTTGTTTTAAAGACTGTTTCAGAATCTGCTACTCAGCCACCAACT
AAAGTTTATAATAATGATTTAACTGCATCATTGATGGTTGCATTAGATAGTAATAATACTATGCCATTTA
CTCCAGCAGCTATGAGATCTGAGACATTGGGTTTTTATCCATGGAAACCAACCATACCAACTCCATGGAG
ATATTATTTTCAATGGGATAGAACATTAATACCATCTCATACTGGAACTAGTGGCACACCAACAAATATA
TACCATGGTACAGATCCAGATGATGTTCAATTTTATACTATTGAAAATTCTGTGCCAGTACACTTACTAA
GAACAGGTGATGAATTTGCTACAGGAACATTTTTTTTTGATTGTAAACCATGTAGACTAACACATACATG
GCAAACAAATAGAGCATTGGGCTTACCACCATTTCTAAATTCTTTGCCTCAATCTGAAGGAGCTACTAAC
TTTGGTGATATAGGAGTTCAACAAGATAAAAGACGTGGTGTAACTCAAATGGGAAATACAAACTATATTA
CTGAAGCTACTATTATGAGACCAGCTGAGGTTGGTTATAGTGCACCATATTATTCTTTTGAGGCGTCTAC
ACAAGGGCCATTTAAAACACCTATTGCAGCAGGACGGGGGGGAGCGCAAACATATGAAAATCAAGCAGCA
GATGGTGATCCAAGATATGCATTTGGTAGACAACATGGTCAAAAAACTACCACAACAGGAGAAACACCTG
AGAGATTTACATATATAGCACATCAAGATACAGGAAGATATCCAGAAGGAGATTGGATTCAAAATATTAA
CTTTAACCTTCCTGTAACGAATGATAATGTATTGCTACCAACAGATCCAATTGGAGGTAAAACAGGAATT
AACTATACTAATATATTTAATACTTATGGTCCTTTAACTGCATTAAATAATGTACCACCAGTTTATCCAA
ATGGTCAAATTTGGGATAAAGAATTTGATACTGACTTAAAACCAAGACTTCATGTAAATGCACCATTTGT
TTGTCAAAATAATTGTCCTGGTCAATTATTTGTAAAAGTTGCGCCTAATTTAACAAATGAATATGATCCT
GATGCATCTGCTAATATGTCAAGAATTGTAACTTACTCAGATTTTTGGTGGAAAGGTAAATTAGTATTTA
AAGCTAAACTAAGAGCCTCTCATACTTGGAATCCAATTCAACAAATGAGTATTAATGTAGATAACCAATT
TAACTATGTACCAAGTAATATTGGAGGTATGAAAATTGTATATGAAAAATCTCAACTAGCACCTAGAAAA
TTATA
-
Molecule Role :
Protective antigen
-
Molecule Role Annotation :
A vaccine based upon a recombinant plant virus (CPMV-PARVO1), displaying a peptide derived from the VP2 capsid protein of canine parvovirus (CPV), has previously been described. To date, studies with the vaccine have utilized viable plant chimaeric particles (CVPs). Results show that the inactivated CVP is able to protect dogs from a lethal challenge with CPV following parenteral immunization with the vaccine. Dogs immunized with the inactivated CPMV-PARVO1 in adjuvant displayed no clinical signs of disease and shedding of CPV in faeces was limited following CPV challenge. (Langeveld et al., 2001).
- Related Vaccine(s):
Canine parvovirus CPMV-PARVO1 protein vaccine
|
| III. Vaccine Related Host Genes |
|
1. IgG Fc fragment |
-
Gene Name :
IgG Fc fragment
-
Sequence Strain (Species/Organism) :
Canis lupus familiaris
-
NCBI Gene ID :
403462
-
NCBI Protein GI :
55742701
-
Protein Accession :
NP_001002976
-
Taxonomy ID :
9615
-
Chromosome No :
17
-
Gene Starting Position :
59093049
-
Gene Ending Position :
59102001
-
Gene Strand (Orientation) :
+
-
Protein Name :
Fc fragment of IgG, high affinity Ia, receptor (CD64)
-
Protein pI :
6.67
-
Protein Weight :
39657.45
-
Protein Length :
372
-
Protein Note :
Also known as FCGAMMARI
-
DNA Sequence : Show Sequence
>gi|357579614:59093049-59102001 Canis lupus familiaris chromosome 17, CanFam3.1, whole genome shotgun sequence
TCAATGTCTTGCATGTTACAGACTTCACTGTTCCCATCAGCTTGGAGATAACATGTGGCTCTTGACAGTT
CTACTCCTTTGGGGTAAGTTGGGTATAGAGGGATAGCTAGAAGGGTAGTGGCTCTGACTGTCTTCCTTTG
GTATCCTAGACTAGAACTCATGAATGTGGGGACAACTATATCTGTGCTTCCATGATTTATTTATGCTCAT
TATACCAAAAGCCTGGGAAGAGAGACTTAGTGATAACATTTAGCCTGGAAGCATCATATCAAAATAAAGC
CTCATCAATAACCATCCATAGGTTGTTCAGTACCACTAGTCCCTGATTTTGAGAAAGGGGGTAGAGAGAG
ACTCAAGACACCTAAGCTGGCCCCTTAGAGTCTATATTAGTTTTGTCTCCTTGATTCTCCTTTCCTTGTC
ATCTCCCACTGACCAACTTATGTCTCTCTTCTTTGGTCTCTTACAGTCCCAGCTGGTGCACAAACAGGTG
AGTAATCTTTAACTTTATTTCTCTTTCTCTGCCACATTCCTGCTTCTGAAGGGTGAGTTTTGTTTTCCTG
AAGAAGAGAGTATAGGGAGAGGATAGAAACAAGAAAGATTTATAAATTATGTAAAATCTCCTATATTCGG
AGTATGATTTTAATAAAATCCTGGTTTTTAAAGTTTCTCTCTAAGATTTCCTGAAAAAGCCCTGAGCTTT
GGACTAAATGCCTATGTGTATATAATAGCAGGAAAAGGCCAGAATTGCAAAACTATAGACGTAGCTCTTC
CAACATTCCTCAAACCTGTCCCCTTTAGAAGAAAGCTGAGTACTTTCTTTTTAGAGAGAACCAAGCAAGT
ACTGAAGGCTTCTTTCTAAGTGAGGAGTTTGAGCCTCTATTTCCAAAGCAGATGCTAATTAAGTCCTGAG
TTTAACCCTCAGGGACAGTATAGCACAGAGGATGAGAGAACCAGCTCCAATCAACTTGCCTGGGTTTAAA
