|
|
Vaccine Detail
|
Human papillomavirus DNA vaccine Pe7(pcDNA3-Sig/sE7/LAMP) encoding E7 |
| Vaccine Information |
- Vaccine Name: Human papillomavirus DNA vaccine Pe7(pcDNA3-Sig/sE7/LAMP) encoding E7
- Target Pathogen: Human Papillomavirus
- Target Disease: HPV infection
- Vaccine Ontology ID: VO_0004329
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E7 Type 16
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcDNA3 expressed HPV oncogenic proteins E7 (Sin, 2009).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0000132
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: Animals immunized with pE7 alone showed almost complete protection from TC-1 tumour challenge. However, animals immunized with pE7 plus pIL-12 displayed a complete loss of antitumour resistance in a manner similar to control groups (Sin, 2009).
|
| References |
Sin, 2009: Sin JI. Suppression of antitumour protective cytotoxic T lymphocyte responses to a human papillomavirus 16 E7 DNA vaccine by coinjection of interleukin-12 complementary DNA: involvement of nitric oxide in immune suppression. Immunology. 2009; 128(1 Suppl); e707-717. [PubMed: 19740332].
|
|
