• Vaccine Name: Human papillomavirus DNA vaccine E7IR
• Target Pathogen: Human Papillomavirus
• Target Disease: HPV infection
• Vaccine Ontology ID: VO_0004332
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• E7 Type 16 gene engineering:
  • Type: DNA vaccine construction
  • Description: Vector APL023expressed the E7 gene (Brinkman et al., 2007).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid:
  • DNA vaccine plasmid name:
  • DNA vaccine plasmid VO ID: VO_0005052
• Immunization Route: Gene gun

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Efficacy: Vaccination with the modified E7IR construct was able to significantly reduce tumor volume and enhance survival in both prophylactic and therapeutic experiments in mice compared to the WT E7 gene. Vaccination with E7IR also prevented tumor formation; after challenge with tumor cells, by day 33 all naïve and vector vaccinated mice were tumor bearing, 3/5 mice vaccinated with the WT construct were tumor bearing and none of the animals vaccinated with the E7IR construct were tumor bearing. As a result, vaccination with the E7IR construct promoted 100% survival in these mice to 57 days (Brinkman et al., 2007).