ACTCTTCTGCTTTACCAACAATGAAAACTAAATTAGTCATTTGTTTCTTCTTCTTCCTTTTTTTTTTTTT
TTTTAGTCATTTGTTTCTTAGGAATCCCAAATCTCCAACATCTAGATGTAGATTTAATAACATGAACGGA
GCTCTGTGCATGGGGTGTGGATGCTCTCAGTAGCTAGCTTTTACAGGTTCCCACTTGCTTATTTTTCAGT
CTCATCTAACTATATATTTTTTACCTTGTGCCTTCCACAAAACCTTATTAATTACTCAGATCTTCCTTTT
ATTCCACTTGGTCTTCTTTTTTCCCTTCTTTTTCTTTTTCGTTTTCTTTCTTTCTTTCTTTCTTTTTTTT
TTTTTAATCCCCAAGCAGACCCCGTAAAGGCAGTGATCACCTTGCAGCCTCCATGGGTCAGTGTATTCCA
AGAGGAAAGTGTAACCTTATGGTGCGAGGGACCCCATTTGCCTGGGGACAGCTCTACACAGTGGTTTCTC
AATGGCACAGCCACTCAGACCTTGACCCCCAGATACAGAATCGCTGCTGCCAGTGTCAATGACAATGGTG
AATACAGGTGCCAGACAGGTCTCTCAGTCCTAAGTGACCCGATACAGCTGGAAATCCACAGAGGTAAGTA
GGGCATGGAACAGGAGAGCTGGAAATCACAAGGTCTCCCTTTATGTTTTCCCCTTTATCGATGCCAGATA
TGTGTGTTTTCATTTATTGGAGTGTAAGTTTCAGCTCTGTGTGCCTACTAGGTGAAATTAAGTCCAAATA
CTTAGAATATCACATGAGGGTCCTTAAACTGTGCCCCAATAGCACCCCTCTGGGACAGCTGTGAGCAGGG
TATCTAGTGTAAAACTCAGACCCTAAGATTTTATTATTTAAAATGATCTAATTTTGTTGAAAATCTGCAC
ACAGTAAATAAGAATTCAGAAAAATGTACAATGATGAACAATGAAATCTCTCTTCCACCTCAGACTCCTA
GTCCCATGGTCACCTTCTATAGAAATAAAACTGTTAATATTTATGAACCGTAAAAAACAGTGGTTGATGA
GGCACCTGGGGGCTCAGTCAGTTAAGTGTCTACCTTCAGCTCAGGTCATGATCCCAGGGCCCTGGGGTTG
AGCCCCATATTGTGCCTCCTGCTCAACAGGGAGAACAGGGAGTCTGCTTCTCCTTCCCCCTCTGCTGTTC
CCTCTGCTTGTGCTCTCTTGCTTTCTCTCTCAAAGAAATGAATTTTTTTTTTTAAATGGTTGGTTGAATA
CTCTATATACTGTTCTACACCTTGCTTTTATCACTTAAAATACCTTGGAGGTCTATTTAAATCAATAGAG
ATCTACCACGAACTTTCAAATGTCTGCCATATGGCTGTGCTGTAACTGATTTAATCATTTACCTATTAGT
AAACTTGTAGTATATTTCCAGTTTTTTGTTTTTACAGTCCTGCAATAGACATCTCTATACTTATAGACTG
GAGCACATTTCATAATATATCTGTAAGATAATATTCTGGACATGAAATTACTTTTGAGACTAAGCATTTT
AAATGTTGATGAATGGAAGGGAACCCCCCCCCCAACATATCCACTTAAATTTGTAAAAGATTTCCATTTG
TCAAGAAATGGAAACTGAATGTTTCATTATTCAGTATAAATCATTCAAATGTGTTGGGGGAGAAGAAGTA
AGGGGAGGGGCAGAAAGAGAGTGAGGAGGAGTCTCCCTACCAAGCAGGGAGCCAGGGGGCACAGGACTTG
GGGATTATGACCTGAGTTGAAGTCAGAGGCTTAACTGACTGTCCCTTGGACAGAACTGTTTTTACAAGAT
ATTTTATATAGTTGAAGTAGAAGAAGTGCTTTATAGTTCAAGTGACAAAAAAAGTGAAACAGGGCTAGGA
AGAGTCCACTTTCTTTGCCTCTGTACAGACTGTAGAAGCCCCAGCATTAATGACTTACTGAGAATAATAT
ATTTTACGTTTTTTTTAAAAAGCTTTATTTATTTATTTGAGAGAGCGAGAGAGAGAGAGAGAGAGAGAGA
GAGCATGATGAGTGGGAGTGGCAGAGAGAGAGGGAGAGAGAATCTCAAGCGGACTCCACGCTGAGTTCAG
AGTCTGTCTCAGGACAGTGAGATCATGACCTGAACCAAAATCAAGGATTGGATGTTTAACCAACTGAGCC
ACTCAGGGGCCCCACTATTTCGGGCCTCTTACAGGTAGTACTGCTATGAACATTTTTCTTTTAAGATGTT
ATTTTTTTAAGTAATCTCTACACCTAACATGGGGCTGGAACTCATAATCCCCAGATCAAGAGTTGCACAC
TGTATCAGCTGAGCCAGCCAGGTGCCCCCACTGTGGACATTTTGATACCTGTTTTTTGGTGCACTTATGT
ATACATATCTGTTGATATGCCTAGGAGTGGAATTGCTCGGTCACAAAATGTACATCTATTTGTTCAGCTT
TAATTTTCCAAAGTGGTTATACCATATTACACTTCTACAGTGGAATGTAAGAGTTCTGGTTCCTTTTCAT
CCTCATCAACACTCGGTGCTTTCTTTCTTTTCTTCTTTCTTTCTCTTTCTCTCTCTCTCTCTCTCTCTCT
CTCTTTCTTTCTTTTTTTTTTTTTCAAGATTTTATTTATTTATTCATGAGAGATGAAGAGAGAGGCAGAG
ACACAGGCAGAGGAAGAAGCAGGCTCTCTGCAGGAGCCTGATGTGGGACTTGATCCCCAACCCTGGGATC
AGGCCCTGAGTCAAAGGCAGATGCTTAACCACTAAGCCACCCAGGCATCCCTCTTCTTTCTTTCTTTCTT
TCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTTCTTCTTTCTTTTTCTTTCTTT
TTAACATACAGAGGTTTCTATATCTTTCAGTTTAGTCATTCTGGTGCATGTGCAGTAGTCATCACATAGC
TTTAATTTGCATTTTCCTGAAGACTCATGACATCAAGCATTTTCTACATTTATTACTTATTTGGATATCC
TCTTTTGTAAAATACCCATCTAGGTTTTTTTTGTCAATTTTTCTTTATTGTTGTCTTTCCTTATCAACTT
GCAGGATCTCTGTAGTTTGGACATGAGTCCTTTTTCAAGTGTTGCAAATATCTTTCACGCTGTGGCTTGT
CTTTTCACTATCTATGCTGTTTTTTCAGTGAAAAAAAGTGCTTACATTTACTGTAGTACAGTATAAATAC
ATCAGGTTTTGGGGTTGGTGCTCTCTATGCCCTTATTTAAAAATGTTTTGCCACAGCTAACCAGCAGAGG
AGAGTTCACCTGTAGGTACACTAACTCTGTCACTTCAGTTAAATCTGTATGTGCTGAGACCACAAAAATA
TAGCTGGTTTGAGGATCTATGAGCATCCCAATCCTGCTTTAAGGTGATGAAGATGGAAAGAATGGCTTTT
GAGGAGGAAATTAATAATGTCTGCTAAAAAGCTGTATCCTGAAATTTTTGATAATACTCCCAACTATCAT
TTAAGACTAAATCTTTTTAATTTTCATTAGTATGTATATAATTCTTTTTTCTTTTTCTTTCCTCATGAAT
TATTTAGAAGTGATTTAGGAAGGTGGCTTTTTGTTACTGATTTCTAATTTTATGTTAAATATGGTATCAG
TTCTTTAGTATTTGTTGAAAATTGCTTGTGGCTTAGTACATACTCGGTATTTTTAACTGTTGCATGTGTG
TTTGGAAAGTATGTGAATTTTCTTTAAACTATAGCTTCTATATAAATCCACAAAAATCAACTCTATTCAT
