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E protein from Dengue Virus 2
Gene Name	E protein from Dengue Virus 2
VO ID	VO_0011311
NCBI Protein GI	202078796
3D structure: PDB ID	1OAN
Other Database IDs	CDD:279241 CDD:213392 CDD:213897
Taxonomy ID	11060
Gene Strand (Orientation)	?
Protein Name	envelope protein
Protein pI	7.67
Protein Weight	50568.28
Protein Length	559
Protein Note	Flavivirus glycoprotein, central and dimerisation domains; pfam00869
Protein Sequence	>ACH96447.1 envelope protein, partial [Dengue virus 2] MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKHPATLRKYCIEAKLTNTTT ASRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKIVQPENLEYTIV ITPHSGEENAVGNDTGKHGKEIKVTPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHR QWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFT GHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVVRVQYEGDGSPCKIPFEIMDLEKRHVLGR LITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLSWFKKGSSIGQMFETTMRGAKRMAILGDTAW DFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVVITWIGMNSRSTSLSVSLVLVGVVTLYLG VMVQA
Molecule Role	Protective antigen
Molecule Role Annotation	A recombinant baculovirus encoding a dengue (DEN)-2 virus envelope glycoprotein truncated of 102 amino acids (aa) at its C-terminus (D2EA102) was constructed. Both intracellular and extracellular D2EA102 induced neutralizing antibodies in mice and were thus immunogenic. Sixty eight percent (P < 0.001) of mice vaccinated with 5 gg of extracellular D2EA102 protein were protected against lethal challenge (Delenda et al., 1994).
Related Vaccines(s)	CAdVax-Den12/Den34 , Dengue Subunit E Protein Vaccine , Dengue virus DNA vaccine 1040D2MEL encoding dengue-2 prM-E-LAMP chimeric protein , Dengue virus DNA vaccine p1012D2ME encoding prM and E from DEN 2 New Guinea C strain , Dengue virus DNA vaccine pE1D2 encoding E from Dengue Virus 2 strain New Guinea C , Dengue virus DNA vaccine sA encoding prM and E from Dengue Virus 4 , Dengue virus DNA vaccine sABC encoding prM and E , Dengue virus DNA vaccine sC encoding prM and E , Dengvaxia , rMV-TDV , TAK-003 , V180 - Aluminum Hydroxide Alhydrogel™ Adjuvant , V180 - ISCOMATRIX™ adjuvant , V180 - unadjuvanted
References

E protein from Dengue Virus 2