VIOLIN: Vaccine Investigation and Online Information Network

Pathogen Page

Atherosclerosis

General Information
1. Disease
2. Introduction
Vaccine Information
1. human apo B-100 peptide-2 protein vaccine
2. MDA-modified human apo B-100 peptide Vaccine
References

I. General Information

1. Disease:

Atherosclerosis, arteriosclerotic vascular disease (ASVD)

2. Introduction

Atherosclerosis is an inflammatory disease characterized by endothelial activation and dysfunction, lipid accumulation, monocyte infiltration and differentiation, T-cell infiltration and activation, foam cell formation, and fibrosis in the lesion area. Two of its common final results, coronary and cerebrovascular disease, are the major causes of morbidity worldwide. Nowadays, atherosclerosis is increasingly considered an immune-mediated inflammatory process of the vasculature in which intense immunological activity is occurring. Hypertension, hyperlipidemia, hyperglycemia, diabetes, obesity, cigarette smoking, age, and sex are well-established risk factors for atherosclerosis (Jan et al., 2010).

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