TGTGTCATTCAGATATGTTATATCATCACTAGTATTTTTGACAGTGTCTGATCCCATCATGTTTGTGGAT
ATATAAAGCTAAGGTGTTTGTGTGTTGGGGTACTGTAATCTTTGAGCACCTCTTGGTTGGGAATGGGAAT
AAGGGAGAGAAGAGCATTATATTTAGAAACACTGTGACAGCATCCAAAACTATAAAAGTCATGCTACATA
TACCACTGGAATACCTCTGCCTTCTGTTCTTAGGTAAATTCTGGAGGGGGAAAAACACTACTGTCCCTTT
TTGTCTTTTGTCCTTTAAGAACCTCCTCCCCATTTAGCCAAATCAACTGCTCCAGGGAAAGAAAAAGGAA
GCATTTTTTTGGTTATGTGTAGAGATGTACATCAAAAGGGAGGGCCCCTTGGACTTGGAGCTTGTTTTTA
GCAGCTAGATCACTGATCTGCGCATGTGTGTATATTCTGTCAATTTAGGGGCACATATACATCTGGAAAT
GTTTGCTATTCTGTGTGCTTGTCTTGGGACAAACAAGTATGTGGGATGCCATTAACATAGTAGTCAGGAG
TTGGAGTGTTTTAGTTTTTTTTATTGCTGTGTAACAAATTACTACAAACACAGCAGTTTAAAACAATGTA
TATTTATTATCTTTCCATGGGTCAGGAGTCTCAGCACAGCTTAGCTGGGTGCTCTGCAGGGGCTGCAGTC
AGGGTATTGACTGAGTTGTGTTCCTTCCTGCAGATCTTCCAAGCTCACATGGTCGTTGGCAGAATTTAGA
ATTCAGTTCTTTATGTTATAAGCCTGAGGTCCCCACCTTTTAGCTGGCTGTCAGTTGGAAGTAATCTCAG
CTCCTCCAGGCAGGCCTTTGCCAGATGGCCCTCTCCCAACATAGTGGCTTACTTCTTCAGGGCCAGTGGG
AGACTCTCAGTCCAGTCAGCTAAGAGAGTCATATAACGTAACCTCATCGTGACAGAGACATCCTGTAACC
TTTTTCATATCCTGTTCATTAAGCAAGTCTCAGGTTACACATACACCCAAGGGGATTACACAAGGGTGTG
ACACACTGGAGTCATCTTAGAATATTGCCTACCACATACAGTAAAATGTTTTTATCCCAACCAACTTCTG
AAATCTGGCAAGGGAAGTAAGAAGGGCCTGTGTGCATGGCTGCTTGTAAAGACTACTTTTCTTCCCAAAA
AAGCTAAAGATAATTGGGGGATGGGCAATAGGCCTCAAATTCGGCAGAGCTCTGAGGTTGAAATGTTGAA
AGAAAAAAAGATAAGAAATCCACCAGGGCCCAGCTTCAGCCTCCTTGTCCCTCTGCTACTGTATACATAC
ATTTTGGGTATATATTTTCCAGATTGGCTAATACTCCAGGTCTCTGGCAGAGTCTTCACGGAAGGGGAAC
CTCTGACTTTGAGGTGTCATGGATGGAATAATAAGCTGGTGTACAATGTGCTTTTCTACCAAAATGGCAC
AGTCTTGAAGTTTTCTCCTCAGAATTCTGAATTTACCATTCTGAAAACCACCCTACATCACAATGGCATC
TATCACTGCTCAGCCATGGGAAAGCATCGCTACGAATCAGCAGGAGTATCTATCACTATAAAAGGTATGT
ATCTGAATAGTCACAGAGCTCTAGTTTTAAGGACCATTATAAATCATCACTTCAGTTTGCAAGAGAAGAG
ACTTAAGTTCCAGAGAGGTAGCTATCTCACTGAAGGCCATACAGTGACCAGTGGCTGGGCCAGAACTGGA
ACTGAAGTCTTCTGGGCCTCCGGTCTATTGCTCTTTCCAGTAAATCGCAATGCCCATCAGTAATCCCAGG
AGCTAACATGAAGGGCAGGGCATAGTGAGGATCTATTTCATCATTTTAGTTGCAAGGAATAGAGATTTAC
TTGAGGTATGTAGGAGGGTTATTAAAAAATAACTCAATGGAGTCTCATAAAAAGCTCCATAGAATCAGAA
GCCATGAAGACATTAGGACTTGGTTTTACATTTTATCTATCTCTCAGGGGCAATATGGACTCTCTGATTC
TACTTCTCTCTGAACATGTGCTAACTAAGCAGCTTTCTCTGTTCCAGCTTACATGAGGGCCTCATTGTGG
TTCTTTCATCTTAGTACTCATATAGTTATAGTTTCTGTTTGAAAAAGAATTCATTCCGATGGGAAAAAGA
GGATTGTCCCAGATTATCTTTGGGGGAAGTGAGTAACACAAGTAATAAGTCACTGACCTGGCGAGTAGTG
TGTGTCAGTGTCCACTCCTGGTGGACCATTACCAAAAGGCATGGTCACATACTCAGTAATATGACTATTC
AGGGAAGCATGGACTGTGTGGAGGTATTCTTTTTTTTTTTAAAAAAAGATTTTATTTTATTTATTTATTC
ATGAGAGATACAGAGGGGGGAGGGCAGAGACACAGGCAGAGGGAGAAGCAGGCTCCATGCAAGGGAGCCC
AGTGTGACGTGGGACTCAATCCCAATTATGCCCTGGGCCGAAGGCAGGCGCTAAACCACTGAGCCACCCA
GGGATCCCTGGAGGTATTCTCCCCAGTAGGAAATGAGGAAGTTGGCAACTATAAGAGTATCTATGAGGAA
ACCCCAAGAATGCCTCTCTGCTGAAAGTGGGAAAATTTGTCTTACAGATGCATTCTCTAGGGGCAGGTTT
CCCAAGGAGGAACCAGGTATATTTTCTGTAAAAAGAACCTTGACACTGAAGCAGGCAACCCTGTCCCCAT
CAACTTTTCTTTAGAGCTATTTCCAGCCCCAGTGCTAAAAGCATCCTTGTCATCACCCATCCTGGAGGGG
CATGTGGTCAATCTGAGCTGTGAAACAAAGCTCCTCCTACAGAGACCTGGTTTGCAACTTTACTTCTCCT
TCTACATGGGCAGTAAGACCCTGCTGAGCAGGAATACATCCTCTGAATACCAGATACTAACAGCTAAGAA
AGAAGATTCAGGGTTATACTGGTGCGAGGCTACCACAGAAGATGGCAATGTCGTCAAGCGCAGCCCTGAG
TTGGAGCTTCAAGTGGTTGGTGAGCATGAGGGGAACTGACAGGCACAAGGAGAAGATGCTCCCTTTTCTC
CTTTGGGGCTGAGGTTTGTTTAAGGGGATTTCATGGCCCACCCAGGAAAAACCCATGAAGGGGCATTTCC
ACTTTTGATTCGTAACTTCATTATTCTCATGAGCTCTATTAAGTTTCCTTTCTTAACTCCATTTATTGCC
TTCCTTTTGTCCTTCTTTTCTTCTTCATTTTCTTTTTCCCCCTGTTCCTCCCCCCACCCTAAAAATCTAA
TCAATATATTGAGTTCCTTCCATCTGTTGTCATAAATGTGGGGATATGAAGACAGTGGGGTACAGCTCTT
ACTTCAAGGAGCTCACATGGTAGATTGGTGACGTAGGGAATTTTGTGGATTGCACATAAATACCTGCCCA
AGTGGCTATATCTGGCTGAGGTAGAGAGACTGTGAGCTCCAAGACAAAGACTCTTTGGGAAAAAAGTTTA
TCTTCAACCCAAATCCATTTCAGGCATTAAATGGCATAGATGTAGCATTTTTGTCTGAAACTAGGAAGTC
CACTTAGTAGGCCCTGGCAGTTAAGCTCTTATGAGGAGCCTGCCCCTGGTCTGTACACCATATAACTCAG
GTGGAGCACCTATCTGCCCCCTGAAATTACCATTGTCTCCACTGGGGACAGGCATACCAGGTGTCAGCCA
