• Vaccine Name: Dengue Subunit E Protein Vaccine
• Target Pathogen: Dengue Virus
• Target Disease: Dengue Fever
• Vaccine Ontology ID: VO_0011457
• Type: Subunit vaccine
• Status: Research
• E protein from Dengue Virus 2 gene engineering:
  • Type: Recombinant protein preparation
  • Description: Baculovirus was used to generate the recombinant protein (Delenda et al., 1994).
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000139
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000142
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Three-week-old female BALB/c mice were immunized by intraperitoneal injection on days 1,7, 21 and 56 with 200 gl of baculovirus infected Sf9 cell lysates (CL) or concentrated supernatant fluids (SF) supplemented with complete Freund adjuvant for the first and with incomplete Freund adjuvant for the three other injections.
• Challenge Protocol: Mice were challenged withDEN-2 virus (Delenda et al., 1994).
• Efficacy: Sixty eight percent (P < 0.001) of mice vaccinated with 5 gg of extracellular D2EA102 protein were protected against lethal challenge (Delenda et al., 1994).