VIOLIN: Vaccine Investigation and Online Information Network

apxIIA
Gene Name	apxIIA
Sequence Strain (Species/Organism)	Actinobacillus pleuropneumoniae
VO ID	VO_0011020
NCBI Protein GI	52630374
Other Database IDs	CDD:280531 CDD:225483 CDD:305016 CDD:285531
Taxonomy ID	715
Gene Strand (Orientation)	?
Protein Name	ApxIIA
Protein pI	5.5
Protein Weight	96615.24
Protein Length	1024
Protein Note	biovar: 1
Protein Sequence	>AAU84700.1 ApxIIA [Actinobacillus pleuropneumoniae] MSKITLSSLKSSLQQGLKNGKNKLNQAGTTLKNGLTQTGHSLQNGAKKLILYIPQGYDSGQGNGVQDLVK AANDLGIEVWREERSNLDIAKTSFDTTQKILGFTDRGIVLFAPQLDNLLKKNPKIGNTLGSASSISQNIG KANTVLGGIQSILGSVLSGVNLNELLQNKDPNQLELAKAGLELTNELVGNIASSVQTVDAFAEQISKLGS HLQNVKGLGGLSNKLQNLPDLGKASLGLDIISGLLSGASAGLILADKEASTEKKAAAGVEFANQIIGNVT KAVSSYILAQRVASGLSSTGPVAALIASTVALAVTPLSFLNVADKFKQADLIKSYSERFQKLGYDGDRLL ADFHRETGTIDASVTTINTALAAISGGVGAASAGSLVGAPVALLVAGVTGLITTILEYSKQAMFEHVANK VHDRIVEWEKKHNKNYFEQGYDSRHLADLQDNMKFLINLNKELQAERVVAITQQRWDNQIGDLAAISRRT DKISSGKAYVDAFEGGQHQSYDSSVQLDNKNGIINISNTNRKTQSVLFRTPLLTPGEENRERIQEGKNSY ITKLHIQRVDSWTVTDGDASSSVDFTNVVQRIAVKFDDAGNIIESKDTKIIANLGAGNDNVFVGSSTTVI DGGDGHDRVHYSRGEYGALVIDATAETEKGSYSVKRYVGDSKALHETIATHQTNVGNREEKIEYRREDDR FHTGYTVTDSLKSVEEIIGSQFNDIFKGSQFDDVFHGGNGVDTIDGNDGDDHLFGGAGDDVIDGGNGNNF LVGGTGNDIISGGKDNDIYVHKTGDGNDSITDSGGQDKLAFSDVNLKDLTFKKVDSSLEIINQKGEKVRI GNWFLEDDLASTVANYKATNDRKIEEIIGKGGERITSEQVDKLIKEGNNQISAEALSKVVNDYNTSKDRQ NVSNSLAKLISPVGSFTSSSDFRNNLGTYVPSSIDVSNNIQLARAA
Molecule Role	Protective antigen
Molecule Role Annotation	The levels of local and systemic antibodies specific to the Apx antigens were investigated in mice orally immunized with Apx antigen-expressing yeast. Specific IgA responses to ApxIA or ApxIIA in the intestines and lungs from mice immunized with yeast expressing Apx antigens were significantly higher than those in the control groups after the second and third immunizations, respectively (p < 0.05). All mice were monitored for up to 72 h after challenge with the MLD of an A. pleuropneumoniae field isolate. Overall, the final survival rates of the vaccinated groups were higher than those of the control groups at each time point (Shin et al., 2007).
Related Vaccines(s)	A. pleuropneumoniae ApxIa and ApxIIa protein vaccine , A. pleuropneumoniae DNA vaccine pcDNA-apxIA/pcDNA-apxIIA , mixture of Salmonella strains delivering ApxIA, ApxIIA, ApxIIIA and OmpA of A. pleuropneumoniae , rS.C-APP-ApxI/ApxII
References

apxIIA