GTATTCCCTCCCAAACATAATTCATCCAGATTCCTCTGCGTTCTAACTAGCATTTCTTCTTGTCATTTTC
TTTTTCAGGCCCCCAGACACTAACTCCTGTTTGGTTTCACGTCCTTTTCTATGTGGCAATGGGAATGATA
TTTTTGGTGGATACCATTTTCTGTATGATTATACATAAGGAACTGCAAAGAAAGAAAAAGTGGAATTTAG
AAATCTCGTTGTACTCTGGTCTTGAGAAAAGAGTAGATTCCTACCTTCAAAAGGAGAGAGATTTAGAAGA
GCCAAAATATCAGGAACTCGAACAGCTGCAAGAAAAGACACCCCAGAAGCCCCCAGAGGGAGAGCAGCAG
TAGAGCCCAGGGGGTGCCCATGGATTGAGATGGTGCCTCCCACTTCTTTTTGGTGCGTGCATTGGGGTGC
AAACACCCAAAAGTTTGAAGACGTTAGAACTCTGAGTCCCATGTCATCTGATTAACTCTGAAA
-
Protein Sequence : Show Sequence
>gi|55742701|ref|NP_001002976.1| high affinity immunoglobulin gamma Fc receptor I precursor [Canis lupus familiaris]
MWLLTVLLLWVPAGAQTDPVKAVITLQPPWVSVFQEESVTLWCEGPHLPGDSSTQWFLNGTATQTLTPRY
RIAAASVNDNGEYRCQTGLSVLSDPIQLGIHRDWLILQVSGRVFTEGEPLTLRCHGWNNKLVYNVLFYQN
GTVLKFSPQNSEFTILKTTLHHNGIYHCSAMGKHRYESAGVSITIKELFPAPVLKASLSSPILEGHVVNL
SCETKLLLQRPGLQLYFSFYMGSKTLLSRNTSSEYQILTAKKEDSGLYWCEATTEDGNVVKRSPELELQV
VGPQTLTPVWFHVLFYVAMGMIFLVDTIFCMIIHKELQRKKKWNLEISLYSGLEKRVDSYLQKERDLEEP
KYQELEQLQEKTPQKPPEGEQQ
-
Molecule Role :
Vaximmutor
- Related Vaccine(s):
Canine parvovirus DNA vaccine pGT36VP1
|
| IV. Vaccine Information |
 |
|
 |
|
|
|
|
1. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.20) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002122 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
 |
|
 |
|
|
|
|
|
|
|
|
|
2. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.21) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002123 |
| c. Type: |
| Live vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
3. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.22) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002124 |
| c. Type: |
| Live vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
4. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002125 |
| c. Type: |
| Live vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
5. Canine Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14R7.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002126 |
| c. Type: |
| Live vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6. Canine Coronavirus-Parvovirus Modified Live Virus Vaccine (USDA: 14R1.20) |
| a. Manufacturer: |
| Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002121 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.20) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002136 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.21) |
| a. Manufacturer: |
| Wyeth, Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002137 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002138 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 1599.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002139 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.20) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002241 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
12. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin (USDA: 47C5.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002242 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Borrelia Burgdorferi Bacterin-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46B9.21) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002219 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002231 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 46J9.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002234 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47L9.20) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002246 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
17. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.21) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002230 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.26) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002232 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
19. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 46J9.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002233 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.20) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002226 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
21. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J7.22) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002227 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
22. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.20) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002229 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
23. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46L9.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002236 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
24. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J9.R1) |
| a. Manufacturer: |
| Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002235 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25. Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Modified Live Virus; Canarypox Vector Vaccine (USDA: 1591.R1) |
| a. Manufacturer: |
| Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002135 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
26. Canine Distemper-Adenovirus Type 2-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine-Leptospira Icterohaemorrhagiae Bacterial Extract (USDA: 46P9.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002237 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
27. Canine Distemper-Adenovirus Type 2-Measles-Parainfluenza Modified Live Virus Vaccine (USDA: 1341.20) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002095 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
28. Canine Distemper-Adenovirus Type 2-Parainfluenza Modified Live Virus Vaccine (USDA: 13C1.20) |
| a. Manufacturer: |
| Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002100 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
29. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.20) |
| a. Manufacturer: |
| Intervet Inc., Aceto Pharma Corp. |
| b. Vaccine Ontology ID: |
| VO_0002101 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
30. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.21) |
| a. Manufacturer: |
| Wyeth, Boehringer Ingelheim Vetmedica, Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002102 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
31. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.22) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002103 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
32. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.23) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002104 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
33. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002105 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
34. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002106 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
35. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.28) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002107 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
36. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002108 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
37. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine (USDA: 13D1.T0) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002110 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
38. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4637.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002211 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
39. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (USDA: 4639.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002214 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
40. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterin (USDA: 47K1.20) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002245 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
41. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002215 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
42. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterial Extract (USDA: 4639.28) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002216 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
43. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.20)_ |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc. |
| b. Type: |
| Live, attenuated vaccine |
| c. Status: |
| Licensed |
| d. Location Licensed: |
| USA |
| e. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
44. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.22) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002209 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
45. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4637.23) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002210 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
46. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.21) |
| a. Manufacturer: |
| Wyeth, Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002212 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
47. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.22) |
| a. Manufacturer: |
| Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002213 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
48. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 46J8.20) |
| a. Manufacturer: |
| Boehringer Ingelheim Vetmedica, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002228 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
49. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Canarypox Vector Vaccine (USDA: 13D1.R1) |
| a. Manufacturer: |
| Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002109 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
50. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Modified Live Virus, Live Canarypox Vector Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 4639.R1) |
| a. Manufacturer: |
| Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002217 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
51. Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus-Rabies Modified Live & Killed Virus Vaccine (USDA: 13G9.20) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002111 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
52. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D7.20) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002117 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
53. Canine Distemper-Coronavirus-Parvovirus Modified Live & Killed Virus Vaccine (USDA: 14D9.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002118 |
| c. Type: |
| Live, attenuated vaccine; Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
54. Canine Distemper-Hepatitis-Parainfluenza-Parvovirus Modified Live Virus Vaccine-Leptospira Canicola-Icterohaemorrhagiae Bacterin (USDA: 47P9.22) |
| a. Manufacturer: |
| Boehringer Ingelheim Vetmedica, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002247 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
55. Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.20) |
| a. Manufacturer: |
| Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0002113 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
56. Canine Distemper-Parvovirus Modified Live Virus Vaccine (USDA: 13P1.27) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0002114 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
