• Vaccine Name: Influenza virus DNA vaccine pDNA encoding M2 and NP
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004355
• Type: DNA vaccine
• Status: Research
• Host Species as Laboratory Animal Model: Mouse
• M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1)) gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine used the plasmid vector VR10551 to express highly‑conserved influenza gene M2 (Jimenez et al., 2007).
  • Detailed Gene Information: Click Here.
• NP from Influenza A virus (A/Puerto Rico/8/34(H1N1)) gene engineering:
  • Type: DNA vaccine construction
  • Description: This DNA vaccine used the plasmid vector VR10551 to express highly‑conserved influenza gene NP (Jimenez et al., 2007).
  • Detailed Gene Information: Click Here.
• DNA vaccine plasmid: VR10551 DNA vaccine plasmid
  • DNA vaccine plasmid name: VR10551 DNA vaccine plasmid
  • DNA vaccine plasmid VO ID: VO_0005008
• Immunization Route: intranasal immunization

Mouse Response

• Vaccine Immune Response Type: VO_0000286
• Immune Response: For instance, NP + M2 may induce both CD4 and CD8 T-cell responses against both antigens and a humoral immune response against the extracellular domain of M2 which collectively contribute to antiviral immunity (Jimenez et al., 2007)
• Efficacy: 100% protection from challenge with A/HK/8/68 (H3N2) was provided in mice by Vaxfectin-formulated NP+M2 (Jimenez et al., 2007).