• Vaccine Name: LM1-2-E7
• Target Pathogen: Human Papillomavirus
• Target Disease: HPV infection
• Vaccine Ontology ID: VO_0004803
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• E7 Type 16 gene engineering:
  • Type: Recombinant vector construction
  • Description: The E7 gene is inserted into the vector of Listeria monocytogenes, strain LM1-2 (Jia et al., 2012).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001041
• Preparation: The E7 fragment was amplified with PCR then cloned into the chromosome of L. monocytogenes (Jia et al., 2012).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Host Strain: C57BL/6
• Vaccination Protocol: Mice were vaccinated in both a prophylactic (where the mice were immunized and then presented with a pathogenic challenge) and therapeutic (where the mice already had tumors and then were injected with the vaccine vector) setting (Jia et al., 2012).
• Vaccine Immune Response Type: VO_0000287
• Challenge Protocol: In the prophylactic assay, "mice were challenged with TC-1 cells on day 4 after the second immunization and were observed for tumor development" and in the mice vaccinated with LM1-2-E7, 87.5% showed no signs of a tumor until after day 50 (Jia et al., 2012).
• Efficacy: The LM1-2-E7 vaccine vector was shown to elicit protection against TC-1 tumor cells in the prophylactic challenges (Jia et al., 2012).