57. Canine parvovirus CPMV-PARVO1 protein vaccine |
| a. Vaccine Ontology ID: |
| VO_0011464 |
| b. Type: |
| Subunit vaccine |
| c. Status: |
| Research |
| d. Antigen |
| Canine parvovirus VP2 |
| e. Gene Engineering of
VP2 |
- Type:
Recombinant protein preparation
- Description:
CPMV–PARVO1 contains a 17-amino acid peptide (DGAVQPDGGQPAVRNER) corresponding to residues 3 to 19 from VP2 of canine parvovirus, inserted between residues 22 and 23 of the S protein of CPMV. Each virion contains 60 copies of this peptide and 1 μg chimera contains approximately 20 ng of peptide. The construction, propagation and purification of CPMV–PARVO1 virions (and wild type CPMV) was carried out. In addition, the virus particles were inactivated by irradiation with UV254 light during the purification, according to the following procedure: after resuspension of the PEG/NaCl pellet and clarification, the concentration of particles was measured by spectrophotometry, and the virus-containing supernatant diluted to 1 mg/ml (Langeveld et al., 2001).
- Detailed Gene Information: Click here.
|
| f. Immunization Route |
| Subcutaneous injection |
| g.
Dog Response |
- Vaccination Protocol:
Dogs were kept in four groups of five or six animals, A–D, each group in a separate room. Groups A, B and C (six dogs in each) were immunized subcutaneously above the shoulder blades on days 0 and 28 with either CPMV–PARVO1, 3L17–KLH or wild type CPMV, respectively, in Quil-A®/Alhydrogel®. A fourth group (D) of five dogs was left unvaccinated. Inoculation sites were checked daily for adverse reactions (Langeveld et al., 2001).
- Challenge Protocol:
On day 42, all 23 dogs were challenged with CPV by the oronasal route [19], by distributing CPV onto their eyes, noses and mouths (1.5 ml/dog). Blood was collected prior to immunization, following immunization (days 28 and 38) and following challenge (day 48 and 57), and sera collected and stored at −20°C. Rectal swabs were performed with cotton wool swab sticks and stored at −20°C prior to analysis for the presence of CPV (Langeveld et al., 2001).
- Efficacy:
Dogs immunized with the inactivated CPMV-PARVO1 in adjuvant displayed no clinical signs of disease and shedding of CPV in faeces was limited following CPV challenge (Langeveld et al., 2001).
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
58. Canine parvovirus DNA vaccine pGT36VP1 |
| a. Vaccine Ontology ID: |
| VO_0011462 |
| b. Type: |
| DNA vaccine |
| c. Status: |
| Research |
| d. Antigen |
| Canine parvovirus VP1 |
| e. Gene Engineering of
VP1 |
- Type:
DNA vaccine construction
- Description:
CPV viral DNA was used as template to amplify the entire VP1 fragment, including VP2, by polymerase chain reaction (PCR). Two deoxyoligonucleotides, coding and noncoding strand primers were synthesized. The product was then electrophoresed in a 0.8% agarose/TAE gel. The band containing the PCR product was excised from the agarose gel by QIAGEN QIAquickTM spin columns (QIAGEN GmbH, Hilden, Germany) and digested simultaneously with BamHI and Not1 (New England Biolabs, Beverly, MA, USA). The digested VP1 fragment was ligated into BamHIINotI digested pGT36 (kindly provided by Dr David Curiel, University of Alabama, Birmingham, AL, USA), a derivative of pCDNA3, which has a CMV promoter and kanamycin resistance gene. Kanamycin resistance clones were screened for appropriate restriction digestion patterns and one clone, designated as pGT36VP1, was then sequenced using an Applied Biosystems Model 373A Automated Sequencer (Perkin-Elmer/Applied Biosysterns Division, Folster City, CA, USA) (Jiang et al., 1998).
- Detailed Gene Information: Click here.
|
| f. Vector: |
| plasmid vector pGT36 |
| g. Immunization Route |
| Intramuscular injection (i.m.) |
| h.
