• Vaccine Name: mixture of Salmonella strains delivering ApxIA, ApxIIA, ApxIIIA and OmpA of A. pleuropneumoniae
• Target Pathogen: Actinobacillus pleuropneumoniae
• Target Disease: porcine pleuropneumonia
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Mouse
• Host Species as Laboratory Animal Model: Mice
• apxIA gene engineering:
  • Type: Recombinant vector construction
  • Description: An attenuated Salmonella Typhimurium was used to express ApxIA (Hur et al., 2016).
  • Detailed Gene Information: Click Here.
• ompA gene engineering:
  • Type: Recombinant vector construction
  • Description: An attenuated Salmonella Typhimurium was used to express OmpA (Hur et al., 2016).
  • Detailed Gene Information: Click Here.
• apxIIA gene engineering:
  • Type: Recombinant vector construction
  • Description: An attenuated Salmonella Typhimurium was used to express ApxIIA (Hur et al., 2016).
  • Detailed Gene Information: Click Here.
• apxIIIA gene engineering:
  • Type: Recombinant vector construction
  • Description: An attenuated Salmonella Typhimurium was used to express ApxIIIA (Hur et al., 2016).
  • Detailed Gene Information: Click Here.
• Immunization Route: intranasal immunization
• Description: (Hur et al., 2016)

Mouse Response

• Immune Response: The splenic lymphocyte proliferation and the levels of IL-4, IL-6 and IL-12 of the inoculated mice were significantly increased, and the T- and B-cell populations were also elevated. Collectively, the candidate may efficiently induce the Th1- and Th2-type immune responses.(Hur et al., 2016)