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CDVgp6 haemagglutinin protein H
Gene Name	CDVgp6 haemagglutinin protein H
Sequence Strain (Species/Organism)	Canine morbillivirus
VO ID	VO_0011052
NCBI Gene ID	1489792
NCBI Protein GI	9630651
Locus Tag	CDVgp6
Genbank Accession	AB472690
Protein Accession	NP_047206
Taxonomy ID	11232
Gene Starting Position	7078
Gene Ending Position	8892
Gene Strand (Orientation)	+
Protein Name	haemagglutinin protein H
Protein pI	7.18
Protein Weight	63919.26
Protein Length	604
DNA Sequence	>NC_001921.1:7078-8892 Canine distemper virus, complete genome AATGCTCCCCTACCAAGACAAGGTGGGTGCCTTCTACAAGGATAATGCAAGAGCCAATTCAACCAAGCTG TCCTTAGTGACAGAAGGACATGGGGGCAGGAGACCACCTTATTTGTTGTTTGTCCTTCTCATCTTATTGG TTGGTATCCTGGCCTTGCTTGCTATCACTGGAGTTCGATTTCACCAAGTATCAACTAGTAATATGGAATT TAGCAGATTGCTGAAAGAGGATATGGAGAAATCAGAGGCCGTACATCACCAAGTCATAGATGTCTTGACA CCGCTCTTCAAGATTATTGGAGATGAGATTGGGTTACGGTTGCCACAAAAGCTAAACGAGATCAAACAAT TTATCCTTCAAAAGACAAATTTCTTCAATCCGAACAGAGAATTCGACTTCCGCGATCTCCACTGGTGCAT TAACCCGCCTAGTACGGTCAAGGTGAATTTTACTAATTACTGTGAGTCAATTGGGATCAGAAAAGCTATT GCATCGGCAGCAAATCCTATCCTTTTATCAGCCCTATCTGGGGGCAGAGGTGACATATTCCCACCACACA GATGCAGTGGAGCTACTACTTCAGTAGGCAAAGTTTTCCCCCTATCAGTCTCATTATCCATGTCTTTGAT CTCAAGAACCTCAGAGGTAATCAATATGCTGACCGCTATCTCAGACGGCGTGTATGGCAAAACTTACTTG CTAGTGCCTGATGATATAGAAAGAGAGTTCGACACTCGAGAGATTCGAGTCTTTGAAATAGGGTTCATCA AAAGGTGGCTGAATGACATGCCATTACTCCAAACAACCAACTATATGGTACTCCCGAAGAATTCCAAAGC CAAGGTATGTACTATAGCAGTGGGTGAGTTGACACTGGCTTCCTTGTGTGTAGAAGAGAGCACTGTATTA TTATATCATGACAGCAGTGGTTCACAAGATGGTATTCTAGTAGTGACACTGGGGATATTTTGGGCAACAC CTATGGATCACATTGAGGAAGTGATACCTGTCGCTCACCCATCAATGAAGAAAATACATATAACAAACCA CCGTGGTTTTATAAAAGATTCAATTGCAACCTGGATGGTGCCTGCCCTGGCCTCTGAGAAACAAGAAGAA CAAAAAGGTTGTCTGGAGTCAGCTTGTCAAAGAAAAACCTACCCCATGTGCAACCAAGCGTCATGGGAAC CCTTCGGAGGAAGACAGTTGCCATCTTATGGGCGGTTGACATTACCTCTAGATGCAAGTGTTGACCTTCA ACTTAACATATCGTTCACATACGGTCCGGTTATACTGAATGGAGATGGTATGGATTATTATGAAAGCCCA CTTTTGAACTCCGGATGGCTTACCATTCCCCCCAAAGACGGAACAATCTCTGGATTGATAAACAAAGCAG GTAGAGGAGACCAGTTCACTGTACTCCCCCATGTGTTAACATTTGCGCCCAGGGAATCAAGTGGAAATTG TTATTTACCTATTCAAACATCTCAAATTAGAGATAGAGATGTCCTCATTGAGTCCAATATAGTGGTGTTG CCTACACAGAGTATTAGATATGTCATAGCAACGTATGACATATCACGAAGTGATCATGCTATTGTTTATT ATGTTTATGACCCAATCCGGACGATTTCTTATACGCACCCATTTAGACTAACTACCAAGGGTAGACCTGA TTTCCTAAGGATTGAATGTTTTGTGTGGGATGACAATTTGTGGTGTCACCAATTTTACAGATTCGAGGCT GACATCGCCAACTCTACAACCAGTGTTGAGAATTTAGTCCGTATAAGATTCTCATGTAACCGTTA
Protein Sequence	>NP_047206.1 haemagglutinin protein H [Canine morbillivirus] MLPYQDKVGAFYKDNARANSTKLSLVTEGHGGRRPPYLLFVLLILLVGILALLAITGVRFHQVSTSNMEF SRLLKEDMEKSEAVHHQVIDVLTPLFKIIGDEIGLRLPQKLNEIKQFILQKTNFFNPNREFDFRDLHWCI NPPSTVKVNFTNYCESIGIRKAIASAANPILLSALSGGRGDIFPPHRCSGATTSVGKVFPLSVSLSMSLI SRTSEVINMLTAISDGVYGKTYLLVPDDIEREFDTREIRVFEIGFIKRWLNDMPLLQTTNYMVLPKNSKA KVCTIAVGELTLASLCVEESTVLLYHDSSGSQDGILVVTLGIFWATPMDHIEEVIPVAHPSMKKIHITNH RGFIKDSIATWMVPALASEKQEEQKGCLESACQRKTYPMCNQASWEPFGGRQLPSYGRLTLPLDASVDLQ LNISFTYGPVILNGDGMDYYESPLLNSGWLTIPPKDGTISGLINKAGRGDQFTVLPHVLTFAPRESSGNC YLPIQTSQIRDRDVLIESNIVVLPTQSIRYVIATYDISRSDHAIVYYVYDPIRTISYTHPFRLTTKGRPD FLRIECFVWDDNLWCHQFYRFEADIANSTTSVENLVRIRFSCNR
Molecule Role	Protective antigen
Molecule Role Annotation	Young mink kits (n=8) were vaccinated with DNA plasmids encoding the viral haemagglutinin protein (H) of a vaccine strain of Canine distemper virus (CDV). The mink were protected against viraemia, lymphopenia, clinical disease and changes in the percentage of IFN-gamma producing peripheral blood leucocytes after challenge inoculation with a recent wild type strain of CDV. Essentially, these results demonstrate that early life DNA vaccination with the H gene of a CDV vaccine strain induced robust protective immunity against a recent wild type CDV (Jensen et al., 2009).
Related Vaccines(s)	ALVAC- CDV-H/F , Canine distemper virus DNA vaccine encoding F and HA , Canine distemper virus DNA vaccine encoding HA , NYVAC- CDV-H/F
References

CDVgp6 haemagglutinin protein H