• Vaccine Name: ALVAC- CDV-H/F
• Target Pathogen: Canine distemper virus
• Target Disease: Canine distemper
• Vaccine Ontology ID: VO_0004773
• Type: Recombinant vector vaccine
• Status: Research
• Host Species for Licensed Use: Baboon
• CDVgp6 haemagglutinin protein H gene engineering:
  • Type: Recombinant vector construction
  • Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
  • Detailed Gene Information: Click Here.
• CDVgp5 gene engineering:
  • Type: Recombinant protein preparation
  • Description: Attenuated vaccinia virus (NYVAC) or canarypox virus (ALVAC) vaccine strains expressing the CDV hemagglutinin (H) and fusion (F) protein genes (NYVAC-HF and ALVAC-HF) (Welter et al., 2000).
  • Detailed Gene Information: Click Here.
• Vector:
  • Vector name:
  • VO vector ID: VO_0001128
• Preparation: An attenuated canarypox virus (ALVAC) vaccine strain expressing the CDV hemagglutinin (H) and fusion (F) protein genes (ALVAC-HF) (Welter et al., 2000).
• Immunization Route: intranasal immunization

Ferret Response

• Vaccination Protocol: Ferrets without maternal antibody were vaccinated intranasally with NYVAC-HF and ALVAC-HF. While ferrets with maternal antibody were vaccinated parenterally with NYVAC-HF and ALVAC-HF (Welter et al., 2000).
• Vaccine Immune Response Type: VO_0003057
• Challenge Protocol: At 12 weeks of age, the ferrets were challenged with CDV (Welter et al., 2000).
• Efficacy: Combined i.n.-parenteral immunization of ferrets with maternal antibody using NYVAC-HF produced higher titers than did i.n. immunization with NYVAC-HF and ALVAC-HF, and survival was also significantly better in the i.n.-parenteral group than in the other HF-vaccinated animals (none of 18) or in controls immunized with RG. Multiple routes were not tested with the ALVAC vaccine (Welter et al., 2000).