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Hendra virus |
| Table of Contents |
- Protective Antigens
- G glycoprotein
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| I. Vaccine Related Protective Antigens |
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1. G glycoprotein
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Gene Name :
G glycoprotein
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Sequence Strain (Species/Organism) :
Hendra henipavirus
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VO ID :
VO_0011310
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NCBI Gene ID :
1446471
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NCBI Protein GI :
29468607
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Locus Tag :
Hvgp5
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Genbank Accession :
AF017149
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Protein Accession :
NP_047112
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3D structure: PDB ID :
2X9M
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Taxonomy ID :
63330
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Gene Starting Position :
8679
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Gene Ending Position :
11242
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Gene Strand (Orientation) :
+
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Protein Name :
glycoprotein
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Protein pI :
7.51
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Protein Weight :
63419.1
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Protein Length :
604
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DNA Sequence : Show Sequence
>NC_001906.3:8679-11242 Hendra virus, complete genome
TAGGACCCAAGTCCTTAACCACATTCTAATGTGAGGGAGAATTAAATGTACATTGAGACTGACAATCTAA
TATACAGAGTGTTTGATCAAGTTAAAACATCAATTGTCAGGAATTCATTGATAAACCAACTTGTTAGTTA
GAATTAAGAAAATATAAGAGCTAATACTCGCAAGTCATTTGCTTCTTCAAGAGCCTGTCTCAACTATCAA
GTGAATACATGATCTAAAACTAGTATGATGGCTGATTCCAAATTGGTAAGCCTGAACAATAATCTATCTG
GTAAAATCAAGGATCAAGGTAAAGTTATCAAGAATTATTACGGCACAATGGACATCAAGAAAATTAACGA
TGGGTTATTAGATAGTAAGATACTTGGGGCGTTTAACACAGTGATAGCTTTGTTGGGATCAATCATCATC
ATTGTGATGAATATCATGATAATTCAAAATTACACCAGAACGACTGATAATCAGGCACTAATCAAAGAGT
CACTCCAGAGTGTACAGCAACAAATCAAAGCTTTAACAGACAAAATCGGGACAGAGATAGGCCCCAAAGT
CTCACTAATTGACACATCCAGCACCATCACAATTCCTGCTAACATAGGGTTACTGGGATCCAAGATAAGT
CAGTCTACCAGCAGTATTAATGAGAATGTTAACGATAAATGCAAATTTACTCTTCCTCCTTTAAAGATTC
ATGAGTGTAATATCTCTTGTCCGAATCCTTTGCCTTTCAGAGAATACCGACCAATCTCACAAGGGGTGAG
TGATCTTGTAGGACTGCCGAACCAGATCTGTCTACAGAAGACAACATCAACAATCTTAAAGCCCAGGCTG
ATATCCTATACTCTACCAATTAATACCAGAGAAGGGGTTTGCATCACTGACCCACTTTTGGCTGTTGATA
ATGGCTTCTTCGCCTATAGCCATCTTGAAAAGATCGGATCATGTACTAGAGGAATTGCAAAACAAAGGAT
AATAGGGGTGGGTGAGGTATTGGATAGGGGTGATAAGGTGCCATCAATGTTTATGACCAATGTTTGGACA
CCACCCAATCCAAGCACCATCCATCATTGCAGCTCAACTTACCATGAAGATTTTTATTACACATTGTGCG
CAGTGTCCCATGTGGGAGATCCTATCCTTAACAGTACTTCCTGGACAGAGTCACTGTCTCTGATTCGTCT
TGCTGTAAGACCAAAAAGTGATAGTGGAGACTACAATCAGAAATACATCGCTATAACTAAAGTTGAAAGA
