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Vaccine Detail
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Dengue virus DNA vaccine sA encoding prM and E from Dengue Virus 4 |
| Vaccine Information |
- Vaccine Name: Dengue virus DNA vaccine sA encoding prM and E from Dengue Virus 4
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Vaccine Ontology ID: VO_0004466
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- E protein from Dengue Virus 2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled (Raviprakash et al., 2006).
- Detailed Gene Information: Click Here.
- prM from Dengue virus 2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pMV10.1 expressed prM and E genes in which the N-terminal 90% of E gene was shuffled (Raviprakash et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005036
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Immune Response: Five of six animals vaccinated developed antibodies that neutralized all 4 dengue serotypes in vitro (Raviprakash et al., 2006).
- Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed (Raviprakash et al., 2006).
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| References |
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].
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