• Vaccine Name: BPZE1- FHA (H1N1/PR8 influenza A virus)
• Target Pathogen: Influenza virus
• Target Disease: Influenza (flu)
• Vaccine Ontology ID: VO_0004650
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• M2 from Influenza A virus (A/Puerto Rico/8/34(H1N1)) gene engineering:
  • Type: Recombinant protein preparation
  • Description: One, two and three copies of the Cys-containing ectodomain of matrix protein 2 (M2e) from influenza A virus were genetically fused to full length FHA and expressed in BPZE1 (Li et al., 2011).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001037
• Preparation: One, two and three copies of the Cys-containing ectodomain of matrix protein 2 (M2e) from influenza A virus were genetically fused to full length FHA and expressed in BPZE1 (Li et al., 2011).
• Immunization Route: Intramuscular injection (i.m.)

Mouse Response

• Vaccination Protocol: The mice were immunized with BPLR3 or BPZE1 (Li et al., 2011).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: The mice were challenged with H1N1/PR8 influenza A virus and the survival rate was determined based on the body weight loss (Li et al., 2011).
• Efficacy: Nasal immunization with BPLR3 bacteria resulted in a significant reduction in the viral loads upon challenge with H1N1/PR8 influenza A virus, but did not improve the survival rate compared to BPZE1-immunized mice (Li et al., 2011).