GGGAAGTACGATAAGGTGATGCCTTACGGTCCATCAGGTATCAAGCAAGGGGATACATTGTACTTTCCGG
CCGTCGGTTTTTTGCCAAGGACCGAATTTCAATATAATGACTCTAATTGTCCCATAATTCATTGCAAGTA
CAGCAAAGCAGAAAACTGTAGGCTTTCAATGGGTGTCAACTCCAAAAGTCATTATATTTTGAGATCAGGA
CTATTGAAGTATAATCTATCTCTTGGAGGAGACATCATACTCCAATTTATCGAGATTGCTGACAATAGAT
TGACCATCGGTTCTCCTAGTAAGATATACAATTCCCTAGGTCAACCCGTTTTCTACCAGGCATCATATTC
TTGGGATACGATGATTAAATTAGGCGATGTTGATACCGTTGACCCTCTAAGAGTACAGTGGAGAAATAAC
AGTGTGATTTCTAGACCTGGACAGTCACAGTGTCCTCGATTTAATGTCTGTCCCGAGGTATGCTGGGAAG
GGACATATAATGATGCTTTTCTAATAGACCGGCTAAACTGGGTTAGTGCTGGTGTTTATTTAAACAGTAA
CCAAACTGCAGAGAACCCTGTGTTTGCCGTATTCAAGGATAACGAGATCCTTTACCAAGTTCCACTGGCT
GAAGATGACACAAATGCACAAAAAACCATCACAGATTGCTTCTTGCTGGAGAATGTCATATGGTGTATAT
CACTAGTAGAAATATACGATACAGGAGACAGTGTGATAAGGCCAAAACTATTTGCAGTCAAGATACCTGC
CCAATGTTCAGAGAGTTGATTGACCAAAAGAGCAATAAATATTATATTATAATTATATCAGTCAAATTGT
AAACATCCTTCTTATAATATACTCAAAAAATTAAAAATTCCCCCAAGAAAATACTAAATGTAATCAAACT
CAATAAACCCTGAAATATTGATAGTTTACAGAGATCATATGACTCTTTGTATAATTCTTTATAGAACTCC
TAAATATCAAAGAGCGATAAACTTGCTACCCTGTACACTTAAAGCAGATACTGTGATTAACTCTGTAAGT
TTATCAGATAATCCTATTAGTGACATACTGAGGGTTATTCTTGTATAATTCTTCTGAAGATGTGATTACA
GATAATCTTTCAATCTAGTCAAGTAAGCCTGATTTCCTAATTATAATCTCCCTCTTAGGAGAAGGAGAAC
GTATCAATGTTCACTATATACTAAGTCTTTTATTTTAAATTTTTCTTATTGTCTTCAGATGAGCCTTATT
ACTTCATCTCATCAGATTATAAATTTTCTAATAAATTAAGAAAA
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Protein Sequence : Show Sequence
>NP_047112.2 glycoprotein [Hendra henipavirus]
MMADSKLVSLNNNLSGKIKDQGKVIKNYYGTMDIKKINDGLLDSKILGAFNTVIALLGSIIIIVMNIMII
QNYTRTTDNQALIKESLQSVQQQIKALTDKIGTEIGPKVSLIDTSSTITIPANIGLLGSKISQSTSSINE
NVNDKCKFTLPPLKIHECNISCPNPLPFREYRPISQGVSDLVGLPNQICLQKTTSTILKPRLISYTLPIN
TREGVCITDPLLAVDNGFFAYSHLEKIGSCTRGIAKQRIIGVGEVLDRGDKVPSMFMTNVWTPPNPSTIH
HCSSTYHEDFYYTLCAVSHVGDPILNSTSWTESLSLIRLAVRPKSDSGDYNQKYIAITKVERGKYDKVMP
YGPSGIKQGDTLYFPAVGFLPRTEFQYNDSNCPIIHCKYSKAENCRLSMGVNSKSHYILRSGLLKYNLSL
GGDIILQFIEIADNRLTIGSPSKIYNSLGQPVFYQASYSWDTMIKLGDVDTVDPLRVQWRNNSVISRPGQ
SQCPRFNVCPEVCWEGTYNDAFLIDRLNWVSAGVYLNSNQTAENPVFAVFKDNEILYQVPLAEDDTNAQK
TITDCFLLENVIWCISLVEIYDTGDSVIRPKLFAVKIPAQCSES
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Molecule Role :
Protective antigen
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Molecule Role Annotation :
A subunit vaccine formulation containing only recombinant, soluble, attachment glycoprotein G from HeV (sG(HeV)) and CpG adjuvant was evaluated as a potential NiV vaccine in the cat model. Upon oronasal challenge with NiV (50,000TCID50), all vaccinated cats were protected from disease although virus was detected on day 21 post-challenge in one animal (McEachern et al., 2008).
- Related Vaccine(s):
Hendra virus G protein vaccine
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| II. References |
1. McEachern et al., 2008: McEachern JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, Feng YR, Broder CC, Wang LF, Bossart KN. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine. 2008; 26(31); 3842-3852. [PubMed: 18556094].
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