|
|
Vaccine Detail
|
Dengue virus DNA vaccine pE1D2 encoding E from Dengue Virus 2 strain New Guinea C |
| Vaccine Information |
- Vaccine Name: Dengue virus DNA vaccine pE1D2 encoding E from Dengue Virus 2 strain New Guinea C
- Target Pathogen: Dengue Virus
- Target Disease: Dengue Fever
- Vaccine Ontology ID: VO_0004471
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Mouse
- E protein from Dengue Virus 2
gene engineering:
- Type: DNA vaccine construction
- Description: Vector pcTPA plasmid , a modified pcDNA3 vector (Invitrogen) expressed amino acids 1–398 of the E protein (Azevedo et al., 2011).
- Detailed Gene Information: Click Here.
- DNA vaccine plasmid:
- DNA vaccine plasmid name:
- DNA vaccine plasmid VO ID: VO_0005035
- Immunization Route: Intramuscular injection (i.m.)
|
| Host Response |
|
Mouse Response
- Vaccine Immune Response Type: VO_0000286
- Efficacy: All pE1D2-vaccinated mice survived challenge, while 45% of animals immunized with the pE2D2 died after infection. Furthermore, only 10% of pE1D2-immunized mice presented some clinical signs of infection after challenge, whereas most of animals inoculated with the pE2D2 showed effects of the disease with high morbidity degrees (Azevedo et al., 2011).
|
| References |
Azevedo et al., 2011: Azevedo AS, Yamamura AM, Freire MS, Trindade GF, Bonaldo M, Galler R, Alves AM. DNA vaccines against dengue virus type 2 based on truncate envelope protein or its domain III. PloS one. 2011; 6(7); e20528. [PubMed: 21779317].
|
|
