Virmugen Home

Introduction

Statistics

News and Updates

Virmugen Query

Virmugen Blast

Data Submission

Data Exchange

Data Download

Documentation

FAQs

Acknowledgements

Disclaimer

Contact Us

VirmugenDB: A Database of Virulent Genes used for Development of Live Attenuated Vaccines

"Virmugen" is coined here to represent a gene that encodes for a virulent factor of a pathogen and has been proven feasible to make a live attenuated vaccine by knocking out this gene. Not all virulence factors can be used for vaccine development. Currently, VIOLIN includes 231 Virmugens that have been verified to be valuable for vaccine development against 59 pathogens. See detailed curated data:

Virmugen Search
Search Field	Search Parameter
Pathogen or Disease	Any pathogen Actinobacillus pleuropneumoniae Aeromonas hydrophila Aeromonas salmonicida African Swine Fever Virus Bacillus anthracis Bordetella bronchiseptica Bordetella pertussis Borrelia burgdorferi Bovine herpesvirus 1 Bovine Respiratory Syncytial Virus Brucella spp. Burkholderia pseudomallei Campylobacter jejuni Classical swine fever virus Edwardsiella ictaluri Edwardsiella tarda Equid herpesvirus Escherichia coli Feline herpesvirus 1 Feline immunodeficiency virus Feline infectious peritonitis virus Francisella tularensis Gallid herpesvirus 1 Hepatitis B virus Herpes simplex virus type 1 and 2 Human metapneumovirus Human Respiratory Syncytial Virus Infectious Hematopoietic Necrosis Virus Influenza virus Leishmania donovani Leishmania infantum Listeria monocytogenes Mannheimia haemolytica Mycobacterium avium Mycobacterium tuberculosis Mycoplasma gallisepticum Neisseria meningitidis Pasteurella multocida Plasmodium spp. Porcine respiratory and reproductive syndrome virus Pseudorabies virus Rabies virus Salmonella spp. SARS-CoV Shigella Simian Immunodeficiency Virus Staphylococcus aureus Streptococcus equi Streptococcus pneumoniae Tick-borne Encephalitis Virus (TBEV) Toxoplasma gondii VEE Virus Vibrio cholerae West Nile virus Western equine encephalomyelitis virus Yersinia enterocolitica Yersinia pestis Yersinia pseudotuberculosis Yersinia ruckeri
Gene Name	(e.g., sodC)
Locus Tag	(e.g., BAB2_0535)
Database ID	NCBI Gene GI NCBI Nucleotide GI NCBI Protein Accesion No NCBI Protein GI Virmugen ID VO ID Other Database ID
COG category	Any Amino acid transport and metabolism Carbohydrate transport and metabolism Cell cycle control, cell division, chromosome partitioning Cell motility Cell wall/membrane/envelope biogenesis Chromatin structure and dynamics Coenzyme transport and metabolism Cytoskeleton Defense mechanisms Energy production and conversion Extracellular structures Function unknown General function prediction only Inorganic ion transport and metabolism Intracellular trafficking, secretion, and vesicular transport Lipid transport and metabolism Nuclear structure Nucleotide transport and metabolism Posttranslational modification, protein turnover, chaperones Replication, recombination and repair RNA processing and modification Secondary metabolites biosynthesis, transport and catabolism Signal transduction mechanisms Transcription Translation, ribosomal structure and biogenesis
Subcellular Localization	Any Localization Cellwall Cytoplasmic Cytoplasmic Membrane Extracellular Outer Membrane Periplasmic Unknown
Maximum Number of Transmembrane Helices	(Note: check box to include)
Minimum Adhesin Probability (0-1.0)
No Similarity to Human Proteins
No Similarity to Mouse Proteins
Description	(e.g., superoxide dismutase)

Statistics: VirmugenDB includes 231 Virmugens for now.

Provenance: The data in VirmugenDB originates from our literature curation and boinformatics analyses.

Citation: Racz R, Chung M, Xiang Z, and He Y. Systematic annotation and analysis of “virmugens” - virulence factors whose mutants can be used as live attenuated vaccines. Vaccine. Available online December 6, 2012. DOI: 10.1016/j.vaccine.2012.11.066.