• Vaccine Name: Human papillomavirus DNA vaccine hCRTE6E7L2 DNA encoding CRT linked to E6, E7 and L2
• Target Pathogen: Human Papillomavirus
• Target Disease: HPV infection
• Vaccine Ontology ID: VO_0004475
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• E6 Type 16 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
  • Detailed Gene Information: Click Here.
• E7 Type 16 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
  • Detailed Gene Information: Click Here.
• L2 HPV 16 gene engineering:
  • Type: Recombinant protein preparation
  • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
  • Detailed Gene Information: Click Here.
• CRTC gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector pNGVL4a vector (National Gene Vector lab) expressed human calreticulin (CRT) linked to HPV16 early proteins, E6 and E7 and the late protein L2 (hCRTE6E7L2) (Kim et al., 2008).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005014
• Immunization Route: Gene gun

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Immunization with DNA vaccines expressing hCRTE6E7 and hCRTE6E7L2 induced a higher percentage of tumor-free mice compared to immunization with the other DNA vaccines (Kim et al., 2008).