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Infectious Hematopoietic Necrosis Virus |
| Table of Contents |
- Protective Antigens
- G glycoprotein
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| I. Vaccine Related Protective Antigens |
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1. G glycoprotein
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Gene Name :
G glycoprotein
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Sequence Strain (Species/Organism) :
Infectious hematopoietic necrosis virus
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VO ID :
VO_0011109
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NCBI Gene ID :
1489848
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NCBI Protein GI :
9628086
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Locus Tag :
IHNVgp4
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Genbank Accession :
KP216199
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Protein Accession :
NP_042679
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Taxonomy ID :
11290
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Gene Starting Position :
2998
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Gene Ending Position :
4524
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Gene Strand (Orientation) :
?
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Protein Name :
glycoprotein
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Protein pI :
6.5
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Protein Weight :
54073.98
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Protein Length :
508
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DNA Sequence : Show Sequence
>NC_001652.1:2998-4524 Infectious hematopoietic necrosis virus, complete genome
AATGGACACCATGATCACCACTCCGCTCATTCTCATTCTGATCACCTGCGGAGCAAACAGCCAAACCGTC
AAACCCGACACCGCAAGCGAATCAGACCAACCCACCTGGTCAAACCCGCTCTTCACCTATCCCGAGGGAT
GCACTCTGGACAAGCTCTCTAAGGTCAATGCCTCTCAACTGAGATGCCCAAGGATCTTCGACGATGAGAA
CAGGGGGCTAATTGCCTATCCCACATCCATCCGGTCCCTGTCAGTCGGAAACGACCTCGGGGACATTCAC
ACCCAAGGGAACCACATCCACAAAGTCCTGTACCGCACAATCTGCTCAACAGGGTTCTTCGGGGGTCAGA
CGATAGAGAAGGCGCTTGTAAAAATGAAACTCTCTACGAAAGAAGCAGGGGCGTATGACACCACAACCGC
AGCCGCTCTGTACTTCCCAGCTCCCCGATGCCAATGGTACACCGACAACGTACAAAACGATCTCATCTTC
TACTACACAACACAAAAGAGTGTTCTTAGAGATCCCTACACCAGAGACTTTCTGGACTCAGATTTTATTG
GAGGAAAATGTACCAAATCACCCTGCCAGACTCATTGGTCCAACGTAGTTTGGATGGGTGATGCAGGGAT
ACCAGCCTGTGATTCCAGCCAAGAGATAAAAGCTCACCTCTTTGTTGATAAAATCTCCAATCGAGTCGTG
AAGGCAACGAGCTACGGACACCACCCCTGGGGACTGCATCAGGCCTGTATGATTGAATTCTGTGGGCAAC
AGTGGATACGGACAGATCTCGGTGACCTAATATCTGTCGTATACAATTCTGGATCAGAAATCCTCTCGTT
CCCGAAGTGTGAAGACAAGACCGTGGGAATGAGGGGAAACTTGGATGACTTTGCCTATCTAGACGATCTG
GTGAAGGCCTCTGAGAGCAGAGAGGAATGTCTTGAGGCGCACGCCGAGATAATATCAACAAACAGTGTGA
CTCCATACCTCCTATCCAAATTCCGATCTCCACATCCCGGAATAAATGACGTCTACGCTATGCACAAAGG
CTCCATCTATCACGGGATGTGCATGACGGTCGCTGTGGACGAGGTATCCAAGGACAGGACAACGTACAGG
GCCCATCGCGCTACCAGCTTCACGAAATGGGAACGACCCTTTGGGGATGAGTGGGAGGGCTTTCACGGAT
TGCACGGAAACAACACCACCATTATTCCAGACCTGGAGAAATACGTCGCCCAGTACAAGATGAGCATGAT
GGAACCGATGAGCATCAAATCCGTACCCCATCCAAGCATCCTGGCCCTCTACAATGAGACAGACGTGTCA
GGGATCTCCATCAGGAAACTGGACTCATTCGACCTTCAATCACTCCACTGGAGTTTCTGGCCCACAATCT
CCGCACTGGGTGGAATTCCCTTTGTTCTCCTCCTTGCTGTTGCCGCGTGCTGCTGCTGGTCAGGGAGACC
TCCCACTCCCTCCGTGCCGCAGAGTATCCCCATGTATCACCTGGCAAACCGGTCCTA
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Protein Sequence : Show Sequence
>NP_042679.1 glycoprotein [Infectious hematopoietic necrosis virus]
MDTMITTPLILILITCGANSQTVKPDTASESDQPTWSNPLFTYPEGCTLDKLSKVNASQLRCPRIFDDEN
RGLIAYPTSIRSLSVGNDLGDIHTQGNHIHKVLYRTICSTGFFGGQTIEKALVKMKLSTKEAGAYDTTTA
AALYFPAPRCQWYTDNVQNDLIFYYTTQKSVLRDPYTRDFLDSDFIGGKCTKSPCQTHWSNVVWMGDAGI
PACDSSQEIKAHLFVDKISNRVVKATSYGHHPWGLHQACMIEFCGQQWIRTDLGDLISVVYNSGSEILSF
PKCEDKTVGMRGNLDDFAYLDDLVKASESREECLEAHAEIISTNSVTPYLLSKFRSPHPGINDVYAMHKG
SIYHGMCMTVAVDEVSKDRTTYRAHRATSFTKWERPFGDEWEGFHGLHGNNTTIIPDLEKYVAQYKMSMM
EPMSIKSVPHPSILALYNETDVSGISIRKLDSFDLQSLHWSFWPTISALGGIPFVLLLAVAACCCWSGRP
PTPSVPQSIPMYHLANRS
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
The DNA vaccine pIHNw-G encodes the glycoprotein of the fish rhabdovirus infectious hematopoietic necrosis virus (IHNV). Vaccine performance in rainbow trout was measured 3, 6, 13, 24, and 25 months after vaccination. At three months all fish vaccinated with 0.1 microg pIHNw-G had detectable neutralizing antibody (NAb) and they were completely protected from lethal IHNV challenge with a relative percent survival (RPS) of 100% compared to control fish (Kurath et al., 2006).
- Related Vaccine(s):
IHNV DNA vaccine pCDNA-G encoding G
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IHNV DNA vaccine pCMV4-G
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IHNV DNA vaccine pIHN-G encoding glycoproteins
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IHNV DNA vaccine pIHNw-G
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| II. References |
1. Kurath et al., 2006: Kurath G, Garver KA, Corbeil S, Elliott DG, Anderson ED, LaPatra SE. Protective immunity and lack of histopathological damage two years after DNA vaccination against infectious hematopoietic necrosis virus in trout. Vaccine. 2006; 24(3); 345-354. [PubMed: 16154239].
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