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Vaccine Detail
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Dengue virus DNA vaccine sABC encoding prM and E |
| Vaccine Information |
- Vaccine Name: Dengue virus DNA vaccine sABC encoding prM and E
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Vaccine Ontology ID: VO_0004469
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Macaque
- E protein from Dengue Virus 2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
- Detailed Gene Information: Click Here.
- prM from Dengue virus 2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pMV10.1 expressed premembrane and envelope genes of each of four serotypes of dengue viruses (Raviprakash et al., 2006).
- Detailed Gene Information: Click Here.
- 18H6 synthetic E protein
gene engineering:
- Type: DNA vaccine construction
- Description: This combination vaccine encoded all the proteins from all 3 vaccines (Raviprakash et al., 2006).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005036
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Macaque Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: When challenged with live dengue-1 or dengue-2 virus, partial protection against dengue-1 was observed. The best protection against dengue-1 viremia was demonstrated by the mixture of shuffled vaccines (sABC) out of all the vaccines tested (Raviprakash et al., 2006).
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| References |
Raviprakash et al., 2006: Raviprakash K, Apt D, Brinkman A, Skinner C, Yang S, Dawes G, Ewing D, Wu SJ, Bass S, Punnonen J, Porter K. A chimeric tetravalent dengue DNA vaccine elicits neutralizing antibody to all four virus serotypes in rhesus macaques. Virology. 2006; 353(1); 166-173. [PubMed: 16814355].
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