Dog Response |
- Vaccination Protocol:
Four mix breed dogs, 9 months of age, from a single litter were injected with doses of 200, 400, 600 or 800 /lg pGT36VPl in a total volume of 1 ml phosphate buffered saline (PBS, 0.067 M, pH 7.2). One negative control sibling was injected with 1 ml PBS. All injections were administered i.m. at the right quadriceps muscle. Blood samples were collected weekly. All dogs were reinjected on week 16 with the same dose of DNA used initially at the same site and the negative control was injected with PBS (Jiang et al., 1998).
- Challenge Protocol:
Challenge infections with virulent CPV were performed in a HEIPA filtered, environmentally controlled kennel facility at the College of Veterinary Medicine, Auburn University. The challenge strains of CPV (AU-H3-WS-93) consist of equal amounts of three virulent CPV slrains, AU-H3 (CPV-2), WS (CPV-2a) and 93 (CPV-2b) at a dose of 10^5 TCID(50) (tissue culture infectious dose) per ml. All challenge strains were purified from fecal extracts. The challenge dose was given intranasally (0.5 ml in each nostril) and orally (1.0 ml). The dogs were monitored three times daily for clinical signs including attitude, appetite, stool consistency, temperature and vomiting (Jiang et al., 1998).
- Efficacy:
All pGT36VP1 vaccinated dogs were protected against infection after virulent CPV challenge regardless of dose and the unvaccinated control dog was fully susceptible (Jiang et al., 1998).
- Host Gene Response of
IgG Fc fragment
- Gene Response:
NAV vaccinated dogs showed an increase of serum IgG titer starting 1 week post-injection which peaked at week 2 and remained detectable for at least 14 weeks. The non-immunized control dog did not show an antibody response at any point pre-challenge (Jiang et al., 1998).
- Detailed Gene Information: Click here.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
59. Canine Parvovirus Modified Live Virus Vaccine-Leptospira Canicola Icterohaemorrhagiae Bacterin (USDA: 47B1.20) |
| a. Manufacturer: |
| Boehringer Ingelheim Vetmedica, Inc. |
| b. Vaccine Ontology ID: |
| VO_0002240 |
| c. Status: |
| Licensed |
| d. Location Licensed: |
| USA |
| e. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
60. Parvovirus Killed Virus Vaccine (USDA: 18P5.20) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc., Novartis Animal Health US, Inc. |
| b. Vaccine Ontology ID: |
| VO_0001752 |
| c. Type: |
| Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
61. Parvovirus Killed Virus Vaccine (USDA: 18P5.21) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0001753 |
| c. Type: |
| Inactivated or "killed" vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
62. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.20) |
| a. Manufacturer: |
| Boehringer Ingelheim Vetmedica, Inc., Intervet Inc., VacciCel, Inc., Neotech, LLC |
| b. Vaccine Ontology ID: |
| VO_0001754 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
63. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.21) |
| a. Manufacturer: |
| Wyeth, Boehringer Ingelheim Vetmedica, Inc., Intervet Inc. |
| b. Vaccine Ontology ID: |
| VO_0001755 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
64. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.22) |
| a. Manufacturer: |
| Intervet Inc., Pfizer, Inc., Merial, Inc. |
| b. Vaccine Ontology ID: |
| VO_0001756 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
65. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.23) |
| a. Manufacturer: |
| Wyeth, Intervet Inc., Pfizer, Inc. |
| b. Vaccine Ontology ID: |
| VO_0001757 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
66. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.25) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0001758 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
67. Parvovirus Modified Live Virus Vaccine (USDA: 18M1.29) |
| a. Manufacturer: |
| Wyeth |
| b. Vaccine Ontology ID: |
| VO_0001759 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Location Licensed: |
| USA |
| f. Host Species for Licensed Use: |
| Gray wolf |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
68. RECOMBITEK Canine Parvo |
| a. Tradename: |
| RECOMBITEK Canine Parvo |
| b. Vaccine Ontology ID: |
| VO_0001123 |
| c. Type: |
| Live, attenuated vaccine |
| d. Status: |
| Licensed |
| e. Host Species for Licensed Use: |
| Dog |
| f. Immunization Route |
| Intramuscular injection (i.m.) |
| g. Description |
| Modified live virus |
|
|
|
|
|
|
|
|
| V. References |
1. Jiang et al., 1998: Jiang W, Baker HJ, Swango LJ, Schorr J, Self MJ, Smith BF. Nucleic acid immunization protects dogs against challenge with virulent canine parvovirus. Vaccine. 1998; 16(6); 601-607. [PubMed: 9569471].
2. Langeveld et al., 2001: Langeveld JP, Brennan FR, MartÃnez-Torrecuadrada JL, Jones TD, Boshuizen RS, Vela C, Casal JI, Kamstrup S, Dalsgaard K, Meloen RH, Bendig MM, Hamilton WD. Inactivated recombinant plant virus protects dogs from a lethal challenge with canine parvovirus. Vaccine. 2001; 19(27); 3661-3670. [PubMed: 11395200].
3. Wiki: Canine parvovirus: Canine parvovirus [http://en.wikipedia.org/wiki/Canine_parvovirus]
|
