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Pathogen Page

Streptococcus pyogenes

General Information
Vaccine Related Pathogen Genes
1. emm
2. emm1
3. emm12 mutant
4. emm3
5. fbaA
6. fbaA
7. fbp54
8. hypothetical protein MGAS2096_Spy1592
9. hypothetical protein SPy_0130
10. hypothetical protein SPy_0843
11. inlA
12. isp2
13. M1
14. M14
15. M18
16. M22
17. M28
18. M6
19. maltodextrin-binding proteinSPy1294
20. mrp
21. mtsA
22. nuclease
23. oppA
24. putative protease maturation proteinSpy1390
25. putative secreted protein SPy0019
26. putative surface exclusion protein SPy0269
27. putative transcriptional antiterminator (BglG family)SPy1325
28. SCPA
29. scpA
30. scpA
31. SfbI
32. shp
33. sib35
34. slo
35. spa
36. spa
37. speA
38. speB
39. Spy0416
40. Spy0469
41. srtA
42. StreptInCor
43. tmbC
Vaccine Related Host Genes
1. IgA
2. IgG
Vaccine Information
References

I. General Information

1. NCBI Taxonomy ID:

1314

2. Disease:

Group A streptococcal infections, Strep throat, Scarlet fever

3. Introduction

Streptococcus pyogenes is a spherical gram-positive bacterium that grows in long chains and is the cause of Group A streptococcal infections. S. pyogenes displays streptococcal group A antigen on its cell wall. S. pyogenes typically produces large zones of beta-hemolysis (the complete disruption of erythrocytes and the release of hemoglobin) when cultured on blood agar plates and are therefore also called Group A (beta-hemolytic) Streptococcus (abbreviated GAS). S. pyogenes is the cause of many important human diseases ranging from mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Examples of mild S. pyogenes infections include pharyngitis ("strep throat") and localized skin infection ("impetigo"). Erysipelas and cellulitis are characterized by multiplication and lateral spread of S. pyogenes in deep layers of the skin. S. pyogenes invasion and multiplication in the fascia can lead to necrotizing fasciitis, a potentially life-threatening condition requiring surgical treatment (Wiki: S. pyogenes).

4. Microbial Pathogenesis

Colonization of tissues by S. pyogenes is thought to result from a failure in the constitutive defenses (normal flora and other nonspecific defense mechanisms) which allows establishment of the bacterium at a portal of entry (often the upper respiratory tract or the skin) where the organism multiplies and causes an inflammatory purulent lesion (Textbook of Bacteriology).

5. Host Ranges and Animal Models

S. pyogenes is a human pathogen and mice are the animal model that is used (Okamoto et al., 2005).

6. Host Protective Immunity

Macrophages and the antibody mediated response are the major defenses for host protective immunity against S. pyogenes infection (Textbook of Bacteriology).

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