VIOLIN: Vaccine Investigation and Online Information Network

E7 Type 16
Gene Name	E7 Type 16
Sequence Strain (Species/Organism)	Human papillomavirus type 16
VO ID	VO_0011105
NCBI Gene ID	1489079
NCBI Protein GI	9627105
Locus Tag	HpV16gp2
Genbank Accession	AB663783
Protein Accession	NP_041326
Taxonomy ID	333760
Gene Starting Position	7603
Gene Ending Position	7899
Gene Strand (Orientation)	+
Protein Name	transforming protein E7
Protein pI	3.97
Protein Weight	10624.95
Protein Length	98
Protein Note	E7 ORF from 544 to 858; putative
DNA Sequence	>NC_001526.4:7603-7899 Human papillomavirus type 16, complete genome CATGCATGGAGATACACCTACATTGCATGAATATATGTTAGATTTGCAACCAGAGACAACTGATCTCTAC TGTTATGAGCAATTAAATGACAGCTCAGAGGAGGAGGATGAAATAGATGGTCCAGCTGGACAAGCAGAAC CGGACAGAGCCCATTACAATATTGTAACCTTTTGTTGCAAGTGTGACTCTACGCTTCGGTTGTGCGTACA AAGCACACACGTAGACATTCGTACTTTGGAAGACCTGTTAATGGGCACACTAGGAATTGTGTGCCCCATC TGTTCTCAGAAACCATA
Protein Sequence	>NP_041326.1 transforming protein E7 [Human papillomavirus type 16] MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQ STHVDIRTLEDLLMGTLGIVCPICSQKP
Molecule Role	Protective antigen
Molecule Role Annotation	Researchers combined the HPV16 E7 peptide(38-61) with a murine IgG heavy chain constant region to construct a chimeric protein compound. The chimeric vaccine candidate was able to effectively protect mice against the challenge of HPV16-positive tumor cells, and to eradicate HPV16-expressing tumors in mice (Qin et al., 2005).
Related Vaccines(s)	ADXS11-001 , Human papillomavirus DNA vaccine CRT/E7 DNA , Human papillomavirus DNA vaccine E7IR , Human papillomavirus DNA vaccine E7SH DNA , Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2 , Human papillomavirus DNA vaccine Pe7(pcDNA3-Sig/sE7/LAMP) encoding E7 , Human papillomavirus E7 protein vaccine , LM1-2-E7 , MEDI0457
References

E7 Type 16