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Vaccine Detail
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Human papillomavirus DNA vaccine CRT/E7 DNA |
| Vaccine Information |
- Vaccine Name: Human papillomavirus DNA vaccine CRT/E7 DNA
- Target Pathogen: Human Papillomavirus
- Target Disease: HPV infection
- Vaccine Ontology ID: VO_0004331
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E7 Type 16
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pCDNA3 expressed E7 protein of HPV 16 and 18 (Cheng et al., 2001).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: 100% of mice receiving CRT/E7 DNA vaccination remained tumor-free 60 days after TC-1 challenge. In contrast, all of the unvaccinated mice and mice receiving plasmid without insert, CRT, or E7 DNA developed tumors within 15 days after tumor challenge (Cheng et al., 2001).
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| References |
Cheng et al., 2001: Cheng WF, Hung CF, Chai CY, Hsu KF, He L, Ling M, Wu TC. Tumor-specific immunity and antiangiogenesis generated by a DNA vaccine encoding calreticulin linked to a tumor antigen. The Journal of clinical investigation. 2001; 108(5); 669-678. [PubMed: 11544272].
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