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M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))
Gene Name	M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))
Sequence Strain (Species/Organism)	Influenza A virus (A/Puerto Rico/8/1934(H1N1))
VO ID	VO_0011119
NCBI Gene ID	956528
NCBI Protein GI	56583270
Locus Tag	FLUAVs7gp2
Genbank Accession	V01099
Protein Accession	NP_040979
3D structure: PDB ID	3BKD
Taxonomy ID	211044
Gene Starting Position	25
Gene Ending Position	1006
Gene Strand (Orientation)	+
Protein Name	matrix protein 2
Protein pI	5.72
Protein Weight	10647.4
Protein Length	97
DNA Sequence	>NC_002016.1:25-1006 Influenza A virus (A/Puerto Rico/8/1934(H1N1)) segment 7, complete sequence GATGAGTCTTCTAACCGAGGTCGAAACGTACGTTCTCTCTATCATCCCGTCAGGCCCCCTCAAAGCCGAG ATCGCACAGAGACTTGAAGATGTCTTTGCAGGGAAGAACACCGATCTTGAGGTTCTCATGGAATGGCTAA AGACAAGACCAATCCTGTCACCTCTGACTAAGGGGATTTTAGGATTTGTGTTCACGCTCACCGTGCCCAG TGAGCGAGGACTGCAGCGTAGACGCTTTGTCCAAAATGCCCTTAATGGGAACGGGGATCCAAATAACATG GACAAAGCAGTTAAACTGTATAGGAAGCTCAAGAGGGAGATAACATTCCATGGGGCCAAAGAAATCTCAC TCAGTTATTCTGCTGGTGCACTTGCCAGTTGTATGGGCCTCATATACAACAGGATGGGGGCTGTGACCAC TGAAGTGGCATTTGGCCTGGTATGTGCAACCTGTGAACAGATTGCTGACTCCCAGCATCGGTCTCATAGG CAAATGGTGACAACAACCAACCCACTAATCAGACATGAGAACAGAATGGTTTTAGCCAGCACTACAGCTA AGGCTATGGAGCAAATGGCTGGATCGAGTGAGCAAGCAGCAGAGGCCATGGAGGTTGCTAGTCAGGCTAG GCAAATGGTGCAAGCGATGAGAACCATTGGGACTCATCCTAGCTCCAGTGCTGGTCTGAAAAATGATCTT CTTGAAAATTTGCAGGCCTATCAGAAACGAATGGGGGTGCAGATGCAACGGTTCAAGTGATCCTCTCGCT ATTGCCGCAAATATCATTGGGATCTTGCACTTGATATTGTGGATTCTTGATCGTCTTTTTTTCAAATGCA TTTACCGTCGCTTTAAATACGGACTGAAAGGAGGGCCTTCTACGGAAGGAGTGCCAAAGTCTATGAGGGA AGAATATCGAAAGGAACAGCAGAGTGCTGTGGATGCTGACGATGGTCATTTTGTCAGCATAGAGCTGGAG TA
Protein Sequence	>NP_040979.2 matrix protein 2 [Influenza A virus (A/Puerto Rico/8/1934(H1N1))] MSLLTEVETPIRNEWGCRCNGSSDPLAIAANIIGILHLILWILDRLFFKCIYRRFKYGLKGGPSTEGVPK SMREEYRKEQQSAVDADDGHFVSIELE
Molecule Role	Protective antigen
Molecule Role Annotation	A targeted fusion protein based on the CTA1-DD adjuvant and containing tandem repeats of the matrix protein 2 (M2e) ectodomain epitope derived from Influenza A virus (A/Puerto Rico/8/34(H1N1)), CTA1-3M2e-DD, confers strong protective immunity against a potentially lethal challenge infection with influenza virus in mice. The formulation was highly effective for mucosal immunizations and promoted high M2e-specific serum IgG and mucosal IgA antibody titers and an hitherto unknown anti-M2e CD4 T cell immunity (Eliasson et al., 2008).
Additional Molecule Role	Virmugen
Additional Molecule Role Annotation	Mutant influenza virus that lacks the transmembrane and cytoplasmic tail domains of M2 (M2 knockout [M2KO]) from Influenza A virus (A/Puerto Rico/8/34(H1N1)) is attenuated in both cell culture and mice. Mice intranasally vaccinated with M2KO virus developed protective immune responses and survived a lethal challenge with the wild-type virus, suggesting that the M2KO virus has potential as a live attenuated vaccine (Watanabe et al., 2009).
Related Vaccines(s)	BPZE1- FHA (H1N1/PR8 influenza A virus) , Influenza virus CTA1-3M2e-DD protein vaccine , Influenza virus DNA vaccine M2-DNA/M2-Ad , Influenza virus DNA vaccine pDNA encoding M2 and NP , M2 mutant from Influenza A
References

M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1))