VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
VaxCT
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo
Pathogen Page
Streptococcus pyogenes

Table of Contents

  1. General Information
    1. NCBI Taxonomy ID
    2. Disease
    3. Introduction
    4. Microbial Pathogenesis
    5. Host Ranges and Animal Models
    6. Host Protective Immunity
  2. Vaccine Related Pathogen Genes
    1. emm (Streptococcus pyogenes)
    2. emm1 (Streptococcus pyogenes)
    3. emm12 mutant (Streptococcus pyogenes)
    4. emm3 (Streptococcus pyogenes)
    5. fbaA (Streptococcus pyogenes SSI-9)
    6. fbaA (Streptococcus pyogenes)
    7. fbp54 (Streptococcus pyogenes )
    8. hypothetical protein MGAS2096_Spy1592 (Streptococcus pyogenes M1 GAS)
    9. hypothetical protein SPy_0130 (Streptococcus pyogenes )
    10. hypothetical protein SPy_0843 (Streptococcus pyogenes M1 GAS)
    11. inlA (Streptococcus pyogenes M1 GAS)
    12. isp2 (Streptococcus pyogenes)
    13. M1 (Streptococcus pyogenes)
    14. M14 (Streptococcus pyogenes)
    15. M18 (Streptococcus pyogenes)
    16. M22 (Streptococcus pyogenes)
    17. M28 (Streptococcus pyogenes)
    18. M6 (Streptococcus pyogenes)
    19. maltodextrin-binding proteinSPy1294 (Streptococcus pyogenes M1 GAS)
    20. mrp (Streptococcus pyogenes)
    21. mtsA (Streptococcus pyogenes )
    22. nuclease (Streptococcus pyogenes)
    23. oppA (Streptococcus pyogenes M1 476])
    24. putative protease maturation proteinSpy1390 (Streptococcus pyogenes M1 GAS)
    25. putative secreted protein SPy0019 (Streptococcus pyogenes)
    26. putative surface exclusion protein SPy0269 (Streptococcus pyogenes)
    27. putative transcriptional antiterminator (BglG family)SPy1325 (Streptococcus pyogenes M1 GAS)
    28. SCPA (Streptococcus pyogenes)
    29. scpA (Streptococcus pyogenes)
    30. scpA (Streptococcus pyogenes M1 GAS)
    31. SfbI (Streptococcus pyogenes DSM 2071)
    32. shp (Streptococcus pyogenes)
    33. sib35 (Streptococcus pyogenes serotype M12)
    34. slo (Streptococcus pyogenes)
    35. spa (Streptococcus pyogenes)
    36. spa (Streptococcus pyogenes)
    37. speA (Streptococcus pyogenes)
    38. speB (Streptococcus pyogenes)
    39. Spy0416 (Streptococcus pyogenes)
    40. Spy0469 (Streptococcus pyogenes)
    41. srtA (Streptococcus pyogenes)
    42. StreptInCor (Streptococcus pyogenes )
    43. tmbC (Streptococcus pyogenes)
  3. Vaccine Related Host Genes
    1. IgA
    2. IgG
  4. Vaccine Information
    1. Group A streptococcal recombinant fusion peptide Vaccine
    2. licensed Group A streptococcal infection human vaccine
    3. S. pyogenes FbaA Protein Vaccine
    4. S. pyogenes FBP54 Protein Vaccine
    5. S. pyogenes M Protein Vaccine
    6. S. pyogenes SfbI Protein Vaccine
    7. S. pyogenes Sib35 Protein Vaccine
    8. SL3261 expressing streptococcal M protein
  5. References
I. General Information
1. NCBI Taxonomy ID:
1314
2. Disease:
Group A streptococcal infections, Strep throat, Scarlet fever
3. Introduction
Streptococcus pyogenes is a spherical gram-positive bacterium that grows in long chains and is the cause of Group A streptococcal infections. S. pyogenes displays streptococcal group A antigen on its cell wall. S. pyogenes typically produces large zones of beta-hemolysis (the complete disruption of erythrocytes and the release of hemoglobin) when cultured on blood agar plates and are therefore also called Group A (beta-hemolytic) Streptococcus (abbreviated GAS). S. pyogenes is the cause of many important human diseases ranging from mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Examples of mild S. pyogenes infections include pharyngitis ("strep throat") and localized skin infection ("impetigo"). Erysipelas and cellulitis are characterized by multiplication and lateral spread of S. pyogenes in deep layers of the skin. S. pyogenes invasion and multiplication in the fascia can lead to necrotizing fasciitis, a potentially life-threatening condition requiring surgical treatment (Wiki: S. pyogenes).
4. Microbial Pathogenesis
Colonization of tissues by S. pyogenes is thought to result from a failure in the constitutive defenses (normal flora and other nonspecific defense mechanisms) which allows establishment of the bacterium at a portal of entry (often the upper respiratory tract or the skin) where the organism multiplies and causes an inflammatory purulent lesion (Textbook of Bacteriology).
5. Host Ranges and Animal Models
S. pyogenes is a human pathogen and mice are the animal model that is used (Okamoto et al., 2005).
6. Host Protective Immunity
Macrophages and the antibody mediated response are the major defenses for host protective immunity against S. pyogenes infection (Textbook of Bacteriology).
Loading...
Loading Pathogen Genes...
Loading...
Loading Host Genes...
Loading...
Loading Vaccines...
Loading References...